Clinical trials: Gastrointestinal Reflux
GERD
Efficacy and Safety of Esomeprazole Once Daily for the Treatment of GERD in Neonatal Patients
The purpose of this study is to assess the difference between esomeprazole and placebo in the treatment of signs and symptoms as observed by 8-hour video and cardiorespiratory monitoring in neonatal patients.
- Trial name
- NCT00427635
- Testing
- Esomeprazole
- Where
- 3 sites in Australia, Germany and 1 more
- Volunteers
- 32 people
- Sponsor
- AstraZeneca
Gastrointestinal Subepithelial Tumors
The Prospective Study on the Effect of Ilaprazole in Non-erosive Reflux Disease Patients; Focused on Histologic Findings and Inflammatory Biomarker
Non-erosive reflux disease (NERD) patients used to be less responsive to proton pump inhibitor (PPI)s as compared with patients with erosive esophagitis.
- Trial name
- NCT02666976
- Testing
- Ilaprazole
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Yonsei University
Gastroesophageal Reflux Disease
Transoral Incisionless Fundoplication Database Repository (TIF)
Collect data on individuals who have a transoral incisionless fundoplication (TIF) performed by physicians at Indiana University for the treatment of gastroesophageal reflux disease.
- Trial name
- TIF (NCT04306380)
- Testing
- no intervention, database study
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Indiana University
GERD (Gastroesophageal Reflux Disease)
Endoscopic Injection of Autologous Fat-Derived Cells (SVF) for Adults With Refractory Gastroesophageal Reflux Disease (GERD). (The GERD-REVIVE Pilot Study)
The purpose of this pilot clinical study is to evaluate the feasibility and safety of an innovative endoscopic treatment for adults with gastroesophageal reflux disease (GERD) that does not respond adequately to standard…
- Trial name
- GERD-REVIVE (NCT07638423)
- Testing
- Autologous Stromal Vascular Fraction (SVF) Endoscopic Injection
- Volunteers
- 15 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Hiatal Hernia With Gastroesophageal Reflux Disease, Gastroesophageal Reflux
Complications, Outcomes and Revisions Following Hiatal Hernia Repair With MIROMESH
Investigator will identify a consecutive cohort of patients who have undergone a hiatal hernia repair and are at least 6 months post index procedure.
- Conditions
- Hiatal Hernia With Gastroesophageal Reflux Disease, Gastroesophageal Reflux, GERD
- Trial name
- NCT03735862
- Testing
- Hepatic derived surgical matrix
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Miromatrix Medical Inc.
Barrett's Esophagus, Gastroesophageal Reflux Disease
Progression of Gastroesophageal Reflux Disease and Barrett's Esophagus and the Creation of a Barrett's Registry
The purpose of this study is to determine or evaluate the risk factors such as smoking, family history etc. that cause esophageal cancer and to determine the genetic changes that lead to esophageal cancer.
- Conditions
- Barrett's Esophagus, Gastroesophageal Reflux Disease, Esophageal Adenocarcinoma
- Trial name
- NCT00574327
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Midwest Biomedical Research
Gastroesophageal Reflux
Pharmacogenetic Testing in Children With Persistent Gastroesophageal Reflux Disease
This study will use a 22 gene pharmacogenomics panel on 30 children with persistent Gastroesophageal Reflux Disease (GERD) who have not responded to therapy.
- Trial name
- NCT03005080
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Mayo Clinic
Pregnancy, Respiratory Aspiration of Gastric Contents
Gastric Emptying Following an Oral Carbohydrate Load in Women Admitted for Elective Cesarean Delivery
Because of the risk of pulmonary aspiration, patients are asked to comply with the fasting guidelines when they are scheduled for an elective cesarean section.
- Trial name
- NCT03593980
- Testing
- Cranberry juice
- Where
- Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Laryngopharyngeal Reflux
Comparison of Voice Therapy and Antireflex Therapy in LPR
This study will be a prospective, randomized, unblinded but controlled trial. Patients presenting to the Otolaryngology clinic who are diagnosed with laryngopharyngeal reflux disorder related dysphonia and meet inclusion criteria…
- Trial name
- NCT02530879
- Testing
- Omeprazole, Lansoprazole, Esomeprazole, Rantidine, Voice therapy, Combination of anti-reflux medication and voice therapy
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Temple University
Eosinophilic Esophagitis
Comparing Anesthetic Techniques in Children Having Esophagogastroduodenoscopies
The purpose of this research study is to compare the safety and effectiveness of three commonly used techniques for delivering anesthesia during a procedure known as esophagogastroduodenoscopy.
- Trial name
- NCT02038894
- Testing
- Intubated with Sevoflurane (IS), Intubated with Propofol (IP), Zofran - no intubation
- Where
- United States
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Scleroderma, Dysphagia
Functional Luminal Imaging Probe (FLIP) Topography Use in Patients With Scleroderma and Trouble Swallowing
FLIP topography has been FDA cleared to evaluate a variety of esophageal conditions, but has never been evaluated in patients with scleroderma.
- Conditions
- Scleroderma, Dysphagia, GERD - Gastro-Esophageal Reflux Disease
- Trial name
- NCT03270722
- Testing
- FLIP topography, Upper Endoscopy
- Where
- United States
- Sponsor
- Stanford University
Morbid Obesity, GERD
GERD After Sleeve Gastrectomy
The main adverse effect is gastroesophageal reflux disease (GERD), with concern on the development of Barrett's esophagus and esophageal adenocarcinoma in the long term. However, the relationship between SG and GERD is complex.
- Trial name
- NCT05178446
- Where
- Italy
- Volunteers
- 14,362 people, healthy volunteers welcome
- Sponsor
- University of Foggia
Gastro-esophageal Reflux Disease, Non-erosive Reflux Disease
Detection of Minimal Change Esophagitis by I-scan
Study design and objective The primary outcome of this prospective cohort study was to identify the endoscopic findings that have diagnostic value for the prediction of NERD (minimal change esophagitis) by using HD endoscopy with…
- Trial name
- NCT01560910
- Where
- Thailand
- Volunteers
- 48 people
- Sponsor
- arpa pungrasamee
Hepatocellular Carcinoma, Liver Cancer
Safety and Efficacy of DEB-TACE Performed With a Novel Reflux-control Microcatheter in Patients With HCC
BACKGROUND: Hepatocellular carcinoma is the fifth most frequent cancer in the world, with a diagnosis of more than 500,000 new cases per year.
- Trial name
- NCT04653701
- Testing
- Chemoembolization with preloaded microparticles 100 micron and reflux control microcatheter
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Juan José Ciampi Dopazo
Gastroparesis, GERD
Domperidone for Relief of Gastrointestinal Disorders
The purpose of this study is to make Domperidone available to patients with gastrointestinal disorders who have failed standard therapy and who might benefit from it.
- Conditions
- Gastroparesis, GERD, Esophagitis, Dyspepsia
- Trial name
- NCT00761254
- Testing
- Domperidone
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Carle Physician Group
Gastrointestinal Health
Viome Nutritional Programs to Improve Clinical Outcomes for Gastrointestinal Conditions
US residents who have gastrointestinal issues sign the informed consent form and are screened and enrolled for this study. Participants who are enrolled complete a survey upon enrollment and are randomized into one of three arms.
- Trial name
- NCT05465629
- Testing
- VIOME Precision Nutrition Program, VIOME-designed condition-based supplements
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Viome
Laryngopharyngeal Reflux, Gastro Esophageal Reflux
LPR Fluorescence Pilot
Comparing the fluorescence signatures from mouthwash samples of patients with laryngopharyngeal reflux (LPR) and healthy volunteers.
- Trial name
- NCT05204303
- Testing
- 24-hour pH-impedance monitoring, Symptom questionnaires, ROME IV Diagnostic Questionnaire
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The Functional Gut Clinic
Barrett Esophagus, Esophageal Adenocarcinoma
Endoscopic Radiofrequency Ablation Versus Hybrid Argon Plasma Coagulation in the Treatment of Barrett's Esophagus
This study compares patients' acceptability and safety of two established endoscopic methods for treating dysplastic Barrett's esophagus: radiofrequency ablation versus hybrid argon plasma coagulation.
- Conditions
- Barrett Esophagus, Esophageal Adenocarcinoma, Reflux Disease
- Trial name
- RATE (NCT05051475)
- Testing
- Endoscopic radiofrequency ablation, Endoscopic hybrid argon plasma coagulation
- Where
- Poland
- Volunteers
- 62 people
- Sponsor
- Centre of Postgraduate Medical Education
Barrett Esophagus, Gastroesophageal Reflux
Multi-Site Detection of Barrett's Esophagus in Patients Without Chronic GERD Symptoms
The goal of this clinical trial is to develop a method to detect Barrett's esophagus in individuals with a new office based diagnostic test.
- Conditions
- Barrett Esophagus, Gastroesophageal Reflux, Esophageal Adenocarcinoma
- Trial name
- NCT06687603
- Testing
- EsoCheck, EsoGuard
- Where
- 5 sites in United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Case Comprehensive Cancer Center
Gastroesophageal Reflux Disease (GERD)
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Efficacy Study Comparing 4 Weeks of Treatment With Esomeprazole 20 mg qd and 40 mg qd to Placebo qd in Patients With Heartburn and Sleep Disturbances Associated With Gastroesophageal Reflux Disease (GERD)
This study includes patients with sleep disturbances associated with gastroesophageal reflux disease (GERD) and has 3 treatment arms.
- Trial name
- NCT00628342
- Testing
- Esomeprazole
- Volunteers
- 600 people
- Sponsor
- AstraZeneca