Clinical trials: Gastrointestinal Transit Time
Magnetic Marker Monitoring, Gastrointestinal-transport
Magnetic Marker Monitoring (MMM) Study With Gel Matrix Tablets Under Fasting and Fed Conditions
The purpose of this study is to monitor the gastrointestinal transport of eroding gel matrix placebo tablets in healthy male volunteers under fasting and fed conditions. The method which is used is an imaging technique.
- Conditions
- Magnetic Marker Monitoring, Gastrointestinal-transport, Gastric Emptying Time, Small Intestinal Transit Time
- Trial name
- MMM (NCT01224587)
- Testing
- D1000078, D1000082, D1000083
- Where
- Germany
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Cystic Fibrosis, Gastrointestinal Dysfunction
Understanding Gut Symptoms in People With Cystic Fibrosis
Although chest infections affect wellbeing and survival in cystic fibrosis (CF), most people with CF also have difficulty digesting food and must take medication for this.
- Trial name
- GRAMPUS-CF SRC (NCT05934656)
- Testing
- Latent class analysis
- Where
- United Kingdom
- Volunteers
- 350 people
- Sponsor
- University of Nottingham
Gastrointestinal Motility, Total Gastrointestinal Transit Time
Gastrointestinal Transit Times and Motility in Healthy Volunteers Obtained by Motilis-3D-transit
The purpose of this study is to describe gastrointestinal motility and transit times in healthy subjects by using Motilis 3D-Transit and to compare the total gastrointestinal transit time (GITT) to GITT obtained using radioopaque…
- Conditions
- Gastrointestinal Motility, Total Gastrointestinal Transit Time, Segmental Transit Time, Gastric Emptying
- Trial name
- NCT01635491
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Intestinal Obstruction
Effects of Methylnaltrexone in Comparison to Naloxone on Loperamide-induced Delay of the Oro-cecal, Whole-gut and Colon Transit Time.
The purpose of this study is to describe the effects of repeated-dose methylnaltrexone in preventing loperamide-induced delay of whole-gut, oro-cecal and colon transit time and to measure pharmacokinetics of methylnaltrexone and…
- Trial name
- NCT01596764
- Testing
- Loperamide, Colon Transit, Sulfasalazine
- Where
- Germany
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Ulcerative Colitis
Gastrointestinal Motility in Severe Ulcerative Colitis Obtained by Motilis-3D-transit
The purpose of this study is to describe gastrointestinal (GI) motility in patients suffering from severe Ulcerative Colitis (UC) and to compare these results with similar results obtained in remission.
- Trial name
- NCT01745029
- Testing
- Motilis-3D-transit
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- University of Aarhus
Mitochondrial Diseases
Low Residue Diet Study in Mitochondrial Disease
Slow movement of patients guts is referred to as intestinal dysmotility, and is increasingly recognised as a debilitating manifestation of mitochondrial disease both in adults and children.
- Trial name
- LRD (NCT03388528)
- Testing
- Low Residue Diet Intervention
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- Newcastle University
Chronic Spinal Cord Injury
Abdominal Electrical Stimulation for Bowel Dysfunction in SCI
Many people with spinal cord injury (SCI) have bowel problems resulting in constipation and need a long time to empty the bowel. Some people spend an hour or more to empty their bowel.
- Trial name
- NCT06948175
- Testing
- Abdominal transcutaneous electrical stimulation (TES)
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University of Alberta
Functional Constipation
Dose-ranging Efficacy of Polydextrose Supplement on Colonic Transit Time and Symptoms in Adults With Functional Constipation
This study will investigate the effectiveness of Polydextrose, a dietary fiber, at decreasing Colonic Transit Time and the gastrointestinal symptoms of Functional Constipation.
- Trial name
- NCT02314936
- Testing
- Litesse powder containing 12 g polydextrose, Litesse powder containing 8 g polydextrose, Litesse powder containing 4 g polydextrose
- Where
- Canada
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- KGK Science Inc.
Colo-rectal Cancer
Motility of the Check-cap's MD1 Colon Capsule in Subjects Following Colon Rectal Cancer Screening by Colonoscopy
To monitor the Whole Gut Transit Time and repeatability of the motility of MD1 capsules in the colon of subjects with known polyps and in healthy subjects. Multi-Center, Open, Home Monitoring, Prospective Study.
- Trial name
- NCT03785665
- Testing
- MDI
- Where
- Israel
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Check-Cap Ltd.
Gastrointestinal Dysfunction, Physiological Stress
Impact of Yogurt on Gastrointestinal Health, Regularity, and Thoughts
This study aims to test the central hypothesis that adding to the diet daily yogurt provides beneficial effects on digestive health and subjective mood in healthy adults.
- Conditions
- Gastrointestinal Dysfunction, Physiological Stress, Cognition - Other
- Trial name
- IYOGHRT (NCT04901390)
- Testing
- Yogurt with B. lactis and added cane sugar
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Intestinal Obstruction
Effects of 500 mg Immediate Release and Extended Release Methylnaltrexone on Loperamide-induced Delay of the Oro-cecal and Whole-gut Transit Time in Healthy Subjects
The purpose of this study is to describe the effects of methylnaltrexone in preventing loperamide-induced delay of the oro-cecal and whole-gut transit time and measure pharmacokinetics of methylnaltrexone after subcutaneous and…
- Trial name
- LOP-MNTX-2009 (NCT01596777)
- Testing
- Loperamide, Methylnaltrexone 12 mg sc., Methylnaltrexone IR capsule
- Where
- Germany
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Constipation
Probiotics and Gut Health
Gastrointestinal discomfort regularly affects >25% of the population worldwide. One of the major contributors to Gastrointestinal discomfort is constipation, which has a prevalence of ~15%, and symptoms of which have a…
- Trial name
- NCT01874301
- Testing
- High quantity probiotic, Low quantity probiotic
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- Société des Produits Nestlé (SPN)
Functional Constipation
Multistrain Probiotic for Functional Constipation
Subjects will be screened and will enter a placebo-only 2-week run-in period during which constipation symptoms will be evaluated and any disallowed products (e.g. probiotics) must be discontinued.
- Trial name
- NCT01618617
- Testing
- High dose Multistrain probiotic, 100 billion cfu/day, Low dose Multistrain probiotic, 15 billion cfu/day
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Renew Life Formulas Inc
Intestinal Diseases
Squatting on the Toilet and Capsule Endoscopy
This study evaluates the effect of squatting on the toilet on gastric transit time and complete examination rate of capsule endoscopy.In the observation group, the patients could go to squatting on the toilet at any time as they…
- Trial name
- SC (NCT04340089)
- Testing
- squatting on the toilet
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Irritable Bowel Syndrome
A Phase I, Randomized, Placebo-controlled, Double Blind, Repeat Dose Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Gastrointestinal Transit Time and Pharmacodynamic Biomarkers of GSK3179106 in Normal Subjects
The current study is designed to assess the safety, tolerability, pharmacokinetics (PK), gastrointestinal (GI) transit time and pharmacodynamic (PD) biomarkers of repeat oral doses of GSK3179106 administered for 14 days in normal…
- Trial name
- NCT02798991
- Testing
- GSK3179106
- Where
- Australia
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Gastrointestinal Motility
Clinical Evaluation Gastrointestinal Motility With PillCam
The purpose of this study is to evaluate the clinical usefulness of a video camera pill (PillCam) in assessing intestinal function in the small intestines of patients.
- Trial name
- NCT01158989
- Testing
- PillCam
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Louisville
Postoperative Ileus
Postoperative Ileus: Duration and Severity Assessment With the SmartPill®
Postoperative ileus (POI) is a frequent complication after abdominal surgery leading to nausea, vomiting and infectious complications.
- Trial name
- PIDuSA (NCT02329912)
- Testing
- SmartPill
- Where
- Germany
- Volunteers
- 55 people
- Sponsor
- University Hospital, Bonn
Gastrointestinal Motility
Evaluation of Gastrointestinal Motility With SmartPill
The purpose of this study is to evaluate the clinical usefulness of a capsule (SmartPill~) measuring pH, pressure and temperature from within the entire GI tract to determine gastric emptying time, combined small and large bowel…
- Trial name
- NCT01159002
- Testing
- SmartPill
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Louisville
Healthy
Efficacy of Pea Hull Fibre Supplementation
The purpose of this randomized, cross-over study is to explore the effects of pea hull fiber on bowel movement frequency, transit time, appetite, gastrointestinal symptoms, microbiota composition and activity.
- Trial name
- NCT02778230
- Testing
- Pea Fiber, Control
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Florida
Healthy
Evaluation of Bacillus Subtilis R0179 in Healthy Young Adults
The purpose of this study is to evaluate the effect of three doses of the probiotic B. subtilis (Bacillus subtilis R0179) delivered in capsules on gastrointestinal and general wellness in healthy young adults, survival through…
- Trial name
- NCT01802151
- Testing
- B. subtilis R0179
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- University of Florida