Clinical trials: Genetic Counseling
BRCA1 Mutation, POLD1 Gene Mutation
An Intervention to Increase Genetic Testing in Families Who May Share a Gene Mutation Related to Cancer Risk and An Intervention to Help Patients and Their Primary Care Providers Stay Up-to-date About Uncertain Genetic Test Results
The purpose of this study is to examine the impact of new cancer genetic counseling models that aim to increase patient engagement with the genetics team.
- Conditions
- BRCA1 Mutation, POLD1 Gene Mutation, CDKN2A Mutation, BRCA2 Mutation
- Trial name
- NCT05420064
- Testing
- Intervention Arm At-risk Relative/ARR Contacts, MyGene Portal, Standard of Care
- Where
- 8 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Solid, Liquid, Central Nervous System Tumors
Next Generation Sequencing of Normal Tissues Prospectively in Pediatric Oncology Patients
The development of next generation sequencing (NGS) techniques, including whole genome (WGS), exome (WES) and RNA sequencing has revolutionized the ability of investigators to query the molecular mechanisms underlying tumor…
- Trial name
- NCT02530658
- Testing
- Study Introduction Visit, Informed Consent Visit, Informed Consent Follow-Up Visit
- Where
- United States
- Volunteers
- 2,500 people
- Sponsor
- St. Jude Children's Research Hospital
Spinal Muscular Atrophy, Fragile X Syndrome
Early Check: Expanded Screening in Newborns
Early Check provides voluntary screening of newborns for a selected panel of conditions. The study has three main objectives: 1) develop and implement an approach to identify affected infants, 2) address the impact on infants and…
- Conditions
- Spinal Muscular Atrophy, Fragile X Syndrome, Fragile X - Premutation, Duchenne Muscular Dystrophy
- Trial name
- NCT03655223
- Testing
- Confirmatory Testing
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RTI International
Hemophilia A, Hemophilia B
The Effect of Patient Counseling on Adolescent Hemophilia Patient Compliance With Bleeding Logs
The study will see if counselling adolescents with severe or moderate Hemophilia A or B results in increased compliance in the maintenance of bleeding logs.
- Trial name
- NCT00212459
- Testing
- Counseling, Control
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- New York Presbyterian Hospital
Amyotrophic Lateral Sclerosis
The Pre-symptomatic Familial Amyotrophic Lateral Sclerosis (Pre-fALS) Study
Pre-fALS is a prospective natural history and biomarker study of people not yet affected with ALS, but who are at genetic risk for developing ALS.
- Trial name
- Pre-fALS (NCT00317616)
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of Miami
Obesity
Clinical & Web-based Diet & Activity Counseling for Men
PACE Project researchers at UCSD are conducting a 2-year study to test the Men in Motion program. The study aims to learn more about how to help men lose weight, become more physically active, and improve their dietary habits.
- Trial name
- NCT00412633
- Testing
- Diet and physical activity interventions, Computer technology to tailor, promote and sustain health behavior change & improve health care delivery.
- Volunteers
- 442 people
- Sponsor
- University of California, San Diego
Poikiloderma
Screening for Genes in Patients With Poikiloderma
In the context of this study, the investigators wish to take advantage of high-throughput genetic techniques (microarray and high-throughput exome sequencing) to identify new genes implicated in syndromic poikiloderma so as to…
- Trial name
- poikiloderma (NCT02862834)
- Testing
- High-throughput exome sequencing
- Where
- France
- Volunteers
- 39 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Breast Cancer Risk
Uptake of Genetic Counseling Among African American Women
A feasibility study incorporating an educational intervention with cancer genetic risk assessment (CGRA) in the UI Health mammography center
- Trial name
- NCT04082117
- Testing
- Educational video
- Where
- 2 sites in United States
- Volunteers
- 960 people
- Sponsor
- University of Illinois at Chicago
Quality, Prostate Cancer
Assessments of Genetic Counseling Augmented With an Educational Video or Pamphlet Versus Traditional Counseling
The purpose of this research study is to understand the impact of an educational video or pamphlet on the patient experience in a hereditary cancer genetic counseling program.
- Conditions
- Quality, Prostate Cancer, Gastrointestinal Cancer, Gynecologic Cancer
- Trial name
- NCT05132868
- Testing
- Educational video and pamphlet, Traditional genetic counseling
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Stanford University
Aneuploidy, Birth Defect
Use of Videos to Improve Patient Knowledge on Prenatal Genetics
This is a randomized controlled trial of a low income and low health literacy population of pregnant women from a diverse racial and ethnic background to assess the effectiveness of a pre-visit educational video on prenatal…
- Trial name
- VPE (NCT03816423)
- Testing
- video
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Breast Carcinoma
Development of a Genetic Counseling Patient Preference Intervention for Women at Elevated Risk for Breast Cancer
This study develops a genetic counseling patient preference intervention for women at elevated risk for breast cancer. This study aims to develop an intervention that may deliver educational videos about breast cancer, heredity…
- Trial name
- NCT05158452
- Testing
- Discussion
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Diabetic Complication
Genetic Testing and Counseling to Reduce Diabetic Complications
The risk of diabetic kidney complications includes non-modifiable risk factors such as genetic predictors, as well as modifiable risk factors such as hyperglycaemia, hypertension, hyperlipidaemia and proteinuria.
- Trial name
- NCT02364323
- Testing
- Personalized Risk Counselling, Normal usual care
- Where
- Hong Kong
- Volunteers
- 435 people
- Sponsor
- Chinese University of Hong Kong
Hereditary Breast Carcinoma, Hereditary Malignant Neoplasm
Chatbot Utilization for Pedigree Creation and Cancer Risk Assessment in Cancer Genetic Counseling
This clinical trial studies whether a chatbot can be used to help collect medical history and perform cancer risk assessment among patients undergoing cancer genetic counseling.
- Trial name
- NCT07887620
- Testing
- Text Message -based Navigation Intervenion, Artificial Intelligence based Intervention
- Where
- United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Roswell Park Cancer Institute
Cystic Fibrosis
Contraceptive Practices and Cervical Screening in Women With Cystic Fibrosis
Little is known about gynaecological follow-up and cervical screening in Cystic Fibrosis (CF). Only few studies have described contraceptive practices in cohorts of CF women.
- Trial name
- NCT02847208
- Testing
- self-report written questionnaire
- Where
- France
- Volunteers
- 155 people
- Sponsor
- Hospices Civils de Lyon
Smoking
Behaviorally Enhanced Counseling on Nicotine Dependence (BEACON) Trial.
The major purpose of this exploratory developmental study will be to develop a patient-centered and feasible protocol for communicating genetic data as it relates to drug efficacy for smoking cessation inpatients receiving…
- Trial name
- NCT00991081
- Testing
- Counseling, Self-help guide, Pharmacotherapy
- Where
- 3 sites in United States
- Volunteers
- 36 people
- Sponsor
- Stanford University
Tay Sachs Disease, Canavan Disease
Efficacy Study of an Online Educational Module Before Carrier Genetic Screening in Persons of Ashkenazi Jewish Descent.
The investigators have developed a new website to educate persons of Ashkenazi Jewish ancestry about their increased risk for having children with certain genetic conditions, and the genetic testing the investigators offer.
- Conditions
- Tay Sachs Disease, Canavan Disease, Familial Dysautonomia
- Trial name
- NCT01999257
- Testing
- Online pre-test genetic education tool
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Genetic Counselling
Telegenetics or In-Person Genetic Counselling
This study aims to compare clinical outcomes (informed choice and genetic counselling outcomes) and cost (provider and patient time, travel, and telehealth platform) between telegenetics and in-person genetic counselling.
- Trial name
- NCT04738708
- Testing
- Patients referred to CGS at NCCS for HBOC or Lynch syndrome pre-test genetic counselling.
- Where
- Singapore
- Volunteers
- 150 people
- Sponsor
- National Cancer Centre, Singapore
Colorectal Cancer
Study of the Results of Education and Counseling for Persons Undergoing Genetic Testing for Hereditary Nonpolyposis Colon Cancer
RATIONALE: Identifying family and individual characteristics may help plan education and counseling for patients who are considering genetic testing.
- Trial name
- NCT00004210
- Testing
- loss of heterozygosity analysis, microsatellite instability analysis, mutation analysis
- Where
- 2 sites in United States
- Volunteers
- 900 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Breast Cancer, BRCA1 Mutation
Decision Support for BRCA Testing in Ethnically Diverse Women
The objective of this study is to expand genetic testing for hereditary breast and ovarian cancer syndrome to a broader population of high-risk women by prompting appropriate referrals from the primary care setting with the use…
- Conditions
- Breast Cancer, BRCA1 Mutation, BRCA2 Mutation, Ovarian Cancer
- Trial name
- NCT03470402
- Testing
- RealRisks, BNAV, iNYP
- Where
- United States
- Volunteers
- 276 people, healthy volunteers welcome
- Sponsor
- Columbia University
Parkinson's Disease
Parkinson's Foundation PD GENEration Genetic Registry
Development of a central repository for PD-related genomic data for future research.
- Trial name
- NCT04994015
- Testing
- Lab Assay for seven genetic variants for Parkinson's Disease
- Where
- 70 sites in United States, Canada and 1 more
- Volunteers
- 35,382 people
- Sponsor
- Parkinson's Foundation