Clinical trials: Gastrointestinal and Digestive Disorder
Gastric Cancer Stage IV, Peritoneal Carcinomatosis
Intraperitoneal Paclitaxel Plus Systemic mFOLFOX6
Treatment for stage 4 gastric cancer with peritoneal carcinomatosis has been unchanged for decades. The median survival for stage 4 gastric cancer is 9-14 months with systemic chemotherapy.
- Conditions
- Gastric Cancer Stage IV, Peritoneal Carcinomatosis, Intraperitoneal Paclitaxel, mFOLFOX6
- Trial name
- IPLUS (NCT03618758)
- Testing
- Paclitaxel, mFOLFOX6 regimen
- Where
- South Korea
- Volunteers
- 35 people
- Sponsor
- Seoul National University Bundang Hospital
HIV Infections, Hepatitis C
Efficacy and Safety to Extend Treatment 24 Weeks in co-Infected HIV-HCV Genotype 1 and/or 4
A study concerning viral kinetic with 10 co-infected HIV-HCV patients on treatment with peginterferon alfa-2a + ribavirin o IFN + ribavirin was reported in Conference on Retroviruses and Opportunistic Infections 2002 by Dr.
- Trial name
- NCT00612755
- Testing
- Peginterferon alfa-2a + ribavirin
- Where
- 19 sites in Spain
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Hospital Clinico Universitario San Cecilio
Cholecystitis, Acute, Cholecystitis, Chronic
BDD With UDCA Therapy After Laparoscopic Cholecystectomy
Prospective Study for the Effects of Biphenyl Dimethyl Dicarboxylate and Ursodeoxycolic Acid Therapy on Liver Function and Quality of Life After Laparoscopic Cholecystectomy Primary endpoint: peak level of postoperative AST…
- Trial name
- BULQ-LC (NCT03578055)
- Testing
- BDD with UDCA
- Where
- South Korea
- Volunteers
- 172 people
- Sponsor
- Ewha Womans University Mokdong Hospital
Gastroparesis, Idiopathic Gastric Motility Disorder
Pyloric Sphincter Abnormalities in Patients With Gastroparesis Symptoms
The overall objective of this study is to determine if there are pyloric sphincter abnormalities in patients with gastroparesis symptoms and determine how prevalent these abnormalities are using tests to assess the pyloric…
- Conditions
- Gastroparesis, Idiopathic Gastric Motility Disorder, Diabetic Gastroparesis
- Trial name
- PSAGS (NCT04661215)
- Where
- 5 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Colorectal Cancer
Educate, Assess Risk and Overcoming Barriers to Colorectal Screening Among African Americans
The burden of colorectal cancer (CRC) is unequal among various populations within the United States. This inequality is most notable among African Americans, who exhibit the highest CRC mortality of all US populations.
- Trial name
- NCT03640208
- Testing
- Education presented by trained caregiver
- Where
- United States
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- Case Comprehensive Cancer Center
Malignant Neoplasms, Tuberculosis (TB)
Prophylaxis of Complications of Basic Therapy Using Naderin in Socially Significant Diseases
This interventional study evaluated the efficacy of Naderin (sodium nucleinate) for the prophylaxis of complications during basic therapy and medical rehabilitation in patients with socially significant diseases, including…
- Conditions
- Malignant Neoplasms, Tuberculosis (TB), HEPATITIS C (HCV)
- Trial name
- NADERIN-SSD (NCT07671508)
- Testing
- Naderin, Standard Therapy
- Volunteers
- 75 people
- Sponsor
- MIPO Clinic
Oncologic Complications, Quality of Life
Nutrition and Pharmacological Algorithm for Oncology Patients Study
Loss of appetite is a common symptom of patients with cancer and can cause distress which impacts patients and caregivers. Patients diagnosed with head/neck, lung or pancreatic cancer will be recruited for this study to decrease…
- Conditions
- Oncologic Complications, Quality of Life, Nutrition Poor, Head and Neck Cancer
- Trial name
- NCT04155008
- Testing
- Dexamethasone, Dronabinol, Mirtazapine
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Montefiore Medical Center
Oral Mucositis
Study of Dentoxol® Mouthrinse for Oral Mucositis
The primary objective of this study is to determine the efficacy of Dentoxol® mouthrinse in reducing the severity of oral mucositis secondary to radiation therapy for head and neck cancer.
- Trial name
- NCT02885376
- Testing
- Dentoxol
- Where
- 3 sites in Chile
- Volunteers
- 108 people
- Sponsor
- Ingalfarma SpA
Pancreatic Fistula
Trans-drain Occlusion for Postoperative Pancreatic Fistula- A Double Blind Randomized Clinical Trial
This is a multicenter, investigator initiated, prospective, superiority, parallel-group, randomized, double-blinded trial that aims to compare the efficacy and safety of trans-drain occlusion followed by gradual withdrawal of…
- Trial name
- NCT03800940
- Testing
- Fistulography and trans-drain occlusion, Fistulography
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Pancreatic Neuroendocrine Neoplasm, Sorafenib
A Clinical Study of Sorafenib Combined With Gefitinib for the Treatment of pNET
The incidence rate of pancreatic neuroendocrine neoplasms (pNENs) is increasing year by year. According to the statistical results of the SEER (Surveillance, Epidemiology, and End Results) database, the incidence rate of pNENs…
- Conditions
- Pancreatic Neuroendocrine Neoplasm, Sorafenib, Gefitinib
- Trial name
- NCT06592989
- Testing
- sorafenib, gefitinib
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Colorectal Cancer, Stoma
Construction and Evaluation of a Flipped Discharge Model for Stomates With Colorectal Cancer
This multicenter randomized controlled trial aims to develop and evaluate the effectiveness of a "Flipped Discharge" intervention for colorectal cancer patients with a new intestinal stoma.
- Trial name
- NCT07463690
- Testing
- Response to Transition Theory-based Flipped Discharge Model
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Sun Yat-sen University
Colorectal Cancer
CRC Post-surgical Assessment and Recurrence Monitoring
The surgical therapeutic effect of stage II-IV CRC patients will be assessed by the plasma mSEPT9 assay, and patients will be followed up by the same assay for recurrence monitoring.
- Trial name
- NCT03334890
- Testing
- plasma mSEPT9 level
- Where
- 4 sites in China
- Volunteers
- 50 people
- Sponsor
- BioChain (Beijing) Science and Technology, Inc.
Irritable Bowel Syndrome
The Efficacy of Sodium Butyrate and Probiotics in Patients With Irritable Bowel Syndrome
According to current IBS management guidelines, probiotic administration reduces IBS-associated symptoms and improves the quality of life.
- Trial name
- IBS-Plus (NCT05013060)
- Testing
- Probiotics and microcapsulated sodium butyrate, Maltodextrin
- Where
- Poland
- Volunteers
- 120 people
- Sponsor
- Nordic Biotic Sp. z o.o.
Irritable Bowel Syndrome
Dietary Interventions for Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is a disorder of gut-brain interaction characterized by recurrent abdominal pain and altered bowel habits.
- Trial name
- IBS-DIET (NCT07774923)
- Testing
- Low-FODMAP Diet, Gluten-Free and Lactose-Free Diet
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istanbul Gelisim University
Liver Cancer (Primary and Metastatic)
Short-term Embolization Using Gelatin Particles for FloW ModulAtion During Y90 Radioembolization
The SEGWAY trial is a prospective, single-arm clinical study to evaluate the efficacy and safety of flow diversion to protect non-tumorous liver function using short-acting gelatin sponge particles during Yttrium-90…
- Trial name
- SEGWAY (NCT06229080)
- Testing
- NexGel
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Next Biomedical Co., Ltd.
Functional Constipation, Gastrointestinal Disorders
A Randomized, Open-label, Three-arm Study of MZRW on Tolerability, Exposure and Pharmacokinetics
This is a randomized open-label, three-arm, phase 1 clinical study. The investigators aim to investigate a Chinese Proprietary Medicine, MZRW on its tolerability, system exposure and pharmacokinetics profile.
- Trial name
- NCT02359396
- Testing
- MZRW
- Where
- China
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Hong Kong Baptist University
Hemorrhoids, Postoperative Pain
Ultrasound-guided Pudendal Nerve Block for Pain After Hemorrhoidectomy
The goal of this clinical trial is to investigate the effects of ultrasound-guided pudendal nerve block on postoperative pain, opioid consumption, and quality of recovery in patients receiving Ferguson hemorrhoidectomy.
- Trial name
- NCT05889962
- Testing
- Pudendal nerve block
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Taipei Medical University Hospital
Gastric Cancer
Comparison of Surgical,Clinical and Oncological Outcomes Between Robotic-assisted and Laparoscopic-assisted Gastrectomy
The study aims to compare the clinical outcomes between robotic-assisted and laparoscopic-assisted gastrectomy for gastric cancer,and evaluate the the feasibility and safety of robotic gastrectomy.
- Trial name
- NCT02413476
- Testing
- Robotic-assisted Gastrectomy(RAG), Laparoscopic-assisted Gastrectomy(LAG)
- Volunteers
- 120 people
- Sponsor
- wei bo
Esophageal Cancer, Non-small Cell Lung Cancer
Early Prediction of Pathology Response of Chemoradiotherapy With FLT PET
The goal of this research study is to learn if a new type of PET scan (18F-FLT) can help to better detect changes of tumor growth rate (or how active) in esophagus cancer and lung cancer Researchers will study at what time during…
- Trial name
- NCT01065818
- Testing
- Fluoro-L-Thymidine
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Columbia University
Hepatocellular Carcinoma
Combination of SBRT and Immunotherapy in Small Hepatocellular Carcinoma (HSBRT2402)
For inoperable small hepatocellular carcinoma (HCC), stereotactic body radiotherapy (SBRT) is an effective and safe local treatment.
- Trial name
- HSBRT2402 (NCT06313190)
- Testing
- Stereotactic body radiotherapy, Sintilimab
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Sun Yat-sen University
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.