Clinical trials: Gastrointestinal Reflux
Gastroesophageal Reflux Disease
Prevalence of Gastroesophageal Reflux Disease in Primary Care Patients With Upper Gastrointestinal Symptoms
The purpose of this study is to provide data on the gastroesophageal reflux disease (GERD) prevalence as percentage of patients with upper gastrointestinal (GI) symptoms that are identified with GERD using the Gerd-Q…
- Trial name
- NCT01020890
- Where
- 12 sites in Bulgaria
- Volunteers
- 2,210 people
- Sponsor
- AstraZeneca
Gastroesophageal Reflux Disease
A Study of Nexium (Esomeprazole) 40 mg Once Daily in Subjects With Symptoms of Gastroesophageal Reflux Disease (GORD) After Treatment With a Full Dose of Proton Pump Inhibitor (PPI)
The purpose of this study is to assess how patients with gastro-oesophageal reflux disease (heartburn) who are currently receiving treatment with a proton pump inhibitor but are still experiencing symptoms will benefit from a…
- Trial name
- NEON (NCT00734097)
- Testing
- Esomeprazole 40 mg, Physical Exam, Quality of Life Questionnaires
- Where
- 10 sites in Argentina, Chile and 2 more
- Volunteers
- 314 people
- Sponsor
- AstraZeneca
GERD, Cough
Ablation of Esophageal Inlet Patches in Patients Referred for Bravo pH-Testing
Patients with suspected extra-esophageal manifestations of gastro-esophageal reflux disease (GERD), such as cough, hoarseness, and globus, are often referred for pH testing.
- Conditions
- GERD, Cough, Metaplasia
- Trial name
- NCT05131932
- Testing
- Endoscopic ablation of inlet patch
- Volunteers
- 100 people
- Sponsor
- Assaf-Harofeh Medical Center
GERD
Twenty-Four Hour Combined Multi-Channel Impedance and pH Ambulatory Monitoring: Impedance Reflux Episodes of Patients On and Off Proton Pump Inhibitor Therapy
The purpose of this study is to determine the effects of proton pump inhibitors (PPIs) on the total number of reflux episodes in the distal esophagus measured by impedance in patients with and without gastroesophageal reflux…
- Trial name
- NCT01710800
- Testing
- Esomeprazole
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Gastroesophageal Reflux Disease, Apnea Infants
Gastroesophageal Reflux and Cardiorespiratory Problems
Cardiorespiratory and gastroesophageal reflux events often coexist in infants in Neonatal Intensive Care Unit (NICU) thus leading to drugs over-prescription and delayed discharge.
- Conditions
- Gastroesophageal Reflux Disease, Apnea Infants, Desaturation of Blood, Bradycardia
- Trial name
- CR-GER (NCT03053609)
- Where
- Italy
- Volunteers
- 72 people
- Sponsor
- University of Turin, Italy
Barrett Esophagus, Gastroesophageal Reflux
Novel Imaging Techniques in Barrett's Esophagus
Primary Aim: In patients with endoscopically suspected BE, compared to standard endoscopy, novel techniques (NBI and AFI) with target biopsies will Detect more patients with intestinal metaplasia Detect more areas of high grade…
- Trial name
- NCT00576498
- Testing
- NBI-AFI imaging, Standard Endoscopy
- Where
- 3 sites in United States, Netherlands
- Volunteers
- 130 people
- Sponsor
- Midwest Biomedical Research
Gastro-Esophageal Reflux, Fundoplication
Health, Economic Analysis and Clinical Aspects of Patients With Neurological Disabilities in Enteral Nutrition With Dedicated Formula. The Role of Nissen's Fundoplication in the Management of Gastroesophageal Reflux
Nutritional difficulties are common in children with neurodisabilities and can be associated with malnutrition and gastrointestinal diseases, such as gastro-esophageal reflux disease (GERD) and constipation.
- Trial name
- NCT05068089
- Testing
- Nissen fundoplication, Enteral nutrition
- Where
- Italy
- Volunteers
- 360 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Gastroesophageal Reflux Disease (GERD)
The Effect of Dexrabeprazole on Intragastric and Intraesophageal Acidity
It is planned to investigate the effect of dexrabeprazole on gastric acid primarily, and then gastroesophageal reflux disease (GERD) symptoms, intraesophageal acidity (reflux) and impedance kinetics.
- Trial name
- NCT02689999
- Testing
- Dexrabeprazole 10 mg Enteric-Coated Tablets
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 12 people
- Sponsor
- Neutec Ar-Ge San ve Tic A.Ş
Gastroesophageal Reflux Disease (GERD)
Endoscopic Cardial Constriction Ligation (ECCL) for Refractory GERD Using a Disposable Endoscope
This study will recruit patients aged 18-80 with refractory gastroesophageal reflux disease (GERD). These patients had a disease course of more than six months, experienced typical symptoms such as acid reflux and heartburn, and…
- Trial name
- ECCL (NCT07176221)
- Testing
- endoscopic cardia constriction ligation
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Ying Zhu
GERD, Bariatric Surgery
Endoscopic Cardiac Band Ligation for the Management of Refractory GERD After Laparoscopic Sleeve Gastrectomy
GERD is a prevalent condition worldwide, estimated to be around 20-30 % in North America. Obesity is rapidly increasing with an estimated prevalence of 66% in the adult population in the United States.
- Conditions
- GERD, Bariatric Surgery, Laparoscopic Sleeve Gastrectomy
- Trial name
- CLEAR (NCT04771247)
- Testing
- Cardia Band Ligation
- Sponsor
- Johns Hopkins University
Gastroesophageal Reflux
A Study of Dexlansoprazole Modified Release Formulation to Treat Night Heartburn
The purpose of this study is to determine whether Dexlansoprazole once daily (QD) is effective in treating patients with night heartburn.
- Trial name
- NCT00627016
- Testing
- Dexlansoprazole
- Where
- 43 sites in United States
- Volunteers
- 305 people
- Sponsor
- Takeda
Gastroesophageal Reflux, Esophageal Motility Disorders
High Resolution Manometry After Partial Fundoplication for Gastro-oesophageal Reflux
This is a combined retro- and prospective, monocentric study. All patients who underwent or are planned for laparoscopic partial fundoplication (180° anterior or 270° posterior) between 2020-2023 are assessed for preoperative…
- Conditions
- Gastroesophageal Reflux, Esophageal Motility Disorders, Upper Gastrointestinal Disorder
- Trial name
- NCT05132816
- Testing
- high-resolution manometry
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Prof Urs Zingg
Gastroesophageal Reflux Disease With Esophagitis
PPI Dosing Per CYP2C19 Genotype
This study is being done to determine if the dosing of proton pump inhibitor (PPI) medication based on CYP2C19 genotype-derived phenotype leads to improved healing of erosive esophagitis compared to conventional PPI medication…
- Trial name
- NCT07843264
- Testing
- CYP2C19 based dosing Proton Pump Inhibitors, Conventional proton pump inhibitor dose
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Florida
GERD
Endomina Suturing Device as a Treatment of GERD.
Gastroesophageal Reflux Disease (GERD) is a common problem affecting 10-20% of the population in the Western World. Surgical therapy is able to restore the EGJ barrier function against reflux of the gastric content, decreases…
- Trial name
- NCT03999502
- Testing
- Endomina
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- Erasme University Hospital
Pulmonary Aspiration of Gastric Contents
Comparison of Different Preoperative Fasting Times in Pediatric Patients Undergoing Elective General Anaesthesia
Rationale of this study is to provide an evidence on minimal safe clear fluid fasting duration without the risk of aspiration of gastric contents during elective pediatric procedures under general anesthesia.
- Trial name
- NCT05922072
- Testing
- Nasogastric aspiration for measurement of Residual Gastric Volume, Nasogastric Aspiration for Measurement of Gastric pH
- Where
- Pakistan
- Volunteers
- 120 people
- Sponsor
- King Edward Medical University
Gastroesophageal Reflux, Functional Dysphonia
Assessment on Effects of Tongjiang Granule in Treating Nonerosive Reflux Disease Overlapping Epigastric Pain Syndrome
Overlapping gastrointestinal symptoms of functional gastrointestinal diseases (FGIDs) is an internationally recognized problem in modern medical diagnosis and treatment.
- Trial name
- NCT05312463
- Testing
- Tongjiang granule, Tongjiang granule simulant
- Where
- China
- Volunteers
- 228 people
- Sponsor
- Xiyuan Hospital of China Academy of Chinese Medical Sciences
Larynx Disease, Gastroesophageal Reflux
Do Laryngeal Tissue Changes in Patients Suspected of Having Laryngopharyngeal Reflux Predict Response to Treatment?
The purpose of the study is to determine if tissue changes are predictor of clinical response to therapy. The hypothesis is that the patients who have laryngeal signs and symptoms related to acid reflux, will have ultrastructural…
- Trial name
- NCT00444145
- Testing
- Prevacid, Esophageal and Laryngeal Biopsies
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Vanderbilt University Medical Center
Irritable Bowel Syndrome, Healthy Subjects
Application of Diaphragmatic Breathing in Patients With Disorders of Gut-brain Interaction
Patients with disorders of gut-brain interaction (DGBI) often present gastrointestinal symptoms that do not show noticeable irregularities in standard examinations.
- Conditions
- Irritable Bowel Syndrome, Healthy Subjects, Functional Gastrointestinal Disorders, Laryngopharyngeal Reflux
- Trial name
- NCT06205446
- Testing
- Healthy subjects : abdominal breathing, Laryngopharyngeal reflux disease subjects : abdominal breathing, Dyspepsia subjects : abdominal breathing
- Where
- Taiwan
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Buddhist Tzu Chi General Hospital
Gastroesophageal Reflux Disease
SThe Effects of Melatonin on GERD Symptoms
We hypothesize that melatonin as compared to PPI and to placebo, improves GERD symptoms by decreasing esophageal acid exposure and esophageal acid sensitivity in GERD.
- Trial name
- NCT00564590
- Testing
- Melatonin, omeprazole
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Rabin Medical Center
Gastroesophageal Reflux
Implementation of PPI Medication PGX Testing
Using genetic information about the individual to pick the right drug for the right disease at the right dose defines personalized medicine.
- Trial name
- PGX (NCT02794844)
- Testing
- Genotype Guided PPI Dosing
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Nemours Children's Clinic
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