Clinical trials: Gastroparesis
Gastroparesis, Diabetes Mellitus
Safety and Efficacy of IV Infusion of Investigational Agent (TZP-101) in Patients With Severe Diabetic Gastroparesis
The purpose of this study is to determine whether TZP-101 is effective in the treatment of symptomatic gastroparesis due to diabetes.
- Trial name
- NCT00612014
- Testing
- 5% dextrose in water, TZP-101
- Where
- 12 sites in United States, Denmark and 4 more
- Volunteers
- 78 people
- Sponsor
- Tranzyme, Inc.
Gastroparesis
Temporary Gastric Electrical Stimulation for Drug Refractory Gastroparesis
The purpose of this research is to determine if temporary gastric electrical stimulation will help improve symptoms of gastroparesis (abnormal stomach emptying).
- Trial name
- NCT00432835
- Testing
- Gastric Electrical Stimulator, Enterra, Medtronics, Inc.
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- University of Mississippi Medical Center
Diabetic Gastroparesis
Evaluation of Diagnostic Methods and Dietary Treatment of Diabetic Gastroparesis
The objective of the study is in subjects with Insulin Treated Diabetes Mellitus type 1 or 2 and gastroparesis: validate radiopaque markers with fluoroscopy with gastric scintigraphy method study the difference of metabolic…
- Trial name
- NCT01557296
- Testing
- dietary treatment: food of small particle size, Validate X-ray diagnostic method., Can the motility be improved
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Göteborg University
Gastroparesis Nondiabetic
Effect of Gastric Electrical Stimulation on Serum Insulin Levels
The goal of this study is to determine how much effect turning off an individual's Gastric Electrical Stimulator (GES) for up to four hours will have on levels of insulin, C-peptide, GLP-1 and glucose levels.
- Trial name
- NCT07635576
- Testing
- Gastric Electrical Stimulator
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Indiana University
Cirrhosis, Hypertension
Modified Vagus Nerve-preserving Laparoscopic Splenectomy and Azygoportal Disconnection
This study aimed to evaluate whether vagus nerve-preserving laparoscopic splenectomy and azygoportal disconnection is effective and safe, and to determine whether a reduction in the incidence of postoperative complications of the…
- Conditions
- Cirrhosis, Hypertension, Splenectomy, Laparoscopy
- Trial name
- ESVLSD (NCT03396796)
- Testing
- Vagus nerve-preserving group
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Yangzhou University
Gastroparesis
Endoscopic Clips Versus Overstich Suturing System Device for Closure of Mucosotomy After G-POEM
Gastric per-oral endoscopic pyloromyotomy (G-POEM) has been assessed as new modality for treatment of refractory gastroparesis. G-POEM is promising method, which is still under investigation as its safety and efficacy has not…
- Trial name
- NCT03679104
- Testing
- Closure of mucosotomy using endoscopic clips, Closure of mucosotomy using OverStitch™ suturing device
- Where
- Czechia
- Volunteers
- 40 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Semaglutide-Induced Gastric Motility, Anesthesia
Effect of Itopride on Semaglutide Gastroparesis
Semaglutide delays gastric emptying and increases the risk of aspiration with anesthesia; So, the addition of prokinetics as Itopride, could enhance gastric emptying and hasten surgery.
- Trial name
- NCT07254715
- Testing
- Itopride HCI 50 mg
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Weight Loss, Diabetic Gastroparesis
Potential Benefits of Sleeve Gastrectomy Surgery on Diabetic Gastroparesis Symptoms
The purpose of this registry is to evaluate if sleeve gastrectomy surgery will help with symptoms of delayed gastric emptying for patients suffering from diabetic gastroparesis.
- Conditions
- Weight Loss, Diabetic Gastroparesis, Bariatric Surgery Candidate, Sleeve Gastrectomy
- Trial name
- NCT03376399
- Testing
- Gastroparesis Cardinal Symptom Index Questionnaire
- Where
- United States
- Sponsor
- Baylor Research Institute
Delayed Gastric Emptying
Impact of Additional DJ (Duodenojejunostomy)-Pexy on Reduction in Delayed Gastric Emptying Following Pylorus-preserving Pancreaticoduodenectomy: A Prospective, Randomized Controlled Trial
Surgical resection in periampullary cancer using pancreaticoduodenectomy is the most important modality in the treatment. In the past, pancreaticoduodenectomy was associated with high morbidity and mortality.
- Trial name
- NCT02635399
- Testing
- PPPD (pylorus-preserving pancreaticoduodenectomy), PPPD (pylorus-preserving pancreaticoduodenectomy) with DJ-pexy
- Where
- South Korea
- Volunteers
- 78 people
- Sponsor
- Yonsei University
Parkinson's Disease, Gastroparesis
RQ-00000010 for Gastroparesis and Constipation in Parkinson's Disease
This is a study to determine the safety and tolerability of a new medicine (RQ10) for gastrointestinal symptoms in Parkinson's disease.
- Conditions
- Parkinson's Disease, Gastroparesis, Constipation
- Trial name
- RQ-10 (NCT02838797)
- Testing
- RQ-00000010
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Virginia Commonwealth University
Diabetes Mellitus, Diabetes Mellitus Complications
Phase 2 Study to Evaluate Safety & Efficacy of RM-131 Administered to Patients With Diabetic Gastroparesis
The purpose of this study is to evaluate the effects of RM-131 on gastric emptying, gastroparesis symptoms, and the safety and tolerability of RM-131 compared to placebo in patients with Type 1 and Type 2 diabetes mellitus and…
- Conditions
- Diabetes Mellitus, Diabetes Mellitus Complications, Gastroparesis
- Trial name
- NCT01571297
- Testing
- RM-131
- Where
- 30 sites in United States
- Volunteers
- 204 people
- Sponsor
- Motus Therapeutics, Inc.
Gastroparesis
Gastric Electrical Stimulation (GES) and Pyloroplasty for the Treatment of Gastroparesis
Gastroparesis (GP) is describing a condition when stomach does not empty as fast as it should. This fact creates the situation, when food stays in the stomach for a long time and it causes symptoms of nausea, vomiting, loss of…
- Trial name
- GES+PP (NCT03123809)
- Testing
- Gastric Electrical Stimulation (GES) System
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Texas Tech University Health Sciences Center, El Paso
Dry Eye Disease, Dry Eye
Neurological Dry Eye Study Stimulating Both Lacrimal and Vagus Nerves
This is a study on neurological dry eye disease, focusing on a patented over-the-counter supplement supporting tear production neurologically, including the lacrimal and vagus nerves.
- Trial name
- NCT06271005
- Testing
- NeuroTears
- Volunteers
- 75 people
- Sponsor
- Genetic Disease Investigators
Motility Disorder, Gastroparesis
Body Surface Gastric Mapping to Evaluate Patients With Upper Gastrointestinal Symptoms and Controls
This is an analytical validation observational cohort study is designed to provide evidence of: safety and reliability of Body Surface Gastric Mapping using the Gastric Alimetry System (GAS), normal reference values, and…
- Conditions
- Motility Disorder, Gastroparesis, Functional Dyspepsia, Cyclical Vomiting
- Trial name
- NCT05812339
- Testing
- Gastric Alimetry System
- Where
- Canada
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Gastroesophageal Reflux Disease, Diabetic Gastroparesis
Improving Metoclopramide Prescribing Practices at Penn Through a Physician-targeted Intervention
The investigators hypothesized that: 1) an intervention targeted at the prescribing physician would increase the rate of a metoclopramide discontinuation among patients prescribed the medication for questionable or unclear…
- Trial name
- NCT01126034
- Testing
- intervention letter
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Diabetic Gastroparesis
Multicenter Study to Evaluate the Efficacy and Safety of Metoclopramide Nasal Spray in Men With Diabetic Gastroparesis
The purpose of this study is evaluate the safety and efficacy of Metoclopramide Nasal Spray compared to placebo in reducing the symptoms of diabetic gastroparesis in adult men.
- Trial name
- NCT02025751
- Testing
- Metoclopramide Nasal Spray
- Where
- 49 sites in United States
- Volunteers
- 53 people
- Sponsor
- Evoke Pharma
Gastroparesis
Impact of KUVAN® on Gastric Relaxation in Women With Diabetic Gastroparesis.
Kuvan® (sapropterin dihydrochloride) for Improving Gastric Accommodation in Women with Diabetic Gastroparesis (KIGA-DG)
- Trial name
- NCT01135186
- Testing
- sapropterin dihydrochloride
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Stanford University
Gastroparesis Due to Diabetes Mellitus Type I
Pathophysiology of Diabetic Gastroparesis
The goal of this study is to explore the pathophysiology of diabetic gastroparesis by conducting an exploratory cohort study. Participants will be type 1 diabetes patients with and without gastroparesis.
- Trial name
- PATODIAG (NCT05717205)
- Testing
- technetium scitigraphy
- Where
- Denmark
- Volunteers
- 52 people
- Sponsor
- Hvidovre University Hospital
Gastroparesis, Delayed Gastric Emptying
Gastric Focused Ultrasound Stimulation
This randomized, sham-controlled crossover pilot study will evaluate whether noninvasive gastric focused ultrasound stimulation is associated with changes in postprandial gastric electrical activity and gastrointestinal symptoms…
- Trial name
- NCT07851727
- Testing
- Gastric Focused Ultrasound Stimulation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Evan (Huiliang) Wang
ERAS, Pancreas Cancer
Compliance With ERAS Protocol in Pancreatic Surgery, Stress Response and Outcomes
The purpose of this study is to evaluate the impact of compliance with enhanced recovery after surgery (ERAS) program on patient reported outcomes (PROs), surgery-specific outcomes and stress response after pancreatic surgery.
- Conditions
- ERAS, Pancreas Cancer, Pancreas; Fistula, Delayed Gastric Emptying
- Trial name
- NCT05518643
- Testing
- ERAS protocol
- Where
- Greece
- Volunteers
- 120 people
- Sponsor
- University of Thessaly