Clinical trials: Gender Differences
Myocardial Ischemia
Sex and Gender Differences in Ischemic Heart Disease - Endocrine Vascular Disease Approach
The application of sex-gender medicine is strongly recommended by World Health Organization and other international organization.
- Trial name
- EVA (NCT02737982)
- Testing
- percutaneous coronary intervention
- Where
- Italy
- Volunteers
- 509 people
- Sponsor
- University of Roma La Sapienza
Metabolic Syndrome
Human Cerebrovascular Blood Flow and Sex Differences in Metabolic Syndrome
This study tests the hypothesis that Metabolic Syndrome (MetSyn) decreases cerebral blood flow (CBF) more in females than males due in part to the sex-specific loss of COX vasodilation.
- Trial name
- NCT07218653
- Testing
- Indomethacin, MRI
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Intracranial Atherosclerosis, Acute Stroke
Vessel Wall MR Imaging to Explore Sex-Differences of Intracranial Arterial Wall Changes After Suspected Stroke
Despite advances in stroke care, women continue to face worse outcomes after stroke than men. This disparity in outcomes may be related to biologic sex-differences that manifest in the development and progression of…
- Conditions
- Intracranial Atherosclerosis, Acute Stroke, Transient Ischemic Attack
- Trial name
- NCT03990545
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Cardiovascular Diseases, Frailty
Managing Frailty Through Mobilization in Males and Female Inpatients With Cardiovascular Disease
Frailty describes the overall health of a person. Inpatients with cardiovascular problems have a higher risk for frailty - or the sick are more likely to get sicker - causing longer hospital stays, hospital readmission, and…
- Trial name
- NCT06810661
- Testing
- Mobility promotion
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Université de Sherbrooke
Heart Failure
Heart Failure in Women: Epidemiological and Prognostic Insights
Heart failure (HF) is a leading cause of hospital admission in older adults and women account for more than half of these admissions, yet they remain under-represented in prospective HF cohorts.
- Trial name
- HER-HF (NCT07847983)
- Where
- 24 sites in Spain
- Volunteers
- 430 people
- Sponsor
- Carolina Ortiz Cortes
Malocclusion, Quality of Life
The Effect of Malocclusions on Oral Health Related Quality of Life
Malocclusions in adolescents may affect oral health related quality of life. The study aims at; 1. Evaluating two instruments measuring oral health related quality of life; "Child Perceptions Questionnaire 11-14" (CPQ 11-14)…
- Conditions
- Malocclusion, Quality of Life, Orthodontics, Adolescent
- Trial name
- NCT05038865
- Testing
- Malocclusion and Orthodontic Treatment
- Where
- 3 sites in Sweden
- Volunteers
- 675 people, healthy volunteers welcome
- Sponsor
- Malmö University
Polycystic Ovary Syndrome, Insulin Resistance
Insulin Resistance Before and During Pregnancy in Women With Polycystic Ovary Syndrome
The polycystic ovary syndrome (PCOS) affects about 10% of reproductive-age women. Women with PCOS are at a higher risk of gestational diabetes, which may lead to more pregnancy complications.
- Conditions
- Polycystic Ovary Syndrome, Insulin Resistance, Insulin Sensitivity, Obesity
- Trial name
- NCT01475565
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Virginia Commonwealth University
Colour Perception, Color Perception
Visual Perception, Binocular Rivalry, and Fatigue-Related Individual Differences in Colour and Illumination Judgement
This observational study aims to characterise individual differences in colour perception and binocular rivalry. Participants will complete computer-based visual perception tasks, including a colour perception task and a…
- Conditions
- Colour Perception, Color Perception, Binocular Rivalry
- Trial name
- NCT07671144
- Testing
- Computer-Based Visual Perception Tasks
- Where
- 2 sites in Hong Kong
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Heart Failure, Acute Heart Failure
Pharmacological Optimization in Prevention in Heart Failure: A Sex-gap?
The goal of this clinical trial is to learn whether a rapid and intensive optimization of heart failure medications in women can improve outcomes after hospitalization for heart failure.
- Conditions
- Heart Failure, Acute Heart Failure, Heart Failure With Reduced Ejection Fraction (HFrEF), Heart Failure With Preserved Ejection Fraction (HFPEF)
- Trial name
- PopS-HF (NCT07295522)
- Testing
- Guideline-Directed Medical Therapy (GDMT)
- Where
- 12 sites in Italy
- Volunteers
- 368 people
- Sponsor
- IRCCS Policlinico S. Donato
Knee Osteoarthritis
Muscle Activation in Knee Osteoarthritis
Muscle activity, as a possible fundamental cause of functional limitation, has been extensively investigated in knee osteoarthritis (KOA).
- Trial name
- NCT05870033
- Testing
- Electromyography (EMG) measurement
- Where
- Hungary
- Volunteers
- 70 people
- Sponsor
- University of Pecs
Parkinson Disease
Gender Differences in Parkinsonian Patients- a Swedish Register Study
BACKGROUND: The complex impact of gender has been studied in different perspectives of health and disease in the literature. However, few attempts have been made to compile data from systematic disease specific registrations…
- Trial name
- NCT04713306
- Where
- Sweden
- Volunteers
- 1,217 people
- Sponsor
- Region Jönköping County
Range of Motion, Articular, Muscle Stretching Exercises
Gender Differences in the Tolerance to Stretch
The effect of stretching on range of motion is believed to rely upon an increased tolerance to stretch. This suggests, that pain modulation has significance in regards to the effect of stretching.
- Trial name
- NCT04146506
- Testing
- Muscle stretching exercises
- Where
- Denmark
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University College of Northern Denmark
Acute Myocardial Infarction, Coronary Angiography
Acute Myocardial Infarction in Iceland, is There a Gender Difference in Treatment and Survival?
All patients in Iceland with STEMI (2008-2018) and NSTEMI (2013-2018) that underwent coronary angiography and had obstructive coronary artery disease were included.
- Trial name
- NCT04544384
- Volunteers
- 3,257 people
- Sponsor
- Landspitali University Hospital
Hemodialysis
A Community Health Worker Service to Address Acute Care Utilization Among Young and Middle-Aged Men and Women Receiving Dialysis in High-Poverty Communities
Among adults receiving in-center hemodialysis, young and middle-aged women (aged 18 to 49) have the highest hospitalization rates at 1.8 per person-year.
- Trial name
- NCT07819487
- Volunteers
- 40 people
- Sponsor
- Johns Hopkins University
type1diabetes
Sexual Dimorphism in Cardiovascular Autonomic Neuropathy in Patients With Type 1 Diabetes
Sex might interact with cardioautonomic neuropathy (CAN) in the development of macrovascular disease in patients with type 1 diabetes (T1D).
- Trial name
- NCT04950634
- Where
- Spain
- Volunteers
- 320 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Patella-Dislocation
Functional Surface Electromyogram of Knee Extensors in Healthy Humans and Patients With Patella-dislocation.
The activation of the knee extensors in adults after patella dislocation. The kneecap can dislocate due to an accident or also only due to an interior turn in the stretched knee joint out of its sliding bearing. E.
- Trial name
- NCT00288847
- Where
- Switzerland
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Temporomandibular Disorder
Myoelectric Activity and Mandibular Movement for the Diagnosis of Temporomandibular Disorder
This study aimed to provide normal reference values of surface electromyography (sEMG) and mandibular kinematics in Chinese young adults, compare the sex differences and assess the diagnosis value of these indices.
- Trial name
- NCT06372769
- Testing
- electromyograph and kinesiograph
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Stomatological Hospital Affiliated with Fujian Medical University
Hemodynamics
The Effect of Age on the Hemodynamic Response During Rest and Exercise in Healthy Humans
Primary: To observe how hemodynamic parameters are affected by age during rest and exercise in healthy humans. Furthermore, how an acute fluid challenge changes hemodynamic parameters.
- Trial name
- HemReX (NCT01974557)
- Testing
- Exercise
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Finn Gustafsson
Alcoholism, Stress
Alcohol and Gender Effects on Stress Circuit Function
The purpose of this study is to look at the stress hormone response to medication-induced stress and a placebo (an inactive compound) in non-drinking, recovering male and female alcoholics, with a specific emphasis on the…
- Conditions
- Alcoholism, Stress, Alcohol Dependence
- Trial name
- NCT00226694
- Testing
- Citalopram
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Vasodilation, Vasoconstriction
Sex Differences in Sympathetic Activity and Vascular Reactivity During Acute and Chronic Hypoxia.
This study aims to investigate sex differences in blood pressure control associated with exposure to acute hypoxia (low oxygen), and short term acclimatization to hypoxia at high altitude.
- Trial name
- NCT05001048
- Testing
- Phenylephrine Hydrochloride, Cold Pressor Test, Isocapnic Acute Hypoxia
- Where
- 2 sites in Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Alberta