Clinical trials: Gene Mutation
Infertility
Age-related Variability of the Efficacy and Tolerability of Alternative Pituitary Suppression Regimens in ART
Age-related variability of the efficacy and tolerability of alternative pituitary suppression regimens in follicular stimulation for assisted reproduction purposes. A randomised, prospective, multi-centre clinical trial
- Trial name
- NCT01107470
- Testing
- hFSH（Fostimon）
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Shandong University
Respiratory Insufficiency
Music Therapy for Patients Being Weaned From Mechanical Ventilation
The purpose of the study is to determine whether Music Therapy interventions can be used as supportive therapy for patients undergoing weaning from mechanical ventilation.
- Trial name
- NCT00178139
- Testing
- Music Therapy
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- University of Rochester
Children's Social Emotional Competence, Children's Well-being
Supporting Social and Emotional Competence in Preschool Children
Social emotional competence is instrumental to children's health and development. The preschool edition of Promoting Alternative THinking Strategies (PATHS®) intervention was tested in this study.
- Trial name
- PsPATHS_STK (NCT04512157)
- Testing
- Promoting Alternative Thinking Strategies (PATHS), Preschool Edition
- Volunteers
- 285 people, healthy volunteers welcome
- Sponsor
- Stockholm University
Vaginal Atrophy, Vulva; Atrophy
LASER and Radiofrequency for Treatment of Vaginal Vulvar Atrophy (VVA) in Women Treated for Breast Cancer (EPMLARF-arm2)
This is a randomized controlled trial to evaluate the use of LASER, Micro Ablative radiofrequency and topic promestriene to treat symptoms of vulvovaginal atrophy of women treated for breast cancer.
- Conditions
- Vaginal Atrophy, Vulva; Atrophy, Breast Cancer
- Trial name
- EPMLARF (NCT04081805)
- Testing
- LASER, Micro Ablative Radiofrequency, Promestriene
- Where
- Brazil
- Volunteers
- 195 people
- Sponsor
- Federal University of São Paulo
Helicobacter Pylori Infection, Helicobacter Pylori Associated Gastrointestinal Disease
Prevalence and Trends of Antimicrobial Resistance of Helicobacter Pylori in Korea
To assess antimicrobial resistance rates and minimal inhibitory concentrations in H. pylori isolated from patients with upper gastrointestinal disease with long-term period.
- Conditions
- Helicobacter Pylori Infection, Helicobacter Pylori Associated Gastrointestinal Disease, Helicobacter Pylori Infection, Susceptibility to, Helicobacter Pylori 23S rRNA Clarithromycin Resistance Mutation
- Trial name
- NCT05247112
- Where
- South Korea
- Volunteers
- 2,000 people
- Sponsor
- Seoul National University Bundang Hospital
Healthy
An Alternative Technique for Measuring Blood Pressure
This cross design study will be conducted to evaluate the combination of palpation and auscultation techniques as an alternative technique for the measurement of blood pressure.
- Trial name
- NCT06119412
- Testing
- blood pressure measurement starting with standard technique or alternative new technique. manual sphygmomanometer will be used.
- Where
- Turkey (Türkiye)
- Volunteers
- 202 people
- Sponsor
- Gazi University
Breast
A Multicenter Prospective Cohort Study of Adjuvant Therapy for BRCA1/2 Mutated Hormone Receptor-positive HER2-negative Early High-risk Breast Cancer
To evaluate the efficacy and safety of different adjuvant treatment options after surgery for early high-risk breast cancer with BRCA1/2 mutation HR+/HER2
- Trial name
- NCT06791161
- Testing
- Endocrine drug +CDK4/6 inhibitor or PRAP inhibitor or Endocrine drug +CDK4/6 inhibitor+PARP inhibitor
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Hyperlipidemia, Coronary Artery Disease
Lipid Lowering in Patients With Statin Intolerance
This study will attempt to further validate a clinical treatment plan to lower LDL values using non-prescription supplements combined with a lifestyle change and education program which could represent an alternative approach to…
- Trial name
- NCT00405769
- Testing
- red yeast rice
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Chestnut Hill Health System
Acute Leukemia, Chronic Myeloid Leukemia
Allo-HSCT With Alternative Donor in Treatment of Hematologic Malignancy
The purpose of this study is to compare the efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT) from matched sibling donor (MSD),matched unrelated donor (MUD) and haploidentical related donors(HRD) in the…
- Conditions
- Acute Leukemia, Chronic Myeloid Leukemia, Myelodysplastic Syndrome
- Trial name
- NCT02487069
- Testing
- HSCT from MSD, HSCT from MUD, HSCT from HRD
- Where
- China
- Volunteers
- 876 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Acute Myeloid Leukemia (AML)
Treatment Patterns and Key Healthcare Resource Use in Acute Myeloid Leukemia (AML) With or Without FMS-like Tyrosine Kinase-3 (FLT3) Mutation Study Based on Retrospective Chart Review
The purpose of this study is to retrospectively evaluate the treatment patterns and AML-related key healthcare resource use among AML patients, stratified by FLT3 mutation status, intensive chemotherapy (IC) eligibility, and…
- Trial name
- NCT03047083
- Testing
- Treatment patterns among AML patients, AML-related healthcare resources
- Where
- United States
- Volunteers
- 1,027 people
- Sponsor
- Astellas Pharma Global Development, Inc.
Cystic Fibrosis
Exploratory Study to Evaluate QR-010 in Subjects With Cystic Fibrosis ΔF508 CFTR Mutation
Exploratory proof of concept study to determine whether intranasal administration of QR-010 in subjects with cystic fibrosis, homozygous or compound heterozygous for the ΔF508 mutation, can increase the function of Cystic…
- Trial name
- NCT02564354
- Testing
- QR-010
- Where
- 5 sites in United States, Belgium and 1 more
- Volunteers
- 18 people
- Sponsor
- ProQR Therapeutics
Fibromyalgia
Intravenous Micronutrient Therapy (IVMT) for Fibromyalgia
The purpose of this study is to determine if intravenous micronutrient therapy (IVMT) is effective in the treatment of fibromyalgia, as assessed by validated functional and pain measures.
- Trial name
- NCT00067405
- Testing
- Intravenous micronutrient therapy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
NVP Plasma Level, NVP Related Mutation
Nevirapine Clearance After Short-term Highly Active Antiretroviral Therapy (HAART) for Prevention of Mother to Child Transmission of HIV (PMTCT)
Three-drug combination of antiretroviral regimens has been used increasingly in HIV-infected pregnant women worldwide, both for the prevention of mother to child transmission of HIV (PMTCT) and for women's own health.
- Conditions
- NVP Plasma Level, NVP Related Mutation, 3TC Related Mutation
- Trial name
- NCT00872872
- Testing
- AZT/3TC 2 weeks after delivery
- Where
- Thailand
- Volunteers
- 30 people
- Sponsor
- Thai Red Cross AIDS Research Centre
RAS Mutation, Neurofibromatosis 1
RASopathy Biorepository
The RASopathies are a group of developmental disorders caused by genetic changes in the genes that compose the Ras/mitogen activated protein kinase (MAPK) pathway. New RASopathies are being diagnosed frequently.
- Conditions
- RAS Mutation, Neurofibromatosis 1, Noonan Syndrome, Noonan Syndrome With Multiple Lentigines
- Trial name
- NCT04395495
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Advanced Solid Neoplasms
Efficacy and Safety of Olaparib (MK-7339) in Participants With Previously Treated, Homologous Recombination Repair Mutation (HRRm) or Homologous Recombination Deficiency (HRD) Positive Advanced Cancer (MK-7339-002 / LYNK-002)
This study will evaluate the efficacy and safety of olaparib (MK-7339) monotherapy in participants with multiple types of advanced cancer (unresectable and/or metastatic) that: 1) have progressed or been intolerant to standard of…
- Trial name
- NCT03742895
- Testing
- Olaparib
- Where
- 130 sites in United States, Argentina and 19 more
- Volunteers
- 329 people
- Sponsor
- Merck Sharp & Dohme LLC
Lateral Epicondylitis (Tennis Elbow)
Comparison of Platelet Rich Plasma and Alternative Therapies for the Treatment of Tennis Elbow (Lateral Epicondylitis)
"Tennis elbow" is the most common cause of lateral elbow pain, generally caused by either work or sports related repetitive strain.
- Trial name
- IMPROVE (NCT01668953)
- Testing
- Platelet Rich Plasma (PRP) Injection, Whole Blood Injection, Dry Needle Fenestration
- Where
- 2 sites in United States, Canada
- Volunteers
- 100 people
- Sponsor
- McMaster University
Advanced Lymphoma, Advanced Malignant Solid Neoplasm
Testing GDC-0032 (Taselisib) as a Potential Targeted Treatment in Cancers With PIK3CA Genetic Changes (MATCH-Subprotocol I)
This phase II MATCH treatment trial identifies the effects of GDC-0032 (taselisib) in patients whose cancer has a genetic change called PIK3CA mutation.
- Conditions
- Advanced Lymphoma, Advanced Malignant Solid Neoplasm, Hematopoietic and Lymphoid Cell Neoplasm, Refractory Lymphoma
- Trial name
- NCT04439175
- Testing
- Taselisib
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- National Cancer Institute (NCI)
Obesity, Blood Pressure
Alternative Blood Pressure Measurements in OB Patients
The incidence of obesity has been increasing worldwide. In women with obesity, the anthropometric differences in the distribution of subcutaneous tissue can make accurate measurement of blood pressure difficult.
- Trial name
- NCT04291365
- Testing
- Blood pressure measurement
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Albany Medical College
Breast Cancer
InheriteD brEast caNcer iTalian regIsTrY A Retrospective-prospective Observational Cohort Study to Evaluate Cancer Prevention Strategies in Women With a Deleterious Mutation in BRCA1-2
The purpose of the study is to obtain and centralize data about cancer prevention strategies in women with a germline deleterious mutation in BRCA1-2 with or without a history of breast cancer in Italy
- Trial name
- IDENTITY (NCT05835739)
- Where
- 12 sites in Italy
- Volunteers
- 78 people
- Sponsor
- Centro di Riferimento Oncologico - Aviano
Relapsed or Advanced Non-small Cell Lung Cancer
Phase Ib/II Study of Almonertinib Combined With SHR-1701 in the Treatment of Relapsed or Advanced Non-small Cell Lung Cancer
To evaluate the tolerability, safety, pharmacokinetic characteristics and immunogenicity of Almonertinib combined with SHR-1701 in relapsed or advanced NSCLC To evaluate the efficacy of Almonertinib combined with SHR-1701 in the…
- Trial name
- NCT05503888
- Testing
- Almonertinib combined with SHR-1701, Almonertinib
- Volunteers
- 160 people
- Sponsor
- Suzhou Suncadia Biopharmaceuticals Co., Ltd.