Clinical trials: Gastrointestinal Vascular Conditions
Gastrointestinal Hemorrhage, Portal Hypertension
Secondary Prophylaxis of Gastrointestinal Bleeding in Cirrhotic Patients Using THALIDOMIDE
The natural history of cirrhosis has a symptomatic and asymptomatic stage. The symptoms include the development of ascites, hepatic encephalopathy, or variceal bleeding.
- Trial name
- NCT00787436
- Testing
- Thalidomide
- Where
- United States
- Sponsor
- The Cleveland Clinic
Venous Thromboembolism
Dalteparin vs Unfractionated Heparin For The Prevention Of Venous Thromboembolism (VTE) In Hospitalized Acutely Ill Medical Patients
The purpose of this study is to compare the efficacy and safety of dalteparin vs unfractionated heparin for the prevention of VTE (Venous Thromboembolism) in hospitalized acutely ill medical patients.
- Trial name
- NCT00445328
- Testing
- Dalteparin (Fragmin), Unfractionated heparin
- Where
- 7 sites in India
- Volunteers
- 84 people
- Sponsor
- Pfizer
Carcinoma, Pancreatic Ductal, Colorectal Neoplasms
Continuous Monitoring on the General Ward
Rationale: Monitoring patients' vital signs is done to detect clinical deterioration. For this, the MEWS, a scoring list comprising seven vital signs measured by nursing staff, is used.
- Conditions
- Carcinoma, Pancreatic Ductal, Colorectal Neoplasms, Arthritis, Hypertension
- Trial name
- NCT02933307
- Testing
- HealthPatch, ViSi Mobile
- Volunteers
- 90 people
- Sponsor
- Radboud University Medical Center
Hemorrhoids, Postoperative Pain
Ice Packing Versus Warm Sitz Baths After Hemorrhoidectomy
Warm sitz baths are commonly recommended after hemorrhoidectomy, although their benefit for early postoperative recovery remains uncertain. Local cold application may reduce postoperative pain and perianal swelling.
- Trial name
- NCT07843563
- Testing
- Cryotherapy (Ice Packing), Warm Sitz Bath
- Where
- Turkey (Türkiye)
- Volunteers
- 89 people
- Sponsor
- Memorial Atasehir Hospital
Acute Appendicitis, Acute Cholecystitis
Web-based International Register of Emergency Surgery and Trauma
The WIRES-T project (Web-based International Registry of Emergency General Surgery and Trauma) has been set up to allow to all the EGS (Emergency General Surgery) and Trauma surgeons to register their activity and to obtain a…
- Conditions
- Acute Appendicitis, Acute Cholecystitis, Acute Diverticulitis, Post-operative Complications
- Trial name
- WIRES-T (NCT03643718)
- Testing
- Emergency General Surgery
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- A.O. Ospedale Papa Giovanni XXIII
Peritoneal Metastases, Peritoneal Carcinomatosis
Changes in Coagulation in Colorectal Cancer Patients Undergoing Surgical Treatment
Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) has prolonged the survival substantially for selected patients with peritoneal metastases from colorectal cancer.Bleeding and thromboembolic disease…
- Conditions
- Peritoneal Metastases, Peritoneal Carcinomatosis, Colorectal Neoplasms Malignant, Intestinal Neoplasms
- Trial name
- CONTEST (NCT04744688)
- Where
- 2 sites in Denmark
- Volunteers
- 90 people
- Sponsor
- University of Aarhus
Cystic Fibrosis
Blood Flow and Vascular Function in Cystic Fibrosis
Cystic fibrosis (CF) has many health consequences. A reduction in the ability to perform exercise in patients with CF is related to greater death rates, steeper decline in lung function, and more frequent lung infections.
- Trial name
- CF-FLOW (NCT02057458)
- Testing
- Sildenafil (Acute-1 hour), Sildenafil (Subchronic-4 weeks)
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Augusta University
Gastric Cancer, Gastroesophageal Junction Adenocarcinoma
A Study of Ramucirumab (LY3009806) Plus MEDI4736 in Participants With Advanced Gastrointestinal or Thoracic Malignancies
The main purpose of this study is to evaluate the safety of ramucirumab plus MEDI4736 in participants with locally advanced and unresectable or metastatic gastrointestinal or thoracic malignancies including gastric or…
- Conditions
- Gastric Cancer, Gastroesophageal Junction Adenocarcinoma, Non-Small Cell Lung Cancer, Hepatocellular Carcinoma
- Trial name
- NCT02572687
- Testing
- Ramucirumab, MEDI4736
- Where
- 28 sites in United States, France and 6 more
- Volunteers
- 85 people
- Sponsor
- Eli Lilly and Company
Venous Thromboembolism, Gastro Intestinal Bleeding
Reducing Gastrointestinal Bleeding With Proton Pump Inhibitor Therapy in Acute Venous Thromboembolism
The investigators are studying whether treatment with a proton pump inhibitor called omeprazole reduces gastrointestinal bleeding in older adults taking blood thinners for a blood clot (venous thromboembolism).
- Conditions
- Venous Thromboembolism, Gastro Intestinal Bleeding, Blood Clot
- Trial name
- NCT06393868
- Testing
- Omeprazole 20 mg Oral Tablet
- Where
- 7 sites in Canada
- Volunteers
- 360 people
- Sponsor
- Ottawa Hospital Research Institute
Ischemic Reperfusion Injury, Liver Injury
Recurrence of Liver Malignancy After Ischemia/Reperfusion Injury
Severe ischemic changes of the liver remnant after hepatectomy could expedite tumor recurrence on the residual liver. Our study aimed at assessing the effect of warm ischemic/reperfusion (I/R) injuries on surgery-to-local…
- Conditions
- Ischemic Reperfusion Injury, Liver Injury, Cancer Recurrence, Malignancy
- Trial name
- annie-liver (NCT04257240)
- Testing
- selective hepatic vascular exclusion, semielective hepatic vascular exclusion
- Volunteers
- 230 people
- Sponsor
- Aretaieion University Hospital
Hemorrhoids, Postoperative Pain
Ultrasound-Guided Versus Landmark-Guided Pudendal Block for Post-Hemorrhoidectomy Pain
Hemorrhoid surgery is often followed by significant pain during the first few days after the operation. Pudendal nerve block is a pain-control technique that can help reduce discomfort after surgery.
- Conditions
- Hemorrhoids, Postoperative Pain, Pudendal Nerve Block
- Trial name
- NCT07889869
- Testing
- Ultrasound-Guided Pudendal Nerve Block, Landmark-Guided Pudendal Nerve Block
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Konya City Hospital
Asthma
Retrospective Analysis of Systemic Glucocorticoid Mediated Long-term Effects, Patient Pathways and Economic Burden Across Multiple Indications
Glucocorticoids are important in the treatment of many inflammatory, allergic, immunologic, and malignant disorders. However, the adverse effects of systemic corticosteroids are one of the most common causes of iatrogenic…
- Trial name
- NCT06488703
- Where
- Germany
- Volunteers
- 107,032 people
- Sponsor
- GlaxoSmithKline
Cancer, Breast Cancer
Biomarker-Guided Allogeneic Single-Target or Dual-Target CAR-NK Cell Therapy for Advanced Solid Tumors
This Phase 1/2 study evaluates the safety, feasibility, and preliminary anti-tumor activity of allogeneic donor-derived CAR-NK cells in participants with advanced solid tumors.
- Conditions
- Cancer, Breast Cancer, Non-Small Cell Lung Cancer (NSCLC), Colorectal Cancer (Locally Advanced or Metastatic)
- Trial name
- SELECT-CAR-NK (NCT07410494)
- Testing
- EB-SELECT Single-Target CAR-NK Cells, Dual-Target Antigen-Selected CAR-NK
- Where
- China
- Volunteers
- 85 people
- Sponsor
- Essen Biotech
Hemorrhoid
Subarachnoid or Infiltration for Hemorrhoidectomy
There will be compared the postoperative analgesic effect of infiltration or spinal block for hemorrhoidectomy
- Trial name
- NCT01927874
- Testing
- Infiltration, Spinal block, Bupivacaine
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of São Paulo
Liver Cirrhosis
Coagulation in Cirrhosis
Out of fear of bleeding, liver cirrhosis patients are often treated prophylactically with blood and coagulation products before minor interventions.
- Trial name
- COUCH (NCT05667805)
- Testing
- Platelet Concentrate, Prothrombin Complex Concentrate, Restricitve Use
- Where
- Austria
- Volunteers
- 400 people
- Sponsor
- Medical University of Vienna
Mesenteric Ischemia, Bowel; Ischemic
Copenhagen Mesenteric Stent Study - A Randomized Trial of Stent Versus Covered Stent Treatment for Chronic Mesenteric Ischemia
Chronic mesenteric ischemia (CMI) is often caused by narrowings in the arteries providing blood to the intestines. Endovascular stent placement is considered the preferred treatment for this condition.
- Conditions
- Mesenteric Ischemia, Bowel; Ischemic, Superior Mesenteric Atherosclerosis, Mesenteric Artery Stenosis
- Trial name
- COMESS (NCT05244629)
- Testing
- BMS vs. CS
- Where
- Denmark
- Volunteers
- 98 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission
Lithium Carbonate in Treating Patients With Acute Intestinal Graft-Versus-Host-Disease (GVHD) After Donor Stem Cell Transplant
RATIONALE: Lithium carbonate may be an effective treatment for intestinal graft-versus-host disease caused by a donor stem cell transplant.
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities
- Trial name
- GVHD (NCT00408681)
- Testing
- lithium carbonate, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Fred Hutchinson Cancer Center
Varicose Veins, Chronic Venous Insufficiency
The Influence of Laser Crossectomy With Different Wavelengths on Varicose Vein Progression
Technically successful laser crossectomy will reduce the risk of reflux recurrence at the sapheno-femoral junction without increasing the risk of endovenous heat-induced thrombosis, which may positively impact the likelihood of…
- Trial name
- LACROSS-VVP (NCT07449728)
- Testing
- Laser crossectomy on 1470 nm, Laser crossectomy on 1940 nm, Standard EVLT with a stump
- Where
- Russia
- Volunteers
- 400 people
- Sponsor
- Pirogov Russian National Research Medical University
Severe Hepatic Veno-Occlusive Disease
Defibrotide for the Treatment of Severe Hepatic Veno-Occlusive Disease in Hematopoetic Stem Cell Transplant Patients
The purpose of this study is to (1) demonstrate the efficacy and safety (toxicity) of 25 mg/kg/day of Defibrotide in patients with severe veno-occlusive disease (sVOD) and (2) evaluate serum and endothelial markers of…
- Trial name
- NCT00358501
- Testing
- Defibrotide
- Where
- 25 sites in United States, Canada
- Volunteers
- 134 people
- Sponsor
- Jazz Pharmaceuticals
Lymphoma
Revlimid® Capsules Drug Use-results Surveillance (Relapsed or Refractory ATLL)
To understand the safety and efficacy of Revlimid® Capsules 2.5 mg and 5 mg (hereinafter referred to as Revlimid) under actual conditions of use in patients with relapsed or refractory adult T-cell leukemia lymphoma (hereinafter…
- Trial name
- NCT03098589
- Testing
- Revlimid
- Where
- Japan
- Volunteers
- 1,149 people
- Sponsor
- Celgene