Clinical trials: Gastrointestinal Tumor Surgery
Rectal Cancer
Quality of Life After Abdominoperineal Resection for Rectal Cancer, Comparing Two Surgical Techniques
The purpose of the study is to compare self-reported health related quality of life after two different operating techniques for low rectal cancer operated by rectal amputation, using a specific and detailed questionnaire.
- Trial name
- APR (NCT01323166)
- Testing
- Excision of the levator muscle
- Where
- Sweden
- Volunteers
- 75 people
- Sponsor
- Sahlgrenska University Hospital
Cancer of Rectum, Lymph Node Disease
Fluorescence Targeted Pelvic Lymph Node Mapping
This study aims to assess the lymphatic drainage of rectal tumours by using ICG as a fluorescent non-specific marker. As a feasibility study, it will also assess its technique and timing along with its ability to assist in…
- Trial name
- NCT03204994
- Testing
- Indocyanine Green
- Where
- United Kingdom
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Oxford University Hospitals NHS Trust
Gastric Cancer
Robotic, Laparoscopic and Open Surgery for Gastric Cancer Compared on Surgical, Clinical and Oncological Outcomes
Gastric cancer represents a great challenge for health care providers and requires a multidisciplinary context in which surgery plays a main role.
- Trial name
- NCT02325453
- Testing
- Robotic Surgery, Laparoscopic Surgery, Open Surgery
- Where
- Italy
- Volunteers
- 7,000 people
- Sponsor
- International Study Group on Minimally Invasive Surgery for Gastric Cancer
GI Cancers, Gastrointestinal Cancer
Sleep Disturbances in Surgical Patients With GI Cancers: A Quantitative and Qualitative Analysis
The primary objective of the study is to determine sleep disturbance and its types among patients with gastrointestinal cancers during the perioperative period (preoperative and in-hospital stay following surgery) by using…
- Trial name
- NCT05044312
- Testing
- Sleeping Disturbances
- Sponsor
- M.D. Anderson Cancer Center
Pancreatic Cancer
Gemcitabine, Cisplatin, and Radiation Therapy Followed By Surgery or Surgery Alone in Treating Patients With Localized Pancreatic Cancer That Can Be Removed By Surgery
RATIONALE: Drugs used in chemotherapy, such as gemcitabine and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00335543
- Testing
- cisplatin, gemcitabine hydrochloride, adjuvant therapy
- Where
- 17 sites in Austria, Germany and 1 more
- Volunteers
- 254 people
- Sponsor
- Interdisziplinare Arbeitsgruppe Gastrointestinaler Tumore der Deutschen Krebsgesellschaft
Hepatocellular Carcinoma, Portal Vein Tumor Thrombus
BITS-TO-HCC Study: HAIC+Iparomlimab/Tuvonralimab + Bevacizumab + Surgery/SBRT for BCLC-C HCC With PVTT and/or Oligometastases
This single-center, prospective, single-arm Phase II clinical trial is designed to evaluate the efficacy and safety of combining hepatic artery infusion chemotherapy (HAIC, for up to 4 cycles) with iparomlimab/tuvonralimab plus…
- Conditions
- Hepatocellular Carcinoma, Portal Vein Tumor Thrombus, Oligometastases, Radiotherapy
- Trial name
- NCT07062055
- Testing
- Anti-VEGF, Immunotherapy, Local Therapy
- Where
- China
- Volunteers
- 54 people
- Sponsor
- Shandong Cancer Hospital and Institute
Rectal Cancer, Surgery
Impact of a Patient-Centered Program for Low Anterior Resection Syndrome a Multicenter Randomized Controlled Trial
After undergoing restorative proctectomy for rectal cancer, many patients are left with significant bowel dysfunction, known as Low Anterior Resection Syndrome (LARS).
- Conditions
- Rectal Cancer, Surgery, Patient Activation, Low Anterior Resection
- Trial name
- NCT03828318
- Testing
- Patient Activation Booklet and nursing support for patients with LARS
- Where
- 6 sites in United States, Canada
- Volunteers
- 160 people
- Sponsor
- Jewish General Hospital
Esophageal Cancer
S-1, Cisplatin, and Radiation Therapy in Treating Patients With Stage IIA, Stage III, or Stage IVA Esophageal Cancer That Can Be Removed by Surgery
RATIONALE: Drugs used in chemotherapy, such as S-1 and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00659113
- Testing
- cisplatin, tegafur-gimeracil-oteracil potassium, cytology specimen collection procedure
- Where
- South Korea
- Volunteers
- 32 people
- Sponsor
- Yonsei University
Oesophageal Cancer Nos
Textbook Outcomes After Oesophagectomy in Regional Australia
The goal of this observational cohort study is to assess textbook outcomes after oesophagectomy in a regional Australian hospital. This is a composite quality measure that include 9 parameters related to cancer care.
- Trial name
- NCT06721715
- Where
- Australia
- Volunteers
- 100 people
- Sponsor
- Launceston General Hospital
Obesity, Weight Loss
Bariatric Embolization of Arteries in Obese Patients With HCC to Allow Salvage Liver Transplantation
Hepatocellular carcinoma (HCC) is the most common primary malignant liver tumor and has a grave prognosis. Obesity is an epidemic in the US.Patients with HCC and obesity are not candidates for liver transplantation, depriving…
- Conditions
- Obesity, Weight Loss, Body Weight, Hepatocellular Carcinoma
- Trial name
- NCT02935478
- Testing
- Embospheres Microspheres
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- St. Louis University
Pancreatic Cancer, Periampullary Cancer
Prehabilitation in Pancreatic Surgery
In patients with pancreatic cancer, older age, multiple comorbidities, frailty, malnutrition and poor functional status are common, especially in individuals receiving neoadjuvant chemotherapy.
- Conditions
- Pancreatic Cancer, Periampullary Cancer, Frailty Syndrome, Malnutrition
- Trial name
- PIPS (NCT06069297)
- Testing
- Multimodal Prehabilitation
- Where
- Italy
- Volunteers
- 238 people
- Sponsor
- IRCCS San Raffaele
Pancreatic Carcinoma
Accelerated Recovery Pathway for Discharge After Surgery in Patients With Pancreatic Cancer
This randomized clinical trial studies accelerated recovery pathway for discharge after surgery in patients with pancreatic cancer.
- Trial name
- WARP (NCT02517268)
- Testing
- Pancreaticoduodenectomy
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Pancreatic Carcinoma, Laparoscopic
Comparing Laparoscopic and Open Surgery for Pancreatic Carcinoma
Background: Pancreatic cancer (PC) is one of the most aggressive malignant neoplasms with poor outcomes. Pancreatoduodenectomy (PD) is the only curative treatment for PC.
- Conditions
- Pancreatic Carcinoma, Laparoscopic, Pancreaticoduodenectomy
- Trial name
- NCT03785743
- Testing
- TLPD Surgery, OPD Surgery
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Tongji Hospital
Cognitive Function
Effect of Acetaminophen Preemptive Analgesia on Postoperative Cognitive Function
Patients undergoing gastrointestinal tumor surgery are prone to delayed recovery and postoperative cognitive dysfunction due to greater trauma and longer operation time.
- Trial name
- NCT06004687
- Testing
- acetaminophen mannitol, Normal saline
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Affiliated Hospital of Nantong University
Colorectal Cancer, Colorectal Cancer Stage III
Multimodal Prehabilitation for Colorectal Surgery
Despite advances in surgical care, the incidence of postoperative complications and prolonged recovery following colorectal surgery remains high.
- Trial name
- NCT01356264
- Testing
- multimodal prehabilitation
- Where
- Canada
- Volunteers
- 89 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Neoplasms Malignant, Rectal Cancer
Prophylactic Mesh Placement During Stoma Closure After Low Anterior Resection
The goal of this clinical trial is to compare the efficacy of using polypropylene mesh for hernia prevention after stoma closure in patients with colorectal cancer and non-mesh repair.
- Conditions
- Neoplasms Malignant, Rectal Cancer, Hernia Incisional, Surgery
- Trial name
- ProMeLAR (NCT05939687)
- Testing
- mesh, non-mesh
- Where
- Russia
- Volunteers
- 142 people
- Sponsor
- Blokhin's Russian Cancer Research Center
Colorectal Cancer, Bowel Ileus
Efficacy of Mosapride on Recovery of Intestinal Motility After Elective Colorectal Cancer Surgery
Postoperative ileus (POI) is one of the most common causes of prolonged hospital stays after abdominal surgery. The pathophysiology of POI is multifactorial and complex.It is known to be associated with sympathetic neural…
- Trial name
- NCT04905147
- Testing
- Mosapride
- Where
- Thailand
- Volunteers
- 44 people
- Sponsor
- Mahidol University
Colon Cancer
Acute Colon Resection Versus Bridge to Colon Surgery With Stent or Stoma
P) patients with acute obstructive colon cancer I) resection or bridge to surgery with stent or stoma C) emergency procedure O ) morbidity and mortality within 30 days, 90 day mortality and 3 \& 5 years overall survival
- Trial name
- ACBC (NCT04450758)
- Testing
- Bridge to Surgery (stent or stoma)
- Where
- Sweden
- Volunteers
- 1,000 people
- Sponsor
- Skane University Hospital
Colon Neoplasms, Rectal Neoplasms
The Role of Indocyanine Green (ICG) Fluorescence Imaging on Anastomotic Leak in Robotic Colorectal Surgery
In colorectal surgery, anastomotic leak and its septic consequences still remain as the most concerning complications resulting in substantial morbidity and mortality.
- Conditions
- Colon Neoplasms, Rectal Neoplasms, Inflammatory Bowel Disease, Diverticular Disease
- Trial name
- NCT02598414
- Testing
- Near-infrared ICG fluorescence imaging, Traditional bowel anastomosis, FireFly™
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Acibadem University
Esophageal Neoplasm, Esophageal Disease
Outcomes After Esophageal Cancer Surgery
Background Esophageal carcinoma is the sixth leading cause of cancer -related mortality and the eighth most common cancer worldwide The incidence is increasing rapidly The overall 5-year survival ranges from 15% to 25% in the…
- Trial name
- FREGAT I (NCT01927016)
- Testing
- Esophagectomy
- Where
- France
- Volunteers
- 2,944 people
- Sponsor
- University Hospital, Lille
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