Clinical trials: Genetic Polymorphism
Dyslipidemias, Single Nucleotide Polymorphism
VDR SNPs & 25OHD Correlated With Dyslipidemia
The project was aimed to explore the associations of single nucleotide polymorphisms (SNPs) of vitamin D receptor gene with specific circulating lipids in adult Chinese.
- Trial name
- NCT04707612
- Testing
- No intervention.
- Where
- China
- Volunteers
- 1,987 people, healthy volunteers welcome
- Sponsor
- Shenzhen Center for Chronic Disease Control
Generalized Chronic Periodontitis, Osteoporosis
A Study to Assess the Disturbances in Calcitonin Gene in Patients With Gum Disease and Osteoporosis
Osteoporosis and Periodontitis are multifactorial diseases which share common risk factors.The aim of the present study is to ellucidate polymorphisms in Calcitonin receptor gene? in patients with Osteoporosis and Periodontitis.
- Trial name
- CTROP (NCT02273128)
- Testing
- CTR Gene
- Where
- India
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Non Metastatic Breast Cancer
Biological Response to Tamoxifen (TAM) in Patients With Breast Cancer Non Metastatic RH+
The biological response to treatment with tamoxifen in the preoperative situation is studying in this protocol. This study will enrolls patients with non-metastatic breast cancer HR +.
- Trial name
- TAM (NCT01220076)
- Testing
- tamoxifen
- Where
- 3 sites in France
- Volunteers
- 140 people
- Sponsor
- Institut Cancerologie de l'Ouest
Breast Cancer
Bioequivalence ANDA SNP Clinical Study - Raloxifene and Single Nucleotide Polymorphisms
Explore the relationship between drug target ER gene single nucleotide polymorphisms and Raloxifene therapeutic effects in patients with Breast Cancer LCIS, based on Oxford precisely sequencing drug targets' genes.
- Trial name
- Drugs-SNPs (NCT06062810)
- Testing
- Raloxifene - Usual, Raloxifene - Study
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Han Xu, M.D., Ph.D., FAPCR, Sponsor-Investigator, IRB Chair
Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia
KIR Favorable Mismatched Haplo Transplant and KIR Polymorphism in ALL/AML/MDS Allo-HCT Children
This is a phase II, open-label, non-randomized, prospective study of haploidentical transplantation using KIR-favorable donors for children with acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML) and myelodysplastic…
- Conditions
- Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Myelodysplastic Syndromes
- Trial name
- NCT02646839
- Testing
- CliniMacs TCR alpha-beta-Biotin system
- Where
- 11 sites in United States
- Volunteers
- 50 people
- Sponsor
- Michael Pulsipher
Acne Vulgaris
Gene Polymorphisms, Skin Barrier, and Inflammation in Acne
This study investigated the relationship between Matrix Metalloproteinase-2 (MMP-2) and Tissue Inhibitor of Metalloproteinase-2 (TIMP-2) gene polymorphisms and acne pathogenesis.
- Trial name
- NCT07069075
- Testing
- MMP-2 Gene Polymorphism (rs243865) Analysis, TIMP-2 Gene Polymorphism (rs8179090) Analysis
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Hong Zhang
High Blood Pressure
STUDY OF THE DOUBLE POLYMORPHISM (THR 555ILE) AND (GLU568PRO) OF THE CORIN GENE AS A RISK FACTOR FOR ARTERIAL HYPERTENSION IN A POPULATION OF AFRICAN DESCENT IN GUADELOUPE
Cardiovascular disease (CVD) mortality is the leading cause of death in high-income countries (particularly the United States), accounting for 23.1% of all deaths It has been established over several decades that hypertension…
- Trial name
- HTAG-CORIN (NCT07330804)
- Testing
- double polymorphism
- Where
- 2 sites in Guadeloupe
- Volunteers
- 370 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Melanoma, Skin Cancer
A Model for Genetic Susceptibility: Melanoma
The goal of this study is to find out if some people are more likely to get melanoma, a form of skin cancer, than others are. To do this we will compare people who have had more than one melanoma to people who have had only one…
- Trial name
- NCT00591500
- Testing
- Questionnaire
- Where
- United States
- Volunteers
- 4,082 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Therapeutic Equivalency, Pharmacogenetics
Bioequivalence of Rebamipide in Korean
The aims of this study were to evaluate the pharmacokinetic properties and bioequivalence of two rebamipide preparations in healthy Korean male volunteers for generic substitution and to evaluate the association between the…
- Trial name
- NCT00997789
- Testing
- Rebamide
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chonnam National University Hospital
Schizophrenia, Chinese Han People
Mutation Screening and Translocation Detection of DISC1 Gene in Schizophrenia
Several chromosomal loci obtained from genetic linkage studies have been reported of relating to schizophrenia. These areas include of 1q32-41, 6p24-21, 8p22-21, 15q13-14, and 22q11-12.
- Trial name
- NCT00155818
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
First Line Metastatic Colorectal Cancer
Individualization of Dosage of Irinotecan in the FOLFIRI According to the Genetic Polymorphism of UGT1A1 in the First Line Treatment of Metastatic Colorectal Cancer
This prospective, non randomized multicenter phase II study, will determine the feasibility of individualized dose of irinotecan with the UGT1A1 polymorphism, in patients with metastatic colorectal cancer treated with FOLFIRI.
- Trial name
- IriGen (NCT01963182)
- Testing
- Irinotecan
- Where
- 3 sites in France
- Volunteers
- 47 people
- Sponsor
- Centre Jean Perrin
Healthy
Effects of Gene Polymorphism After Transcranial Cranial Direct Current Stimulation on the Corticobulbar Excitability
This study aims to examine the effects of transcranial direct current stimulation at corticobulbar excitability in individuals with different gene polymorphism.
- Trial name
- NCT03712150
- Testing
- tdcs
- Where
- 2 sites in South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The Catholic University of Korea
Age-related Macular Degeneration
Association of Previously Verified Gene Polymorphisms With AMD in Turkish Population
The purpose of this study is to determine whether common genetic polymorphisms that have been verified to be related to age-related macular degeneration (AMD) in some populations are also associated with AMD in Turkish population
- Trial name
- AMD-SNP (NCT02248324)
- Where
- Turkey (Türkiye)
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Kocatepe University
Alcohol Intolerance, Alcohol Drinking in College
ALDH2 rs671, Alcohol Use, and Health Education in University Students
Alcohol intolerance is common in East Asian populations and is strongly influenced by the rs671 variant in the ALDH2 gene. This study examined the associations of ALDH2 genotype with drinking behavior and alcohol-related…
- Conditions
- Alcohol Intolerance, Alcohol Drinking in College, Aldehyde Dehydrogenase-2 (ALDH2) Deficiency
- Trial name
- NCT07802613
- Testing
- Individual ALDH2 Genotype Feedback, Standardized Alcohol Health Education
- Where
- Taiwan
- Volunteers
- 622 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Peripartum Cardiomyopathy
Irisin Expression and Gene Polymorphism With Peripartum Cardiomyopathy.
this is an observertional study aimed at Study the association between the level of irisin expression and (Fibronectin Type III Domain Containing 5 (FDNC5) gene polymorphism in female patients with peripartum cardiomyopathy.
- Trial name
- NCT04927715
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Sohag University
Sepsis
Algorithm for Predicting the Unfavorable Course of Sepsis in Children
A comprehensive strategy will be used to investigate the relationship and correlation between 4 diagnostically significant markers relevant for early diagnosis and prediction of complications and death in the development of…
- Trial name
- NCT05908162
- Testing
- Bood leukocyte subsets
- Where
- Belarus
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- The Republican Research and Practical Center for Epidemiology and Microbiology
Sick Sinus Syndrome
The Role of Angiotensinogen Gene Polymorphism in the Pathogenesis of Non-familial Sick Sinus Syndrome
Evidence has been documented for the close relationship between the arrhythmia pathogenesis and the gene expression in renin-angiotensin system.
- Trial name
- NCT01310920
- Testing
- observation
- Where
- Taiwan
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Alopecia Areata, TLRs
Association of TLR7 Gene rs3853839 Polymorphism With Disease Severity in Alopecia Areata: A Case-Control Study
Alopecia areata is an autoimmune, non-scarring hair loss disorder characterized by variable clinical severity. Toll-like receptor 7 (TLR7) plays a key role in innate immune activation and autoimmune responses.
- Trial name
- TLR7-AA (NCT07454876)
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Benha University
Anticoagulant
Determinants of Oral Anticoagulants' Activity
The primary objective of the present study is to determine the clinical, biological and genetic determinants of the anticoagulant activity in patients treated with either anti-IIa or anti Xa oral anticoagulants.
- Trial name
- ANTIGOAG (NCT03172546)
- Testing
- PK-PD genetic polymorphisms
- Where
- France
- Volunteers
- 3 people
- Sponsor
- University Hospital, Lille
Ulcerative Colitis (UC)
The Association Between Interleukin-7 Receptor Gene Polymorphism and the Risk of Ulcerative Colitis
From January 2020 to December 2024, diagnosed ulcerative colitis(UC) patients and gender- and age-matched normal controls were enrolled from the Department of Gastroenterology, the Second Affiliated Hospital of Wenzhou Medical…
- Trial name
- NCT07398586
- Testing
- Vedolizumab
- Where
- China
- Volunteers
- 898 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University