Clinical trials: Gene Expression Profiling
Burkitt Lymphoma, Diffuse Large B-cell Lymphoma, c-MYC Positive
Phase II Study of Dose-Adjusted EPOCH-Rituximab in Adults With Untreated Burkitt Lymphoma and c-MYC+ Diffuse Large B-Cell Lymphoma
Background: Burkitt lymphoma/leukemia (BL) is highly treatable, but most of the standard therapies require multiple doses of intensive chemotherapy that may require long hospital stays and frequently have severe side effects.
- Conditions
- Burkitt Lymphoma, Diffuse Large B-cell Lymphoma, c-MYC Positive, Plasmablastic Lymphoma
- Trial name
- NCT01092182
- Testing
- EPOCH-R, EPOCH-RR
- Where
- 30 sites in United States
- Volunteers
- 194 people
- Sponsor
- National Cancer Institute (NCI)
Endometrial Endocrine Regulation, Progesterone Supplementation in Women After Mifepristone
Endometrial Transcript Profile with Progesterone After Post-ovulatory Mifepristone
The goal of this exploratory trial is to determine the endometrial gene expression profile induced by exogenous progesterone after postovulatory administration of mifepristone.
- Trial name
- NCT06616077
- Testing
- Micronized Progesterone 600 mg, mifepristone 200 mg
- Where
- Chile
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Reproductive Health Research Insritute, Chile
Breast Cancer
IMproving PAtient UndeRstanding of GEP TEst Results: Phase 4
The primary aim of the study is to determine if provision of a patient information film about Oncotype DX improves patients' knowledge and understanding about Gene Expression Profiling (GEP) test and risk of recurrence results in…
- Trial name
- IMPARTER (NCT06703567)
- Testing
- Standard Policy, Standard Policy + GEP Information Film
- Where
- Italy
- Volunteers
- 82 people
- Sponsor
- European Institute of Oncology
Breast Cancer
Studying Tumor Samples From Women Who Have Undergone Chemotherapy for Breast Cancer
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00897845
- Testing
- RNA analysis, microarray analysis, immunohistochemistry staining method
- Volunteers
- 2,541 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
First Cadaveric Renal Graft
Evaluation of an Early Screening Test of Chronic Rejection and of Operational Tolerance by MicroArray in Renal Graft (Protocol DPRC Array)
The aim of the study is to explore the possibility to identify, at an early stage after a renal graft and from blood samples collected within first months after graft, a predictive transcriptional profile of long term occurence…
- Trial name
- NCT00746057
- Testing
- DNA chip
- Where
- France
- Volunteers
- 134 people
- Sponsor
- Nantes University Hospital
Postmenopause, Osteoporosis
Effects of Tibolone Treatment on the Endometrium
Tibolone, a tissue-selective compound with a combination of estrogenic, progestogenic and androgenic properties, is used as an alternative for estrogen or estrogen plus progesterone hormone therapy for the treatment of symptoms…
- Trial name
- NCT00294463
- Testing
- Tibolone, Estradiol, Estradiol + Medroxy Progesterone Acetate
- Where
- Netherlands
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Actinic Keratosis
Cellular and Molecular Events During Treatment of Actinic Keratosis With Imiquimod 5% Cream
Treatment of actinic keratosis with imiquimod cream is expected to cause changes in the genes that are turned on, and turned off, by skin cells.
- Trial name
- NCT00335179
- Testing
- Aldara (imiquimod 5% cream), Vehicle cream
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Graceway Pharmaceuticals, LLC
Tension-Type Headache, Unspecified, Intractable
Tension-Type Headache Gene Expression and Methylation
Tension-type headache (TTH) refers to pain radiating from the forehead to the back of the head as a bilateral band. It often occurs without warning and spreads to the neck muscles.
- Trial name
- TTH (NCT06562855)
- Testing
- Peripheral blood sampling
- Where
- 2 sites in Turkey (Türkiye)
- Sponsor
- University of Gaziantep
Williams Beuren Syndrome, Autism Spectrum Disorder
Molecular Characterization of Patients Affected by Williams Syndrome and Autism.
Williams Beuren syndrome (WBS) is a multiple malformations/intellectual disability (ID) syndrome caused by 7q11.23 microdeletion and clinically characterized by a typical neurocognitive profile including excessive talkativeness…
- Trial name
- WBA (NCT04095585)
- Testing
- chromosomal microarray analysis (CMA) and whole exome sequencing (WES)
- Volunteers
- 6 people
- Sponsor
- Hospices Civils de Lyon
Adenocarcinoma, Colon Cancer
Trial for Microarray Analysis of Colon Cancer Outcome-A (MACCO-A)
The purpose of this study is to determine if the investigators can predict the sensitivity or resistance of colon cancer to the two available first line chemotherapy agents.
- Trial name
- NCT00127036
- Testing
- XELOX, XELIRI, Bevacizumab
- Where
- 12 sites in United States
- Volunteers
- 65 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Wounds
Study of Functional Microarray-Facilitated Lidocaine Liposomal Cream Absorption for Cutaneous Anesthesia in Volunteers
The study's aim is to determine whether use of a mechanical device can improve the timeliness of anesthesia provided by liposomal lidocaine cream.
- Trial name
- NCT00387296
- Testing
- functional microarray
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Male Infertility
Study of Sperm Molecular Factors Implicated in Male Fertility
Sperm analysis following World Health Organization guidelines is unable to explain the molecular causes of male infertility when basic sperm parameters are within a normal range and women do not present gynaecological pathology.
- Trial name
- NCT00481403
- Testing
- Microarray analysis, Microarray
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Breast Neoplasm, Hereditary Neoplastic Syndrome
Microarray Analysis for Human Genetic Disease
This study will look at genetic changes which occur in the development of male and female breast cancer and other cancer. It will use a new technology called DNA microarray hybridization that looks at a wide array of genes to…
- Conditions
- Breast Neoplasm, Hereditary Neoplastic Syndrome, Melanoma, Ovarian Neoplasm
- Trial name
- NCT00001898
- Where
- 8 sites in United States, Finland and 2 more
- Volunteers
- 1,500 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Pancreatic Cancer
Identification of Biomarkers for Early Detection of Pancreatic Cancer
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00897494
- Testing
- protein expression analysis, laboratory biomarker analysis, mass spectrometry
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Barbara Ann Karmanos Cancer Institute
Breast Cancer Female, Metastases Breast
MicroRNAs and Prognosis in Breast Cancer
Mono-centric, observational retrospective and prospective study, designed for breast cancer patients to identify novel miRNA based biomarker able to predict metastases development in breast cancer patients.
- Trial name
- BREMIR (NCT06555354)
- Testing
- miRNA targeted analysis on breast cancer tissues, miRNA targeted analysis on plasma samples, miRNA profiling of breast cancer tissues
- Where
- Italy
- Volunteers
- 1,432 people
- Sponsor
- Casa Sollievo della Sofferenza IRCCS
Dermatomyositis, Polymyositis
Infliximab (Remicade ) to Treat Dermatomyositis and Polymyositis
This study will examine whether infliximab (Remicade ) is safe and effective for the treatment of dermatomyositis and polymyositis.
- Trial name
- NCT00033891
- Testing
- Infliximab
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Breast Cancer
Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer
The purpose of this study is to analyze gene expression signature and immunohistochemical markers associated with clinical and pathological response to neoadjuvant chemotherapy in locally advanced breast cancer.
- Trial name
- LABC (NCT00820690)
- Testing
- doxorubicin, cyclophosphamide, paclitaxel
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Barretos Cancer Hospital
Ageing
Human Skin Aging: Clinical Parameters and Gene Expression Profiling
Skin aging is a complex process involving genetic and environmental factors. The investigators hope to learn more about how human genes and their function can contribute to skin aging and human health.
- Trial name
- GEP (NCT01451476)
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Stanford University
Childhood Obesity, Morbid Obesity
Whole Transcriptome Profiling and Metabolic Phenotyping in Children With ROHHAD Syndrome
Rapid onset Obesity, Hypoventilation, Hypothalamic dysfunction and Autonomic Dysregulation (ROHHAD) is a syndrome named in 2007. The hallmark of the syndrome is the rapid onset obesity and dysregulation of central ventilation.
- Trial name
- NCT02602769
- Testing
- Transcriptome profiling
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Columbia University
Advanced Triple Negative Breast Cancer, Breast Cancer Metastatic
First-Line Sacituzumab Govitecan in Advanced Untreated Triple-Negative Breast Cancer Patients.
The goal of this clinical trial is to learn if the drug Sacituzumab govitecan (SG) reduces disease progression when used as a first-line treatment in adults with advanced triple-negative breast cancer (TNBC) who have not received…
- Conditions
- Advanced Triple Negative Breast Cancer, Breast Cancer Metastatic, Breast Cancer
- Trial name
- NCT07299409
- Testing
- Sacituzumab Govitecan (SG)
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Nathalie Levasseur