Clinical trials: Gastrointestinal Tract
Acute Cholecystitis
One-year Outcomes by Index Treatment in Elderly Patients With Acute Cholecystitis
Background: The GOLDENEYE study is an international, multicenter, prospective observational investigation designed to compare the outcomes of various management strategies for acute cholecystitis in patients aged 70 years and…
- Trial name
- GOLDENEYE (NCT07006298)
- Where
- Spain
- Volunteers
- 376 people
- Sponsor
- Instituto de Investigación Sanitaria y Biomédica de Alicante
Coronary Disease
Bile Acids and Gut Microbiota as Potent Coronary Atheroma Risk Factors: a Prospective Study in Human
The purpose of this study is to describe the composition of bile acids and the gut microbiota comparing two populations: patients with coronary atheroma and the healthy subjects.
- Trial name
- MABAC (NCT02375893)
- Testing
- No intervention, Healthy subject
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hemodialysis, Sarcopenia
Innovative Functional Food Based on Apulian Lens Culinaris for Contrasting Sarcopenia in Dialysis Patients
The objective of the pilot study is to validate the clinical use of a dietary supplement for contrasting sarcopenia in dialysis patients.
- Trial name
- ALTIS (NCT04223206)
- Testing
- NATURLENS
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
ER+, HER 2- Breast Cancer, Non-small Cell Lung Cancer (NSCLC)
A Study to Investigate the Safety, Pharmacokinetics, and Preliminary Efficacy of IDE574 Therapy in Adult Participants With Advanced Solid Tumors
IDE574 is a synthetically manufactured small molecule inhibitor that co-targets the lysine acetyltransferase enzymes KAT6 and KAT7.
- Conditions
- ER+, HER 2- Breast Cancer, Non-small Cell Lung Cancer (NSCLC), Castration-resistant Prostate Cancer (CRPC), Microsatellite Stable (MSS) Colorectal Carcinoma
- Trial name
- NCT07540572
- Testing
- IDE574, Fulvestrant injection
- Where
- 11 sites in United States
- Volunteers
- 160 people
- Sponsor
- IDEAYA Biosciences
Lung; Disease, Cystic Fibrosis
Orkambi Exercise Study
Shortness of breath (dyspnea) during exercise is a major source of distress and is a commonly reported symptom in patients with cystic fibrosis (CF).
- Trial name
- Orkambi (NCT02821130)
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- University of British Columbia
Pruritus, Primary Biliary Cholangitis
TH104 for the Treatment of Pruritus in Primary Biliary Cholangitis
A phase 2a, multicenter, randomized, double-blind, placebo-controlled study of TH104 in primary biliary cholangitis (PBC) participants with moderate to severe pruritus.
- Trial name
- NCT06733519
- Testing
- Nalmefene
- Volunteers
- 40 people
- Sponsor
- Tharimmune Inc
Lower Gastrointestinal Bleeding, Diverticular Bleeding
Clinical Trial to Evaluate the Efficacy and Safety of Nexpowder™ for Diverticular Bleeding in the Lower Gastrointestinal Tract
Clinical Trial to Evaluate the Efficacy and Safety of Nexpowder™ for Diverticular Bleeding in the Lower Gastrointestinal Tract
- Trial name
- NCT06939907
- Testing
- Nexpowder™
- Where
- 6 sites in South Korea
- Volunteers
- 60 people
- Sponsor
- Next Biomedical Co., Ltd.
Colorectal Cancer, Pancreatic Adenocarcinoma
Circulating Tumor DNA Exposure in Peripheral Blood
This is a prospective, multi-center, blinded feasibility study. The objective of this study is to test the feasibility of the detection of tumor DNA of a variety of tumors in peripheral blood using a novel process for the…
- Conditions
- Colorectal Cancer, Pancreatic Adenocarcinoma, Gastric Cancer, Hepatocellular Carcinoma
- Trial name
- NCT03517332
- Where
- 6 sites in United States, Switzerland
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Quantgene Inc.
Cholestasis
Compassionate Use of Omegaven
This expanded access protocol is for infants or children with conditions preventing them from taking in enough nutrients from food and must receive nutrition intravenously.
- Trial name
- NCT02778698
- Testing
- Omegaven
- Sponsor
- Geisinger Clinic
Monoclonal Gammopathy of Undetermined Significance (MGUS), Intestinal Flora
Characteristics and Clinical Significance of Gut Microbiota in Patients With Monoclonal Gammopathy
This is an observational case-control study, aiming to systematically analyze the gut microbiome characteristics of patients with monoclonal gammopathy of undetermined significance (MGUS).
- Conditions
- Monoclonal Gammopathy of Undetermined Significance (MGUS), Intestinal Flora, Multiple Myeloma, M-Protein
- Trial name
- NCT06690593
- Where
- China
- Volunteers
- 2,990 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Biliary Tract Disease, Bile Duct Obstruction
Endo-biliary Laser Excision of Biliary Stenoses
The biliary system normally empties into the intestines, however, some patients have biliary system narrow areas ("stenosis") that prevent the bile to drain normally.
- Trial name
- NCT02118493
- Testing
- Benign Biliary Stenosis, Laser
- Sponsor
- University of Florida
Healthy
The Effects of the Bile Acid Supplement, 7-keto Lithocholic Acid, on Human Gut Microbiota and Risk Factors for Disease.
In humans and most mammals, bile acids play a role in the metabolism of glucose and the transport and absorption of lipids (such as cholesterol and triglycerides), vitamins, and nutrients by allowing for emulsification (mixing)…
- Trial name
- BioMet-7 (NCT07499414)
- Testing
- 7-KLCA, Maltodextrin
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Reading
Biliary Tract Cancer
The Efficacy and Safety of Nab-paclitaxel Plus S-1 in First-line Treatment of Advanced Biliary Tract Adenocarcinoma
Advanced biliary tract adenocarcinoma has a poor prognosis with limited therapeutic options. Nab-paclitaxel plus S-1 chemotherapy will be given to untreated patients with advanced biliary tract adenocarcinoma for the first-line…
- Trial name
- NCT03830606
- Testing
- Nab-paclitaxel,S-1
- Where
- China
- Volunteers
- 54 people
- Sponsor
- Aiping Zhou
Obsessive-Compulsive Disorder, Tic Disorder
Pathogenesis of Pediatric Obsessive-compulsive Disorder: Based on the Microbiota-gut-brain Axis
This study aims to investigate the characteristics of the microbiota-gut-brain axis in pediatric patients with obsessive-compulsive disorder (OCD) through performing an integrated analysis of gut microbiota, serum metabolomics…
- Trial name
- NCT06754319
- Where
- China
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Gut-Brain Disorders, GERD Without Erosive Esophagitis
Cognitive-behavioral Therapy for the Diseases Associated With Esophageal-brain-gut Axis Communication Abnormalities.
Gastroesophageal reflux disease (GERD) is a challenging gastrointestinal disorder, and proton pump inhibitors (PPIs) are typically the first line of treatment.
- Trial name
- NCT06939465
- Testing
- Cognitive Behavioral Therapy (CBT)
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Hualien Tzu Chi General Hospital
Bacterial Infections, Virus Diseases
Safety, Tolerability, and Immunogenicity of V419 Given Concomitantly With Prevnar 13™ and RotaTeq™ (V419-005)
This is a study to assess the safety, tolerability, and immunogenicity of V419 (PR5I) when administered as an infant series at 2, 4, and 6 months of age followed by a toddler dose of DAPTACEL™, Prevnar 13™ and PedvaxHIB™ at 15…
- Trial name
- NCT01337167
- Testing
- V419, DAPTACEL™, PedvaxHIB™
- Volunteers
- 1,473 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Extrahepatic Cholangiocarcinoma
Repeated Endobiliary Radiofrequency Ablation Plus Durvalumab, Gemcitabine, and Cisplatin for Unresectable Extrahepatic Cholangiocarcinoma
This international, multicenter, open-label randomized controlled trial evaluates whether repeated endobiliary radiofrequency ablation (EB-RFA) improves overall survival in patients with unresectable extrahepatic…
- Trial name
- BRAVE (NCT07235007)
- Testing
- Endobiliary Radiofrequency Ablation (EB-RFA), Plastic Biliary Stent
- Where
- 8 sites in Japan, South Korea
- Volunteers
- 120 people
- Sponsor
- Aichi Medical University
Cystic Fibrosis
Prospective Analysis of Urine LAM to Eliminate NTM Sputum Screening
This is a prospective, single-center, nonrandomized observational study to investigate the utility of urine lipoarabinomannan (LAM) as a test to identify individuals at very low risk for having a sputum culture positive for…
- Trial name
- PAINLESS (NCT04579211)
- Testing
- urine lipoarabinomannan (LAM)
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Jerry A. Nick, M.D.
Low Mood
Effect of a Nutritional Supplement on Mental Wellness in Adults
Trillions of microbes reside in human gut and constitute "gut microbiota". Composition of these microbes and substances produced by them play an important role in human health and wellness.
- Trial name
- NCT06058364
- Testing
- Intervention 1 - Triglyceride
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Pharmavite LLC
Leaky Gut Syndrome
Effect of Colostrum on Gut Permeability and Endotoxin Level in Chronic Alcoholic Disease
Chronic alcohol ingestion is related with leaky gut syndrome. Colostrum is well-studied that it has a effect of decreasing the degree of leaky gut syndrome.
- Trial name
- NCT01088087
- Testing
- colostrum
- Where
- South Korea
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Gangnam Severance Hospital
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