Clinical trials: Gene Expression Profiling
Colorectal Cancer
Pomegranate Extract Supplementation in Colorectal Cancer Patients
The most relevant pomegranate phenolics (ellagitannins and ellagic acid) are extensively metabolized by the human gut microbiota to yield a number of metabolites called urolithins (mainly Uro-A).
- Trial name
- POMEcolon (NCT01916239)
- Testing
- Standard pomegranate extract formulation, Pomegranate extract formulation-1, Pomegranate extract formulation-2
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- National Research Council, Spain
Breast Neoplasms, Neoplasm Metastasis
Gene Expression Profiling of Metastatic Breast Cancer Predict the Therapeutic Response to Chemotherapy
The investigators want to develop a gene expression profile the for prediction the chemotherapeutic response of patients with metastatic breast cancer.
- Trial name
- NCT01198301
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Peking University Cancer Hospital & Institute
Overweight and/or Obesity
Semaglutide Delivered Epi-Intradermally by Microarray Patch (VX-201) Versus Subcutaneous Administration in Healthy Overweight and Obese Participants
VX-201-101 is a first-in-human Phase 1 clinical study evaluating VX-201, a needle-free microneedle (MN) array patch (MAP) that delivers semaglutide through the skin as an alternative to subcutaneous (SC) injection.
- Trial name
- NCT07673900
- Testing
- VX-201, semaglutide SC
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Terrestrial Bio, Inc.
Chronic Idiopathic Urticaria
Three-month, Single-center Study to Identify Biomarkers/Response to Xolair Therapy in Chronic Idiopathic Urticaria
This is a single center, non-comparative exploratory study, to investigate the effect of omalizumab over a 3-month treatment period in adult (≥18 years) patients with chronic idiopathic urticaria who had remained symptomatic…
- Trial name
- NCT02814630
- Testing
- Xolair
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Asthma Inc Clinical Research Center
Breast Cancer
IMproving PAtient UndeRstanding of GEP TEst Results: Phase 4
The primary aim of the study is to determine if provision of a patient information film about Oncotype DX improves patients' knowledge and understanding about Gene Expression Profiling (GEP) test and risk of recurrence results in…
- Trial name
- IMPARTER (NCT06703567)
- Testing
- Standard Policy, Standard Policy + GEP Information Film
- Where
- Italy
- Volunteers
- 82 people
- Sponsor
- European Institute of Oncology
Cardiovascular Disease, The Metabolic Syndrome
Acute Fatty Acid Intervention Study (AFAST)
The main objective of this study is to elucidate whether different dietary fatty acids (SFA, PUFA, butter fat and margarine fat) in a high fat load will have different effects on PBMC gene expression profiles.
- Trial name
- AFAST (NCT01000194)
- Testing
- High fat meal
- Where
- Netherlands
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Prostate Cancer Metastatic, Prostate Cancer Recurrent
Molecular Profiling in Prostate Cancer
We aim to employ targeted DNA NGS to evaluate the prevalence of germline and somatic mutations in cancer predisposing genes, such as BRCA1 and BRCA2, and other HR and DDR genes, including also a few additional clinically relevant…
- Conditions
- Prostate Cancer Metastatic, Prostate Cancer Recurrent, Germline BRCA1 Gene Mutation, Germline BRCA2 Gene Mutation
- Trial name
- ProProstate (NCT04983628)
- Testing
- Tumor molecular profiling
- Where
- Greece
- Volunteers
- 250 people
- Sponsor
- Hellenic Cooperative Oncology Group
Colon Cancer
A Prospective Study of Pharmacogenetic Factors and Gene Expression Profile
This study is a parallel translational study of a Randomized Phase III trial Investigating the Role of Oxaliplatin duration (6 Cycles Versus 12 Cycles) in modified FOLFOX-6 Regimen as Adjuvant Therapy for Patients with Stage…
- Trial name
- NCT01472601
- Where
- South Korea
- Volunteers
- 2,660 people
- Sponsor
- Samsung Medical Center
Rheumatoid Arthritis, Psoriatic Arthritis
Centocor Microarray Study of Patients
Specific Aim 1. To determine the transcriptome of peripheral blood mononuclear cells isolated monocytes and target tissues in IMIDs. Specific Aim 2.
- Conditions
- Rheumatoid Arthritis, Psoriatic Arthritis, Psoriasis, Crohn's Disease
- Trial name
- NCT00462072
- Testing
- Infliximab
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Head and Neck Neoplasms
Molecular and Genomic Profiling of Head and Neck Tumors
The purpose of this study is to study the genetic profile of head and neck tumors and their relationship to treatment response and outcome
- Trial name
- NCT00200486
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Montefiore Medical Center
Multiple Myeloma
Microdose Study of Melphalan, Bortezomib and Dexamethasone
The purpose of the study is to identify specific genes that are up- or downregulated in multiple myeloma patients who receive a microdose of either Melphalan (Alkeran®), Bortezomib (Velcade®) or Dexamethasone (Dexaven®).
- Trial name
- Phase-0-MM (NCT02109861)
- Testing
- Melphalan, Bortezomib, Dexamethasone
- Where
- Denmark
- Volunteers
- 6 people
- Sponsor
- Henrik Gregersen
Stem Cells
Isolation and Characterization of Mammary Stem Cells
Background: Cancer stem cells in breast cancer have been identified as a small population of tumor cells whose self-renewal mechanism is highly deregulated. This deregulation seems to be necessary for cancer to develop.
- Trial name
- NCT00340392
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- National Cancer Institute (NCI)
Brain Disease, Metastasis
Gene-expression Profiles in CNS-metastatic Non-small Cell Lung Cancer
Non small-cell lung cancer (NSCLC) accounts 85% of all lung cancer.The development of brain metastasis diminished life expectancy to less than one year with a median survival of less than three months.
- Conditions
- Brain Disease, Metastasis, Lung Cancer
- Trial name
- NCT00862173
- Where
- 2 sites in Mexico
- Volunteers
- 120 people
- Sponsor
- National Institute of Cancerología
Zinc Deficiency
Zinc and the Synthesis of Zinc Binding Proteins (Protocol B)
The specific aim of this protocol is to examine differential expression of specific mRNAs and proteins that occur when the dietary intake of zinc is acutely reduced below the dietary requirement for a period of ten days.
- Trial name
- NCT01221129
- Testing
- Acclimation, Dietary zinc depletion, Dietary zinc repletion
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Florida
Endometrial Receptivity Diagnosis
Quantitative Identification of Implantation Receptivity by Single Cell Transcriptome Analysis
This project aims to study the endometrial transcriptome at the single cell level in both endometrial native tissue (biopsies) and endometrial fluid.
- Trial name
- NCT03091023
- Testing
- Endometrial Biopsy and endometrial fluid collection
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Igenomix
Male Infertility
Study of Sperm Molecular Factors Implicated in Male Fertility
Sperm analysis following World Health Organization guidelines is unable to explain the molecular causes of male infertility when basic sperm parameters are within a normal range and women do not present gynaecological pathology.
- Trial name
- NCT00481403
- Testing
- Microarray analysis, Microarray
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Atherosclerosis
Early Therapeutic Effects of Statins and Fibrates on Unstable Atherosclerotic Plaques
Rupture of unstable atherosclerotic plaques is the underlying pathophysiologic mechanism of acute coronary syndromes and thus also of perioperative myocardial ischemia.
- Trial name
- NCT00243672
- Testing
- Atorvastatin, Gemfibrozil
- Volunteers
- 100 people
- Sponsor
- University Hospital Muenster
Pulmonary Disease, Chronic Obstructive
Inert Dusts and Pathology of Chronic Obstructive Pulmonary Disease
The main objective of the study is the exploration of the natural course of COPD and its biological background. To this end, active workers without COPD and workers in functional classes GOLD 0-III are investigated by a combined…
- Trial name
- NCT00618137
- Where
- Austria
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Myelodysplastic Syndrome
Prognostic Molecular Markers in Patients With Myelodysplastic Syndrome
In the era of hypomethylating agent in MDS treatment, the investigators aimed to investigate the prognostic impact of mutations in spliceosome machinery genes (SRSF2, U2AF1, and ZRSR2) on the outcomes of 1st line decitabine…
- Trial name
- NCT02060409
- Testing
- spliceosome
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Samsung Medical Center
Kidney Transplant Immunosuppression
Use of DNA Testing and Gene Expression Profiling to Help Transition Kidney Transplant Recipients to Belatacept-only Immunosuppression
The purpose of the study is to provide immunosuppression weaning and/or monitoring for an additional 12-months to evaluate the safety and efficacy of belatacept monotherapy in patients previously enrolled in the clinical trial…
- Trial name
- NCT06336863
- Testing
- Allosure and TruGraf, Immunosuppression Taper
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Texas Southwestern Medical Center