Clinical trials: Genetic Factors
Ocular Diseases
Epidemiologic, Laboratory, and Clinical Characterization of Individuals With Ocular Diseases
Environmental and genetic factors may play a role in the progression of ocular diseases (cataract, retinopathy, age-related macular degeneration, glaucoma, retinal detachment, ocular tumor, etc.).
- Trial name
- NCT00249392
- Where
- China
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Nanjing Medical University
Hereditary Spastic Paraplegia
Identification of Modifying Factors in Hereditary Spastic Paraplegia
A first questionnaire - MODIFSPA conducted in 2014 - identified several environmental factors influencing spasticity in HSP: cold, fatigue, and especially physical activity.
- Trial name
- MODIFSPA2 (NCT05373082)
- Testing
- questionnaire completion
- Where
- France
- Volunteers
- 311 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chikungunya Fever
Genetic Factors and Immunological Determinism of Persistent Consequences of Chikungunya
Chikungunya virus (CHIKV) infection has become a threat to public health worldwide. Reunion Island, due to the 2005-2006 epidemic, has acquired unique expertise and remains at the forefront of global research on this disease.
- Trial name
- CHIKGENE (NCT03690648)
- Testing
- Quality of life survey, Saliva collection, Blood collection
- Where
- Reunion
- Volunteers
- 600 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
CYP1A2 Polymorphism, CYP2C19 Polymorphism
Clinical and Genetic Influencing Factors on Clozapine Pharmacokinetics
Clozapine (Clz), an atypical antipsychotic, is the reference medication for patients with treatment-resistant schizophrenia. Due to the high inter-individual variability of its pharmacokinetics and its narrow therapeutic index, a…
- Conditions
- CYP1A2 Polymorphism, CYP2C19 Polymorphism, Clozapine, Schizophrenia
- Trial name
- NCT04240496
- Testing
- Determination of plasma concentration of clozapine/ Genotyping
- Where
- Tunisia
- Volunteers
- 51 people
- Sponsor
- University of Monastir
Autism Spectrum Disorder (ASD), Neurodevelopmental Disorders
Multi-observational Study for the Early Identification of Autism Spectrum Disorder (ASD) and Other Neurodevelopmental Disorders (NDD) in At-risk Populations
Autism spectrum disorder (ASD) is a neurodevelopmental disorder (NDD) that affects about 78 million people worldwide. Its prevalence and degree of impact on individuals and families place it among disorders of global importance.
- Trial name
- BABY@NET (NCT06915805)
- Where
- 5 sites in Italy
- Volunteers
- 296 people, healthy volunteers welcome
- Sponsor
- Istituto Superiore di Sanità
Migraine Disorders
Temporal, Environmental, and Genetic Factors Regulating Exercise and Migraine
Chronic pain, of which migraine is among the most common, affects 100 million US adults and costs between $560 to $635 billion dollars annually.
- Trial name
- NCT04553445
- Testing
- Chronotype, Green exercise
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Nevada, Las Vegas
Pulmonary Disease, Chronic Obstructive, Lung Diseases, Obstructive
Genetic Factors That Influence Chronic Obstructive Pulmonary Disease in Hispanics
The purpose of this study is to examine genetic factors that influence the development of chronic obstructive pulmonary disease (COPD) in Hispanics, a minority group at high risk for the disease.
- Trial name
- NCT00106470
- Where
- Costa Rica
- Volunteers
- 679 people
- Sponsor
- University of Pittsburgh
PSC
Colangioids to Define the Genetic Factors Involved in Atypical Primary Sclerosing Cholangitis
Primary sclerosing cholangitis (PSC) is a rare, progressive and often fatal disease of the intrahepatic or extrahepatic bile ducts, with an estimated prevalence in Western countries of 1/10,000.
- Trial name
- CILIA (NCT06865924)
- Testing
- Use of assembloids as in vitro models to test new pharmacological approaches
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico