Clinical trials: General Anesthesia With Propofol
General Anaesthesia, Depth of Anaesthesia
Epileptiform EEG Patterns During Induction of General Anaesthesia With Sevoflurane Compared to Those With Propofol
The aim of the study was to assess the influence of volatile induction of general anaesthesia with sevoflurane using two different techniques and intravenous anaesthesia with propofol on the possible presence of epileptiform…
- Conditions
- General Anaesthesia, Depth of Anaesthesia, Intraoperative Awareness, Seizures
- Trial name
- EEG (NCT03209323)
- Testing
- electroencephalography (EEG), bispectral index (BIS), response and state entropy (RE and SE)
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Medical University of Silesia
Anesthesia, General, Neuromuscular Blockade
Comparison of 2.0 mg/kg Sugammadex and Neostigmine at Reappearance of T2 in Chinese and European Subjects (Study 19.4.324)(P05768AM1)(COMPLETED)
The present trial was set up to evaluate the efficacy and safety of 2.0 mg.kg-1 sugammadex compared to neostigmine administered at reappearance of T2 in Chinese and Caucasian subjects for registration purposes in China.
- Trial name
- NCT00825812
- Testing
- Sugammadex, neostigmine
- Volunteers
- 308 people
- Sponsor
- Merck Sharp & Dohme LLC
Hypnotic Effect
Monitoring of Hypnosis State During General Anesthesia With Propofol by Patient State Index From SEDLine®
The purpose of this study is the evaluation of possible relationships and correlation between PSI values obtained from the SEDLine® monitor and the infusion rate of propofol during general anesthesia.
- Trial name
- NCT02706665
- Testing
- SEDline monitor
- Where
- Spain
- Volunteers
- 12 people
- Sponsor
- Hospital Universitario de Canarias
Analgesia
Correlation Between qNOX and Analgesia Nociception Index (ANI) Values During General Anesthesia
qNOX and ANI are two indexes evaluting the analgesia conduction during general anesthesia. No trials have compared them, so with this trial authors want to explore the correlations between them.
- Trial name
- ANI (NCT06351072)
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- University of Padova
Anesthesia, General
Use of Bispectral Index (BIS) for Monitoring of Total Intravenous Anaesthesia in Pediatric Patients
The objective of the study is to determine wether the use of the Bispectral Index Monitor (BIS) as a method to guide anaesthesia for children in different groups of age, undergoing ear nose and throat surgery anaesthetized with…
- Trial name
- NCT01043952
- Testing
- Propofol, Remifentanil, Bispectral Index Monitor
- Where
- Denmark
- Volunteers
- 157 people
- Sponsor
- Aalborg University Hospital
Hemodynamic Instability, Anesthesia, General
Hemodynamics During Induction of General Anesthesia With Medium or Low Remifentanil Doses.
In this trial the investigators want to examine if there is any difference in hemodynamic stability during induction when comparing two low and a medium remifentanil dose and keeping propofol induction dose at about 2.0 mg/kg.
- Conditions
- Hemodynamic Instability, Anesthesia, General, Anesthesia, Intravenous
- Trial name
- RH (NCT03861377)
- Testing
- Remifentanil R2, Remifentanil R4, Remifentanil R8
- Where
- Norway
- Volunteers
- 99 people
- Sponsor
- Helse Fonna
Used to Induce and Implement General Anesthesia in Combination With Sedative Anesthetics (Such as Propofol)
Pharmacokinetics, Safety and Efficacy of HR020602 Injection in Children Undergoing General Anesthesia
This study is divided into two stages: the first stage is a dose verification trial, with a multicenter, open, single arm trial design, which is planned to enroll 10 children with general anesthesia surgery (all using HR020602…
- Trial name
- NCT04867343
- Testing
- HR020602 injection, fentanyl injection ； remifentanil injection
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Target Controlled Infusion, General Anesthesia
The Application of Target Controlled Infusion of Etomidate Combined With Propofol in the Maintenance of Anesthesia During Brain Surgeries
To explore the application of target controlled infusion of etomidate combined with propofol in the maintenance of anesthesia during brain surgeries.
- Trial name
- NCT02174120
- Testing
- propofol, etomidate
- Volunteers
- 120 people
- Sponsor
- Henan Provincial People's Hospital
General Anaesthesia
Evaluation of Equivalent Minimum Alveolar Concentration (eMAC) During Propofol/Remifentanil Anesthesia
The aim of this study is to verify the accuracy of eMAC compared to Bispectral Index (BIS) for depth and nociceptive stimulation monitoring of anesthesia during general anesthesia.
- Trial name
- eMAC (NCT05789992)
- Testing
- Propofol, Low Remifentanil, Heigh Remifentanil
- Where
- China
- Volunteers
- 62 people
- Sponsor
- Zhang Haopeng
Persistent Atrial Fibrillation
Sevoflurane Versus Propofol Anesthesia in Intracardiac Echocardiography-Guided Atrial Fibrillation Ablation
This prospective, randomized, single-center study will compare sevoflurane inhalational anesthesia with propofol intravenous anesthesia in patients undergoing intracardiac echocardiography-guided radiofrequency catheter ablation…
- Trial name
- NCT07877116
- Testing
- Sevoflurane, propofol
- Where
- Turkey (Türkiye)
- Volunteers
- 124 people
- Sponsor
- Hüseyin Ulaş Pinar
Thyroid Operation Under General Anesthesia
Comparison Between Propofol-remifentanil Total Intravenous Anesthesia and Desflurane-remifentanil Balanced Anesthesia With Regard to Post-anesthetic Functional Recovery Measured With QoR-40
Total intravenous anesthesia (TIVA) and inhalation anesthesia are both widely and safely used, and there are many clinical trials comparing these on various aspects of anesthesia.
- Trial name
- NCT01760018
- Testing
- desflurane group, TIVA group
- Where
- South Korea
- Volunteers
- 76 people
- Sponsor
- Yonsei University
E03.155.253, Bispectral Index Monitor
The Use of Sedation Score and Bispectral Index for Induction in Geriatric Patients
The main objective of this clinical study is to determine the effectiveness of BIS-guided propofol administration in avoiding hypotension during propofol induction in geriatric patients.
- Conditions
- E03.155.253, Bispectral Index Monitor, Hypotension
- Trial name
- NCT06232980
- Testing
- urological surgical intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 134 people
- Sponsor
- Ankara City Hospital Bilkent
Surgery With General Anesthesia
Validation of the Effect of Propofol and Opiates Closed-loop Administration Device During Anesthesia and Sedation
Sleeping medication and analgesia are standard administered during anesthesia. Sleeping medication, Propofol (Diprivan, AstraZeneca), and analgesia, Remifentanil (GlaxoSmithKline), are most frequently used In the University…
- Trial name
- NCT00764855
- Testing
- Automatic administration of propofol and opiates during routine clinical practice
- Where
- Belgium
- Volunteers
- 180 people
- Sponsor
- University Hospital, Ghent
Rotator Cuff Tears, Rotator Cuff Injuries
Total Intravenous Anesthesia With Propofol vs. General Anesthesia in Outpatient Shoulder Arthroscopic Surgeries
This study is comparing total intravenous anesthesia with propofol with a regional nerve block against general anesthesia with a regional nerve block on the primary endpoint of time to meet discharge criteria.
- Conditions
- Rotator Cuff Tears, Rotator Cuff Injuries, Orthopedic Disorder, Sports Injury
- Trial name
- TIVA (NCT04793022)
- Testing
- TIVA with Propofol, Inhaled Anesthesia
- Where
- United States
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Carilion Clinic
Intraoperative Hypotension, Jugular Veins
Internal Jugular Vein Ultrasound and Acute Kidney Injury After Abdominal Surgery
This observational study aims to learn whether changes in the internal jugular vein during anesthesia induction can help predict low blood pressure and kidney injury after surgery. The main questions it aims to answer are: 1.
- Conditions
- Intraoperative Hypotension, Jugular Veins, Hypotension on Induction, General Anesthesia With Propofol
- Trial name
- PRO-JUGULAR (NCT07638306)
- Testing
- Internal Jugular Vein Ultrasound Assesment
- Where
- Romania
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Tîrgu Mureș Emergency Clinical County Hospital, Romania
General Anesthesia
Comparison of Different Propofol Formulations
The objective of this study is to evaluate the influence of different propofol formulations(plain or with lidocaine)on anesthetic induction.
- Trial name
- Propofols (NCT01041872)
- Testing
- Propofol Astrazeneca plain, Propofol Astrazeneca plus lidocaine, Propofol-lipuro B. Braun plain
- Where
- 3 sites in France
- Volunteers
- 212 people
- Sponsor
- Hopital Foch
General Anesthesia With Propofol
Comparison Between Ondansetron 8 mg and Lidocain 40 mg in Preventing Pain Due to Propofol Injection
This study aims to compare the effectivity between ondansetron 8 mg and lidocain 40 mg in preventing pain due to propofol injection
- Trial name
- NCT03134612
- Testing
- Ondansetron 8 mg, Lidocain 40 mg
- Where
- Indonesia
- Volunteers
- 104 people
- Sponsor
- Universitas Indonesia
General Anaesthesia
Evaluation of Analgesia Nociception Index (ANI) During Propofol/Remifentanil and Sevoflurane/Remifentanil Anesthesia
The aim of this prospective randomized study was to evaluate the ability of the new Analgesia Nociception Index ANI, derived by heart rate variability, to detect painful stimulation during either propofol or sevoflurane…
- Trial name
- NCT01522508
- Testing
- tetanic stimulation
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University Hospital Schleswig-Holstein
Anesthesia Brain Monitoring
Describe Relations Between qCON and qNOX Indicies During Propofol-Remifentanil General Anesthesia
CONOX is a neuromonitoring EEG- device for sedation (qCON) and analgesia (qNOX) monitoring during general anesthesia. It is unknown on how the indicies can differentiate themselves so aim of this study is to determine the…
- Trial name
- NCT06349681
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- University of Padova
General Anesthesia
Safety and Efficacy of HSK3486 Compared to Propofol for Induction of General Anesthesia in Adults With Elective Surgery
To demonstrate HSK3486 0.4/0.2 mg/kg (0.4 mg/kg intravenous [IV] slow injection over 30 [±5] seconds for the first dose, an additional 0.2 mg/kg if needed) is non-inferior to Propofol 2.0/1.0 mg/kg (2.0 mg/kg IV slow injection…
- Trial name
- NCT05486416
- Testing
- HSK3486, Propofol
- Where
- 28 sites in United States, Poland and 1 more
- Volunteers
- 465 people, healthy volunteers welcome
- Sponsor
- Haisco-USA Pharmaceuticals, Inc.