Clinical trials: Genetic Linkage
HIV/AIDS
Multi-component HIV Intervention Packages for Chinese Men Who Have Sex With Men -Test, Link and Care (TLC)
1. The number of MSM who are tested for HIV in the 4 study clinics over 12 months will increase compared with historical data from the same 4 clinics over the past 12 months prior to the intervention. 2.
- Trial name
- MP3 (NCT01904877)
- Testing
- Enhancing HIV testing
- Volunteers
- 3,760 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Mental Health, Substance Use Disorders
Supporting Treatment Access and Recovery in Re-entry (STAR-R)
This application is aimed at testing a multicomponent intervention called "Maintaining Independence and Sobriety through Systems Integration, Outreach, and Networking-Criminal Justice (MISSION-CJ) or Peer Linkage Support…
- Conditions
- Mental Health, Substance Use Disorders, Co-occurring Mental and Substance Use Disorders
- Trial name
- STAR-R (NCT07555145)
- Testing
- Full MISSION-CJ, Peer Linkage Support
- Where
- 2 sites in United States
- Volunteers
- 240 people
- Sponsor
- University of Massachusetts, Worcester
HIV
Mobile Health Intervention to Increase HIV Testing and Linkage to Care
This 5-year project will test an mobile health approach to improve HIV self-testing (HST) and linkage to HIV-related care among high-risk men in China.
- Trial name
- NCT05484895
- Testing
- WeTest-WeLink, Control condition
- Where
- 3 sites in China
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Emory University
Tuberculosis, Pulmonary, Rifampicin Resistant Tuberculosis
GeneXpert Performance Evaluation for Linkage to Tuberculosis Care
The investigators' overall objective is to assess the effectiveness, implementation and costs of a streamlined TB diagnostic evaluation strategy based around rapid, onsite molecular testing.
- Trial name
- XPEL-TB (NCT03044158)
- Testing
- GeneXpert I, Process re-design, Performance Feedback
- Where
- 20 sites in Uganda
- Volunteers
- 10,644 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Genetic Skin Disease, Keratosis Follicularis
Study of Scaling Disorders and Other Inherited Skin Diseases
The purpose of this study is to identify the genes responsible for certain scaling disorders and other inherited skin diseases and to learn about the medical problems they cause.
- Conditions
- Genetic Skin Disease, Keratosis Follicularis, Lamellar Ichthyosis
- Trial name
- NCT00001292
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Crohn Disease, Complex Perianal Fistula
A Study to Check How Often People Treated With Darvadstrocel for Crohn's Disease Are Diagnosed With Cancer
The main aim is to learn about the risk of cancer after treatment with darvadstrocel compared to other standards of care in people with Crohn's Disease (CD).
- Trial name
- NCT04971525
- Where
- 4 sites in France, Germany and 2 more
- Sponsor
- Takeda
Family Planning Services, Substance-Related Disorders
Increasing Linkage to Family Planning Care for Individuals With Substance Use Disorder
This study will utilize mixed methods to develop and assess the feasibility and acceptability of a health educator intervention designed to connect patients in recovery from substance use disorder to reproductive health education…
- Conditions
- Family Planning Services, Substance-Related Disorders, Opiate Substitution Treatment, Sexual Health
- Trial name
- NCT04162184
- Testing
- Sexual Health Initiative for Navigation and Education (SHINE) Health Educator Intervention
- Where
- United States
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- Denver Health and Hospital Authority
HIV, Care-seeking
Linkage to Care - Part II
This is the second phase of a two-phase, cross-sectional study of linkage to medical care of HIV positive youth. Social, psychological and behavioral factors associated with receipt of care will be evaluated.
- Conditions
- HIV, Care-seeking, HIV Infections
- Trial name
- NCT00891644
- Testing
- Case Management, Snowball sampling, Referral Lists
- Where
- 5 sites in United States
- Volunteers
- 59 people
- Sponsor
- University of North Carolina, Chapel Hill
Age-Related Macular Degeneration
Investigating Age-Related Macular Degeneration
Age-related macular degeneration (ARMD) affects older Americans and can lead to irreversible blindness. Although the cause if ARMD is unclear, it appears to be a condition that is affected by both genetic and environmental…
- Trial name
- NCT00342251
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- National Eye Institute (NEI)
Hereditary Oral Clefts
Genetic Analysis of Hereditary Non-Syndromic Oral Clefts
In a collaborative effort with the IBN AL-NAFEES Hospital (Damascus, Syrian Arab Republic), individuals from multiplex families determined to have hereditary oral clefts will be studied.
- Trial name
- NCT00340626
- Where
- Syria
- Volunteers
- 690 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)
Emergency Maternity Care, Health Inequalities in Maternity Care Access
Disparities In Access to the Northwest Ambulance Service During Pregnancy, Birth and Postpartum Period and Its Association With Neonatal and Maternal Outcomes
This study is the first in the United Kingdom (UK) to look at how women and families from different backgrounds use ambulance services during the 'perinatal period' - through pregnancy, birth, and shortly after having a baby.
- Conditions
- Emergency Maternity Care, Health Inequalities in Maternity Care Access, Disparities in Access to Maternity Care, Deprivation
- Trial name
- DIAAS (NCT07049263)
- Where
- United Kingdom
- Volunteers
- 18,000 people
- Sponsor
- Manchester University NHS Foundation Trust
Multiple Sclerosis (MS)
MS PATHS COVID-19 Questionnaire Data Linkage Sub-Study
The primary objective of this sub-study is to supplement the Multiple Sclerosis Partners Advancing Technology and Health Solutions (MS PATHS) dataset with coronavirus disease 2019 (COVID-19)-related health information obtained…
- Trial name
- NCT05058729
- Where
- 6 sites in United States
- Volunteers
- 1,507 people
- Sponsor
- Biogen
HIV Infections
Simplified Model of Linkage and Retention to Care, Using a Mobile Unit and a Same-day Test and Treat Approach Among Excluded Population. (SIMPLIFIED)
Implementation of a model for access and retention of HIV care for vulnerable and excluded population using a mobile screening unit and a strategy of diagnosis and initiation of treatment with Bictegravir (BIC) 50 mg/…
- Trial name
- SIMPLIFIED (NCT05405751)
- Testing
- Bictegravir/Emtricitabine/Tenofovir Alafenamide 50 MG-200 MG-25 MG Oral Tablet [BIKTARVY]
- Where
- Spain
- Volunteers
- 101 people
- Sponsor
- Fundacion SEIMC-GESIDA
HIV, Chlamydia
National Rapid TLC: Testing and Linkage to Care
The goal of this cross-sectional study is to learn if the GeneXpert system is a practical system for HIV and STBBI testing in community-based organizations and health clinics.
- Conditions
- HIV, Chlamydia, Gonorrhea, HCV
- Trial name
- NCT07730801
- Testing
- Xpert® HIV-1 Qual XC
- Where
- 2 sites in Canada
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Cervical Cancer, Cervical Cancer Screening
Accelerating Adoption of Patient-centered Cervical Cancer Screening and Treatment Linkage in Kenya
This study aims to test the use of a multi-component care strategy (DADA LINK) designed to improve cervical cancer screening and linkage to treatment.
- Conditions
- Cervical Cancer, Cervical Cancer Screening, HPV DNA
- Trial name
- DADA-LINK (NCT07050745)
- Testing
- DADA LINK
- Where
- Kenya
- Volunteers
- 1,980 people, healthy volunteers welcome
- Sponsor
- Kenyatta National Hospital
HIV
Assisted Partner Notification to Augment HIV Treatment and Prevention in Kenya
The main purpose of this implementation science study is to find out if providing aPS at 18 different Ministry of Health (MOH) VCT clinics in Kenya works and is cost-effective.
- Trial name
- APS (NCT01616420)
- Testing
- Assisted-partner notification services
- Where
- 18 sites in Kenya
- Volunteers
- 2,424 people, healthy volunteers welcome
- Sponsor
- University of Washington
End Stage Renal Disease (ESRD)
Mapping of End Stage Renal Disease Genetic Susceptibility in African Americans by Admixture Linkage Disequilibrium
This study will identify which regions on the genes, and genes themselves, may account for an increased risk of end stage renal disease (ESRD), that is, near-total loss of kidney function, for people of African American descent.
- Trial name
- NCT00559767
- Where
- United States
- Volunteers
- 2,860 people
- Sponsor
- National Cancer Institute (NCI)
ART Adherence, PMTCT
HIV Self Testing of Male Partners of Women in PMTCT
The investigators will conduct a randomized trial to evaluate whether provision of oral HIV self-test kits (HIVST) to HIV-positive pregnant women to provide to their male partner, increases the proportion of male partners who…
- Conditions
- ART Adherence, PMTCT, Linkage to Care, HIV
- Trial name
- NCT03484533
- Testing
- HIV self-test kit, Standard of Care (invitation letters for fast-track HIV testing in the clinic)
- Where
- Uganda
- Volunteers
- 736 people, healthy volunteers welcome
- Sponsor
- University of Washington
Hepatitis C
Use of a Patient-Centered Electronic App to Increase ED Patient's Knowledge on HCV to Improve the HCV Care Continuum
The investigators will conduct a randomized controlled clinical trial study in an urban emergency department in Baltimore to determine the impact of an educational app which is based on Leventhal's Common-Sense Model of Illness…
- Trial name
- NCT04162938
- Testing
- Patient-Centered Electronic App
- Where
- United States
- Volunteers
- 308 people
- Sponsor
- Johns Hopkins University
HIV Counseling and Testing, HIV Risk Behavior
Safe Spaces 4 Sexual Health
In an earlier study, the study team carried out an HIV/Sexually transmitted infection (STI) testing approach which found men who have sex with men (MSM) at-risk of getting or spreading HIV in online spaces and linked them to…
- Conditions
- HIV Counseling and Testing, HIV Risk Behavior, HIV Prevention
- Trial name
- SS4SH (NCT07133555)
- Testing
- Healthcare counseling service
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University