Clinical trials: General Anesthetic
Breast Cancer
Natriuretic Peptide Concentrations of B-type (BNP) During Anesthesia in Patients Previously Sensitized to Anthracyclines
The cardiotoxicity of anthracyclines chemotherapy remains a major problem, despite clinical and echocardiographic monitoring. In the case of treatment for breast cancer, surgery requiring general anesthesia may follow…
- Trial name
- PEP-NAT-B (NCT01754597)
- Testing
- Dosage of B-type natriuretic peptide (NT-proBNP)
- Where
- France
- Volunteers
- 54 people
- Sponsor
- Institut Bergonié
Ventilation
A Comparison of Different Ventilation Strategies in Infants Using the PLMA™
The purpose of this research study is to compare difference between breathing by oneself or with the partial help from an anesthesia machine in infants under general anesthesia.
- Trial name
- NCT03235817
- Testing
- Spontaneous ventilation, Pressure support ventilation, Pressure control ventilation
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Wake Forest University
Intubation Complication
Suction Catheter as a Guide for Nasotracheal Intubation Under General Anesthesia
The goal of this clinical trial to study the efficacy of suction catheter guided technique and conventional technique during nasotracheal intubation.
- Trial name
- NCT05717907
- Testing
- suction catheter
- Where
- Thailand
- Volunteers
- 52 people
- Sponsor
- Mahidol University
Anesthesia, Surgery
Norepinephrine vs Phenylephrine During General Anesthesia
50 million patients undergo surgery each year in the United States. Postoperative mortality is considered the third leading cause of death worldwide.
- Conditions
- Anesthesia, Surgery, Hypotension
- Trial name
- VEGA-1 (NCT04789330)
- Testing
- Norepinephrine, Phenylephrine
- Where
- 5 sites in United States
- Volunteers
- 3,626 people
- Sponsor
- University of California, San Francisco
Underdosing of Other General Anesthetics
Influence of Mild Hypothermia on Reversal of Rocuronium With Sugammadex
The primary efficacy endpoint is the time from the start of administration of sugammadex to recovery of the TOF ratio to 0.9 in deep neuromuscular block (1-2 twitches post-tetanic count) induced by rocuronium during mild…
- Trial name
- NCT01965067
- Testing
- sugammadex
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- MSD Korea Ltd.
Thyroidectomy
Superficial, Cervical Block in Thyroid Surgery, a Randomized Controlled Trial
The study investigates the impact on post-operative pain of the superficial cervical block with bupivacaine combined with subcutaneous infiltration of the incisional area in thyroid surgery under general anesthesia.
- Trial name
- NCT00472446
- Testing
- bilateral superficial cervical block
- Where
- Switzerland
- Volunteers
- 183 people
- Sponsor
- Cantonal Hospital of St. Gallen
Orthopedic Surgery, Ventilation
Ventilation Strategy During General Anesthesia for Orthopedic Surgery: A Quality Improvement Project
The objective is to determine the optimal intraoperative ventilation strategy among the chosen tidal volume and positive end-expiratory pressure (PEEP) levels, and standardize it in an enhanced recovery pathway for orthopedic…
- Trial name
- NCT03657368
- Testing
- Low tidal Volume, High tidal Volume, Low PEEP
- Where
- United States
- Volunteers
- 2,860 people
- Sponsor
- The Cleveland Clinic
Awareness During General Anesthesia
Bispectral Index (BIS) Versus Electronic Alerts in the Prevention of Anesthesia Awareness: the Michigan Awareness Control Study
Awareness during anesthesia is a problem receiving increased attention by patients, clinicians, and the general public. The incidence of intraoperative awareness has been reported to be between 1-2/1000 cases, but recent data…
- Trial name
- MACS (NCT00689091)
- Testing
- Bispectral Index Monitor, Electronic MAC alert
- Where
- United States
- Volunteers
- 22,185 people
- Sponsor
- University of Michigan
Anesthesia, Tubal Ligation
Comparative Analysis of Spinal Anesthesia Versus General Anesthesia for vNOTES
This study compares general anesthesia and spinal anesthesia for vNOTE tubal sterilization. A direct comparison of these methods has not been done before for this surgical approach.
- Trial name
- NCT05688943
- Testing
- Spinal Anesthesia, General Anesthesia
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Atrial Fibrillation
General Anesthesia With ETT vs LMA in Patients Undergoing Ablation for Atrial Fibrillation
In recent years it has been shown that catheter ablation of symptomatic atrial fibrillation (PAF) is superior to antiarrhythmic drug therapy with regards to effectiveness and clinical outcomes.
- Trial name
- NCT02896595
- Testing
- General Anesthesia with endotracheal tube, General Anesthesia with laryngeal mask airway
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Virginia Commonwealth University
Obstructive Sleep Apnea, Delayed Emergence From Anesthesia
Evaluation of Modafinil vs Placebo for Treatment of Anesthesia Delayed Emergence in Obstructive Sleep Apnea
The purpose of this study is to determine whether modafinil use in patients with obstructive sleep apnea will improve postoperative delayed emergence after general anesthesia.
- Trial name
- ModOSA (NCT02494102)
- Testing
- Modafinil
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Milton S. Hershey Medical Center
Anesthesia Induced Hypothermia, Inadvertent Perioperative Hypothermia
Study to Evaluate Safety and Efficacy of Blanket Used to Prevent Anesthesia Induced Hypothermia
The investigation was designed as an Open-Label, Multicenter, Randomised, Controlled Investigation to Evaluate the Efficacy and Safety of the BARRIER® EasyWarm Active Self-Warming Blanket Used for Continuous Active Warming to…
- Trial name
- NCT01900067
- Testing
- BARRIER® EasyWarm Active Self-Warming Blanket
- Volunteers
- 271 people
- Sponsor
- Molnlycke Health Care AB
General Anesthesia, Elective Surgery
The Rotational Insertion Technique for ProSeal Laryngeal Mask Airway
The purpose of this study is to compare two insertion techniques of large size ProSeal laryngeal mask airway. We hypothesized that insertion of ProSeal laryngeal mask airway with 90-degree rotation would reduce the contact…
- Trial name
- NCT00966186
- Testing
- Insertion fo ProSeal laryngeal mask airway
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Seoul National University Hospital
Anesthesia, General
Evaluation of Volatile Induction and Maintenance Anesthesia (VIMA) With Sevorane in Adult Patients Requiring General Anesthesia for Surgery in Terms of Quality of Anesthesia and Its Influence on the Cardiovascular System in Common Clinical Practice
The main objective of this post-marketing observational study (PMOS) is to collect data of using general anesthesia in patients undergoing any surgery to create local recommendations.
- Trial name
- SEVOPROTECTION (NCT01282086)
- Where
- 10 sites in Ukraine
- Volunteers
- 1,365 people
- Sponsor
- Abbott (Ukraine)
Gastric Cancer
Propofol EC50 for Inducing Loss of Consciousness in General Combined Epidural Anesthesia
The beneficial of perioperative usage of thoracic epidural anesthesia and analgesia in various thoracic and upper abdominal surgery are well studied.
- Trial name
- NCT05124704
- Testing
- 5-8ml 0.375% ropivacaine, 5-8ml normal saline
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Wang Jiangling
Propofol, Anesthesia
Investigating Near-Threshold Perception During Anesthetic Sedation
The researchers expect to gain a deeper understanding of mental function during different levels of anesthesia. Propofol is FDA approved for use in patients undergoing an anesthetic for medical treatment but is not approved for…
- Conditions
- Propofol, Anesthesia, fMRI
- Trial name
- NCT06403852
- Testing
- Functional Magnetic Resonance Imaging (fMRI) with propofol
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Airway Complication of Anaesthesia, Healthy
The Effects of General Anesthetics on Upper Airway Collapsibility in Healthy Subjects
The investigators hypothesize that propofol, when compared to sevoflurane, causes the upper airway to collapse more easily and causes less activity in the tongue muscle.
- Trial name
- NCT01557920
- Testing
- Propofol, Sevoflurane
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Anesthesia, General, Neuromuscular Blockade
Pharmacokinetic-pharmacodynamic Analysis of Sugammadex in Children
This study administers sugammadex sodium to pediatric patients under general anesthesia with rocuronium. Pharmacokinetic and pharmacodynamic analysis are performed based on plasma concentration of sugammadex sodium and monitoring…
- Trial name
- NCT03943888
- Testing
- Sugammadex Injection 2mg/kg, Sugammadex Injection 4mg/kg, Sugammadex Injection 8mg/kg
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Seoul National University Hospital
Hysterectomy (MeSH nr: E04.950.300.399)
Effects of General Anesthesia and Spinal-Morphine Anesthesia on Recovery and Comfort After Benign Abdominal Hysterectomy
The purpose of this study is to determine whether spinal anesthesia combined with intrathecal morphine in abdominal hysterectomy on benign gynecological indications gives better outcome concerning duration of hospital stay and…
- Trial name
- NCT00527332
- Testing
- Bupivacain, Morphine, Propofol
- Where
- 5 sites in Sweden
- Volunteers
- 180 people
- Sponsor
- Preben Kjolhede
Stress Reaction
Effect of Location of Tetanic Stimuli on Photoplethysmogram Under General Anesthesia
The effect of the location of tetanic stimulus on photoplethysmography signals will be studied in patients under general anesthesia.
- Trial name
- NCT05899686
- Testing
- Tetanic Stimulus
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco