Clinical trials: Gastroparesis
Gastroparesis
Pioglitazone for Idiopathic Gastroparesis
The principal objective of this pilot study will be to evaluate whether 8 weeks of treatment of pioglitazone will improve symptoms as measured by the Gastrointestinal Symptom Index (GCSI) in patients with Idiopathic Gastroparesis.
- Trial name
- PIOGAS (NCT04300127)
- Testing
- Pioglitazone 30 mg
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Johns Hopkins University
Gastroparesis, Healthy
Intestinal Permeability and Gastroparesis
The purpose of this study is to investigate potential mechanisms that could lead to the development of a condition known as gastroparesis.
- Trial name
- NCT04894656
- Testing
- Labs, urine tests, upper endoscopy with biopsy and confocal laser endomicroscopy
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mayo Clinic
Esophagectomy, No Signs of Cancer Recurrence
Pylorus Dysfunction After Esophagectomy and Gastric Tube Reconstruction. Effect of Pneumatic Pylorus Dilatation During Hospital Stay, Surgical Complications During in Hospital Stay
Delayed emptying of the gastric tube after esophagectomy is a frequent and durable problem. No treatment is currently available.
- Conditions
- Esophagectomy, No Signs of Cancer Recurrence, Delayed Gastric Emptying
- Trial name
- NCT02086461
- Testing
- Pneumatic pyloric dilatation, 15 mm pyloric balloon dilatation
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Karolinska University Hospital
Gastrointestinal Motility Disorders in Children, Functional Gastrointestinal Disorders
BSGM to Evaluate Patients With GI Symptoms
The goal of this observational study is to learn about gastric myoelectric activity in children with GI symptoms. The main question it aims to answer is which patterns or signals are associated with GI symptoms as measured by a…
- Conditions
- Gastrointestinal Motility Disorders in Children, Functional Gastrointestinal Disorders, Gastroparesis, Dyspepsia and Other Specified Disorders of Function of Stomach
- Trial name
- NCT05880199
- Testing
- Body surface gastric mapping device
- Where
- 5 sites in United States
- Volunteers
- 685 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Gastroparesis
Temporary Gastric Electrical Stimulation for Gastroparesis
This is a prospective study of temporary gastric mucosal electrical stimulation (tGES) in 30 patients with gastroparesis (GP). After a 7 day baseline assessment of symptoms, subjects will have an endoscopically-placed tGES lead…
- Trial name
- NCT01054794
- Testing
- Gastric mucosal stimulation
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Calgary
Gastroparesis
Growth Hormone for the Treatment of Gastroparesis
The purpose of this study is to determine whether treatment with Growth Hormone results in symptomatic improvement in patients with gastroparesis.
- Trial name
- NCT06803589
- Testing
- Growth Hormone
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Mayo Clinic
Gastroparesis, Diabetes Mellitus
A Safety and Efficacy Study of Relamorelin in Diabetic Gastroparesis Study 03
A 46-week study to compare the efficacy of relamorelin with that of placebo in participants with diabetic gastroparesis (DG). At the end of the 40-week Treatment Period, participants will either continue on relamorelin or placebo…
- Trial name
- NCT03420781
- Testing
- Relamorelin
- Where
- 337 sites in United States, Argentina and 24 more
- Volunteers
- 467 people
- Sponsor
- Allergan
Diabetic Gastroparesis
Effects and Mechanism of Mosapride Citrate on Diabetic Gastroparesis
The purpose of this study is to evaluate the effects and mechanism of mosapride citrate on diabetic gastroparesi.
- Trial name
- MDGP (NCT02264587)
- Testing
- Mosapride, domperidone
- Volunteers
- 60 people
- Sponsor
- Liangzhou Wei
Gastroparesis
The Effect of Single Doses of the Motilin Receptor Agonist GSK962040 in Type I Diabetic Patients With Gastroparesis
The purpose of this study is to assess the pharmacodynamic effects (gastric emptying), safety, tolerability, and pharmacokinetics of single doses of GSK962040 in Type 1 diabetic patients with gastroparesis.
- Trial name
- NCT00861809
- Testing
- GSK962040 25 mg, GSK962040 50 mg, GSK962040 1250 mg
- Where
- 2 sites in Belgium, Sweden
- Volunteers
- 11 people
- Sponsor
- GlaxoSmithKline
Delayed Gastric Emptying
The Effect of taVNS on the Prognosis of Patients Undergoing Pancreatoduodenectomy
To explore the effects of transcutaneous auricular vagus nerve stimulation (taVNS) during the perioperative period on the incidence of delayed gastric emptying after pancreatoduodenectomy and its possible mechanisms.
- Trial name
- NCT06786923
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulator
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Affiliated Hospital of Nantong University
Gastroparesis
Cardiac Vagal Effects of GES in Patients With Gastroparesis and Vagal Nerve Action Potentials in Vagus Nerve
The objective of this study is to determine if Gastric Electrical Stimulation may influence vagal outflow via vagal afferent fibers that terminate in the Central Nervous System.
- Trial name
- GES (NCT02159586)
- Testing
- gastric electrical stimulator
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- Indiana University
Gastroparesis, Healthy Subjects
ABVN Phase 2 - Ear Stimulation
The vagus nerve is a nerve that controls many bodily functions, including stomach function. Investigators hope that electrically stimulating the nerve around the external ear will also stimulate the internal vagus nerve.
- Trial name
- ABVN2 (NCT06491758)
- Testing
- ML1101 Stimulus Isolator
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Indiana University
Gastroparesis
Clinical Management With SPM System and Validation of the SPM 5 Hour Cutoff in Patients With Symptoms of Gastroparesis
This protocol is designed to validate use of the SPM for diagnosis of delayed gastric emptying in patients with symptoms of gastroparesis and assess impact of a SmartPill study on patient management in the gastroparetic…
- Trial name
- NCT02022826
- Testing
- SmartPill Monitoring System
- Where
- 11 sites in United States
- Volunteers
- 167 people
- Sponsor
- Medtronic - MITG
Gastroparesis
A Study to Evaluate Safety, Side Effects, Muscle Activity and Speed of Gastric Emptying of GSK962040
Motilin is a peptide whose action is controlled by motilin receptors located in the gut. Action of Motilin at motilin receptors increases the gastric emptying rate (rate of emptying of food and fluid from the stomach).
- Trial name
- NCT00562848
- Testing
- GSK962040
- Where
- Belgium
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Delayed Gastric Emptying
Evaluating Neostigmine Effect on Reducing Gastric Residual Volume as Compared With Metoclopramide and Ondansetron
One big problem in mechanically ventilated ICU patients is delayed gastric emptying. Delayed gastric emptying in these patients, causes intolerance and high gastric residual volume (GRV) that can lead to abdominal distention…
- Trial name
- NCT05342818
- Testing
- Neostigmine, Ondansetron 8mg, Metoclopramide Injection
- Where
- Saudi Arabia
- Volunteers
- 90 people
- Sponsor
- Tanta University
Gastroparesis
Ultrasound Assessment of Gastric Contents in Fasted Patient Undergoing Cholecystectomy
Investigators assess the gastric contents by ultrasonography in fasted patients undergoing cholecystectomy.
- Trial name
- NCT03259841
- Testing
- Ultrasound assessment of gastric contet
- Where
- South Korea
- Volunteers
- 140 people
- Sponsor
- SMG-SNU Boramae Medical Center
Gastroparesis
Gastric Pacemaker Implantation for Gastroparesis
Gastric pacemakers and/or temporary gastric stimulators will be implanted in eligible patients.
- Trial name
- HUD (NCT00568373)
- Testing
- Enterra Gastric Pacemaker
- Sponsor
- Indiana University
Bariatric Surgery, Gastric Motor Dysfunction
EGG Test as a Predictor for an Individual Response to Treatment by Various Bariatric Procedures
Total body weight loss (TBWL) after bariatric endoscopy (BE) is variable. Gastric emptying may be normal, rapid or delayed in patients with obesity and be a factor in variable BE outcomes.
- Conditions
- Bariatric Surgery, Gastric Motor Dysfunction, Gastroparesis
- Trial name
- NCT05731531
- Testing
- ELECTROGASTROGRAPHY
- Where
- India
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Asian Institute of Gastroenterology, India
Gastroparesis
Placebo Controlled Trial of Botulinum Toxin for Gastroparesis
It is hypothesized that in some patients with gastroparesis increased pyloric tone may be a contributing feature. Botox relaxes the pylorus so that food can empty the stomach more rapidly.
- Trial name
- NCT00372970
- Testing
- Botulinum toxin A
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Temple University
Gastroparesis
GEBT Lot-to-Lot and Biological Variability
The purpose of this study is to collect information regarding lot-to-lot variability in 13C-Spirulina test meal lets and within-subject biological variability.
- Trial name
- NCT04772261
- Testing
- 13C-Spirulina GEBT
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Cairn Diagnostics