Clinical trials: Gender Incongruence
Gender Incongruence, Transgenderism
Effect of Transgender Therapy on Muscle, Fat and Tissue Receptors
The purpose of this research is to find out if hormone therapy in transgender subjects' changes hormone receptors in blood, muscle and fat; fat production; muscle production; and inflammation processes.
- Trial name
- NCT04551144
- Testing
- testosterone cypionate, Estradiol Valerate
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- St. Louis University
Gender Dysphoria
Understanding Perceived Access and Receipt of Gender-affirming Treatments Among Transgender Veterans
Transgender Veterans (trans Vets) frequently experience gender dysphoria or distress related to discord between their gender identity and birth sex.
- Trial name
- NCT06615401
- Where
- United States
- Volunteers
- 986 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Erectile Dysfunction, Gender Dysphoria
ZEPHYR: A Study Evaluating Surgical Outcome After Implantation of the Zephyr ZSI 475 FTM Inflatable Penile Implant in the Neophallus After Female-to-male Sex Reassignment Surgery
This study will look into the surgical outcome after implantation of the Zephyr ZSI 475 FTM in the neophallus.
- Trial name
- NCT04064671
- Testing
- Implantation of the Zephyr ZSI 475 FTM erectile implant
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- University Hospital, Ghent
Gender Dysphoria, Gender Identity Disorder
Sexuality in Transmen During Hormone and Operative Treatment
With this analysis the investigators aim at discovering a difference in sexuality between transmen, cissexual women and cissexual men. A potential impact of body satisfaction will also be explored.
- Conditions
- Gender Dysphoria, Gender Identity Disorder, Transsexualism, Body Image
- Trial name
- Transmann (NCT03637920)
- Where
- Austria
- Volunteers
- 160 people
- Sponsor
- Medical University of Graz
Transgenderism, Gender Dysphoria
Pubertal Blockade and Estradiol Effects on Cardiometabolic Health for Transitioning Youth
To evaluate the effect of estradiol with or without a prior gonadotropin releasing hormone analogue on insulin sensitivity and vascular function in transgender females compared to cisgender controls.
- Conditions
- Transgenderism, Gender Dysphoria, Insulin Sensitivity
- Trial name
- PUBERTY (NCT04596592)
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Colorado, Denver
Gender Incongruence, Cardiovascular Disease (CVD) Risk Factors
Cardiomodulatory Effects of Gender-Affirming Hormone Therapy
Gender-affirming hormone therapy is today a well-established treatment for individuals experiencing gender-incongruence. However, little is known about the long-term effects of gender-affirming hormone therapy on the…
- Trial name
- CARMEN (NCT07128771)
- Where
- Norway
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- University Hospital, Akershus
Gender Dysphoria, Adolescent
Psychological Vulnerabilities and Transgender Adolescents: A Descriptive Epidemiology Study
The number of adolescents engaging in a transidentity journey has been increasing rapidly over the last decade. However, the knowledge of the medical world concerning the specificities of these adolescents is still too little in…
- Trial name
- VATED (NCT05126134)
- Testing
- KSADS (Kiddie Schedule for Affective Disorders and Schizophrenia)
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Toulouse
Transsexualism
Testosterone and Its Metabolites in GID
The purposes of this study are: to determine the role of testosterone versus dihydrotestosterone with respect to the following physiological functions: bone metabolism, body composition, insulin resistance and lipid profile to…
- Trial name
- NCT00146146
- Testing
- testosterone undecanoate alone, testosterone undecanoate plus letrozole, testosterone undecanoate plus dutasteride
- Where
- Italy
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Unita Complessa di Ostetricia e Ginecologia
Gender Dysphoria
Demographic Characteristics and Psychosocial Health of Transgender People
To study demographic characteristics of subjects referred to endocrine care for gender dysphoria and their psychosocial health
- Trial name
- DyGeDem (NCT04554849)
- Testing
- Gender dysphoria psychosocial health
- Where
- France
- Volunteers
- 320 people
- Sponsor
- Central Hospital, Nancy, France
Gender Incongruence, Gender Dysphoria
Sex Hormone Overdose and Misuse in Chinese Transgender and Gender Non-conforming Population
The investigators propose to investigate the definition of hormone overdose and misuse (HODM) in Chinese transgender and gender nonconforming population (TGNCs), address the incidence of HODM in Chinese TGNC population, related…
- Trial name
- HODMChina (NCT05583058)
- Testing
- Hormone Overdose and Misuse
- Where
- China
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Xiamen University
Gender Dysphoria in Children, Puberty
Skeletal Health and Bone Marrow Composition Among Youth
Children and adolescents experiencing gender dysphoria feel increased distress with the onset of puberty. Gender clinics treat these young adolescents by "blocking" puberty using gonadotropin-releasing hormone (GnRH) agonist…
- Conditions
- Gender Dysphoria in Children, Puberty, Bone Development
- Trial name
- NCT04203381
- Testing
- GnRH Agonist
- Where
- 2 sites in United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Amy DiVasta, MD
Gender Dysphoria
The Relation of GnRH Treatment to QTc Interval in Transgender Females
Background: The QT interval of the electrocardiogram (ECG), corrected for heart rate (QTc), is a measure of the duration of ventricular repolarization and is a widely used marker of ventricular arrhythmia risk.
- Trial name
- NCT03078829
- Testing
- Treatment with a GnRh agonists
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of California, San Francisco
Gender Dysphoria, Emotion Regulation
Internet-delivered Treatment for Transgender Individuals With Co-occurring Mental Health Problems
This project aims to develop and evaluate if an internet delivered psychological intervention for transgender individuals undergoing assessment for gender dysphoria and a support person, is feasible, acceptable and effective in…
- Conditions
- Gender Dysphoria, Emotion Regulation, Internet Delivered Treatment
- Trial name
- IERGD (NCT05534763)
- Testing
- IERGD, IER SUPPORT
- Where
- Sweden
- Volunteers
- 24 people
- Sponsor
- Karolinska Institutet
Gender Dysphoria, Adult
Gender Affirming Vaginoplasty With Tubularized Augmented Peritoneal Cap (TAPCap) Utilizing Fish Skin Xenograft (Kerecis™)
Bottom gender affirming surgery is one of the key steps towards aligning the physical appearance and gender identity in transgender women.
- Trial name
- NCT07286123
- Testing
- Tubularized augmented peritoneal cap vaginoplasty, Biopsy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University Hospitals Cleveland Medical Center
Gender Dysphoria
Gender Dysphoria in Children and Adolescents : Parents' Perspectives
Gender dysphoria is defined as a persistent incongruence between an experienced gender and the assigned sex at birth Transgender and gender nonconforming persons desire to modify their appearance to be consistent with their…
- Trial name
- GeDyPar (NCT04160364)
- Testing
- qualitative study
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Central Hospital, Nancy, France
Gender Dysphoria, Adult
Comparative Study of Gender Identity Disorder Versus Control
Gender dysphoria is manifested by an internal tension between biological sex and gender, that is, by a non-congruence, in the subjects who suffer from it, between their sex of birth and their social gender identity.
- Trial name
- TRANSIDENT (NCT04935164)
- Testing
- Psychiatric evaluations
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Henri Laborit
Fertility Preservation, Parenting
Fertility Desires and Reproductive Needs of Transgender People
Majority of transgender and gender nonconforming people seeking medical care are in pubertal and reproductive age. Cross-sex hormones may compromise fertility especially when preceded by puberty blocking regimen.
- Conditions
- Fertility Preservation, Parenting, Gender Dysphoria
- Trial name
- PaFer (NCT03836027)
- Testing
- No intervention
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Central Hospital, Nancy, France
Gender Dysphoria, Adolescent
Fertility Preservation for Transfeminine Adolescents Via Semen Cryopreservation or Testicular Sperm Extraction
The goal of this observational cohort study is to identify and predict parameters for successful testicular sperm extraction (TESE) procedures or semen cryopreservation more accurately and to evaluate the decision making process…
- Trial name
- TESE (NCT06400199)
- Where
- 2 sites in Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Gender Dysphoria, Gender Dysphoria, Adult
Metoidioplasty and Phalloplasty Surgery Decision Making
The goal of this clinical trial is to test a new online tool designed to provide clear and understandable information to help individuals considering Metoidioplasty and Phalloplasty Surgeries (MaPS) make informed decisions The…
- Conditions
- Gender Dysphoria, Gender Dysphoria, Adult, Gender Incongruence, Transgenderism
- Trial name
- MaPS (NCT06565663)
- Testing
- MaPS Decision Aid
- Where
- 2 sites in United States
- Volunteers
- 140 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Rokitansky Kuster Hauser Syndrome, Vaginal Neoplasms
Peritoneum Vaginoplasty; Implementation According to IDEAL Framework
This study aims to assess if a single flap peritoneum vaginoplasty is safe and feasible.The IDEAL framework for evaluation and implementation of surgical techniques will be used.
- Conditions
- Rokitansky Kuster Hauser Syndrome, Vaginal Neoplasms, Gender Incongruence, Vaginal Obstruction
- Trial name
- PeriVaS (NCT05925361)
- Testing
- Laparoscopic pedicled single flap peritoneum vaginoplasty
- Where
- Netherlands
- Volunteers
- 13 people
- Sponsor
- Amsterdam UMC, location VUmc