Clinical trials: Gastrointestinal and Digestive Disorder
Delayed Gastric Emptying, Gastroparesis
Using Point-of-Care-Ultrasound (POCUS) to Assess Gastric Contents Among Fasting Pre-operative Patients Taking GLP-1 Agonists.
Given the increased prescription of GLP-1 agonists for both diabetes and obesity management and the implications of the proposed delayed gastric emptying in the setting of an anesthetic, it is critical to determine if patients…
- Trial name
- NCT06038734
- Testing
- gastric ultrasound
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Pancreatic Cancer, Bile Duct Cancer
Effects of Preoperative Immunonutrition in Patients Undergoing Pancreaticoduodenectomy
The purpose of this study is to determine whether preoperative immunonutrition is effective on infectious complication and Th1/Th2 differentiation in patients with pancreaticoduodenectomy.
- Trial name
- EPIPD (NCT01256034)
- Testing
- Oral IMPACT
- Where
- Japan
- Volunteers
- 50 people
- Sponsor
- Chiba University
Healthy Volunteer, Prostate Cancer
Circulating Tumor DNA (ctDNA) for Early Treatment Response Assessment of Solid Tumors
Earlier detection of disease recurrence will enable greater treatment options and has strong potential to improve patient outcomes.
- Conditions
- Healthy Volunteer, Prostate Cancer, Head and Neck Cancer, Esophageal Cancer
- Trial name
- NCT04354064
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
IPMN, Pancreatic, Pancreas Cancer
The LINFU® U.S. Registry in Patients With IPMN (Intraductal Papillary Mucinous Neoplasm of the Pancreas)
In this study, LINFU® will be evaluated in patients who have been identified with IPMN to determine if it can be used to help identify early, pancreatic ductal adenocarcinoma and its noninvasive precursor lesions (dysplasia).
- Conditions
- IPMN, Pancreatic, Pancreas Cancer, Pancreatic Cyst
- Trial name
- NCT06276764
- Testing
- LINFU®
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Adenocyte, LLC
Locally Advanced Rectal Cancer, Older People
Efficacy and Safety of Conventional Neoadjuvant Therapy Versus Total Neoadjuvant Therapy in Older Patients With Locally Advanced Rectal Cancer
The SHAPERS study is a multicentre, open-label, randomised, pragmatic clinical trial, comparing standard-of-care neoadjuvant treatment options for older (i.e., ≥70 years) subjects with high-risk stage II and stage III rectal…
- Trial name
- SHAPERS (NCT06052332)
- Testing
- Short course radiotherapy, Adjuvant chemotherapy (optional), Total mesorectal excision
- Where
- 19 sites in Belgium
- Volunteers
- 230 people
- Sponsor
- Jules Bordet Institute
Cystic Fibrosis
Intermittent Versus Continuous Infusion Meropenem in Cystic Fibrosis
The purpose of this study is to compare the incidence of nausea and vomiting following short intermittent versus prolonged intermittent infusion of meropenem.
- Trial name
- NCT02048163
- Where
- United States
- Sponsor
- Dayton Children's Hospital
Colon Cancer, Breast Cancer
Improving Food Pleasure and Intake of Oncology Patients Receiving Chemotherapy
The global cancer burden is estimated to have risen to 18.1 million new cases in 2018 (WHO), with a trend of ongoing growth. This very frequent illness exerts tremendous physical, emotional and financial strain on individuals…
- Conditions
- Colon Cancer, Breast Cancer, Chemotherapeutic Toxicity
- Trial name
- NCT04495387
- Testing
- Chemotherapy
- Volunteers
- 100 people
- Sponsor
- University of Florence
Appendicitis, Abdominal Pain
The Value of Pancreatic Stone Protein in Predicting Acute Appendicitis
PSP (Pancreatic Stone Protein) is a compound naturally produced mainly in the pancreas and the gut. There is evidence from experimental and clinical trials that the levels of PSP in the blood rise in the presence of inflammation…
- Conditions
- Appendicitis, Abdominal Pain, Abdominal Sepsis
- Trial name
- NCT01610193
- Testing
- Appendicectomy
- Where
- 2 sites in Switzerland
- Volunteers
- 245 people
- Sponsor
- University of Zurich
Carcinoma
Systems Intervention to Promote Colorectal Cancer (CRC) Screening
Colorectal cancer is the second leading cause of cancer death and one of the most commonly diagnosed malignancies. Screening is effective at reducing incidence and mortality from colorectal cancer.
- Trial name
- NCT01299493
- Testing
- Systems-level intervention to promote colon cancer screening
- Where
- United States
- Volunteers
- 490 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Breast Cancer, Gastric Cancer
Anti-HER2 Bispecific Antibody Zanidatamab (ZW25) Activity in Combination With Chemotherapy With/Without Tislelizumab
The purpose of the study is to assess the safety, tolerability and preliminary antitumor activity of zanidatamab in combination with docetaxel in participants with human epidermal growth factor receptor 2 (HER2)-positive breast…
- Conditions
- Breast Cancer, Gastric Cancer, Gastroesophageal Junction Cancer
- Trial name
- NCT04276493
- Testing
- Zanidatamab, Docetaxel, Tislelizumab
- Where
- 21 sites in China, South Korea and 1 more
- Volunteers
- 71 people
- Sponsor
- BeiGene
Rectal Neoplasms
Effective Study of Preoperative Short-course Radiotherapy for the Advanced Resectable Rectal Cancer
The local recurrence of rectal cancer is one of the main problem that fail the treatment. The preoperative neoadjuvant (chemo)radiotherapy has been confirmed to reduce the local recurrence rate,especially in the advanced rectal…
- Trial name
- NCT01437514
- Testing
- preoperative short-course radiotherapy
- Where
- 4 sites in China
- Volunteers
- 410 people
- Sponsor
- West China Hospital
Cystic Fibrosis
Identification of Predictive Epigenetic Biomarkers of Lung Disease Severity in Cystic Fibrosis
The general aims of this project are (i) to identify predictive epigenetic biomarkers of lung disease severity in Cystic Fibrosis, (ii) to characterize a non-invasive cellular model, spontaneous sputum, for the analysis of these…
- Trial name
- MethylBiomark (NCT02976714)
- Testing
- spontaneous sputum
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Montpellier
Gastric Neoplasm, Gastroesophageal Junction Adenocarcinoma
OPPOSITE: Outcome Prediction of Systemic Treatment in Esophagogastric Carcinoma
Patients with locally advanced, resectable gastric or esophagogastric junction adenocarcinoma will receive a biopsy of the primary tumor, followed by standard-of care neoadjuvant systemic treatment; after neoadjuvant therapy…
- Conditions
- Gastric Neoplasm, Gastroesophageal Junction Adenocarcinoma, Esophageal Adenocarcinoma, Gastric Adenocarcinoma
- Trial name
- OPPOSITE (NCT03429816)
- Testing
- Biopsy
- Where
- 2 sites in Germany
- Volunteers
- 120 people
- Sponsor
- University Hospital Heidelberg
Ulcerative Colitis, Crohn's Disease
A Study of Intravenous Vedolizumab Administered Every 4 Weeks in Japanese Participants With Moderate to Severe Ulcerative Colitis or Crohn's Disease
The main aim of the study is to learn if 4-weekly vedolizumab improves symptoms of Japanese participants with moderate to severe ulcerative colitis (UC) or Crohn's disease (CD).
- Trial name
- NCT04738942
- Testing
- Vedolizumab
- Where
- 20 sites in Japan
- Volunteers
- 56 people
- Sponsor
- Takeda
Hypoxia, Gastric Cancer
Capnographic Monitoring in Gastrointestinal Endoscopy for Elderly Patients
Hypoxia is the most common adverse event in gastrointestinal endoscopes sedated with propofol and sufentanil, especially in elderly people.
- Conditions
- Hypoxia, Gastric Cancer, Gastric Polyp, Colon Polyp
- Trial name
- CapnoGI (NCT05030870)
- Testing
- Capnography monitoring, Standard monitoring
- Where
- 3 sites in China
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Intestinal Failure-associated Liver Disease
Prevalence of Liver Disease in Patients Dependent on Parenteral Nutrition
This is a multi-center prospective cross-sectional observational study that will assess the prevalence of liver disease in patients dependent on parenteral nutrition (PN) for 4 or more days per week.
- Trial name
- THRIVE-1 (NCT05011370)
- Where
- 15 sites in United States, Denmark and 2 more
- Volunteers
- 80 people
- Sponsor
- Protara Therapeutics
Symbiotic, Cancer Colorectal
Effect of the Use of Symbiotics in Patients With Colon Cancer
Due to the high incidence, cancer and the concomitant presence of malnutrition are currently a worldwide public health problem. The loss of weight and body tissues is a common condition in cancer patients with lesions of the…
- Conditions
- Symbiotic, Cancer Colorectal, Cancer Head Neck, Intestinal Dysbiosis
- Trial name
- NCT04874883
- Testing
- Simbyotic, Control Group
- Where
- 2 sites in Brazil
- Volunteers
- 42 people
- Sponsor
- Federal University of Minas Gerais
Gastric Cancer
IN10018 Monotherapy or in Combination With Docetaxel in Gastric or GEJ Adenocarcinoma
This is a phase I, multi-center clinical trial to evaluate the safety, tolerability, antitumor activities and pharmacokinetics of IN10018 as monotherapy or in combination with docetaxel in previously-treated locally advanced or…
- Trial name
- NCT05327231
- Testing
- IN10018, Docetaxel
- Where
- 8 sites in China
- Volunteers
- 33 people
- Sponsor
- InxMed (Shanghai) Co., Ltd.
Appendicitis Acute, Appendicitis
Safety & Feasibility of PERIsign System in Demonstrating Involuntary Muscle Defense as a Sign of Peritonitis in Subjects With Appendicitis
This will be an explorative, proof-of-principle, open, multi-center investigation. The investigation aims to investigate the safety of the PERIsign system and the ability of physicians to differentiate between healthy individuals…
- Conditions
- Appendicitis Acute, Appendicitis, Abdominal Pain, Peritonitis
- Trial name
- PeriSaFe01 (NCT06296953)
- Testing
- PERIsign examination
- Where
- 2 sites in Sweden
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- STB INN AB
Crohn's Disease
Study of Sargramostim in Moderately to Severely Active Crohn's Disease
The purpose of this study is to assess the tolerability, pharmacokinetics and safety of 2 and 6 micro g/kg/day sargramostim administered subcutaneously once daily for 4 weeks, and to assess the efficacy and safety of 6 micro…
- Trial name
- NCT00329537
- Testing
- Sargramostim (Leukine)
- Volunteers
- 11 people
- Sponsor
- Genzyme, a Sanofi Company
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