Clinical trials: Gastrointestinal Tumor Surgery
Colorectal Cancer
Leucovorin and Fluorouracil Compared With Observation in Treating Patients With Colorectal Cancer That Has Been Surgically Removed
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00005586
- Testing
- L-leucovorin, fluorouracil, adjuvant therapy
- Where
- United Kingdom
- Volunteers
- 2,500 people
- Sponsor
- Institute of Cancer Research, United Kingdom
Sentinel Lymph Node, Early Gastric Cancer
Feasibility Study of Sentinel Navigation Surgery After Non-curative Endoscopic Resection
Purpose: To prove the feasibility of sentinel node navigation surgery (SNNS) in early gastric cancer patients with the risk of lymph node metastasis after endoscopic resection and preparation of multicenter phase 3 trial of…
- Trial name
- SENORITA2 (NCT03123042)
- Testing
- Sentinel basin dissection
- Where
- 9 sites in South Korea
- Volunteers
- 243 people
- Sponsor
- National Cancer Center, Korea
Rectal Neoplasm With Metastasis to the Liver
Simultaneous Versus Staged Resection for Initially Resectable Synchronous Rectal Cancer Liver-limited Metastasis
The purpose of this study is to investigate the safety and efficacy of simultaneous liver resections compared to staged hepatectomies of rectal cancer with liver metastasis and to compare the short and long-term survival between…
- Trial name
- NCT00677586
- Testing
- simultaneous resection of liver metastasis and the rectal primary tumor, staged resection of liver metastasis and the rectal primary tumor
- Volunteers
- 180 people
- Sponsor
- Fudan University
Tumor of Pancreas, Surgical Blood Loss
Enucleation of Pancreatic Tumor by Blocking Abdominal Trunk and Superior Mesenteric Artery
Pancreatic enucleation could preserve more healthy pancreatic tissues and functions with a low recurrence risk. However, conventional enucleation can cause significant intraoperative bleeding, especially in which tumors in the…
- Trial name
- NCT06164769
- Testing
- blocking both the abdominal trunk and superior mesenteric artery in the pancreatic enucleation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Zhejiang University
Esophageal Neoplasms, Stomach Neoplasm
Health and Employment After Gastro Intestinal Surgery - HEAGIS1
By using the M.A.D.I.T. methodology and the Dialogics science, SALVO Project aims to develop operational guidelines to support oncological target patients in the resumption of their daily post-operative activities.
- Conditions
- Esophageal Neoplasms, Stomach Neoplasm, Colonic Neoplasms
- Trial name
- HEAGIS1 (NCT04466592)
- Testing
- Promotion of competences of participant involved in the management of the post operative period
- Where
- 2 sites in Italy
- Volunteers
- 47 people
- Sponsor
- University of Padova
Locally Advanced Rectal Cancer
TNT of SCRT+CAPOX vs SCRT+CAPOXIRI for Locally Advanced Rectal Cancer
This trial is a multicenter randomized Phase III study to verify the superiority of short-course preoperative radiation (SCRT) and CAPOXIRI over SCRT and CAPOX as preoperative treatments for locally advanced rectal cancer.
- Trial name
- ENSEMBLE (NCT05646511)
- Testing
- SCRT, CAPOX, CAPOXIRI
- Where
- 34 sites in Japan
- Volunteers
- 608 people
- Sponsor
- National Cancer Center Hospital East
Pancreatic Cancer
Feasibility of a Health Care Provider Guided Exercise Intervention Prior to Surgical Resection of Pancreatic Cancer
Pilot study evaluating the feasibility of a 2-4 week health care provider guided exercise intervention prior to surgery for pancreatic cancer.
- Trial name
- NCT05483075
- Testing
- HCP-Guided Exercise Training Program
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- NYU Langone Health
Urinary Dysfunction, Rectal Cancer
Effect of ICCAUT Strategy on Postoperative Urinary Dysfunction After Radical Rectal Cancer Surgery
In this study, the bladder training include intermittent urethral catheter clamping combined with active urination training, which the investigators called ICCAUT strategy.
- Conditions
- Urinary Dysfunction, Rectal Cancer, Urinary Catheterization, Urinary Retention Postoperative
- Trial name
- ICCAUT-1 (NCT06241703)
- Testing
- ICCAUT, Free drainage
- Where
- 2 sites in China
- Volunteers
- 400 people
- Sponsor
- The First Hospital of Jilin University
Colon Cancer, Colon Diverticulosis
Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery
The General Objective of this study is to investigate the cost and efficacy of treating patients undergoing colorectal surgical resections with an opioid limited pain control regimen as part of an Enhanced Recovery After Surgery…
- Conditions
- Colon Cancer, Colon Diverticulosis, Colonic Neoplasms, Colonic Diverticulitis
- Trial name
- NCT02958566
- Testing
- Acetaminophen, Gabapentin, Orphenadrine
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Illinois College of Medicine at Peoria
Peritoneal Cancer
Pathophysiology of Inflammation After Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
The purpose of this study is to assess the dynamics of inflammatory parameters in presence or absence of infectious complications after cytoreductive surgery with hyperthermic intraperitoneal chemotherapy.
- Trial name
- NCT02741167
- Testing
- CRS and HIPEC
- Where
- Switzerland
- Volunteers
- 90 people
- Sponsor
- University of Zurich
Colon Neoplasm
A Novel Adaptive Anastomotic Technique for Left-sided Colonic Resection
The goal of this pilot clinical trial is provide preminary evidence of the effectiveness of the C-REX device, developed by CarpoNovum AB, in preventing anastomotic leak and improving anastomosis healing after sigmoid or high…
- Trial name
- NOVA (NCT06615583)
- Testing
- Surgical device
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Istituto Clinico Humanitas
Rectal Cancer
Laparoscopic Assisted Transanal Total Mesorectal Excision for Rectal Cancer in Low Site
At present, surgical resection is still the main treatment for the potential cure of rectal cancer. Total mesorectal excision (TME) is the gold standard.
- Trial name
- LATERAL-01 (NCT03253302)
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Beijing Friendship Hospital
Gastric Cancer, Gastric Adenocarcinoma
Evaluation of Intra-operative Photographs for the Assessment of a Proper Lymphadenectomy in Minimally-invasive Gastrectomies for Gastric Cancer (PhotoNodes)
Even after the wide introduction of chemo/radiotherapy in the treatment algorithm, adequate surgery remains the cornerstone of gastric cancer treatment with curative intent.
- Conditions
- Gastric Cancer, Gastric Adenocarcinoma, Lymphadenectomy, Minimally Invasive Surgery
- Trial name
- PhotoNodes (NCT06466902)
- Testing
- Quality assessment of D2 lymphadenectomy using the PhotoNode Score
- Where
- 8 sites in Italy
- Volunteers
- 326 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Parma
Gastric Cancer
RCT With Adjuvant Mistletoe Treatment in Gastric Cancer Patients
Evaluation of safety and efficacy of a standardized mistletoe extract (abnobaVISCUM® Quercus, aVQ) in patients with gastric cancer receiving oral chemotherapy.
- Trial name
- NCT01401075
- Testing
- mistletoe extract, doxifluridine
- Where
- South Korea
- Volunteers
- 32 people
- Sponsor
- Abnoba Gmbh
Rectal Cancer, Advanced Cancer
Non Inferiority Study of Preoperative Chemotherapy Without Pelvic Irradiation for Rectal Cancer
This study is a non-inferiority phase III randomised trial comparing preoperative chemotherapy alone (modified FOLFIRINOX) to chemotherapy followed by chemoradiotherapy in patients with primary resectable locally advanced rectal…
- Trial name
- NORAD01 (NCT03875781)
- Testing
- Chemotherapy, Radiochemotherapy
- Where
- France
- Volunteers
- 540 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Gastric Cancer, Venous Thromboembolism
Incidence of Venous Thromboembolism Following Surgery in Patients With Gastric Cancer
Venous thromboembolism (VTE) has considerably harmful effects on morbidity and mortality of cancer patients. Several guidelines recommendations have been made about the use of anticoagulation for the prevention and treatment of…
- Conditions
- Gastric Cancer, Venous Thromboembolism, Postoperative Period
- Trial name
- NCT01345773
- Testing
- Gastric surgery
- Where
- South Korea
- Volunteers
- 375 people
- Sponsor
- Seoul National University Bundang Hospital
Breast Cancer, Lung Cancer
hTERT Immunotherapy Alone or in Combination With IL-12 DNA Followed by Electroporation in Adults With Solid Tumors at High Risk of Relapse
This is a Phase I, open label study to evaluate the safety, tolerability, and immunogenicity of INO-1400 or INO-1401 alone or in combination with INO-9012, delivered by electroporation in subjects with high-risk solid tumor…
- Conditions
- Breast Cancer, Lung Cancer, Pancreatic Cancer, Head and Neck Cancer
- Trial name
- TRT-001 (NCT02960594)
- Testing
- INO-1400, INO-9012, INO-1401
- Where
- 6 sites in United States
- Volunteers
- 93 people
- Sponsor
- Inovio Pharmaceuticals
Esophageal Neoplasms, Gastric Neoplasm
Health and Employment After Gastro Intestinal Surgery - HEAGIS2
By using the M.A.D.I.T. methodology and the Dialogics science, SALVO Project aims to develop operational guidelines to support oncological target patients in the resumption of their daily post-operative activities.
- Conditions
- Esophageal Neoplasms, Gastric Neoplasm, Colon Neoplasms
- Trial name
- HEAGIS2 (NCT04466631)
- Where
- 2 sites in Italy
- Volunteers
- 50 people
- Sponsor
- University of Padova
Colon Cancer, Rectal Cancer
Effects of Abdominal Nerve Block on Postoperative Recovery in Patients Undergoing Gastrointestinal Surgery
To explore the effect of general anesthesia combined with transversus abdominis plane block (TAPB) and/or rectus sheath block (RSB) on the recovery of patients with gastrointestinal tumor after surgical treatment.
- Conditions
- Colon Cancer, Rectal Cancer, Gastric Cancer
- Trial name
- NCT04147481
- Testing
- Group Abdominal Nerve Block with local anesthetics, Group Abdominal Nerve Block with saline
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Yi Liu
Colon Adenocarcinoma
Inhalational or Intravenous Anesthesia During Surgery for Patients With Colon Cancer, VIVA Study
This trial evaluates how inhalational anesthesia (drawn in through the lungs) and total intravenous anesthesia (TIVA) (through a needle in a vein in the arm) change the body's ability to recover from surgery or whether they…
- Trial name
- NCT06017141
- Testing
- Biospecimen Collection, Electronic Health Record Review, Fentanyl Citrate
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Kansas Medical Center
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