Clinical trials: Genetic Counselling
Breast Cancer, Colorectal Cancer
Connecting Black Families in Houston, Texas to Hereditary Cancer Genetic Counseling, Genetic Testing, and Cascade Testing by Using a Simple Genetic Risk Screening Tool and Telegenetics
To identify Black individuals who are eligible for genetic testing through trusted community organizations, and to connect Black individuals and their families to genetic testing and counseling so that they can know their cancer…
- Trial name
- NCT05694559
- Testing
- Genetic Testing and Counseling, Screening Form
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Colon Cancer
Screening for Gynecologic Cancers in Hereditary Nonpolyposis Colorectal Cancer (HNPCC) Patients
Among women with HNPCC, this study will assess: 1. Knowledge of screening recommendations for endometrial and ovarian cancers. 2. Perceived risk and cancer worries regarding endometrial, ovarian and colorectal cancers. 3.
- Trial name
- NCT00508846
- Testing
- Questionnaire
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- M.D. Anderson Cancer Center
Cancer, Psychological Distress
Assessment Psychological Distress for Cancer Heredity Test
The study of hereditary cancer related syndromes allows reducing the risk of suffering in cancer to patients and close relatives.
- Conditions
- Cancer, Psychological Distress, Hereditary Diseases, Genetic Counseling
- Trial name
- NCT04428710
- Testing
- assessment with psychometric questionnaire
- Where
- Spain
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario La Fe
Breast Cancer, Ovarian Cancer
Risk Education and Assessment for Cancer Heredity
Individuals living in geographically underserved areas encounter considerable barriers to access of quality cancer genetic services.
- Conditions
- Breast Cancer, Ovarian Cancer, Genetic Predisposition
- Trial name
- REACH (NCT01346761)
- Testing
- Telephone Genetic Counseling, In-Person Genetic Counseling
- Where
- United States
- Volunteers
- 1,012 people, healthy volunteers welcome
- Sponsor
- University of Utah
Genetic Counseling, Prenatal Diagnosis
Influence of Prenatal Counseling in Invasive Testing
It is well established that screening for Down syndrome should be offered in the first trimester to each pregnant woman. The most common screening method is nowadays the first trimester combined test which consists of a Bayesian…
- Trial name
- INVASIVE (NCT04119349)
- Testing
- Extra counseling
- Where
- Spain
- Volunteers
- 75 people
- Sponsor
- Hospital Clinic of Barcelona
Hypertension, Atherosclerotic Cardiovascular Disease
Polygenic Risk Score Implementation and Stratification for Managing Blood Pressure
In a multi-ethnic population, a genome-wide polygenic risk score (PRS) for systolic blood pressure (SBP), incorporating over one million common genetic variants, predicts blood pressure (BP) traits and the risk of adverse…
- Trial name
- PRISM-BP (NCT06962488)
- Testing
- Regular Care, SBP PRS Dissemination
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Alabama at Birmingham
Hereditary Breast and Ovarian Cancer Syndrome, Lynch Syndrome
Telemedicine vs. Face-to-Face Cancer Genetic Counseling
Cancer genetic counseling (CGC) has been found to have "substantial" benefits for individuals with breast cancer and their family members; it has been deemed by multiple organizations as "standard of care" for women with breast…
- Trial name
- NCT00609505
- Testing
- Telemedicine, Face-to-Face
- Where
- 4 sites in United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Duke University
Aneuploidy, Genetic Counseling
GEM: Impact of a Video Education Tool on Decisional Conflict Among Prenatal Patients
The goal of this randomized clinical trial is to assess the impact of a video educational tool on patient decisional conflict at the time when making a decision about prenatal genetic testing.
- Conditions
- Aneuploidy, Genetic Counseling, Informed Consent, Decisional Conflict
- Trial name
- GEM (NCT06771453)
- Testing
- Video Educational Tool Regarding Prenatal Genetics
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Women and Infants Hospital of Rhode Island
Moral Value Conflicts, Moral Distress
Genetic Counselors' Experiences of Moral Value Conflicts With Clients
This study will examine the experience of moral value conflicts among genetic counselors. Previous research has shown that value conflicts do exist among genetic counselors, but little is known about the nature or consequences of…
- Conditions
- Moral Value Conflicts, Moral Distress, Genetic Counseling
- Trial name
- NCT00360711
- Where
- United States
- Sponsor
- National Human Genome Research Institute (NHGRI)
Familial Mediterranean Fever, Exercise
Effects of Online Aerobic Exercise Training and Physical Activity Counseling in Juvenile Familial Mediterranean Fever
The aim of the study is to investigate comparison the effectiveness of online aerobic dance exercises versus physical activity counselling in patients with Juvenile Familial Mediterranean Fever.
- Conditions
- Familial Mediterranean Fever, Exercise, Physical Activity
- Trial name
- NCT04724993
- Testing
- Online Aerobic Dance Exercises, Physical Activity Counseling
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Istanbul University
Prostate Cancer, Prostate Biopsy
The PROFILE Study: Germline Genetic Profiling: Correlation With Targeted Prostate Cancer Screening and Treatment
Prostate cancer is now the most common cancer in men in the Western world. In the United Kingdom (UK), there were over 52,000 new cases diagnosed in 2016-2018 and a lifetime risk of 1 in 8.
- Conditions
- Prostate Cancer, Prostate Biopsy, Genetic Counselling, Genetic Markers
- Trial name
- PROFILE (NCT02543905)
- Testing
- Prostate MRI and Biopsy
- Where
- United Kingdom
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Institute of Cancer Research, United Kingdom
Genetic Predisposition
Care Plans for Cancer Predisposition
Develop and evaluate acceptability, feasibility, and preliminary efficacy of digital care plan and accompanying text message reminders for children and adolescents with a known Cancer Predisposition Syndromes (CPS).
- Trial name
- NCT05736497
- Testing
- Digital Care Plans
- Where
- United States
- Volunteers
- 177 people
- Sponsor
- Children's Hospital of Philadelphia
Genetic Counseling Profession
Me-GC: A Randomized Controlled Trial of Meditation for Genetic Counselors
This study is designed to determine whether meditation is beneficial for genetic counselors and genetic counseling students. The main goal is to see if meditation can help with professional well-being (burnout for genetic…
- Trial name
- NCT03723018
- Testing
- Meditation
- Where
- United States
- Volunteers
- 605 people, healthy volunteers welcome
- Sponsor
- Stanford University
Quality, Prostate Cancer
Assessments of Genetic Counseling Augmented With an Educational Video or Pamphlet Versus Traditional Counseling
The purpose of this research study is to understand the impact of an educational video or pamphlet on the patient experience in a hereditary cancer genetic counseling program.
- Conditions
- Quality, Prostate Cancer, Gastrointestinal Cancer, Gynecologic Cancer
- Trial name
- NCT05132868
- Testing
- Educational video and pamphlet, Traditional genetic counseling
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Stanford University
Mitochondrial Diseases
Establishment of Reproductive Cohort and Prediction Model of Genetic Counseling for Mitochondrial Genetic Diseases
The goal of this observational study is to provide a reference for clinicians to conduct genetic counseling and carry out preimplantation genetic testing of mitochondrial patients.
- Trial name
- NCT06450964
- Testing
- Biological samples such as blood, urine, oral epithelial cells and nails of carriers were collected, and the mitochondrial DNA mutation heterogeneity level was determined.
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Anhui Medical University
Breast Neoplasms
RCT of a Group Intervention for Women With a Family History of Breast Cancer
One in 10 Canadian women will be diagnosed with breast cancer (BC) and approximately 5% of all BC is believed to be hereditary. Women with a family history experience high levels of perceived risk for developing BC.
- Trial name
- NCT00150917
- Testing
- Supportive-Expressive Group Therapy
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Alzheimer Disease
REVEAL III: Risk Evaluation and Education for Alzheimer's Disease
The purpose of this study is to provide healthy adults with genetic testing and information about their chances of developing Alzheimer's disease.
- Trial name
- REVEAL (NCT00462917)
- Testing
- Pleiotropic info, in-person disclosure, AD-only info, in-person disclosure, Pleiotropic info, phone disclosure
- Where
- 4 sites in United States
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Genetic Disease, CNV
Reinterpretation of CNV With Unknown Significance: a 5-year Retrospective Analysis
We aim to assess the usefulness of systematic reinterpretation of CNV of unknown significance. To investigate this question we will study all CNV of unknown significance detected between 2010 and 2017.
- Conditions
- Genetic Disease, CNV, Genetic Counseling, Array CGH
- Trial name
- ReAC (NCT04575350)
- Testing
- reinterpretation of CNV
- Where
- France
- Volunteers
- 282 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Diabetic Complication
Genetic Testing and Counseling to Reduce Diabetic Complications
The risk of diabetic kidney complications includes non-modifiable risk factors such as genetic predictors, as well as modifiable risk factors such as hyperglycaemia, hypertension, hyperlipidaemia and proteinuria.
- Trial name
- NCT02364323
- Testing
- Personalized Risk Counselling, Normal usual care
- Where
- Hong Kong
- Volunteers
- 435 people
- Sponsor
- Chinese University of Hong Kong
Genetic Counselling
Telegenetics or In-Person Genetic Counselling
This study aims to compare clinical outcomes (informed choice and genetic counselling outcomes) and cost (provider and patient time, travel, and telehealth platform) between telegenetics and in-person genetic counselling.
- Trial name
- NCT04738708
- Testing
- Patients referred to CGS at NCCS for HBOC or Lynch syndrome pre-test genetic counselling.
- Where
- Singapore
- Volunteers
- 150 people
- Sponsor
- National Cancer Centre, Singapore