Clinical trials: Genetic Association Studies
Breast Cancer, Metastatic Disease
Evaluation of the Association Between CYP2D6 Genetic Polymorphisms and the Treatment Effect of Tamoxifen
Primary objectives of this study is to evaluate the effects of CYP2D6 genotypes on time to progression after tamoxifen treatment in pre- or postmenopausal women with metastatic breast cancer.
- Trial name
- NCT00532454
- Testing
- Tamoxifen
- Where
- 2 sites in South Korea
- Volunteers
- 21 people
- Sponsor
- National Cancer Center, Korea
Hemophilia
Oral Health Status and Oral Health Related Quality of Life in a Group pf Egyptian Hemophilic Children
aim of the study: 1. to assess, investigate, and compare the oral health status and oral health related quality of life of a group of hemophilic Egyptian children before and after an oral health educational program 2.
- Trial name
- NCT07161596
- Testing
- oral health educational program
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Cairo University
Inflammatory Disease, Drug Side Effect
Active Pharmacovigilance Study of the Medicine Rinvoq™ (Upadacitinib)
The LOOK-UP is an investigator-initiated clinical study with the aim of monitoring the post-marketing safety of the medicine Rinvoq™ (upadacitinib), which is indicated for the treatment of rheumatoid arthritis, psoriatic…
- Conditions
- Inflammatory Disease, Drug Side Effect, Drug Use, Adverse Drug Event
- Trial name
- LOOK-UP (NCT06498167)
- Testing
- Upadacitinib
- Where
- 3 sites in Portugal
- Volunteers
- 150 people
- Sponsor
- Universidade do Porto
Cystic Fibrosis
Exercise Training Study for Patients With Cystic Fibrosis
The aim of this study is to test the effect of a 6-month program of self-regulated, home-based exercise with telephone reinforcement on the cardiorespiratory fitness, pulmonary function and health-related quality of life of…
- Trial name
- NCT00609050
- Testing
- Self-Regulated Exercise with Telephone Reinforcement, Standard Treatment, Qualitative Approach
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Pittsburgh
Cystic Fibrosis
A Pilot and Feasibility Study to Evaluate High vs Low Glycemic Index Mixed Meal Tolerance Test in Adolescents and Young Adults With Cystic Fibrosis
The goal of this study is to determine the extent to which excess dietary simple sugars serve as a secondary mediating factor in Cystic fibrosis-related diabetes (CFRD) development.
- Trial name
- NCT06350149
- Testing
- Sugar Sweetened Beverages (SSB), Hi GI, Lo GI
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Emory University
Cystic Fibrosis, Cystic Fibrosis-related Diabetes
A CFit Study - Acute Exercise
A great medical success is the increase in the median survival age associated with cystic fibrosis (CF). However, this success has led to a new era of research aiming to maximise the quality of life (QoL) of the aging CF…
- Trial name
- NCT03237767
- Testing
- MIE, HIIE
- Where
- United Kingdom
- Volunteers
- 2 people
- Sponsor
- University of Portsmouth
Osteoporosis, Cystic Fibrosis
Randomized Study of Alendronate in Adult Patients With Cystic Fibrosis Related Osteoporosis
OBJECTIVES: I. Determine the bioavailability and biologic effect of alendronate on bone metabolism in patients with cystic fibrosis. II.
- Trial name
- NCT00004489
- Testing
- alendronate sodium, calcium carbonate, cholecalciferol
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of North Carolina
Bone Avascular Necrosis, Sickle Cell Anemia
Decompression Coring Versus Conservative Therapy in Patients With Avascular Necrosis of the Hip Related to Sickle Cell Disease
OBJECTIVES: I. Phase II trial to determine surgical morbidity of decompression coring, including any adverse events in the perioperative period and the rate of secondary medical or surgical interventions. II.
- Trial name
- NCT00006130
- Testing
- Core decompression
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- UCSF Benioff Children's Hospital Oakland
IGA Glomerulonephritis
Study of Genetic Anomalies of Complement Related Proteins in Patients With IgA Glomerulonephritis
OBJECTIVES: I. Determine whether allelic differences associated with the fourth component of complement, type-1 complement receptor expressed on erythrocytes, and Fc receptor FcgRIII contribute to the pathogenesis of IgA…
- Trial name
- NCT00004305
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- National Center for Research Resources (NCRR)
Muscle Strength, Vitamin B 12 Deficiency
Study of the Association of Muscle Strength, Balance and Other Factors With Vitamin Levels Among Elderly Diabetics
Vitamin B12 deficiency can cause severe problems with the blood, nerves, brain and psychological well-being. Ironically, our modern methods for the control of diabetes mellitus can actually contribute to vitamin B12 deficiency.
- Conditions
- Muscle Strength, Vitamin B 12 Deficiency, Folate Deficiency, Vitamin D Deficiency
- Trial name
- NCT03376490
- Where
- Singapore
- Volunteers
- 56 people
- Sponsor
- SingHealth Polyclinics
Ebola Virus Disease
PREVAIL VI: Identification of Host Genetic Factors Underlying Ebola Virus Disease Risk, Mortality, Long-term Sequelae, Viral RNA Persistence, Humoral Immunity, and Ebola Vaccine Response
Background: Genes are instructions that tell the body how to work and grow. They can affect how the body responds to infection. Researchers want to learn more about genes that affect how the body responds to the Ebola virus.
- Trial name
- NCT03098862
- Where
- 4 sites in Liberia
- Volunteers
- 4,830 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Cytomegalovirus Retinitis, HIV Infections
A Study of Foscarnet Plus Ganciclovir in the Treatment of Cytomegalovirus of the Eye in Patients With AIDS Who Have Already Been Treated With Ganciclovir
To examine the safety and tolerance of the administration of ganciclovir and foscarnet given together or alternately; to determine the interactive pharmacokinetics (blood level) profile of long-term combined and alternating…
- Trial name
- NCT00000970
- Testing
- Foscarnet sodium, Ganciclovir
- Where
- 6 sites in United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Amyloidosis, Hereditary, Transthyretin Amyloidosis
HELIOS-A: A Study of Vutrisiran (ALN-TTRSC02) in Patients With Hereditary Transthyretin Amyloidosis (hATTR Amyloidosis)
The purpose of this study is to evaluate the efficacy and safety of vutrisiran (ALN-TTRSC02) in participants with hereditary transthyretin amyloidosis (hATTR amyloidosis).
- Trial name
- NCT03759379
- Testing
- Patisiran, Vutrisiran
- Where
- 64 sites in United States, Argentina and 20 more
- Volunteers
- 164 people
- Sponsor
- Alnylam Pharmaceuticals
Stroke
Fangshan / Family-based Ischemic Stroke Study In China
The exact etiology of ischemic stroke remains unclear, because multiple genetic predispositions and environmental risk factors may be involved, and their interactions dictate the complexity.
- Trial name
- FISSIC (NCT00534742)
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Peking University
Cystic Fibrosis, Venous Thrombosis
Cystic Fibrosis and Totally Implantable Vascular Access Devices
The purpose of this study is to evaluate the incidence of venous thrombosis occurring on totally implantable vascular access devices in cystic fibrosis patients who need a new device (it can be the first one or a subsequent one)…
- Trial name
- RITHM (NCT00244270)
- Testing
- totally implantable vascular access device
- Volunteers
- 97 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Invasive Candidiasis, Candidemia
Genetic Susceptibility Factors for Candidemia.
This is a prospective case-control physiopathological study, which main objective is to determine the genetic host factors predisposing to candidemia.
- Conditions
- Invasive Candidiasis, Candidemia, Genetic Predisposition to Disease
- Trial name
- NCT02841501
- Testing
- Analysis of genetic polymorphisms
- Where
- France
- Volunteers
- 453 people
- Sponsor
- University Hospital, Lille
Bipolar Disorder, Attention Deficit Disorder With Hyperactivity
Juvenile Bipolar Disorder Outpatient Program
This is an outpatient program for children and adolescents with bipolar disorders. The naturalistic approach of the program will allow a proper investigation of the disorder, assessment of environmental and biological factors…
- Trial name
- ProCAB (NCT01000402)
- Testing
- Psychopharmacotherapy
- Where
- Brazil
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
Age-Related Macular Degeneration, Eye Diseases
Blood and Saliva Sample Collection for AREDS 2
Background: The Age-Related Eye Disease Study 2 (AREDS 2) is looking at different eye diseases. Study participants will provide blood and saliva samples. The samples will be stored for research on eye diseases.
- Trial name
- NCT01553474
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- National Eye Institute (NEI)
Cystic Fibrosis
Phase II Study of Growth Hormone in Children With Cystic Fibrosis
OBJECTIVES: I. Determine the effect of growth hormone on height, height velocity, body weight, and lean body mass in patients with cystic fibrosis. II.
- Trial name
- NCT00016445
- Testing
- growth hormone
- Where
- 9 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of Utah
Systemic Lupus Erythematous
Pilot Study Related to the Effect of Clopidogrel on Plasmatic Soluble CD40 Ligand During Systemic Lupus Erythematous
CD40 Ligand (CD40L) has been identified as a key feature in systemic lupus erythematosus (SLE) pathogenesis, a systemic autoimmune disease characterized by a multiorgan involvement.
- Trial name
- CLOPUS (NCT02320357)
- Testing
- Treatment by clopidogrel
- Where
- 3 sites in France
- Volunteers
- 18 people
- Sponsor
- University Hospital, Bordeaux