Clinical trials: Gastrointestinal Tumor Surgery
Rectal Cancer
Robotic vs. TaTME Rectal Surgery (ROTA STUDY)
Background Recent novel surgical techniques for resection of low rectal cancer have been introduced and these approaches have the potential to overcome anatomical limitations like obesity, narrow male pelvis and bulky and low…
- Trial name
- ROTA (NCT04200027)
- Testing
- total mesorectal excision
- Where
- 2 sites in Denmark, United Kingdom
- Volunteers
- 330 people
- Sponsor
- Odense University Hospital
Rectal Cancer
Anterior Resection Syndrome Following Sphincter-preserving Surgery
Bowel cancer is the third most common cancer in the UK in both males and females. The rectum is the most commonly affected part of the bowel.
- Trial name
- NCT02190656
- Where
- United Kingdom
- Volunteers
- 1,197 people
- Sponsor
- Queen Mary University of London
Colorectal Cancer
Surgery With or Without Chemotherapy and Radiation Therapy in TreatingPatients With Stage I Rectal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00023751
- Testing
- fluorouracil, leucovorin calcium, conventional surgery
- Where
- 180 sites in United States, Canada and 1 more
- Volunteers
- 320 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Esophageal Disease
The French EsoGastricTumours Data Base
This retrospective study aims at evaluating the outcomes of gastrointestinal stromal tumor after surgery.
- Trial name
- FREGAT (NCT02526095)
- Where
- 31 sites in France
- Volunteers
- 15,000 people
- Sponsor
- University Hospital, Lille
Body Image Disorder
Prevention of Body Image Disorder by Nurse Intervention on the Patient and Family Prior to Breast and Colon Surgery
This is a non-blinded, randomized, controlled clinical trial consisting of 64 participants, which aims to assess the effectiveness of a nursing intervention for family members and patients prior to surgery to prevent body image…
- Trial name
- NCT03726801
- Testing
- HEALTH EDUCATION
- Where
- Spain
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Colorectal Cancer
Fluorouracil and Irinotecan With or Without Leucovorin Compared With Observation in Treating Patients Who Have Undergone Surgery for Stage II Colon Cancer
RATIONALE: Drugs used in chemotherapy, such as irinotecan, leucovorin, and fluorouracil, work in different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00091312
- Testing
- FOLFIRI regimen, fluorouracil, irinotecan hydrochloride
- Where
- 9 sites in Egypt, France and 4 more
- Volunteers
- 1,976 people
- Sponsor
- Federation Francophone de Cancerologie Digestive
Tumor Microenvironment
Clinical Study of Lung Protective Ventilation Strategies and Tumor Microenvironment
This study will be conducted in the Affiliated Hospital of Nantong University. Sixty colorectal cancer(CRC) patients are randomized into traditional ventilation strategy group (control group) and lung protective ventilation…
- Trial name
- NCT06230965
- Testing
- Lung protective ventilation strategy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Affiliated Hospital of Nantong University
Colorectal Cancer
Comparison of NOSES and Conventional Laparoscopic Surgery in Colorectal Cancer
Radical surgery for rectal cancer has evolved from the initial concept of total mesorctal excision (TME) to the wide application of laparoscopic surgery in the radical treatment of rectal cancer.
- Trial name
- NCT04559087
- Testing
- Laparoscopic Surgery
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Zunyi Medical College
Hepatocellular Carcinoma (HCC)
Radiation Therapy Followed by Durvalumab (MEDI4736) and Tremelimumab And Surgery Versus Radiation Therapy Followed by Surgery for Resectable Hepatocellular Carcinoma.
The objectives of this study is to estimate the biological activity of combination chemotherapy and radiation versus radiation alone in patients with Hepato Cellular Carcinoma (HCC).
- Trial name
- DARTS (NCT07027436)
- Testing
- Chemotherapy/Radiation
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- Hamilton Health Sciences Corporation
Cancer, Rectal
Safety & Efficacy of Ischemic Preconditioning by Embolization of the Inferior Mesenteric Artery in Surgery for Tumors of Lower and Middle Rectum
The present study will investigate the safety of inferior mesenteric artery embolization prior to rectal surgery, according to IDEAL recommendations (Lancet 2009).
- Trial name
- AMIREMBOL_2 (NCT06236633)
- Testing
- Ischemic preconditioning, Arteriogram
- Where
- 3 sites in France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Colorectal Cancer
A Multicenter Clinical Trial on Laparoscopic Colorectal Cancer Surgery Compared With Open Surgery
The purpose of this study is to verify the 5-year disease free survival (DFS) of resectable colorectal cancer after laparoscopic surgery according to a Chinese Operative Standard was not inferior to open surgery.
- Trial name
- NCT02248038
- Testing
- open surgery, laparoscopic surgery
- Where
- China
- Volunteers
- 1,300 people
- Sponsor
- Cai Kailin
Hepatocarcinoma, Hepatic Metastasis
Robotic Endomicroscopy to Better Define Resection Strategies Applied to Hepatic Surgery
This study aims at assessing the feasibility of Probe-based Confocal Laser Endomicroscopy (pCLE) during laparoscopic hepatic masses resection for intra-operative characterisation of hepatic masses and surgical margins assessment.
- Conditions
- Hepatocarcinoma, Hepatic Metastasis, Hepatic Tumor
- Trial name
- PERSEE (NCT03718078)
- Testing
- Confocal Laser Endomicroscopy
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Mauna Kea Technologies
Colorectal Neoplasms
Performance of SGM-101 for the Delineation of Primary and Recurrent Tumor and Metastases in Patients Undergoing Surgery for Colorectal Cancer
The performance of SGM-101, an intraoperative imaging agent, will be compared to that of standard "white light" visualization during surgical resections of colorectal cancer.
- Trial name
- NCT03659448
- Testing
- SGM-101
- Where
- 11 sites in United States, Germany and 2 more
- Volunteers
- 300 people
- Sponsor
- Surgimab
Colorectal Cancer
Rofecoxib After Surgery in Treating Patients With Stage II or Stage III Colorectal Cancer
RATIONALE: Rofecoxib may stop the growth of cancer by stopping blood flow to the tumor and killing tumor cells that remain after surgery. It is not yet known if rofecoxib is effective in treating colorectal cancer.
- Trial name
- NCT00031863
- Testing
- rofecoxib, adjuvant therapy
- Where
- United Kingdom
- Sponsor
- Cancer Research Campaign Clinical Trials Centre
Pancreatic Cancer
Two Stage Study Of Single Dose PEGPH20 And Cetuximab In Patients With Pancreatic Adenocarcinoma Prior To Surgical Resection
This study has several purposes. DCE-MRI will be used to image the tumor. Safety of cetuximab given before surgery will be studied. Cetuximab delivery to the tumor will be studied.
- Trial name
- NCT02241187
- Testing
- PEGPH20, Cetuximab, DW & DCE-MRI
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Esophageal Cancer
Chemotherapy and Radiation Therapy in Treating Patients With Cancer of the Esophagus
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00002884
- Testing
- chemotherapy, cisplatin, fluorouracil
- Where
- France
- Volunteers
- 326 people
- Sponsor
- Centre Hospitalier Lyon Sud
Breast Cancer, Gynecologic Cancer
Evaluating Smoking Cessation Protocols in Cancer Patients: NRT, MI, CBT or Hypnotherapy
This trial offers support and assistance to patients wishing to quit smoking in order to increase the success rate of smoking cessation and all the benefits associated with it.
- Conditions
- Breast Cancer, Gynecologic Cancer, Digestive Cancer, Melanoma
- Trial name
- RESPIRE (NCT04899492)
- Testing
- Motivational Interviewing (MI), Cognitive Behavioural Therapy (CBT), Hypnotherapy
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Institut Cancerologie de l'Ouest
Gastric Outlet Obstruction
Randomized Trial of EUS-guided Gastrojejunostomy and Surgical Gastrojejunostomy in Gastric Outlet Obstruction
Malignant gastric outlet obstruction (GOO) results from the mechanical obstruction of the duodenum or distal stomach from an underlying cancer.
- Trial name
- NCT05548114
- Testing
- EUS-guided gastrojejunostomy, Surgical gastrojejunostomy
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Orlando Health, Inc.
Anesthesia, Colon Cancer
Anesthesia and Immunological and Oxidative Stress in Relation to Abdominal Cancer Surgery
Colorectal cancer is a frequent type of cancer accounting for 600,000 deaths annually. Surgical resection remains the best treatment for long-term survival.
- Conditions
- Anesthesia, Colon Cancer, Surgery
- Trial name
- ANIMOX (NCT03974984)
- Testing
- Colon Resection, Epidural anesthesia, NSAID
- Where
- Denmark
- Sponsor
- University of Copenhagen
Colorectal Cancer, Surgery
The Effect of Wound Problems Wound Dressing in Patients With Colorectal Cancer Surgery
This study was conducted as a randomized controlled trial in order to determine the effect of prophylactic negative pressure wound therapy for the prevention of surgical site complications in high-risk colorectal cancer surgery.
- Conditions
- Colorectal Cancer, Surgery, Surgery--Complications, Surgical Site Infection
- Trial name
- NCT04735133
- Testing
- pNBYT
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- TC Erciyes University
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