Clinical trials: Gene Expression
TNBC - Triple-Negative Breast Cancer
PSMA-PET/CT to Assess the Expression of Specific Membrane Antigen (PSMA) in Patients With Progressive Triple-negative Breast Cancer.
This is a descriptive, prospective, single centre study. This study will assess PSMA expression via the uptake of radiolabelled PSMA-ligand using PET/CT imaging in mTNBC lesions pre-identified on 18F-FDG PET/CT in order to…
- Trial name
- PRISMA (NCT06059469)
- Testing
- Ga-PSMA PET/CT
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Jules Bordet Institute
Non-Hodgkin Lymphoma (NHL), Cutaneous Lymphoma
Brentuximab Vedotin (SGN-35) in Patients With Mycosis Fungoides With Variable CD30 Expression Level
The purpose of this study is to learn the effects of brentuximab vedotin (SGN-35), an investigational medication, on patients with cutaneous T cell lymphoma (CTCL), specifically mycosis fungoides (MF) and Sezary syndrome (SS).
- Conditions
- Non-Hodgkin Lymphoma (NHL), Cutaneous Lymphoma, Cutaneous T-cell Lymphoma (CTCL), Mycosis Fungoides
- Trial name
- NCT01396070
- Testing
- Brentuximab vedotin
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Youn Kim
Irritable Bowel Syndrome
Is There Any Correlation Between Plasmatic Zonulin and Expression of Intestinal Tight Junction Proteins in IBS Patients?
Increased intestinal permeability is one of the main pathophysiological mechanisms involved in irritable bowel syndrome. The expression of some intestinal tight junction proteins is decreased mostly in IBS-diarrhoea patients.
- Trial name
- BISII (NCT02877654)
- Testing
- colonoscopy with biopsies in the left colon to assess intestinal permeability
- Where
- France
- Volunteers
- 67 people
- Sponsor
- University Hospital, Rouen
Autoimmune Diseases
Study of STIM1 Membrane Expression
The aim of this study is to determine the expression of STIM1 in the plasma membrane of lymphocytes from patients suffering from different autoimmune diseases in order to identify new pathologies of interest presenting an…
- Trial name
- STIMEX (NCT04978948)
- Where
- 4 sites in France
- Volunteers
- 670 people
- Sponsor
- University Hospital, Brest
Gene Expression
Gene Expression Study Between Two Dermal Injectables Hydroxylapatite Semi-permanent Filler
To compare gene expression stimulated by a semi-permanent filler and a biostimulator via punch biopsy
- Trial name
- Sculptra (NCT05620043)
- Testing
- Sculptra, Radiesse Plus
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Visual Acuity, Meibomian Gland
Clinical Evaluation of Therapeutic Meibomian Gland Expression
This will be a single centre pilot study to evaluate appearance of the Meibomian glands.
- Trial name
- NCT04997135
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Non-small-cell Lung Cancer
PEmbRolizumab verSus chEmotherapy and pEmbrolizumab in Non-small-cell Lung Cancers (NSCLC) With PDL1 ≥ 50 %
PERSEE is a French national phase 3 academic study comparing the chemotherapy-pembrolizumab combination to pembrolizumab alone as a first-line treatment for advanced NSCLC molecularly defined by a PDL1 expression ≥ 50% of tumour…
- Trial name
- PERSEE (NCT04547504)
- Testing
- Pembrolizumab, Pembrolizumab and Chemotherapy drugs
- Where
- 29 sites in France
- Volunteers
- 349 people
- Sponsor
- University Hospital, Brest
Breast Milk Collection
Establishment of the Breast Milk Database in China
Collect breast milk samples in various administrative regions of China to measure the nutrients in breast milk; analyze the composition of nutrients; and establish the database of breast milk in China.
- Trial name
- NCT03675204
- Testing
- No intervention
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Heilongjiang Feihe Dairy Co. Ltd.
Esophageal Cancer, Lung Cancer
Decitabine in Treating Patients With Unresectable Lung or Esophageal Cancer or Malignant Mesothelioma of the Pleura
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase I trial to study the effectiveness of decitabine in treating patients who have unresectable…
- Conditions
- Esophageal Cancer, Lung Cancer, Malignant Mesothelioma, Metastatic Cancer
- Trial name
- NCT00019825
- Testing
- decitabine
- Where
- 2 sites in United States
- Sponsor
- National Cancer Institute (NCI)
Her2-positive/Low-expression Urinary and Digestive Tract Tumors
A Study of BL-M07D1 in Patients With a Variety of Solid Tumors Including Locally Advanced or Metastatic HER2-positive/Low-expressing Urinary and Gastrointestinal Tumors
Phase Ib: Explore the safety and tolerability of BL-M07D1 to further define RP2D in a variety of solid tumors, including locally advanced or metastatic urinary and gastrointestinal tumors.
- Trial name
- NCT06031584
- Testing
- BL-M07D1
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Sichuan Baili Pharmaceutical Co., Ltd.
Interpersonal Psychotherapy, Family Caregivers
Application of Group Interpersonal Psychotherapy (IPT-G) to Family Members Caring for Patients With Schizophrenia
The goal of this re-measured quasi-experimental study is to evaluate the effect of Group Interpersonal Psychotherapy (IPT-G) intervention given to caregiver family members of people with schizophrenia on caregiver burden…
- Trial name
- IPT-G (NCT05870384)
- Testing
- Group Interpersonal Psychotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Sickle Cell Disease
Atorvastatin Therapy to Improve Endothelial Function in Sickle Cell Disease
This study will examine the effects of oral atorvastatin on the linings of blood vessels in patients with sickle cell disease, plus the agent's effect on blood markers of inflammation and blood vessel function.
- Trial name
- NCT00072826
- Testing
- Oxypurinol, L-NMMA, Acetylcholine
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Ageing
Human Skin Aging: Clinical Parameters and Gene Expression Profiling
Skin aging is a complex process involving genetic and environmental factors. The investigators hope to learn more about how human genes and their function can contribute to skin aging and human health.
- Trial name
- GEP (NCT01451476)
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Stanford University
SCHIZOPHRENIA 1 (Disorder)
Effect of Fluvoxamine on Cognition, Behavior, Symptoms and mRNA and Protein Expression in Schizophrenia Patients
The purpose of this study is to determine effect of Fluvoxamine augmentation on cognitive function , aggressive behavior , clinical symptoms and mRNA (messenger ribonucleic acid) and protein expression in human peripheral…
- Trial name
- NCT01832285
- Testing
- fluvoxamine
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Sha'ar Menashe Mental Health Center
Stomach Neoplasms
A Phase 2 Trial of Optimizing Platinum-Based Chemotherapy Based on ERCC1 Expression as First-Line Treatment in Patients With Locally Advanced or Metastatic Gastric Cancer
The purpose of this study is to determine whether ERCC1(excision repair cross-complementation 1 ) expression has effects on platinum-based chemotherapy for patients with locally advanced or metastatic gastric cancer, and to…
- Trial name
- NCT01967875
- Testing
- Capecitabine+Cisplatin, Docetaxel+Capecitabine
- Where
- 7 sites in China
- Volunteers
- 27 people
- Sponsor
- China Medical University, China
Type 2 Diabetes
Effect of Meal Frequency and Timing on Insulin Dose and Clock Gene in Type 2 Diabetic Patients
This study is undertaken to explore in patients with uncontrolled T2D treated with insulin, whether a diet with large breakfast and lunch with small dinner (Bdiet) will enhance CG expression and will be more effective for weight…
- Trial name
- Bdiet-6Mdiet (NCT02709915)
- Testing
- Breakfast Diet (Bdiet), 6Meal Diet (6Mdiet
- Where
- Israel
- Volunteers
- 28 people
- Sponsor
- Tel Aviv University
Peripheral Arterial Occlusive Disease
Gene Expression and Tolerability Study of NV1FGF in Patients With Peripheral Artery Occlusive Disease Planned to Undergo Major Amputation
The primary objective is to evaluate the transgene expression (synthesis of FGF-1 mRNA) in injected tissue, at injection site, after Intra Muscular (IM) administration of increasing single doses of NV1FGF.
- Trial name
- NCT01157143
- Testing
- XRP0038 (NV1FGF)
- Where
- 2 sites in United States, Switzerland
- Volunteers
- 6 people
- Sponsor
- Sanofi
Biliary Tract Cancer
A Study of SHR-A1904 in Previous Systemic Treatment Failed Biliary Tract Cancer
This is a multicenter, Phase 2 clinical trial to evaluate the efficacy and safety, PK and immunogenicity of SHR-A1904 in patients with advanced or metastatic biliary tract cancer (BTC).
- Trial name
- NCT07450976
- Testing
- SHR-A1904 for Injection
- Where
- 2 sites in China
- Volunteers
- 151 people
- Sponsor
- Suzhou Suncadia Biopharmaceuticals Co., Ltd.
Rheumatoid Arthritis
Quantification of GADD34 Expression in RA
GADD34 is an inducible cofactor of protein phosphatase 1, which has an important role in the Unfolded Protein Response (UPR). UPR is a cellular response to ER stress which is implicated in several autoimmune diseases.
- Trial name
- GADD34-RA (NCT02401165)
- Testing
- Blood test
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Infertility
Implantation and Cytokine Expression
Implantation failure of the embryo might be the result from the environment in the uterus. Proteins (cytokines) are screted by the endometrium which can result in a pro or anti inflammatory environment.
- Trial name
- NCT00264992
- Where
- Netherlands
- Volunteers
- 160 people
- Sponsor
- UMC Utrecht