Clinical trials: Gene Expression Profiling
Inflammatory Myofibroblatic Tumor
Molecular Profiling and Molecular Labeling of Inflammatory Myofibroblastic Tumor
Gene mutation is a research hotspot in the occurrence of multiple malignant tumors. The somatic gene mutations of many different types of tumors not only help to study the tumorigenesis mechanism and molecular diagnosis, but also…
- Trial name
- NCT04572594
- Where
- China
- Volunteers
- 29 people
- Sponsor
- Sun Yat-sen University
Non-small Cell Lung Cancer
Detection of Early Lung Cancer by Serum Protein Expression Profiling
Promising new technology exists to examine small proteins that are shed by cancers into the blood stream. The purpose of this study is to see if there are differences in the proteins and protein levels in blood from individuals…
- Trial name
- NCT00175578
- Where
- Canada
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Gastrointestinal Cancer, Pancreatic Cancer
Intestinal Microbiome, Oral Microbiome, and Whole Blood Transcriptome Analyses in Gastrointestinal Malignancies
The primary objective of this prospective observational study is to characterize the gut and oral microbiome as well as the whole blood transcriptome in gastrointestinal cancer patients and correlate these findings with cancer…
- Conditions
- Gastrointestinal Cancer, Pancreatic Cancer, Esophageal Cancer, Gastric Cancer
- Trial name
- NCT05462314
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Viome
Multiple Myeloma
Pomalidomide in Gene Expression Profiling (GEP)-Defined High-risk Multiple Myeloma
This is a phase II study, open-label, single institution trial of pomalidomide in GEP-defined, high-risk relapsing/refractory multiple myeloma. Prior therapy must have included lenalidomide.
- Trial name
- NCT01177735
- Testing
- Pomalidomide
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- University of Arkansas
Idiopathic Juvenile Arthritis
Biomarkers in Idiopathic Juvenile Arthritis
Juvenile idiopathic arthritis (JIA) is the most common form of arthritis in children. The etiology is unknown. Several types of arthritis fall under the JIA heading.
- Trial name
- NCT02343770
- Testing
- blood sample for identifying biomarkers
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Chronic Periodontitis
Gene Expression Profiles in Chronic Periodontitis
Current concepts of the causes of periodontitis implicate a bacterial infection as the primary cause of the disease. Several bacterial species residing in a biofilm on tooth surfaces are closely associated with periodontitis.
- Trial name
- NCT02467283
- Testing
- Genom-based whole-genome transcriptomic
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Keloid, Keloid of Ear Lobe
Gene Expression and Biomarker Profiling of Keloid Skin
This study aims to examine both the genetic profile and the biomarkers implicated in keloid scar formation. Hypothesis: 1. Differences in the genetic profiles of lesional and non-lesional skin contribute a given population's…
- Conditions
- Keloid, Keloid of Ear Lobe, Healthy Adults
- Trial name
- NCT03228693
- Testing
- Biopsy and/or triamcinolone injection, Excisional Biopsy
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Hip Arthroplasty
Anesthetic Methods and Gene Expression Profile
The study will analyze differentially regulated genes involved in oxidative stress and toxicology in peripheral blood mononuclear cells (PBMCs) of patients who underwent arthroplasty under three different anesthetic methods.
- Trial name
- GeSTA (NCT03585647)
- Testing
- hip arthroplasty
- Where
- Italy
- Volunteers
- 99 people
- Sponsor
- University of Bologna
Antibody-mediated Rejection
Analysis of Biopsies With Antibody Mediated Rejection According to the Therapy Response
In adult kidney transplant recipients a therapy-responder and non-responder phenotype by antibody mediated rejection will be precisely defined according to clinical and histological characteristics such as creatinine, proteinuria…
- Trial name
- NCT03430414
- Testing
- Transcriptome Analysis
- Volunteers
- 50 people
- Sponsor
- Thomas Mueller
Breast Cancer
MIRNA Profiling of Breast Cancer in Patients Undergoing Neoadjuvant or Adjuvant Treatment for Locally Advanced & Inflammatory Breast Cancer
MicroRNAs (MiRNAs) regulate the translation of RNAs and are implicated in cell proliferation and renewal both under physiologically normal as well as in malignant conditions.
- Trial name
- NCT01231386
- Where
- United States
- Volunteers
- 199 people
- Sponsor
- City of Hope Medical Center
Breast Cancer
Validation of 70-gene MammaPrint Profile in Japanese Population
By using gene-expression profiling, Van't Veer and colleagues developed a 70-gene prognosis profile, MammaPrint, to identify breast cancer patients who are at low risk of developing distant metastases and therefore might safely…
- Trial name
- NCT00904566
- Where
- Japan
- Volunteers
- 102 people
- Sponsor
- Agendia
Androgenetic Alopecia
Microarray Analysis of Scalp Biopsies After Minoxidil Treatment
The purpose of this study is to determine whether Minoxidil treatment affects hair growth in patients with male pattern baldness or androgenetic alopecia.
- Trial name
- NCT01309191
- Testing
- Minoxidil
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Pain Perception, Phlebotomy
Functional Microarray Augmentation of Skin Treatment With Lidocaine
The purpose of this study is to determine whether co-application of a functional microarray of needles (FMA) speeds the rate at which topical anesthesia is provided.
- Trial name
- FAST (NCT01145326)
- Testing
- Microneedle-facilitated lidocaine application
- Where
- United States
- Sponsor
- University of Oklahoma
Neurofibromatosis Type 1
Microarray CGH Analysis of Circulating Tumoral Plasma DNA in NF1 Patients With MPNSTs
Neurofibromatosis type 1 (NF1) is a frequent autosomal dominant disorder, caused by heterozygous mutations of the NF1 tumor suppressor gene (chr.17q11.2).
- Trial name
- NCT01218152
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- KU Leuven
Inflammatory Bowel Diseases
Mucosal Gene Expression Defects in IBD
This study investigated the mucosal gene expression defects associated with active Crohn's disease (CD)and ulcerative colitis (UC), and studied the effect of infliximab induced downregulation of inflammation and mucosal healing…
- Trial name
- NCT00639821
- Where
- Belgium
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Solid and Hematological Malignancies
Screening Protocol for Tumor Antigen Expression Profiling and HLA Typing for Eligibility Determination
This screening study is intended for men and women ≥ 18 to ≤ 75 years of age who have advanced solid or hematologic malignancy. The study will assess a subject's human leukocyte antigen (HLA) subtype and tumor antigen expression…
- Trial name
- NCT02636855
- Where
- 36 sites in United States, Canada and 2 more
- Volunteers
- 9,122 people
- Sponsor
- Adaptimmune
Chronic Rhinosinusitis
Microarray Analysis of Sinus Samples From Patients With and Without Chronic Rhinosinusitis.
The purpose of this study is to compare the bacteria, fungi, and viruses that are present in the sinuses of patients with chronic rhinosinusitis to patients without sinus disease using a new technology, called a microarray, that…
- Trial name
- NCT00847041
- Sponsor
- University of California, San Francisco
Blast Phase Philadelphia Chromosomes Positive (Ph+) Chronic Myelogenous Leukemia (CML), Philadelphia Chromosome Positive (Ph+) Acute Lymphocytic Leukemia (ALL)
Growth Factor Signature (GFS) Pilot Study (MK0000-098)(COMPLETED)
This study will evaluate a gene expression signature (Growth Factor Signature [GFS]) as a biomarker for response/resistance to BRC-ABL oncogene inhibitors.
- Trial name
- NCT00860535
- Testing
- Comparator: Biomarker evaluation
- Volunteers
- 9 people
- Sponsor
- Merck Sharp & Dohme LLC
Soft Tissue Sarcoma, Osteosarcoma
Huntsman Biopsy Study
Bone and soft tissue sarcomas are currently classified based upon light microscopy supplemented by immunohistochemistry, but within many if not all of these tumor histologic types, considerable heterogeneity exists not only in…
- Trial name
- NCT00615329
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- State University of New York - Upstate Medical University
Leukemia
Identifying Cancer Genes in in Blood and Bone Marrow Samples From Patients With Acute Myeloid Leukemia
RATIONALE: Studying samples of blood and bone marrow in the laboratory from patients with cancer may help doctors learn more about changes that occur in DNA and identify genes related to cancer.
- Trial name
- NCT00897182
- Testing
- microarray analysis, polymerase chain reaction
- Where
- 2 sites in United States
- Volunteers
- 96 people
- Sponsor
- Alliance for Clinical Trials in Oncology