Clinical trials: Gender Differences
Heat Acclimation and Thermotolerance, Heat Effect
Exercise in Extreme Hot Weather Conditions
Background: Core body temperature increases in hot climates due to exercise workload, disrupting heat gain and loss of balance. The human thermoregulatory system regulates core body temperature through factors such as metabolic…
- Trial name
- EXHOTCON (NCT07307391)
- Testing
- hot wet high (HWH), hot dry high (HDH), Experimental: hot dry low (HWL)
- Where
- Spain
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Valladolid
Cannabis
Gender Related Differences in the Acute Effects of Delta-9-Tetrahydrocannabinol in Healthy Humans
The purpose of the study is to characterize the acute effects of cannabinoids in women relative to men and to begin probing the mechanisms that may underlie gender differences.
- Trial name
- THC-Gender (NCT02781519)
- Testing
- THC
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Yale University
Major Depressive Disorder
Impact of Transcutaneous Vagal Nerve Stimulation on Stress Response in Major Depression
This study will identify the sex-dependent impact of expiratory-gated transcutaneous vagus nerve stimulation (tVNS) on the modulation of the stress response circuitry and associated physiology in major depressive disorder (MDD).
- Trial name
- tVNS_MDD_Sex (NCT04448327)
- Testing
- active tVNS
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Massachusetts General Hospital
Cryptogenic Stroke, Atrial Fibrillation
Stroke of Unknown Cause in Women: The Impact of Long-term Heart Monitoring on Stroke Recurrence
The goal of this observational study is to investigate sex - differences in detection rate of atrial fibrillation after cryptogenic stroke (embolic stroke of unknown cause) - using an implantable cardiac rhythm monitor - and the…
- Conditions
- Cryptogenic Stroke, Atrial Fibrillation, Implantable Cardiac Monitor, Secondary Stroke Prevention
- Trial name
- STROKEWISE (NCT07194811)
- Where
- Norway
- Volunteers
- 1,400 people
- Sponsor
- University Hospital, Akershus
Nutrient Deficiency
Sex Differences in Neuropeptide Y Serum, But Not in Fat Intake and Body Mass Index
One's appetite has a role in controlling food intake and maintaining energy balance, but its effect on body metabolism related to obesity is still questionable.
- Trial name
- NCT04650308
- Testing
- Neuropeptide Y examination
- Where
- Indonesia
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Universitas Sumatera Utara
HELICOBACTER PYLORI INFECTIONS, Osteoporosis
Preventive Effect of H.Pylori Eradication on Osteoporosis
In this study, the investigators observed the long-term incidence rate of osteoporosis in patients who received Helicobacter pylori eradication and examined differences by age and sex.
- Trial name
- NCT06818591
- Testing
- DEXA(Dual-Energy X-ray Absorptiometry)
- Where
- South Korea
- Volunteers
- 846 people
- Sponsor
- Seoul National University Bundang Hospital
Obesity
Circulating IL-6, Clusterin and Irisin in Obese Subjects
evaluate the circulating levels of IL-6, clusterin and irisin in obese subjects of both sexes who had different classes of obesity and their sexual dimorphism also identify the association of IL-6, clusterin and irisin with…
- Trial name
- NCT04133896
- Testing
- IL-6, Clusterin, Irisin Level
- Where
- Egypt
- Volunteers
- 176 people
- Sponsor
- Rehab Werida
AAA - Abdominal Aortic Aneurysm
Sex-specific Differences in AAA Complexity
A retrospective cohort study of computed tomography scans of AAA patients considered for repair, in order to identify sex specific differences in abdominal aortic aneurysm (AAA) metrics and the association between anatomical…
- Trial name
- NCT05399706
- Testing
- CTA Aorta
- Where
- United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- Imperial College London
Primary Headache Disorder
Gender Differences and Features of the Clinical Course of Primary Headaches
The pathophysiological mechanisms that underlie primary headache disorders, such as migraine and cluster headache (CH), are complex and not yet fully clarified.
- Trial name
- NCT05760625
- Testing
- analysis BDNF
- Where
- Uzbekistan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Tashkent Medical Academy
Pre-diabetes, Diabetes
Gender Differences in Prevalence of Undiagnosed Diabetes in ACS
The primary goal of this study is to measure the prevalence of undiagnosed pre-diabetes/diabetes among women hospitalized with acute coronary syndromes (ACS) compared to men.
- Trial name
- NCT00589459
- Where
- 2 sites in United States
- Volunteers
- 103 people
- Sponsor
- Yale University
Myocardial Infarction, Sex Differences
Hs-cTn - Optimizing the Diagnosis of Acute Myocardial Infarction/Injury in Women
The project is focussed on evaluating the impact of using a female-specific threshold in the diagnosis of myocardial infarction. This female threshold is lower than the overall hs-cTn threshold currently in use.
- Conditions
- Myocardial Infarction, Sex Differences, High Sensitivity Troponin
- Trial name
- CODE-MI (NCT03819894)
- Testing
- Introduction of a lower female hs-cTn threshold
- Where
- Canada
- Volunteers
- 24,000 people
- Sponsor
- BC Centre for Improved Cardiovascular Health
Diabetes Mellitus, Type 2, Hyperuricemia
Sex-related Differences in Arterial Stiffness in Type 2 Diabetics: Role of Uric Acid
Three separate interventions will be undertaken with the primary outcome of improving pulse wave velocity. Initially, age and BMI-matched men and post-menopausal women, all with type 2 diabetes, will be treated with allopurinol…
- Trial name
- NCT03648996
- Testing
- Low-fructose diet, isocaloric, Allopurinol, Low-fructose, hypocaloric
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Missouri-Columbia
Urinary Incontinence Awareness, Gender Differences
Taboo Perception of Incontinence, Depression and Cancer
Objective/study hypothesis To evaluate how much of a taboo UI is and how it compares to other medical conditions that may also pose a taboo issue like depression and cancer.
- Trial name
- NCT00939432
- Where
- Austria
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Sex Differences, Postoperative Sleep Quality
Sex Differences in Postoperative Sleep Quality and Inflammation
Video-Assisted Thoracoscopic Surgery(VATS) is among the most common and disabling persistent pain and inflammation conditions, with increasing prevalence in the developed world, and affects women to a greater degree than men.
- Conditions
- Sex Differences, Postoperative Sleep Quality, Postoperative Pain, Inflammation Function
- Trial name
- NCT04608435
- Testing
- Video-Assisted Thoracoscopic Surgery
- Where
- China
- Volunteers
- 213 people
- Sponsor
- Shengjing Hospital
Type 1 Diabetes Mellitus, Glycemic Variability
Impact of Dietary Fat and Menstrual Cycle Phases in Type 1 Diabetes
This clinical trial aims to evaluate how variations in dietary fat content and hormonal status influence postprandial glycemic response in individuals with type 1 diabetes (T1D), with a special focus on women.
- Conditions
- Type 1 Diabetes Mellitus, Glycemic Variability, Sex Characteristics, Menstrual Cycle
- Trial name
- DIABETEXX/3 (NCT07278063)
- Testing
- Low Fat Mixed Meal, High Fat Mixed Meal
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Instituto de Investigacion Sanitaria La Fe
Diet Therapy, Mediterranean Diet
Exploring Gender Differences in the Effects of Diet and Physical Activity on Metabolic Parameters
This study investigates the gender-specific effects of diet and physical activity on metabolic parameters in a cohort of adults.
- Conditions
- Diet Therapy, Mediterranean Diet, Body Composition Changes, Physical Activity
- Trial name
- GENDIET (NCT06661330)
- Testing
- Behavioral Treatment
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- San Raffaele Telematic University
Cerebral Arterial Diseases
Human Cerebral Blood Flow Regulation
To determine cerebrovascular control mechanisms in humans and provide mechanistic knowledge to offer new sex-specific therapeutic options for cerebrovascular diseases.
- Trial name
- Gas Challenge (NCT04265053)
- Testing
- Indomethacin 25 MG/50 MG
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Cerebral Blood Flow, Cerebral Blood Flow Regulation
The Role of Estrogen and Testosterone in Determining Brain Blood Flow and Metabolic Regulation in Humans
Due to historical exclusion of females from research, there are gaps in the understanding of female physiology, how it differs from males, and how sex-specific hormones contribute.
- Conditions
- Cerebral Blood Flow, Cerebral Blood Flow Regulation, Sex Differences, Exercise
- Trial name
- NCT07212712
- Testing
- GnRH antagonist, Estradiol (E2), Testosterone
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Cocaine Dependence
Gender Differences in Response to Cues in Cocaine Dependence
The purpose of this study is to evaluate whether men and women respond differently to seeing items related to cocaine use or to remembering stressful events.
- Trial name
- NCT00969943
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Chronic Kidney Disease
Chat-based Instant Messaging Support Health Education Program
The purpose of this study is to explore the effectiveness of a CKD-specific chatbot-based instant messaging support health education (CIM-SHE) program and determine its user evaluation by CKD patients.
- Trial name
- NCT05665517
- Testing
- Chatbot Little K Nurse
- Where
- Taiwan
- Volunteers
- 55 people
- Sponsor
- National Taiwan Normal University