Clinical trials: General Anesthetics
Quality of Recovery, Anesthesia Recovery Period
Comparing Quality of Recovery Between Desflurane & Isoflurane in Eye Surgery Patients at Dr George Mukhari Acad Hospital
Recovery after surgery and anaesthesia has traditionally been assessed with objective measures including time to awakening, time to regaining airway reflexes, duration of stay in the recovery room and/or hospital, and incidence…
- Trial name
- DIQoR (NCT04188314)
- Testing
- Desflurane, Isoflurane
- Where
- South Africa
- Volunteers
- 170 people
- Sponsor
- Sefako Makgatho Health Sciences University
Respiration, Artificial
The Correlational Study of PPV in Various VT in Mechanically Ventilated Patients
Mesquida, J et al showed there was a significant linear correlation between pulse pressure variations under tidal volume 6 ml/kg and 8 ml/kg in patients after the resuscitation phase of severe sepsis and septic shock.
- Trial name
- NCT01950949
- Testing
- 300 ml Hydroxyethyl Starch 130/0.4 and Sodium Chloride Injection infusing in 15 minutes if PPV under VT 8 ml/kg was larger than 13% in the initial investigation
- Volunteers
- 69 people
- Sponsor
- Yi Liu
Open Angle Glaucoma
Study on the Impact of Ocular Anesthetic Procedures in Ocular Blood Flow
Anaesthetic procedures in ophthalmology surgery have been a subject rapidly evolving in the past decades. When deciding for a retrobulbar block, the local injection of varying mixtures and volumes of fast-acting anesthetics (such…
- Trial name
- NCT01840215
- Where
- Belgium
- Volunteers
- 240 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Anxiety and Fear, Anesthesia
Evaluating Stress Response and Anxiety Score in Paediatric Patients
To date, there have been no studies done relating serum cortisol levels and intranasal dexmedetomidine sedation. However, there was a behavioral study done on pediatric patients confirming reduction serum cortisol levels with…
- Trial name
- NCT04526652
- Testing
- Dexmedetomidine
- Where
- Malaysia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Anesthesia, Analgesia
The Impact of the Anaesthetic Technique Employed on the Quality of Recovery in Patients Undergoing Hysterectomy Surgery.
The objective of this study is to evaluate the results of different anesthesia methods (general anesthesia with epidural catheter application and spinal anesthesia with epidural catheter application) applied in elective…
- Conditions
- Anesthesia, Analgesia, Acute Pain
- Trial name
- NCT06461832
- Testing
- Group 1, Group 2
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Samsun University
Pain Due to Propofol Injection, Hemodynamic Changes Due to Propofol Injection
The Effect of Combined Ephedrine and Lidocaine Pretreatment on Pain and Hemodynamic Changes Due to Propofol Injection
Objectives: Injection pain and hypotension are two main adverse effects of propofol which distresses patient. The aim of this prospective double blind study was to compare the effect of ephedrine -lidocaine combination with…
- Trial name
- NCT01186549
- Testing
- Ephedrine 30microgram/kg, lidocaine0.5mg/kg -ephedrine30 micrograms/kg, ephedrine 70 microgram/kg
- Where
- Iran
- Volunteers
- 165 people
- Sponsor
- Qazvin University Of Medical Sciences
General Anaesthesia
Evaluation of Analgesia Nociception Index (ANI) During Propofol/Remifentanil and Sevoflurane/Remifentanil Anesthesia
The aim of this prospective randomized study was to evaluate the ability of the new Analgesia Nociception Index ANI, derived by heart rate variability, to detect painful stimulation during either propofol or sevoflurane…
- Trial name
- NCT01522508
- Testing
- tetanic stimulation
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University Hospital Schleswig-Holstein
Pain, Postoperative, Acute Pain
EFFECT - EFFectiveness of ESPB (Erector Spinae Plane Block) in Laparoscopic Cοlectomies Trial
The aim of the trial is to study the efficacy of continuous bilateral Erector Spinae Plane Block (ESPB) in managing perioperative pain in patients who undergo elective laparoscopic colectomy.
- Conditions
- Pain, Postoperative, Acute Pain, Postoperative Complications, Pain
- Trial name
- EFFECT (NCT04879004)
- Testing
- Ropivacaine injection
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- Democritus University of Thrace
Magnesium Sulfate, Remifentanil
Anesthesia Techniques, Neuroprotection and Surgical Field in FESS Under Controlled Hypotension
This prospective, randomized controlled trial investigates the effect of four different anesthetic maintenance techniques on surgical field conditions, hemodynamic stability, and neuroprotection during functional endoscopic sinus…
- Conditions
- Magnesium Sulfate, Remifentanil, S 100beta, S100 Beta Protein, Human
- Trial name
- NCT07181564
- Testing
- Propofol / Remifentanil, Ketamine + Magnesium sulfate (drug combination), Sevoflurane and Remifentanil
- Where
- Greece
- Volunteers
- 150 people
- Sponsor
- University General Hospital of Patras
Perfusion Index, Hypothermia; Anesthesia
The Impact of Intraoperative Change in the Body Temperature on the Perfusion Index
The goal of this observational study is to learn about the impact of intraoperative change in temperature in adult patients undergoing surgeries under general anaesthesia.
- Trial name
- NCT06998849
- Testing
- Perfusion index
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Auditory Brainstem Response
Comparative Effects of Two Anesthetic Techniques on Auditory Brain Response in Children
This will be a prospective, blinded, cross-over study to compare the effects of two anesthetic techniques on the interpretability of auditory brainstem response testing in children.
- Trial name
- NCT02830815
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Undergoing General Anaesthesia
Risk Factors of POCD in General Anesthesia Patients Underwent Noncardiac and Non Neurological Procedures.
The study was a prospective cohort study to assess the effect of age, duration of anesthesia, repeated surgery, and type of surgery on cognitive impairment in 108 geriatric patients (≥60 years) who underwent general anesthesia…
- Trial name
- NCT04215263
- Testing
- Questionaire
- Where
- Indonesia
- Volunteers
- 109 people
- Sponsor
- Universitas Indonesia
Postoperative Pain
Adductor Canal Block (ACB) Versus ACB /Saphenous Block in Patients Undergoing Anterior Cruciate Ligament Repair
Knee surgeries are associated with severe postoperative pain. Blocking the femoral nerve (or saphenous nerve) in the adductor canal is increasingly used for knee analgesia.
- Trial name
- NCT04443634
- Testing
- Ultrasound Guided Adductor Canal Block, Ultrasound Guided Saphenous Nerve Block, General anesthesia
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Cairo University
General Surgery, Orthopedic Procedures
Implementing Virtual Reality in the Operating Room
"Recently, virtual reality has become more accessible thanks to the use of smaller, more comfortable and easier-to-use devices. Its use in operating theatres is growing.
- Trial name
- IRVABO (NCT06333639)
- Testing
- orthopaedic surgery, orthopaedic surgery and fitted with a virtual reality headset
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Postoperative Delirium, Elderly Patient
Automated Administration of Intravenous Compared With Inhalatory Anesthesia on the Occurrence of Postoperative Delirium
The intravenous administration of anesthetic agents by a controller automatically-guided by an index of cerebral activity (i.e. the bispectral index) decreases the incidence of postoperative delirium, compared with an…
- Conditions
- Postoperative Delirium, Elderly Patient, General Anesthetic Drug Adverse Reaction
- Trial name
- AG-DPO (NCT03705728)
- Testing
- Propofol, Sevoflurane, Remifentanil automatic
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Centre Clinical, France
Postoperative Neuromuscular Block, Postoperative Complications
Residual Neuromuscular Block in the Post-Anesthetic Unit and Postoperative Complications
The use of neuromuscular blockers (NMB) is essential to optimize surgical conditions, ensure patient immobility during the intervention and prevent complications derived from involuntary movements.
- Trial name
- Porcerito (NCT06386354)
- Testing
- Train-of-four
- Where
- 2 sites in Spain
- Volunteers
- 296 people
- Sponsor
- Hospital Universitario de Gran Canaria Doctor Negrín
General Anaesthesia, Induction of Anaesthesia
Efficacy and Safety Study of Two Propofol Formulations
The purpose of the study to compare Propofol-MCT/LCT with LCT in terms of their efficacy and safety during total intravenous anaesthesia
- Trial name
- NCT00506246
- Testing
- Propofol
- Where
- 3 sites in China
- Volunteers
- 220 people
- Sponsor
- B. Braun Melsungen AG
Surgery, Anesthesia Intubation Complication
MAsk VEntilation With Paratracheal Pressure In Children. Para Tracheal Compression to Prevent Gastric Insufflation in Children
The use of cricoid pressure to prevent gastric aspiration or regurgitation in case of "full stomach" situation or emergency is still controversial in the adult population.
- Trial name
- MAVEPPIC (NCT05279170)
- Testing
- MAVEPPIC: MAsk VEntilation with Paratracheal Pressure In Children
- Where
- 2 sites in France
- Volunteers
- 72 people
- Sponsor
- University Hospital, Lille
Pulmonary Resection Surgery, One Lung Ventillation (OLV)
BMI-Adjusted PEEP During One-Lung Ventilation in Thoracic Surgery
One-lung ventilation (OLV) is required during many thoracic surgical procedures and is associated with reduced functional residual capacity, atelectasis, ventilation-perfusion mismatch, hypoxemia, and potentially…
- Conditions
- Pulmonary Resection Surgery, One Lung Ventillation (OLV), General Anesthetic
- Trial name
- SIMPLE-PEEP (NCT07851740)
- Testing
- Fixed PEEP, BMI-adjusted PEEP
- Where
- 4 sites in Spain
- Volunteers
- 150 people
- Sponsor
- Jesús Manuel Nieves Alonso
Anesthesia, General
Muscle Relaxants and Laryngeal Local Anesthetics for Laryngeal Mask Airway Insertion Decreasing Propofol in Elderly
Laryngeal mask airway (LMA) is currently the most widely used supraglottic airway device with advantages of simple and fast placement, reduced anesthesia drug use, more stable hemodynamics, and less throat discomfort after…
- Trial name
- LMA (NCT05310110)
- Testing
- 10% lidocaine spray, Cisatracurium, Propofol
- Where
- Taiwan
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital