Clinical trials: Gender Differences
Lipid Metabolism
Acute Effect of Fructose on Lipid Metabolism and Gender Differences
It has been widely documented that fructose overfeeding increases plasma triglycerides and hepatic de novo lipogenesis, and impairs insulin sensitivity in healthy male volunteers.
- Trial name
- NCT00620360
- Testing
- fructose
- Where
- Switzerland
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Lausanne
Heart Diseases, Left Ventricular Dysfunction
Sex Differences in Myocardial Steatosis Induced Left Ventricular Dysfunction
To test the specific research questions, healthy men and age-matched healthy premenopausal females will be enrolled. Subjects will undergo cardiac magnetic resonance imaging and spectroscopy (MRI/MRS) to evaluate cardiac…
- Trial name
- NCT04671966
- Testing
- Estradiol patch, Cetrotide, Fasting
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Arlington
Cannabis Use Disorder
SCORE Emerging Adult Cannabis Use & Stress
The interface between cannabis use and stress is a particularly important focus for sex differences research in emerging adults.
- Trial name
- NCT05885542
- Testing
- Cannabidiol oral solution
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- Medical University of South Carolina
Parkinson Disease
Effect of Biological Sex on Multimodal Biomarkers of Disease Progression in Patients with Parkinson's Disease
The GENDERIZE-PD study is a research project to understand how biological sex affects the progression of Parkinson's disease (PD). PD is a brain disorder that causes both movement and non-movement symptoms.
- Trial name
- GENDERIZE-PD (NCT06790381)
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Melanoma, Lung Cancer
Gender Difference in sidE eFfects of ImmuNotherapy: a Possible Clue to Optimize cancEr tReatment
The study aim is to investigate the differences between sex and gender in the immune-related adverse events (irAEs) development associated with immune checkpoint inhibitors (ICI) treatment.
- Conditions
- Melanoma, Lung Cancer, Head and Neck Cancer, Urogenital Neoplasms
- Trial name
- G-DEFINER (NCT04435964)
- Testing
- Immunotherapy
- Where
- Italy
- Volunteers
- 247 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Gender Identity
Sexual Dimorphism Analysis in Egyptian Population by Locating the Mandibular Canal Using CBCT
Sexual dimorphism analysis in Egyptian population by locating the mandibular canal using cone-beam computed tomography: an observational cross sectional study
- Trial name
- NCT03175445
- Testing
- CBCT scan by planmeca promax
- Where
- Egypt
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Cairo University
Hyponatremia
Postoperative Hyponatremia - Are There Gender Differences?
The proposed study will focus on anesthesia and anesthesia-induced hypotension as a possible cause for postoperative fluid retention and hyponatremia, and investigate gender differences in this response.
- Trial name
- NCT00636857
- Testing
- Fluid administration, Perioperative fluid management based on Lean Body Mass
- Where
- 5 sites in Sweden
- Volunteers
- 60 people
- Sponsor
- Karolinska University Hospital
Aneurysm Dissecting
Gender-related Differences in Chinese Patients With AAD
Few data exist on gender-related differences in clinical features, management, and outcomes of acute aortic dissection (AAD) in China.
- Trial name
- NCT02200835
- Volunteers
- 2,015 people, healthy volunteers welcome
- Sponsor
- General Hospital of Beijing PLA Military Region
Healthy
Inorganic Nitrate: Sex Differences in Muscle Contractile Function and Efficiency
Dietary inorganic nitrate, in the form of beet root juice, is a nutritional intervention, considered to be an exercise enhancer due to its capacity to increase Nitric Oxide (NO) bioavailability.
- Trial name
- NCT04588740
- Testing
- concentrated beet root juice
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Cocaine Dependence
Gender and Neural Substrates of Stress and Craving
Cocaine dependence is an insidious disease underscored by a powerful proclivity to relapse despite an individual's ability to recognize the deleterious consequences of continued drug use.
- Trial name
- NCT00756925
- Testing
- Acthrel
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Medical University of South Carolina
Suicidal Ideation, Mental Health
Gamified Virtual Reality Exercise for Suicidal Ideation in Older Adults
This is a two-arm, parallel-group randomized controlled trial designed to evaluate the effectiveness of a gamified virtual reality (VR)-based exercise program in reducing suicidal ideation among community-dwelling older adults…
- Conditions
- Suicidal Ideation, Mental Health, Depression, Geriatric Psychiatry
- Trial name
- VR-GAME-SI (NCT07862803)
- Testing
- Gamified VR-Based Exercise Program, Conventional Exercise Program
- Where
- Iran
- Volunteers
- 200 people
- Sponsor
- Islamic Azad University, Sanandaj
Cognitive Assessment, Cognition
Effects of Transcutaneous Auricular Vagus Nerve Stimulation on Cognitive Performance and Sex Differences
This study investigates the effects of transcutaneous auricular vagus nerve stimulation (taVNS) on cognitive performance in healthy adults.
- Conditions
- Cognitive Assessment, Cognition, taVNS, Vagus Nerve Stimulation
- Trial name
- NCT07256080
- Testing
- Active taVNS
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University
Aging
Sex Differences in Vascular Responses to Exercise
A key early event in cardiovascular disease development is endothelial dysfunction, characterized by impaired flow-mediated dilation.
- Trial name
- NCT04128215
- Testing
- Control Period, Exercise Period
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Florida
Cigarette Smoking-Related Carcinoma
Gender Differences in Switching From Smoking Regular Cigarettes to E-Cigarettes
This early phase I trial studies potential differences between men and women when switching from the use of combustible cigarettes to the National Institute on Drug Abuse's Standard Research E-Cigarette (SREC).
- Trial name
- NCT03856515
- Testing
- Nicotine Replacement, Questionnaire Administration, Electronic Cigarette
- Where
- United States
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Diabetes Mellitus, Visceral Adipose Tissue
Sex-specific Differences in the Association Between Leg Fat and Diabetes Risk
This study investigates the association between LFP, VAT and T2DM using DXA in 542 adults. We apply penalized regression, generalized additive models (GAM), and causal mediation analysis to explore whether higher LFP reduces…
- Conditions
- Diabetes Mellitus, Visceral Adipose Tissue, Body Fat Distribution
- Trial name
- NCT07261800
- Testing
- Not Applicable - Retrospective study
- Where
- China
- Volunteers
- 542 people
- Sponsor
- Qianfoshan Hospital
Dental Erosion
Influence of Gender Specific Differences of Saliva Composition on the Development of Dental Erosion - an In-situ Study
Healthy volunteers are observationally wearing an intraoral device with bovine tooth samples once for two hours. Afterwards, Calcium release from the bovine enamel and dentin samples is measured after extraoral erosion.
- Trial name
- NCT02780973
- Testing
- Wearing of an intraoral device with bovine tooth samples
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Göttingen
Hemodynamic, Exercise
Sex and Exercise-mode Differences in Post Exercise Blood Pressure and Heart Rate Variability Responses During Workday
The present study compared the acute effects of Sex and exercise mode on subsequent blood pressure (BP) and heart rate variability (HRV) responses during daily work in healthy adults.
- Trial name
- NCT03080636
- Testing
- Aerobic exercise, Resistance exercise, Control session
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Federal University of Uberlandia
Status Epilepticus
Status Epilepticus in Men and Women: Clinical Presentation, Management, and Outcomes
Sex-specific differences in neurological emergencies such as Status epilepticus (SE) remain understudied despite growing recognition of gender disparities in medicine.
- Trial name
- NCT07443241
- Volunteers
- 779 people
- Sponsor
- University Hospital Marburg
Healthy Nutrition
Sex Differences in Metabolism Following a High-fat Meal
Long-term consumption (i.e., several weeks to months) of a diet that is high in fat (>35% daily calories from fat) is associated with the development of insulin resistance, a condition that can lead to a diagnosis of type 2…
- Trial name
- HFM (NCT05332301)
- Testing
- High-fat test meal
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Kirsten Bell
Post Acute COVID-19 Syndrome
Gender Differences in the Recovery Rate Following PR in Patients With Long COVID-19
The goal of this retrospective analysis is to compare the magnitude of improvement in respiratory and peripheral muscle strength, following the completion of a hybrid pulmonary rehabilitation programme, in men and women with long…
- Trial name
- NCT05736939
- Testing
- Out-patient Pulmonary Rehabilitation
- Where
- Greece
- Volunteers
- 30 people
- Sponsor
- National and Kapodistrian University of Athens