Clinical trials: Gastrointestinal and Digestive Disorder
Primary Ciliary Dyskinesia, Cystic Fibrosis
Respiratory Function, Exercise Capacity and Peripheral Muscle Strength Among Patients With CF, PCD and Healthy Children
The aim of this study is to compare pulmonary function, respiratory muscle strength, exercise capacity and peripheral muscle strength of patients with CF, PCD and healthy childrens.
- Trial name
- NCT04161313
- Testing
- Measurement of functional capacity, pulmonary function test, Functional capacity
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Crohn Disease
Effects of Acupuncture on Abdominal Pain-related Intestinal Flora in Patients With Crohn's Disease
Crohn's disease is an intestinal inflammatory disease, causing abdominal pain, diarrhea and other symptoms. The intestinal flora disorder is closely related to the occurrence and development of Crohn's disease.
- Trial name
- NCT06375382
- Testing
- acupuncture
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Shanghai Institute of Acupuncture, Moxibustion and Meridian
Gastric Cancer/Gastroesophageal Junction Adenocarcinoma
XELOX Combined With Fruquintinib and Sintilimab Regimen Conversion Therapy for Gastric Cancer/Gastroesophageal Junction Adenocarcinoma Only With Liver and/or Retroperitoneal Lymph Node Metastasis, a Prospective Single-arm, Multicenter Study
Gastric cancer is the third leading cause of morbidity and mortality among malignant tumors in China, and less than 30% of patients can be cured by surgery.
- Trial name
- NCT06091423
- Testing
- XELOX combined with Fruquintinib and Sintilimab
- Where
- China
- Volunteers
- 43 people
- Sponsor
- Xiaofeng Chen
Cutaneous Melanoma, Pleural Mesothelioma
A Study of SGN-CD228A in Advanced Solid Tumors
This trial will study SGN-CD228A to find out whether it is an effective treatment for different kinds of cancer. It will also look at what side effects (unwanted effects) may occur. The study will have two parts.
- Conditions
- Cutaneous Melanoma, Pleural Mesothelioma, HER2 Negative Breast Neoplasms, Non-small Cell Lung Cancer
- Trial name
- NCT04042480
- Testing
- SGN-CD228A
- Where
- 14 sites in United States, France and 3 more
- Volunteers
- 88 people
- Sponsor
- Seagen Inc.
GERD, Hiatal Hernia
Antireflux Surgery Without Preoperative Esophageal Manometry
The goal of this clinical trial is to learn if people can safely skip a test called esophageal manometry before surgery for acid reflux (gastroesophageal reflux disease, or GERD) or a hiatal hernia.
- Conditions
- GERD, Hiatal Hernia, Heartburn, Paraesophageal Hernia
- Trial name
- NOMA (NCT07659080)
- Testing
- Preoperative workup without high-resolution esophageal manometry, Standard preoperative workup with high-resolution esophageal manometry
- Where
- 2 sites in United States, Canada
- Volunteers
- 96 people
- Sponsor
- McMaster University
Esophagus Cancer
Neoadjuvant Comprehensive Treatment for Unresectable Esophageal Cancer
Patients diagnosed with locally advanced esophageal squamous cell carcinoma (ESCC) that is deemed unresectable face a bleak prognosis.
- Trial name
- NEXUS-2 (NCT06430658)
- Testing
- Tislelizumab (BGB-A317) with chemoradiotherapy
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Digestive System Disease, Urologic Diseases
Low-dose Droperidol for Prevention of Postoperative Delirium in Elderly Patients After Non-cardiac Surgery
The aim of this multicenter, prospective, randomized, double-blind and large sample study is to explore the preventive effect of low-dose droperidol on POD in elderly patients after non-cardiac surgery, providing new approach for…
- Conditions
- Digestive System Disease, Urologic Diseases, Gynecological Disease, Orthopedic Surgery
- Trial name
- NCT05401058
- Testing
- Droperidol Injection, Saline
- Where
- 9 sites in China
- Volunteers
- 797 people
- Sponsor
- RenJi Hospital
Cirrhosis, Liver
Comparison of the Effect of Two Interventions on Liver Frailty Index in Pre-frail and Frail Cirrhotic Patients Enlisted for Liver Transplantation
The goal of this prospective, double blind randomized clinical trial is to compare the effectiveness of two interventions in improve frailty (measured by Liver Frailty Index) and quality of life (measured by Chronic Liver Disease…
- Trial name
- NCT06149026
- Testing
- Physical and nutritional therapy
- Where
- Chile
- Volunteers
- 80 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Rectal Adenocarcinoma
Neo-adjuvant Chemoradiotherapy Using Infusional Gemcitabine Followed by Surgery for Locally Advanced Rectal Cancer
Phase II Study of Neo-adjuvant Chemoradiotherapy using infusional Gemcitabine followed by Surgery for Locally Advanced (T3 and T4 or Node positive) Rectal Adenocarcinoma.
- Trial name
- NCT02919878
- Testing
- Gemcitabine, XRT, capecitabine
- Where
- Saudi Arabia
- Volunteers
- 25 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Chronic Pancreatitis
Analysis of Graft Function Following Autologous Islet Transplantation
Analyze inflammatory markers and islet graft function through blood samples collected from subjects with chronic pancreatitis who undergo total pancreatectomy with auto islet transplantation.
- Trial name
- NCT03097185
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Baylor Research Institute
Cholecystitis, Cholecystitis, Chronic
Shortwave Infrared Surgical Imaging Device Study
The goal of this observational study is to perform an in-human assessment of an investigational shortwave infrared (SWIR) imaging device, aimed to enhance the visualization of critical anatomical structures during surgical…
- Conditions
- Cholecystitis, Cholecystitis, Chronic, Chronic Calculous Cholecystitis, Primary Hyperparathyroidism
- Trial name
- NCT07744425
- Testing
- Observational study of SWIR imaging device in surgery
- Where
- 6 sites in United States
- Volunteers
- 50 people
- Sponsor
- Cision Vision, Inc.
Pancreas Cyst, Pancreas Mass
RNA Sequencing of Solid and Cystic Lesions of the Pancreas
The nature of cysts and solid masses in the pancreas can be difficult to diagnose. They may be benign, precancerous, or cancer. Current tests such as cytology (looking under a microscope) and tumor markers do not always give us…
- Trial name
- NCT01807325
- Testing
- pancreas biopsy
- Where
- 2 sites in United States
- Volunteers
- 72 people
- Sponsor
- Oregon Health and Science University
Gastrointestinal System Disease, Respiratory System
Probiotics Prevent Health Problems in Children
Randomized controlled field trial of a probiotics to assess its roles in the prevention or improvement of constipation and diarrhea, acute respiratory infection, nutrition improving in Vietnam children.
- Trial name
- Shirota (NCT04346576)
- Testing
- Probiotics prevent health problems in children
- Where
- Vietnam
- Volunteers
- 1,036 people, healthy volunteers welcome
- Sponsor
- National Institute of Nutrition, Vietnam
Gastrectomy, Laparoscopy
A Clinical Study for Comparison of the Effects Between Gasless Laparoscopy and Conventional Laparoscopy for Distal Gastric Cancer
The aim of this trial is to confirm the non-inferiority of Gasless laparoscopy-assisted distal D2 radical gastrectomy to the conventional laparoscopy-assisted distal D2 radical gastrectomy for the treatment of advanced gastric…
- Trial name
- NCT05495217
- Testing
- Conventional Laparoscopy, Gasless Laparoscopy
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xue Yingwei
HIV Infection, Hepatitis C
Interferon Alfa Sensitivity in HIV/HCV Persons Before and After HIV Meds
The chief purpose of this research is to evaluate interferon alpha sensitivity and cell type specific levels of interferon receptor and interferon stimulated genes and proteins in HIV/ HCV (hepatitis C virus) coinfected persons…
- Trial name
- NCT01285050
- Testing
- Antiretroviral therapy (ART), raltegravir, Emtricitabine and tenofovir disoproxil fumarate
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Johns Hopkins University
Liver Cancer
Interventional X-ray and Scintigraphy Imaging of 99mTc-MAA During the Radioembolisation Pretreatment Procedure
To establish the safety and feasibility of interventional x-ray and scintigraphy imaging during the pre-treatment procedure of hepatic radioembolization
- Trial name
- IXSI (NCT06013774)
- Testing
- IXSI
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- UMC Utrecht
Hepatitis B Virus, Hepatocellular Carcinoma
TACE and Adefovir Compared With Transarterial Chemoembolization (TACE) Alone for Hepatitis B Virus (HBV)-Related Unresectable Hepatocellular Carcinoma (HCC)
Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies in China, and approximately 90% of the patients with HCC are also infected with hepatitis B virus (HBV).
- Trial name
- TACE (NCT00960518)
- Testing
- adefovir, TACE
- Where
- 2 sites in China
- Volunteers
- 216 people
- Sponsor
- Tongji University
Locally Advanced Esophageal Squamous Cell Carcinoma
Sintilimab Injection Combined With Concurrent CCRT in Locally Advanced Esophageal Squamous Cell Carcinoma
This study evaluated the effectiveness and safety of sintilimab combined with cCRT in patients with locally advanced ESCC.
- Trial name
- NCT04602013
- Testing
- Sintilimab, Chemotherapy, Radiation Therapy
- Where
- China
- Volunteers
- 53 people
- Sponsor
- Sichuan Cancer Hospital and Research Institute
Stomach Cancer, Esophageal Cancer
A Study of Ramucirumab in Participants With Gastric, Esophageal, and Gastroesophageal Cancer
The purpose of this study is to determine whether ramucirumab when used in conjunction with chemotherapy treatment can help participants with stomach, esophagus, and gastroesophageal cancer.
- Trial name
- NCT01246960
- Testing
- Ramucirumab, Oxaliplatin, Leucovorin
- Where
- 58 sites in United States
- Volunteers
- 168 people
- Sponsor
- Eli Lilly and Company
Hepatitis C
Hepatitis c and Vitamin D and Iron Status
HCV is associated with vitamin D deficiency. Iron overload is frequently occurred in chronic hepatitis C patients; more than one third of HCV positive patients have elevated serum iron, ferritin, and transferrin which were linked…
- Trial name
- hepatitisc (NCT03166280)
- Testing
- Sofosbuvir 400 mg, Daclatasvir 60 mg/day
- Volunteers
- 87 people
- Sponsor
- Eman Sayed Hassan Abd Allah
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