Clinical trials: Gastrointestinal Tumor Surgery
Gastrointestinal Neoplasms
A Study to Test the Safety and Effectiveness of GSK5764227, Alone or With Other Treatments, in Participants With Advanced Gastrointestinal Cancers That Cannot be Surgically Removed (EMBOLD PanGI-201)
This study will check how well a new medicine, Risvutatug rezetecan, (Ris-Rez, also known as GSK5764227) works, how safe it is and how the body handles it in participants all around the world with advanced inoperable or…
- Trial name
- NCT06885034
- Testing
- Risvutatug Rezetecan
- Where
- 85 sites in United States, Australia and 17 more
- Volunteers
- 346 people
- Sponsor
- GlaxoSmithKline
Colorectal Cancer
Assessment of Autologous Blood Marker Localization in Laparoscopic Colorectal Cancer Surgery
Laparoscopic colorectal surgery has been proved to have similar oncological outcomes with open surgery. Due to the lack of tactile perception, surgeons may have misjudgments in laparoscopic colorectal surgery.
- Trial name
- ABILITY (NCT05597384)
- Testing
- Laparoscopic colorectal cancer resection
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Shanghai East Hospital
Cancer, Rectal
Safety & Efficacy of Ischemic Preconditioning by Embolization of the Inferior Mesenteric Artery in Surgery for Tumors of Lower and Middle Rectum
The present study will investigate the safety of inferior mesenteric artery embolization prior to rectal surgery, according to IDEAL recommendations (Lancet 2009).
- Trial name
- AMIREMBOL_2 (NCT06236633)
- Testing
- Ischemic preconditioning, Arteriogram
- Where
- 3 sites in France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Peritoneal Carcinomatosis
Representation of the Body for Patients With Cancer
The project aims to understand better how patients live the event of cancer and live its consequences on their bodily representations.
- Trial name
- CORCAN (NCT01560533)
- Testing
- Interviews
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Hospices Civils de Lyon
Pancreatic Cancer, Pancreatic Fistula
Anastomotic Techniques in Pancreaticoduodenectomy
There are two principal ways of draining the remnant of the pancreas back into the intestine after removal of the head of the pancreas for cancer. This can be performed either to the jejunum or to the stomach.
- Trial name
- PG/PJ (NCT00855985)
- Testing
- type of anastomosis after pancreaticoduodenectomy
- Where
- India
- Volunteers
- 312 people
- Sponsor
- Lakeshore Hospital
Pancreatic Surgery, Pancreatic Duct Stenting
Pancreatic Stent to Prevent Leak After Distal Pancreatectomy
The purpose of this study is to investigate an intervention to prevent complications after pancreas surgery. The goal is to determine if placing a stent into the pancreatic duct before surgery will decrease or prevent leaking…
- Conditions
- Pancreatic Surgery, Pancreatic Duct Stenting, Pancreatic Cancer, Distal Pancreatectomy
- Trial name
- LEAPS (NCT00671463)
- Testing
- Pancreatic duct stenting
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Gastrointestinal Malignancy
Mobility and Activity Training (MAT) to Optimize Outcomes for Older Adult Abdominal Surgery Patients
In this pilot study a group of older adults undergoing midline laparotomy for gastrointestinal malignancy will participate in a mobility and activity training (MAT) program.
- Trial name
- MAT (NCT02007876)
- Testing
- Mobility and Activity Training
- Where
- 2 sites in United States
- Sponsor
- University of Michigan
Liver Neoplasms
Assessment of Indocyanine Green as a Near-Infrared Fluorescent Contrast Agent for Image-guided Liver Surgery
This is a prospective, monocentric, non-randomized, phase I-II study. The goal is to assess the faisability and the capabilities of fluorescence imaging in hepatic surgery, and specially to help the surgeon while performing liver…
- Trial name
- HEPATOFLUO (NCT01738217)
- Testing
- Fluobeam
- Where
- France
- Volunteers
- 48 people
- Sponsor
- Centre Leon Berard
Rectal Cancer, Quality of Life
The OPERa Study: Evaluating QoL After Rectal Cancer Surgery
Advances in rectal cancer management have significantly reduced morbidity and mortality. The most commonly performed operation for rectal cancer is restorative proctectomy (RP), leaving up to 70% with long-term bowel dysfunction…
- Conditions
- Rectal Cancer, Quality of Life, Bowel Dysfunction, Sexual Dysfunction
- Trial name
- NCT04893876
- Volunteers
- 1,200 people
- Sponsor
- Jewish General Hospital
Esophageal Squamous Cell Carcinoma
Study Compare Adjuvant Chemotherapy, Chemoradiotherapy and Surgery Alone for pN1-2(pT1b-3N1-2M0) Esophageal Carcinoma
A multi-center prospective randomized controlled study was conducted to compare the effects of adjuvant chemotherapy, chemoradiotherapy and surgery alone for the patients with esophageal cancer.
- Trial name
- NCT04009265
- Testing
- adjuvant treatment
- Where
- China
- Volunteers
- 145 people
- Sponsor
- Fujian Medical University Union Hospital
Colonic Neoplasms
Comparison of MORbidity of Submucosal DIssection Resection of Giant cOlon Lesions Versus Surgery: a National Multicenter Study (MORDIGO)
Propose a one-piece endoscopic resection such as endoscopic submucosal dissection (ESD) rather than surgery for benign lesions and superficial T1 cancers colorectal cancers offers comparable efficacy with better tolerability.
- Trial name
- MORDIGO (NCT06371898)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Brest
Pancreatic Cyst
Study Using Hyperpolarized 13C-Pyruvate Magnetic Resonance Spectroscopic Imaging in Patients With Pancreatic Cysts Undergoing Surgical Resection
To learn if Hyperpolarized C-Pyruvate Magnetic Resonance (HP-MR) Spectroscopic Imaging can help doctors detect low-risk (benign) and high-risk (malignant) cysts.
- Trial name
- NCT05873699
- Testing
- Hyperpolarized 13-C-pyruvate
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- M.D. Anderson Cancer Center
Tumor Microenvironment
Clinical Study of Lung Protective Ventilation Strategies and Tumor Microenvironment
This study will be conducted in the Affiliated Hospital of Nantong University. Sixty colorectal cancer(CRC) patients are randomized into traditional ventilation strategy group (control group) and lung protective ventilation…
- Trial name
- NCT06230965
- Testing
- Lung protective ventilation strategy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Affiliated Hospital of Nantong University
Rectal Cancer, Surgery
Transanal Versus Laparoscopic Total Mesorectal Excision For Rectal Cancer
Total mesorectal excision (TME) has been prevailingly accepted as a crucial surgical intervention within the latest oncological therapeutic regime for mid-low rectal cancer.
- Trial name
- TLTME (NCT03359616)
- Testing
- Transanally curable surgical resection, Laparoscopic total mesorectal excision
- Volunteers
- 258 people
- Sponsor
- Shanghai Minimally Invasive Surgery Center
Lymph Leakage, Chyle Into Mesentery; Extravasation
Prevention of Chyle-leak After Major Pancreatic Surgery
Chyle is lymphatic fluid present in the wall of the intestine. It flows trough lymphatic vessels to cisterna chyli and to venous circulation carrying lymphatic fluid, long-chain triglyceride fatty acids and proteins, fatty…
- Conditions
- Lymph Leakage, Chyle Into Mesentery; Extravasation, Pancreatic Cancer, Complication of Surgical Procedure
- Trial name
- NCT03167814
- Testing
- Diet group
- Where
- Finland
- Volunteers
- 96 people
- Sponsor
- Helsinki University Central Hospital
Rectal Cancer
Intraoperative Assessment of Distal Resection Margins Using Frozen Section in Mid and Low Rectal Cancer Surgery
This study aims to improve the safety of distal surgical margins in patients with middle and low rectal cancer who receive neoadjuvant radiotherapy.
- Trial name
- NCT07398716
- Testing
- Intraoperative Frozen Section Assessment, Standard Surgery Without Frozen Section
- Where
- Turkey (Türkiye)
- Volunteers
- 99 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Gastrointestinal Cancer, Frailty
Preoperative Frailty and Postoperative Outcomes in Older Patients Undergoing Surgery for Gastrointestinal Cancer
This prospective observational cohort study will evaluate whether preoperative frailty, assessed using the Fried Frailty Index and the Clinical Frailty Scale, is associated with postoperative outcomes in patients aged 60 years or…
- Trial name
- NCT07815392
- Testing
- Fried Frailty Index, Clinical Frailty Scale
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Van Training and Research Hospital
Liver Cancer, Esophageal Cancer
Pre- and Post-operative TEG Indices in Patients With or Without Adenocarcinoma Undergoing Surgical Resection
The investigators hypothesize that abnormalities in thromboelastography (TEG) parameters in patients with liver, pancreas, biliary, esophageal, colorectal, and lung adenocarcinoma can serve as biomarkers for oncologic disease…
- Conditions
- Liver Cancer, Esophageal Cancer, Colorectal Cancer, Lung Adenocarcinoma
- Trial name
- TEG (NCT05517811)
- Testing
- TEG indices
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Colorectal Cancer
A Study of Xeloda (Capecitabine) as Adjuvant Monotherapy in Patients With Colon Cancer.
This single arm study will evaluate the safety profile of Xeloda as monotherapy for adjuvant treatment of colon cancer. All patients will receive Xeloda 1250mg/m2 p.o.
- Trial name
- NCT00502671
- Testing
- capecitabine [Xeloda]
- Where
- 46 sites in Russia
- Volunteers
- 228 people
- Sponsor
- Hoffmann-La Roche
Pancreatic Cancer
PGHD-AI Intelligent Model for the Nutritional Assessment and Intervention of Patients After Radical Surgery for Pancreatic Cancer.
This study will collect patient PRO (physical strength, pain, defecation, appetite, weight, etc.) data through the APP, use corpus collection cards, facial photography and other technologies to collect PGHD characteristic…
- Trial name
- NCT07167264
- Testing
- PGHD's AI intelligent model(APP)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
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