Clinical trials: Gender Dysphoria
Transgender, Gender Incongruence
The Effect of Tucking on Semen Quality of Adult Trans Women
Because gender-affirming hormone therapy (GAHT) can lead to fertility impairment, current guidelines and treatment recommendations require that patients be informed about the possibility of fertility preservation prior to…
- Conditions
- Transgender, Gender Incongruence, Fertility Issues
- Trial name
- NCT06530992
- Testing
- tucking break
- Where
- Austria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Gender Incongruence, Transgenderism
Effect of Transgender Therapy on Muscle, Fat and Tissue Receptors
The purpose of this research is to find out if hormone therapy in transgender subjects' changes hormone receptors in blood, muscle and fat; fat production; muscle production; and inflammation processes.
- Trial name
- NCT04551144
- Testing
- testosterone cypionate, Estradiol Valerate
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- St. Louis University
Gender Dysphoria, Gender Identity
Early Mental Response - The EMRE Study
Primary question: Does transgender men's experience of gender incongruence improve within 6 weeks of hormonal treatment compared to placebo? Long before any bodily changes occur.
- Conditions
- Gender Dysphoria, Gender Identity, Gender Issues
- Trial name
- EMRE (NCT05649605)
- Testing
- Testosterone treatment
- Where
- Sweden
- Volunteers
- 70 people
- Sponsor
- Karolinska University Hospital
Transsexualism
Sex Steroids and the Serotonin Transporter
The aim of this study is to prove the influence of the sex steroid hormones estrogen, progesterone and testosterone on the serotonin transporter (5-HTT) binding using positron emission tomography (PET) and the selective…
- Trial name
- NCT01065220
- Testing
- Testolactone undecanoate, Lynestrenol, Cyproterone Acetate
- Where
- Austria
- Volunteers
- 32 people
- Sponsor
- Medical University of Vienna
Gender Dysphoria Vaginoplasty Sexuality
Sexual Function of Trans Women After Vaginoplasty
Genital feminine affirming surgery may be an important step for transgender women. Vaginoplasty consists in the creation of external female genitalia and an operational vaginal cavity, and thus responds to major functional and…
- Trial name
- GGAS-SEX (NCT05292820)
- Testing
- Validated and non-validated questionnaire for exploration of sexuality and satisfaction after surgical procedure
- Where
- 3 sites in France
- Volunteers
- 158 people
- Sponsor
- Hospices Civils de Lyon
Erectile Dysfunction, Gender Dysphoria
ZEPHYR: A Study Evaluating Surgical Outcome After Implantation of the Zephyr ZSI 475 FTM Inflatable Penile Implant in the Neophallus After Female-to-male Sex Reassignment Surgery
This study will look into the surgical outcome after implantation of the Zephyr ZSI 475 FTM in the neophallus.
- Trial name
- NCT04064671
- Testing
- Implantation of the Zephyr ZSI 475 FTM erectile implant
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- University Hospital, Ghent
Gender Dysphoria
Trans Care: An Online Intervention to Reduce Symptoms of Gender Dysphoria
The current project aims to improve the well-being of trans and nonbinary (TNB) individuals through an online intervention (Trans Care) targeting the reduction of symptoms of gender dysphoria.
- Trial name
- NCT05884307
- Testing
- Trans Care Web App
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Gender Dysphoria
Gender Dysphoria Among Adolescents (Norwegian Title: Kjønnsdysfori Blant Ungdom)
The aim of this study is to explore how gender dysphoria is experienced among adolescents aged 13 - 18 from a clinical population. The method is qualitative, with a phenomenological approach.
- Trial name
- NCT03643120
- Testing
- Qualitative interview
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- Oslo University Hospital
Transgenderism, Gender Dysphoria
Pubertal Blockade and Estradiol Effects on Cardiometabolic Health for Transitioning Youth
To evaluate the effect of estradiol with or without a prior gonadotropin releasing hormone analogue on insulin sensitivity and vascular function in transgender females compared to cisgender controls.
- Conditions
- Transgenderism, Gender Dysphoria, Insulin Sensitivity
- Trial name
- PUBERTY (NCT04596592)
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Colorado, Denver
Gender Dysphoria, Adolescent
Psychological Vulnerabilities and Transgender Adolescents: A Descriptive Epidemiology Study
The number of adolescents engaging in a transidentity journey has been increasing rapidly over the last decade. However, the knowledge of the medical world concerning the specificities of these adolescents is still too little in…
- Trial name
- VATED (NCT05126134)
- Testing
- KSADS (Kiddie Schedule for Affective Disorders and Schizophrenia)
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Toulouse
Gender Dysphoria, Transgender
Ovarian Tissue Cryopreservation in the Setting of Gender-affirming Therapy
The goal of this study is to learn about fertility preservation in the gender-diverse community. The main objectives it aims to understand are to: 1.
- Trial name
- NCT05863676
- Testing
- Oophorectomy, Infectious Disease Testing
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pittsburgh
Gender Dysphoria, Gender Identity Disorder
Sexuality in Transmen During Hormone and Operative Treatment
With this analysis the investigators aim at discovering a difference in sexuality between transmen, cissexual women and cissexual men. A potential impact of body satisfaction will also be explored.
- Conditions
- Gender Dysphoria, Gender Identity Disorder, Transsexualism, Body Image
- Trial name
- Transmann (NCT03637920)
- Where
- Austria
- Volunteers
- 160 people
- Sponsor
- Medical University of Graz
Gender Dysphoria
Brain Health in Transgender Adults
The purpose of this study is to test whether and how a person's brain changes in the first few months after starting gender affirming hormone therapy (GAHT).
- Trial name
- NCT07624747
- Testing
- Magnetic Resonance Imaging, Cognition and Health Tests, Optional Exercise Test
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Gender Dysphoria
Chest Dysphoria in Transmasculine Spectrum Adolescents
The investigators hypothesize that masculinizing top surgery (e.g., mastectomy and chest masculinization) leads to an improvement in self-report chest dysphoria, gender dysphoria, and gender congruence in…
- Trial name
- NCT04195659
- Testing
- Mastectomy and chest masculinization
- Where
- 3 sites in United States
- Volunteers
- 81 people
- Sponsor
- Northwestern University
Gender Dysphoria in Adolescents and Adults
Transgender Therapeutic Support Groups
This study seeks to explore the effects for transgender people undergoing surgical interventions of participating in pre/post-surgical therapeutic support groups in order to assess the value of adding these programs to hospital…
- Trial name
- NCT04217707
- Testing
- Pre- and Post-Surgical Transgender Therapeutic Support Group
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Denver Health and Hospital Authority
Transgender Health, Gender Dysphoria
Evaluating Drug Interactions Between Doravirine With Estradiol and Spironolactone in Healthy Transgender Women
Transgender women living with Human Immunodeficiency Virus (HIV) may prioritize gender-affirming hormonal therapy over antiretroviral drug therapy.
- Conditions
- Transgender Health, Gender Dysphoria, Transgender Women, Human Immunodeficiency Virus
- Trial name
- IDENTIFY (NCT04283656)
- Testing
- Doravirine/Lamivudine/Tenofovir, Spironolactone 100mg, Estradiol 2mg
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Transgenderism, Erectile Dysfunction
Erectile Aid Use in Post-phalloplasty and Post-metoidioplasty Transgender Patients
This study seeks to explore the various methods used by transgender men for sexual intercourse following phalloplasty or metoidioplasty, focusing on their satisfaction with different erectile aids, as well as the satisfaction of…
- Conditions
- Transgenderism, Erectile Dysfunction, Gender Dysphoria, Sexual Dysfunction
- Trial name
- AID (NCT06639763)
- Testing
- Questionnaire
- Where
- Belgium
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Gender Dysphoria
Developmental Correlates and Hormone Therapy Effects in Gender Dysphoria
The aim of the research is to study longitudinally the effects of reassignment hormonotherapy on the connectome of MtF (biological men who are transitioning to the female gender) dysphoric subjects after 6 months of hormone…
- Trial name
- DCHGD (NCT04309760)
- Testing
- MRI
- Volunteers
- healthy volunteers welcome
- Sponsor
- Hôpital le Vinatier
Gender Incongruence
Transgender In Transition
Prospective trial in gender dysphoric patients who undergo gender-affirming hormone therapy, aiming to investigate psychological, biological and behavioural consequences of hormonal therapy.
- Trial name
- TRANSIT (NCT04028219)
- Testing
- Online surveys
- Where
- 5 sites in Germany, Switzerland
- Volunteers
- 750 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Transgender Individuals, Gender Incongruence
Swiss ProspectivE Cohort of TRAnsgender and Gender Diverse Individuals - The SPECTRA Study
The goal of this observational study is to understand the factors influencing the well-being and health of transgender and gender-diverse (TGD) individuals undergoing gender-affirming therapies in Switzerland.
- Trial name
- SPECTRA (NCT06774053)
- Testing
- Group A (start of GAHT), Group B (on-going GAHT), Group C (GAS)
- Where
- 3 sites in Switzerland
- Volunteers
- 600 people
- Sponsor
- University Hospital, Basel, Switzerland