Clinical trials: Gastrointestinal Tumor Surgery
Colorectal Cancer
Capecitabine, Cetuximab, Oxaliplatin, and Bevacizumab in Treating Patients With Metastatic or Recurrent Colorectal Cancer That Cannot Be Removed By Surgery
RATIONALE: Drugs used in chemotherapy, such as capecitabine and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00290615
- Testing
- bevacizumab, cetuximab, capecitabine
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Herbert Hurwitz
Gastric Cancer, Surgery
Indocyanine Green Tracer Using in Laparoscopic Radical Gastrectomy for Locally Advanced Gastric Cancer
Patients with locally advanced gastric adenocarcinoma (CT2-4a N0/+ M0) were selected as study subjects to investigate the safety, efficacy, and feasibility of ICG near-infrared imaging tracing in guiding laparoscopic D2 lymph…
- Trial name
- CLASS-11 (NCT04593615)
- Testing
- ICG near-infrared imaging
- Where
- China
- Volunteers
- 1,070 people
- Sponsor
- Fujian Medical University
Esophageal Cancer
Modular Robot-Assisted Versus Conventional Minimally Invasive Esophagectomy for Esophageal Cancer
This study evaluates the safety, efficacy, and health economic outcomes of modular robotic-assisted minimally invasive esophagectomy (RAMIE) compared with conventional thoracoscopic minimally invasive esophagectomy (MIE) in…
- Trial name
- mRAMIE2026 (NCT07888140)
- Testing
- Modular Robot-Assisted Esophagectomy, Conventional Minimally Invasive Esophagectomy
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Ruijin Hospital
Rectal Mucinous Adenocarcinoma, Rectal Signet Ring Cell Adenocarcinoma
Radiation Therapy and Capecitabine With or Without Curcumin Before Surgery in Treating Patients With Rectal Cancer
This randomized phase II trial studies how well radiation therapy and capecitabine with or without curcumin before surgery works in treating patients with rectal cancer.
- Conditions
- Rectal Mucinous Adenocarcinoma, Rectal Signet Ring Cell Adenocarcinoma, Recurrent Rectal Carcinoma, Stage IIA Rectal Cancer AJCC v7
- Trial name
- NCT00745134
- Testing
- Capecitabine, Curcumin, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- M.D. Anderson Cancer Center
Esophageal Cancer, Gastric Cancer
Fluorescence Image Guided Foregut Surgery
A high number of resected lymph nodes is an independent prognostic factor for improved survival after esophagectomy or gastrectomy for cancer.
- Trial name
- FOREGUT (NCT04734821)
- Testing
- Near Infra-Red Fluorescence Guided Surgery
- Where
- France
- Volunteers
- 60 people
- Sponsor
- IHU Strasbourg
Stomach Neoplasm
Cytoreductive Surgery Combined With HIPEC and Chemotherapy for Gastric Cancer With Peritoneal Metastasis
This study evaluates the survival benefit and safety of cytoreductive surgery(CRS) combined with HIPEC and chemotherapy in gastric cancer with peritoneal metastasis.
- Trial name
- NCT03023436
- Testing
- Cytoreductive surgery, Hyperthermic Intraperitoneal Chemotherapy, Fluoropyrimidine
- Where
- 13 sites in China
- Volunteers
- 220 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Gastric Cancer
Standardization of D2 Lymphadenectomy and Surgical Quality Control: KLASS-02-QC
Gastric cancer is one of the most common cancers in Korea. Having achieved excellent long-term survival for early gastric cancer patients, there is a growing interest in improving the quality of life of these patients without…
- Trial name
- NCT01283893
- Testing
- Laparoscopic distal gastrectomy with D2 lymphadenectomy
- Where
- South Korea
- Volunteers
- 160 people
- Sponsor
- Yonsei University
Liver Neoplasms, Postoperative Analgesia
Ultrasound-guided Continuous Low Serratus Anterior Plane Block in Hepatocellular Carcinoma Surgery
To investigate the clinical application of ultrasound-guided continuous low serratus anterior plane block in open surgery for hepatocellular carcinoma.
- Conditions
- Liver Neoplasms, Postoperative Analgesia, Serratus Anterior Plane Block
- Trial name
- RCT (NCT05531864)
- Testing
- Ultrasound-guided continuous low serratus anterior plane block, Ultrasound-guided single serratus anterior plane block
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Liu Di
Gastric Cancer
Escorting Octogenarian for Gastric Cancer Surgery
An objective analysis of postoperative complications is vital to escort octogenarian for gastric cancer surgery. Investigator carefully collected clinical data prospectively to pave way for standard management in high risk…
- Trial name
- NCT03639792
- Testing
- gastric cancer surgery
- Where
- China
- Volunteers
- 61 people
- Sponsor
- Ruijin Hospital
Colon Cancer, Primary Tumour
The Role of Surgery of the Primary Tumour in Patients With Synchronous Unresectable Metastases of Colorectal Cancer
The clinical benefit of resection of the primary tumour in patients with synchronous unresectable metastases is not known. In the literature studies usually describe retrospective selected patients with synchronous metastases…
- Conditions
- Colon Cancer, Primary Tumour, Rectal Cancer
- Trial name
- CAIRO4 (NCT01606098)
- Testing
- Surgery of the primary tumour, Systemic treatment
- Where
- 46 sites in Denmark, Netherlands
- Volunteers
- 206 people
- Sponsor
- Dutch Colorectal Cancer Group
Stomach Cancer, Pancreatobiliary Cancer
Effects of Red Ginseng on Gastrointestinal Symptoms and Microbiota After Surgery for Gastrointestinal Cancer
After surgery for gastrointestinal cancer (stomach cancer, pancreaticobiliary cancer, colorectal cancer), many patients experiences various symptoms such as weight loss, diarrhea, constipation and excessive gas due to structural…
- Conditions
- Stomach Cancer, Pancreatobiliary Cancer, Colorectal Cancer
- Trial name
- NCT06561516
- Testing
- Arm I (Red ginseng)
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Gangnam Severance Hospital
Colon Cancer, Pancreatic Cancer
Negative Pressure Therapy in Preventing Infection After Surgery in Patients With Colon, Rectal, Pancreatic, or Peritoneal Surface Cancer
The purpose of this research study is to evaluate if a negative-pressure dressing placed over a surgical incision can reduce the risk of developing a surgical site infection compared to a commonly-used sterile gauze incision…
- Conditions
- Colon Cancer, Pancreatic Cancer, Perioperative/Postoperative Complications, Primary Peritoneal Cavity Cancer
- Trial name
- NCT01656044
- Testing
- wound care management
- Where
- United States
- Volunteers
- 375 people
- Sponsor
- Wake Forest University Health Sciences
Esophageal Cancer
Oxaliplatin, Capecitabine, and Radiation Therapy in Patients Undergoing Surgery for Stage II, III, IV Esophageal Cancer
RATIONALE: Drugs used in chemotherapy, such as oxaliplatin and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00470184
- Testing
- capecitabine, oxaliplatin, gene expression analysis
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Roswell Park Cancer Institute
Surgical Resection, HCC
The Efficacy of Hepatectomy or TILA-TACE in Patients With Resectable Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is one of the most common cancers in the world with major occurrences in eastern Asian countries such as China. HCC is the third leading cause of cancer-related deaths in the world.
- Trial name
- NCT03314532
- Testing
- TILA-TACE
- Where
- China
- Volunteers
- 230 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Rectal Cancer, Anastomotic Leak
Efficacy and Safety of LifeSeal™ Kit for Colorectal Staple Line Sealing
LifeSeal™ Kit, surgical sealant designed for staple-line reinforcement that is applied over the anastomotic line to prevent bowel content leakage until full physiological function is restored.
- Trial name
- NCT02907385
- Testing
- LifeSeal™ Kit
- Where
- 39 sites in United States, Belgium and 5 more
- Volunteers
- 736 people
- Sponsor
- LifeBond Ltd.
Sarcopenia, Colon Cancer
Preoperative Sarcopenia and Surgical Outcomes in Colorectal Cancer Patients
Colorectal cancer is the third most common malignant neoplasm worldwide and the fourth leading cause of cancer-related deaths. Muscle mass loss in oncology patients is most often the result of cancer-related malnutrition.
- Conditions
- Sarcopenia, Colon Cancer, Rectal Cancer, Surgical Outcomes
- Trial name
- NCT06698289
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Mersin University
Esophageal Squamous Cell Carcinoma, Esophagectomy
Surgery Versus Non-surgical Treatment for Esophageal Squamous Cell Carcinoma in Patients Older Than 70 Years
To determine whether older patients who underwent esophagectomy had better outcome survival than those who were non-surgically treated.
- Conditions
- Esophageal Squamous Cell Carcinoma, Esophagectomy, Radiotherapy, Chemotherapy
- Trial name
- NCT05604950
- Testing
- Since the data were collected retrospectively, there were no interventions
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Yongtao Han
Esophageal Squamous Cell Carcinoma (ESCC)
Risk of Esophageal Cancer Returning After Immunotherapy, Chemotherapy, and Surgery
This observational study aims to understand the risk of cancer returning after surgery in people with esophageal squamous cell carcinoma, a type of cancer of the food pipe.
- Trial name
- NCT07822906
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University Cancer Hospital & Institute
Colorectal Cancer
Surgical Prehabilitation of Cancer Patients Undergoing Colorectal Resection.
Psychological distress is common among adults newly diagnosed with cancer and those awaiting cancer treatment(s). Although preoperative psychological distress has been shown to be associated with poorer physical health and…
- Trial name
- NCT04248647
- Testing
- Multimodal prehabilitation
- Volunteers
- 20 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Neoplasm of Rectum, Surgery--Complications
Validation of Low Anterior Resection Syndrome Score in Korean Version
In contemporary era of rectal cancer treatment, development of surgical technique and tool, adaptation of chemoradiation therapy, as well as multidisciplinary approach have led increased survival as well as rate of sphincter…
- Conditions
- Neoplasm of Rectum, Surgery--Complications, Surgery
- Trial name
- NCT03211715
- Testing
- questionnaire
- Volunteers
- 300 people
- Sponsor
- Saint Vincent's Hospital, Korea
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