Clinical trials: Gastrointestinal Tumor Surgery
Colo-rectal Cancer
Does Omission of NSAIDs After Colorectal Cancer Operation Affect the Consumption of Opioids?
Patients undergoing an operation for colorectal cancer are normally treated with non-steroid-anti-inflammatory-drugs (NSAIDs) e.g. ibuprofen as pain medication after the operation.
- Trial name
- NCT04448652
- Testing
- NSAID
- Where
- Denmark
- Volunteers
- 502 people
- Sponsor
- Zealand University Hospital
Colonic Neoplasms, Diverticulosis, Colonic
Interest of the Nefopam and PCA Morphine Combination for Postoperative Analgesia in Patients Undergoing Colon Surgery
This study analyses interest of iv nefopam in combination with paracetamol after major abdominal surgery because the effect of morphine-sparing is discussed when combined these agents.
- Trial name
- NEFOPAM (NCT03619538)
- Testing
- Nefopam, saline solution
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Colon Cancer
Feasibility of Intraperitoneal Chemotherapy in the Surgical Treatment of Colon Cancer cT4
This is a randomised controlled study aims to determine the oncological effectiveness of adjuvant HIPEC, using intraperitoneal Mytomicin C following a curative resection of a cT4 Colon cancer in preventing the development of…
- Trial name
- NCT03561948
- Testing
- Experimental group, Control group
- Where
- Russia
- Volunteers
- 90 people
- Sponsor
- State Scientific Centre of Coloproctology, Russian Federation
Colorectal Cancer
Fluorouracil and Leucovorin and/or Levamisole After Surgery In Treating Patients With Dukes' B Or Dukes' C Colon Cancer
RATIONALE: Drugs used in chemotherapy, such as fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00425152
- Testing
- fluorouracil, leucovorin calcium, levamisole hydrochloride
- Volunteers
- 2,151 people
- Sponsor
- NSABP Foundation Inc
Colorectal Neoplasms, Neoplasm Metastasis
New Adjuvant Chemotherapy of Asymptomatic Resectable Primary Lesion With Unresectable Liver-limited Metastases
To evaluate the survival benefit of pre-operation chemotherapy of primary tumor tesection (PTR) compared upfront PTR for colorectal cancer (CRC) patients with an asymptomatic resectable primary tumor and synchronous unresectable…
- Conditions
- Colorectal Neoplasms, Neoplasm Metastasis, Liver Neoplasms, Chemotherapy; Maternal, Affecting Fetus
- Trial name
- NCT01307878
- Testing
- chemotherapy ± targeted therapy
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Fudan University
Gastrointenstinal Stromal Tumor (GIST)
Safety of Robotic Surgery for GISTs at Special Anatomic Sites
This study is a prospective, multicenter, single-arm, phase II clinical trial. It plans to enroll 182 patients with localized gastric gastrointestinal stromal tumors (GISTs) at special anatomic sites.
- Trial name
- NCT07405125
- Testing
- Robotic Surgery
- Where
- China
- Volunteers
- 182 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Adult Primary Hepatocellular Carcinoma, Advanced Adult Primary Liver Cancer
Erlotinib in Treating Patients With Liver Cancer That Cannot be Surgically Removed
Phase II trial to study the effectiveness of erlotinib in treating patients who have liver cancer that cannot be surgically removed. Erlotinib may stop the growth of tumor cells by blocking the enzymes necessary for their growth
- Conditions
- Adult Primary Hepatocellular Carcinoma, Advanced Adult Primary Liver Cancer, Localized Unresectable Adult Primary Liver Cancer
- Trial name
- NCT00047333
- Testing
- erlotinib hydrochloride, laboratory biomarker analysis, pharmacological study
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- National Cancer Institute (NCI)
Gastrointestinal Tumors, Surgical Wound Infection
Non-Dressing vs. Routine Dressing Change After Gastrointestinal Cancer Surgery
The goal of this randomized non-inferiority trial is to evaluate whether omitting postoperative wound dressings is noninferior to routine dressing changes in patients undergoing gastrointestinal cancer surgery.
- Conditions
- Gastrointestinal Tumors, Surgical Wound Infection, Pain, Postoperative
- Trial name
- Dressing (NCT06263205)
- Testing
- Non-Dressing of Surgical Wound, Regular Dressing Change of Surgical Wound
- Where
- 4 sites in China
- Volunteers
- 1,138 people
- Sponsor
- Fudan University
Colorectal Cancer
Celecoxib in Preventing Polyps in Patients Who Have Undergone Surgery for Stage I Colon Cancer
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development of cancer. It is not yet known whether celecoxib is effective in preventing polyps in patients with colon cancer.
- Trial name
- NCT00087256
- Testing
- Celecoxib
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- NSABP Foundation Inc
Pancreatic Neoplasms
EUS Fiducial for Pancreas Surgery
RATIONALE: Pancreas tumor localization makes minimally invasive surgical resection of pancreas tumors very challenging. Recently, an endoscopic ultrasound needle system has been developed which enables fiducial coils to be placed…
- Trial name
- NCT02863783
- Testing
- EUS with Fiducial
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Southern California
Colorectal Liver Metastases, Hepatocellular Carcinoma
Alternative Surgical Policy for Central Liver Tumors
Major hepatectomies have not negligible morbidity and mortality. However, when tumors invade middle hepatic vein (MHV) at caval confluence major surgery is usually recommended.
- Trial name
- NCT00600522
- Testing
- Ultrasound-guided hepatectomy
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- University of Milan
Colorectal Cancer
Assessment of Quality of Life and Social Support Gained in Patients Before and After Colorectal Cancer Surgery
evaluation of the quality of life of patients before and after laparoscopic surgery for rectal cancer and cancer of the right part of the intestine at different stages of the disease, whether it depends on the size of the tumor…
- Trial name
- NCT06395766
- Testing
- BREF,MSPSS
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Andrzej Frycz Modrzewski Krakow University
Gastric Cancer, Peritoneal Carcinomatosis
Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy in Peritoneal Carcinomatosis From Gastric Cancer
Gastric cancer associated peritoneal carcinomatosis has a poor prognosis with a median survival of less than one year. Systemic chemotherapy including targeted agents has not been found to significantly increase the survival in…
- Trial name
- CYTO-CHIP (NCT03253939)
- Testing
- Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy procedure, Cytoreductive surgery alone
- Where
- France
- Volunteers
- 275 people
- Sponsor
- Hospices Civils de Lyon
Home Care, Enhanced Recovery
The Impact of AI-Assisted Nursing Care Intervention Within the Enhanced Recovery Framework on Outcomes of Colorectal Surgery Patients
Colorectal cancer is one of the most common cancers worldwide, affecting a large number of people each year (Bray et al., 2022). Surgical intervention remains the gold standard in treatment.
- Conditions
- Home Care, Enhanced Recovery, Colo-rectal Cancer, Colorectal Surgery
- Trial name
- NCT07369219
- Testing
- Educational intervention, Standard maintenance therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Bahçeşehir University
Pancreatic Cancer, Pancreatic Adenocarcinoma
Near-infrared Image Guided Surgery in Pancreatic Adenocarcinoma
There is a need for better visualization of resection margins and detection of small tumor deposits during surgery for pancreatic cancer.
- Trial name
- PENGUIN (NCT02743975)
- Testing
- Bevacizumab-800CW
- Where
- 3 sites in Netherlands
- Volunteers
- 10 people
- Sponsor
- University Medical Center Groningen
Rectal Adenocarcinoma
Avoiding Surgery in Rectal Cancer After Pre-Operative Therapy
The objective of Timing and Deferral of Rectal Surgery Following a Continued Response to Pre-operative CRT study is to establish the time to maximum tumour response following CRT, and to investigate whether surgery can be safely…
- Trial name
- NCT01047969
- Testing
- Adjuvant Chemotherapy, Surgery
- Where
- United Kingdom
- Volunteers
- 99 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Colorectal Liver Metastases, Hepatocellular Carcinoma
Anatomical Right Posterior Sectionectomy of the Liver by IOUS-Guided Finger Compression
The use of intraoperative ultrasound (IOUS) allows us to perform new conservative hepatectomies. The investigators previously reported the systematic subsegmentectomy by IOUS-guided finger compression for segments 2-3, which is…
- Conditions
- Colorectal Liver Metastases, Hepatocellular Carcinoma, Liver Malignancies
- Trial name
- NCT00797251
- Testing
- Anatomical right posterior sectionectomy of the liver by IOUS-guided finger compression.
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- University of Milan
Rectal Neoplasm
Prospective Multicenter Randomized Controlled Trial On Two-Stage Turnbull-Cutait Coloanal Anastomosis For Rectal
The aim of this study is to decrease the morbidity by 30% using the Turnbull-Cutait procedure in comparison to the standard surgery for low rectal cancer.
- Trial name
- TURNBULL-BCN (NCT01766661)
- Testing
- Hand-sewn coloanal anastomosis, Two staged Turnbull-Cutait procedure, Ultralow anterior rectal resection with total mesorectal excision
- Where
- 4 sites in Italy, Spain
- Volunteers
- 92 people
- Sponsor
- Hospital Universitari de Bellvitge
Myoma of Uterus, Colon Cancer
Anxiety Before Non-cardiac Surgery in Adults
Adult patients undergoing elective non-cardiac surgery were enrolled. Anxiety before the operation was evaluated by The State Anxiety Inventory (S-AI).
- Conditions
- Myoma of Uterus, Colon Cancer, Gastric Carcinoma, Prostate Cancer
- Trial name
- NCT05596188
- Where
- China
- Volunteers
- 424 people
- Sponsor
- RenJi Hospital
Antibiotic, Bowel Cancer
Mechanical Bowel Preparation With or Without Oral Antibiotics for Colorectal Cancer Surgery
Investigation of the role of adding oral antibiotics to preoperative mechanical bowel preparation before colorectal surgery for cancer.
- Conditions
- Antibiotic, Bowel Cancer, Colorectal Cancer, Surgical Site Infection
- Trial name
- MECCA (NCT03563586)
- Testing
- Bowel Preparation plus antibiotics, Bowel Preparation
- Where
- Greece
- Volunteers
- 210 people
- Sponsor
- National and Kapodistrian University of Athens
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