Clinical trials: Gastrointestinal and Digestive Disorder
Advanced Solid Tumors, MSI-H/dMMR Tumors
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of INCB099318 in Participants With Advanced Solid Tumors
The purpose of this study is to evaluate the safety and tolerability, pharmacokinetics, and pharmacodynamics of INCB099318 in select solid tumors.
- Conditions
- Advanced Solid Tumors, MSI-H/dMMR Tumors, Cutaneous Squamous Cell Carcinoma, Urothelial Carcinoma, HCC
- Trial name
- NCT04272034
- Testing
- INCB099318
- Where
- 24 sites in United States, Belgium and 5 more
- Volunteers
- 105 people
- Sponsor
- Incyte Corporation
Pancreatitis, Chronic, Stricture; Bile Duct
GORE® VIABIL® Biliary Endoprosthesis in the Treatment of Benign Biliary Strictures Secondary to Chronic Pancreatitis
This study will evaluate the safety and effectiveness of the GORE® VIABIL® Biliary Endoprosthesis in the treatment of benign biliary strictures secondary to Chronic Pancreatitis (CP).
- Trial name
- VIABILITY (NCT05820009)
- Testing
- GORE® VIABIL® Biliary Endoprosthesis, GORE® VIABIL® Short Wire Biliary Endoprosthesis
- Where
- 2 sites in United States
- Volunteers
- 133 people
- Sponsor
- W.L.Gore & Associates
Pancreatic Cancer, Surgery
Laparoscopic vs Open Pancreatectomy for Body and Tail Pancreatic Cancer
Open distal pancreatectomy (ODP) has been commonly employed for the treatment of a variety of cancers in body and tail of pancreas.
- Conditions
- Pancreatic Cancer, Surgery, Laparoscopy
- Trial name
- NCT03792932
- Testing
- Laparoscopic distal pancreatectomy, Open distal pancreatectomy
- Where
- 11 sites in China
- Volunteers
- 306 people
- Sponsor
- Fudan University
Sperm Motility (Focus of Study)
Influence of Ribavirin and Interferon on Semen Quality, IRIS Study
The aim of this study is to study the effect of peginterferon alpha and ribavirin on spermatozoa.
- Trial name
- IRIS (NCT00455832)
- Testing
- peginterferon alpha and ribavirin
- Where
- Netherlands
- Volunteers
- 23 people
- Sponsor
- Foundation for Liver Research
Non Small Cell Lung Cancer, Esophageal Cancer
Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors
The objective of this study is to evaluate the safety, tolerability, and efficacy of BL-B01D1 in patients with Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors.
- Conditions
- Non Small Cell Lung Cancer, Esophageal Cancer, Small Cell Lung Cancer, Nasopharyngeal Cancer
- Trial name
- NCT05983432
- Testing
- BL-B01D1
- Where
- 37 sites in United States, France and 3 more
- Volunteers
- 540 people
- Sponsor
- SystImmune Inc.
Prostate Cancer, Colorectal Cancer
Impact of Exercise on Mitochondria in Cancer Patients.
The aim is to investigate the impact of prostate and colorectal cancer on mitochondrial quantity and quality along with muscle mass and function and whether this can be modified through the use of a home-based short-term exercise…
- Trial name
- ICCE-Mito (NCT04558398)
- Testing
- Resistance exercise training, High-intensity interval training
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- University of Nottingham
Hepatocellular Carcinoma, Liver Cancer
Radioembolization With Yttrium-90 Microspheres for Intermediate or Advanced Hepatocellular Carcinoma
Rationale: Patients diagnosed with hepatocellular carcinoma (HCC) at an intermediate or advanced stage (according to the BCLC classification system) are not amenable of curative treatment.
- Trial name
- NCT00910572
- Testing
- Yttrium-90 microspheres (Therasphere MDS Nordion)
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Liver Diseases, Alagille Syndrome
Longitudinal Study of Genetic Causes of Intrahepatic Cholestasis (LOGIC)
Cholestasis is a condition in which bile is not properly transported from the liver to the small intestine. Cholestasis can be caused by an array of childhood diseases, including the genetic diseases Alagille syndrome (ALGS)…
- Conditions
- Liver Diseases, Alagille Syndrome, Alpha 1-Antitrypsin Deficiency
- Trial name
- LOGIC (NCT00571272)
- Where
- 17 sites in United States, Canada
- Volunteers
- 1,675 people
- Sponsor
- Arbor Research Collaborative for Health
Esophageal Cancer, Kidney Cancer
GI Organ Tracking Via Balloon Applicators
The hypothesis of this study is that an occlusion balloon catheter placed in the stomach via an oral or nasogastric route will be safe and permit tracking of the stomach during radiation therapy.
- Conditions
- Esophageal Cancer, Kidney Cancer, Larynx Cancer, Liver Cancer
- Trial name
- NCT05471401
- Testing
- Balloon-tipped catheter
- Sponsor
- Washington University School of Medicine
Functional Gastrointestinal Disorders, Infant, Newborn, Diseases
Quantification of Fecal Calprotectin Concentration Difference Between Infants Aged Under 4 Months Old Suffering From Functional Gastrointestinal Disorders (FGID) and Infants Aged Under 4 Months Old Free From Disorders : a Transversal Case-control Monocentric Study
There is a high prevalence of FGID among infants : 30 % for regurgitations, 20 % for colitis , 15 % for functional constipation.This represents a frequent motive for pediatrics consultation : 23 to 28 % of medical consultations…
- Trial name
- Cal-IBS (NCT05936112)
- Testing
- Fecal calprotectin dosage, Questionnaire and interview with parents
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Gastrointestinal Hemorrhage
Evaluation the Performance of Given Diagnostic System in Detection of Bleeding Events in the Small Bowel
Obscure gastrointestinal bleeding (OGIB) has been one of the most challenging area in the field of gastroenterology, as small bowel is beyond the reach of ordinary endoscopes like oesophagogastroduodenoscopy (OGD) and…
- Trial name
- NCT01441219
- Testing
- Colon 2
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Chinese University of Hong Kong
Cystic Fibrosis
Urinary and Anorectal Functional Disorders and Their Impact on CF Adults (PerineoMucoRMO)
This observational study evaluates prevalence of functional perinea disorders (stress urinary incontinence, overactive bladder syndrome, dysuria, anal incontinence) on CF adults patients of the North-West CF Network.
- Trial name
- PerineoMuco (NCT02894619)
- Where
- 6 sites in France
- Volunteers
- 180 people
- Sponsor
- Fondation Ildys
Cystic Fibrosis
Antibiotic Treatment Of Staphylococcus Aureus In Stable People With CF
This is a randomized, double-blinded study that aims to assess the effect of an oral antibiotic called Cephalexin (150 mg/kg/day) compared to placebo in clinically stable children with cystic fibrosis who have grown a bacteria…
- Trial name
- ASAP-CF (NCT04553419)
- Testing
- Cephalexin
- Where
- 2 sites in Canada
- Volunteers
- 86 people
- Sponsor
- University of British Columbia
GIST
A Phase 2 Trial of Ponatinib in Participants With Metastatic and/or Unresectable Gastrointestinal Stromal Tumor
The purpose of this study is to evaluate the efficacy and safety of ponatinib in participants with metastatic and/or unresectable gastrointestinal stromal tumor (GIST) following failure of prior tyrosine kinase inhibitor (TKI)…
- Trial name
- GIST (NCT01874665)
- Testing
- Ponatinib
- Where
- 4 sites in United States
- Volunteers
- 45 people
- Sponsor
- Ariad Pharmaceuticals
Ulcerative Colitis
Oligofructose-enriched Inulin for the Treatment of Mild to Moderate Active Ulcerative Colitis
Based on the efficacy of inulin and oligofructose in treating experimental colitis and emerging evidence suggesting probiotics are efficacious in maintaining and inducing remission in human ulcerative colitis (UC), the…
- Trial name
- NCT02093767
- Testing
- Synergy1
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- University of Alberta
Non-Alcoholic Steatohepatitis (NASH), Type2 Diabetes Mellitus
A Pilot Study to Assess the Safety of Oral Insulin in Patients With Nonalcolholic Steatohepatitis (NASH)
This is an open, pilot study using the oral ORMD-0801 insulin formulation in patients with NASH and confirmed type 2 DM or pre-diabetes.
- Trial name
- NCT02653300
- Testing
- Oral Insulin
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Oramed, Ltd.
Esophageal Carcinoma, Gastroesophageal Junction Carcinoma
A Study to Evaluate Nivolumab in the Treatment of Early Stage Esophageal or Gastroesophageal Cancer
The purpose of this study is to describe the effectiveness and use of nivolumab after surgery in participants with early stage (Stage II/III) Esophageal Cancer/Gastroesophageal Junction Cancer (EC/GEJC).
- Trial name
- PROSPECT-ESO (NCT05780736)
- Where
- 24 sites in United States, Germany
- Volunteers
- 33 people
- Sponsor
- Bristol-Myers Squibb
Colorectal Cancer
A Multi-centre Study Comparing the Polyp Detection Rate of Two Different Types of Bowel Preparation: a 2-litre Solution (MOVIPREP®) Versus a Hyperosmotic and Stimulant Combined Low Volume Bowel Preparation (Sodium Picosulfate and Magnesium Citrate)
To compare the polyp and adenoma detection rate of MOVIPREP versus an oral Sodium Picosulfate/Magnesium Citrate solution.
- Trial name
- NCT01689792
- Testing
- MOVIPREP, CitraFleet
- Where
- Germany
- Volunteers
- 398 people
- Sponsor
- Norgine
Chronic Hepatitis C, Organ Transplantation
Randomized Controlled Trial in Liver Transplant Recipients Treated in Steroid Sparing Regimen
Liver transplant subjects will be given Mycophenolate (MMF) and Tacrolimus in order to help prevent post-transplant rejection.
- Conditions
- Chronic Hepatitis C, Organ Transplantation, Immunosuppression
- Trial name
- NCT00286871
- Testing
- Neoral, Tacrolimus
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Duke University
Rectal Cancer
Monitoring by Microdialysis of Postoperative Complications After Proctectomy
The aim of this study is to monitor by microdialysis the postoperative outcomes in order to identify anastomotic leaks after rectal surgery.
- Trial name
- MTM-COLON-II (NCT01999634)
- Testing
- cma microdialysis catheter placement
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
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