Clinical trials: Gene Expression Profiling
Poor Response to Ovulation Induction
Effect of LH Supplementation on the Endometrial Gene Expression Profile in Poor Ovarian Responders
This is a prospective randomized open-label cross-over study. Poor responder patients will undergo two ovarian stimulation cycles.
- Trial name
- NCT05405686
- Testing
- Lutropin alfa, Follitropin alfa, Endometrial biopsy
- Sponsor
- CRG UZ Brussel
NSCLC, Stage IV
Early Response Evaluation in NSCLC Patients Treated With Immunotherapy
A pilot study with biomarker exploration.50 patients with stage IV non-small cell lung cancer (NSCLC) that are eligible for treatment with nivolumab.
- Trial name
- NCT04082988
- Testing
- 18F-FDG PET-CT
- Where
- 2 sites in Netherlands
- Volunteers
- 9 people
- Sponsor
- The Netherlands Cancer Institute
Sinus Floor Augmentation
Transcriptome Analysis of Human Bone Regeneration After Using an Anorganic Bovine Bone Graft With or Without a Combination of Polynucleotides and Hyaluronic Acid
The goal of this clinical trial is to compare the expression of multiple genes related to bone regeneration in maxillary bone after being grafted with a commonly used biomaterial supplemented or not with a combination of…
- Trial name
- NCT06156488
- Testing
- Maxillary sinus floor augmentation
- Where
- Spain
- Volunteers
- 5 people
- Sponsor
- Universidad de Granada
Indeterminate Thyroid Cytology
Clinical Validation of ThyroidPrint: A Gene Expression Signature for Diagnosis of Indeterminate Thyroid Nodules
A clinical trial is proposed, to clinically validate, in a US population, the diagnostic performance of a new genetic test (ThyroidPrint).
- Trial name
- NCT03309631
- Testing
- In vitro Diagnostic
- Where
- 6 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Head and Neck Neoplasms
Molecular and Genomic Profiling of Head and Neck Tumors
The purpose of this study is to study the genetic profile of head and neck tumors and their relationship to treatment response and outcome
- Trial name
- NCT00200486
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Montefiore Medical Center
Type 2 Diabetes Mellitus
Genetic Variants and Phenotypic Characteristics of Patients With T2DM
Background: Genetic risk-markers associated with T2DM are thoroughly studied. So far, only a few genetic variants, also termed single nucleotide polymorphisms (SNP's), have been replicated in several studies and each of them…
- Trial name
- GenVarT2DM (NCT00760292)
- Where
- Denmark
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Rheumatoid Arthritis
Gene Expression Profiling in PBMCs as a Tool for Prediction of Anakinra Responsiveness in Rheumatoid Arthritis
The objective of the study is to identify and validate predictive markers of anakinra responsiveness in RA patients by a transcriptomic approach.
- Trial name
- NCT00213538
- Testing
- Response to anakinra associated with methotrexate
- Where
- France
- Volunteers
- 341 people
- Sponsor
- University Hospital, Rouen
Healthy
Cell Lines From High-Risk Breast Tissue
Background: Many risk factors for breast cancer have been identified, including family history, endocrine background, changes in breast tissue, cancer in one breast, radiation exposure, obesity and others.
- Trial name
- NCT00032201
- Where
- 2 sites in United States
- Volunteers
- 43 people
- Sponsor
- National Cancer Institute (NCI)
Coronary Disease
Expression Profiling of microRNA Following Administration of Dexmedetomidine
The purpose of the study is to find out the differential expression profiling of microRNA before and after adiministration of dexmedetomidine in patients undergoing procedures, and then investigators will do some in vitro studies…
- Trial name
- NCT03213743
- Testing
- Dexmedetomidine Injection
- Where
- China
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Kunming Medical University
Adult Acute Megakaryoblastic Leukemia, Adult Acute Monoblastic Leukemia
Tipifarnib in Treating Older Patients With Acute Myeloid Leukemia
This phase II trial is studying how well tipifarnib works in treating older patients with acute myeloid leukemia. Tipifarnib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.
- Conditions
- Adult Acute Megakaryoblastic Leukemia, Adult Acute Monoblastic Leukemia, Adult Acute Monocytic Leukemia, Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11
- Trial name
- NCT01361464
- Testing
- Tipifarnib, Laboratory Biomarker Analysis
- Where
- 7 sites in United States
- Volunteers
- 21 people
- Sponsor
- National Cancer Institute (NCI)
Advanced Malignant Solid Neoplasm
MPACT Study to Compare Effects of Targeted Drugs on Tumor Gene Variations
This phase II trial studies molecular profiling-based assignment of cancer therapy (MPACT) in treating patients with solid tumors that have spread to other places in the body and usually cannot be cured or controlled with…
- Trial name
- NCT01827384
- Testing
- Adavosertib, Carboplatin, Everolimus
- Where
- 8 sites in United States
- Volunteers
- 208 people
- Sponsor
- National Cancer Institute (NCI)
Salivary Gland Cancer, Metastatic
A Study of Drug Therapies for Salivary Gland Cancers Based on Testing of Genes
This is a study of select drug therapies in patients with salivary gland cancer. The study has two phases: a molecular profiling phase (phase 1) and a treatment phase (phase 2).
- Conditions
- Salivary Gland Cancer, Metastatic, Advanced, Recurrent
- Trial name
- NCT02069730
- Testing
- Selinexor, EGFR or HER2 Inhibitor, FGFR Inhibitor
- Where
- Canada
- Volunteers
- 114 people
- Sponsor
- University Health Network, Toronto
Metastatic Melanoma
RATIO: Rational Approach To Immuno-Oncology
This trial will utilize a Molecular MicroscopeTM diagnostic system (MMDxTM) that combines the molecular and histopathological features of biopsies, plus clinical and laboratory parameters, to create the first Integrated…
- Trial name
- RATIO (NCT02700971)
- Testing
- Molecular Microscope Diagnostic system
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- AHS Cancer Control Alberta
Repetitive Implantation Failure
ERA Test in Patients With Recurrent Implantation Failure
The purpose of this study is to demonstrate the clinical efficiency of the Endometrial Receptivity Array (ERA) diagnostic tool in patients with repetitive implantation failure (RIF), leading to the new concept of the personalized…
- Trial name
- ERA (NCT01668693)
- Testing
- ERA (Endometrial Receptivity Array), Personalized Embryo Transfer, Second ERA
- Where
- Spain
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Igenomix
Corona Virus Infection
Differential Expression of Cytokines, Transcriptome and miRNA in Coronavirus Disease 2019 (COVID-19) Egyptian's Patients
The aim of this effort is to study host-pathogen interaction in Egyptian patients infected with COVID-19. The investigators will perform genome-wide miRNA and transcriptome screens in the infected patients along with healthy ones…
- Trial name
- NCT04583566
- Testing
- COVID-19 Diagnostic and Assessment Tests
- Where
- 2 sites in Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tanta University
Prostate Cancer
Changes in DNA After Radiation Therapy in Patients With Prostate Cancer
RATIONALE: Collecting and storing samples of tissue from patients with cancer to study in the laboratory may help doctors learn more about changes that may occur in DNA after radiation therapy and identify biomarkers related to…
- Trial name
- NCT00899912
- Testing
- microarray analysis, diagnostic laboratory biomarker analysis
- Where
- 10 sites in United States
- Volunteers
- 13 people
- Sponsor
- Radiation Therapy Oncology Group
Lung Cancer
Construction and Use of Lung Tumor Microarray for the Analysis of Gene Expression in Lung Cancer
The proposed research intends to construct a set of tissue microarrays containing different types of normal and lung cancer tissues for the study of genes associated with lung cancer.
- Trial name
- NCT00340847
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- National Cancer Institute (NCI)
Cervical Cancer, Precancerous Condition
Gene Expression Profiling of Cervical Cancer Progression in Biopsies and Tissue Samples
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- SAGE (NCT00629577)
- Testing
- microarray analysis, flow cytometry, biopsy
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- British Columbia Cancer Agency
Rheumatoid Arthritis
Gene Expression Profiling in PBMCs as a Tool for Prediction of Infliximab Responsiveness in Rheumatoid Arthritis
The objective of the study is to identify and validate predictive markers of infliximab responsiveness in RA patients by 2 approaches: i) measuring biochemical, immunological and bone markers in sera because of their involvement…
- Trial name
- NCT00213564
- Testing
- response to infliximab associated with methotrexate
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Rouen
Malignant Tumor
Gene Expression Profiling of Malignant Tumor Predict the Therapeutic Response of DC-CIK Immunotherapy
To investigate gene expression profile and immunological associated analysis relating to immunotherapy response of patients with malignant tumor after DC-CIK immunotherapy.
- Trial name
- NCT01906632
- Testing
- DC-CIK Immunotherapy
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Capital Medical University