Clinical trials: Genetic Polymorphism
Psychosis, Schizophrenia
The BC Psychosis Program Biobank and Database for Genetic Polymorphisms and Their Associations With Psychosis Disorder
The purpose of this study is to determine if candidate polymorphisms in brain-derived neurotrophic factor (BDNF) and catechol-o-methyl transferase (COMT) are predictive of psychosis disorder severity, symptomology, and resolution…
- Trial name
- BCPP BIODA (NCT02322918)
- Testing
- Blood samples for whole genomic/transcriptomic sequencing
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University of British Columbia
Gene Abnormality, Asthma
B2 Adrenergic Receptor Gene Polymorphism in Bronchial Asthma
The b2-adrenoceptor (b2AR) mediates the physiological responses in the airway, which include bronchodilation, bronchoprotection.
- Trial name
- polymorphism (NCT03118869)
- Where
- Egypt
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Assiut University
Crohn's Disease
An Analysis of the Relationship Between the Genetic Polymorphisms of Interleukin 12 Receptor Subunit Beta 1 and Crohn's Disease in Chinese Patients
From January 2018 to May 2025, diagnosed CD patients and gender- and age-matched normal controls were collected from Department of Gastroenterology, the Second Affiliated Hospital of Wenzhou Medical University.
- Trial name
- NCT07057856
- Testing
- Ustekinumab (UST)
- Where
- China
- Volunteers
- 866 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Cardiovascular Diseases, Heart Diseases
Genetics of Hypertension Associated Treatments (GenHAT)
To examine whether the association between selected hypertensive genes and combined fatal coronary heart disease and nonfatal myocardial infarction in high-risk hypertensives is modified by the type of antihypertensive treatment…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension, Coronary Disease
- Trial name
- GenHAT (NCT00006294)
- Testing
- Chlorthalidone, Lisinopril, Amlodipine
- Where
- United States
- Volunteers
- 37,939 people
- Sponsor
- Donna Arnett, 257-5678
Psychoses
DNA Diagnostics for Minimizing Metabolic Side-Effects of Antipsychotics
The purpose of this study is to assess patients treated with the antipsychotics aripiprazole (Abilify®), olanzapine (Zyprexa®), quetiapine (Seroquel®), risperidone (Risperdal®), or ziprasidone (Geodon®) and to identify genetic…
- Trial name
- DIMS (NCT00752960)
- Where
- 2 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Genomas, Inc
Infertility, Female
Effects of SNP of GnRH Receptor Genes in IVF Patients
Gonadotropin-releasing hormone analogue (GnRH-a) "long protocol" is a protocol for pituitary down-regulation in IVF. However, it is common in clinic that some patients are hypersensitive to pituitary down-regulation and have…
- Trial name
- NCT02979886
- Testing
- GnRH-a, Human Menopausal Gonadotropins
- Volunteers
- 1,500 people
- Sponsor
- Miao benyu
Cigarette Smoking Behavior
Nicotine Reinforcement and Smoking-Cue Reactivity: Association With Genetic Polymorphisms
In this study, potential associations between several genetic polymorphisms and nicotine dependence will be examined. The relative reinforcing efficacy of cigarettes using the forced-choice procedure will be assessed.
- Trial name
- NCT02921282
- Testing
- Genotype dopamine, Genotype cannabinoids
- Where
- Canada
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Genetic Underpinning of Substance Abuse, Polymorphism-genetic
Impact of Delta Opioid Receptor Gene (OPRD1) Variations on Treatment Outcome in African Americans
Background: Differences in peoples genes can make them respond to drugs in different ways. Methadone and buprenorphine are two drugs used to treat drug addiction.
- Conditions
- Genetic Underpinning of Substance Abuse, Polymorphism-genetic, Drug Abuse/Dependence, Opiod-Related Disorders
- Trial name
- NCT02225184
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Polymorphism, VEGF
Study of the Impact of VEGF Polymorphism on the Development of Renal Carcinoma in Renal Transplant Patients
Renal transplant patients have on average 3-5 times more risk of developing cancer than the general population. This rate can be increased up to 10 to 15 times in some type of cancer like kidney cancer.
- Conditions
- Polymorphism, VEGF, Renal Carcinoma, Renal Transplantation
- Trial name
- VE-CART (NCT03114826)
- Testing
- To study the polymorphism of the gene encoding VEGF (rs699947) as a predictive marker
- Where
- France
- Volunteers
- 272 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Sustained Virologic Response, IL28B Polymorphism
100% VS 80% Of Pegasys In Koreans With Chronic Hepatitis C (CHC)
1. Randomized controlled multicenter study 2. The response of reducing dose of peginterferon alfa-2a in Koreans with chronic hepatitis C genotype 1 3. IL28B polymorphism in Koreans with CHC
- Trial name
- NCT01378104
- Testing
- peginterferon alfa 2a (pegasys), peginterferon alfa-2a (pegasys)
- Where
- 14 sites in South Korea
- Volunteers
- 178 people
- Sponsor
- The Catholic University of Korea
Tuberculosis
Soy, Catfish, Anchovy, and Rice Supplementation Increases 25(OH)D Serum Levels in Tuberculosis Patients With Complications
Tuberculosis patients that have complications (e.g., diabetes mellitus and human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS)) who live in tropical regions experience vitamin D deficiency, especially in…
- Trial name
- NCT04613258
- Testing
- SCAR Porridge, Counseling
- Where
- Indonesia
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Universitas Sumatera Utara
Asthma
Investigating Dupilumab's Effect in Asthma by Genotype
The Goal of this study is to investigate if individuals ages 12 years and older, carrying the IL-4RαR576 gene variant, will have a greater response to therapy acting directly on the anti-IL-4R.
- Trial name
- IDEA (NCT03694158)
- Testing
- Dupilumab
- Where
- 6 sites in United States
- Volunteers
- 150 people
- Sponsor
- Boston Children's Hospital
Choroidal NeoVascularization, Age-Related Macular Degeneration
Does Vascular Endothelial Growth Factor (VEGF) or Complement Factor H Gene Polymorphism Play a Role in the Treatment Success With VEGF Inhibitors in Patients With Choroidal NeoVascularization (CNV)?
Age related macular degeneration (AMD) is a multifactorial disease with a strong genetic component. Most importantly a genetic polymorphism in the gene encoding for the complement factor H (CFH) has been recently identified which…
- Trial name
- NCT00813514
- Testing
- VEGF genotyping
- Where
- Austria
- Sponsor
- Medical University of Vienna
Weight Gain
Effect of Bitter Melon Seed Oil on Body Weight
To investigate the metabolic benefits of bitter melon seed oil (BMSO), overweight or obese healthy Taiwanese adults (n=60) were randomly assigned to receive capsules containing either olive oil (OO; placebo) or BMSO at 4.5 g/d…
- Trial name
- NCT03785821
- Testing
- BMSO, OO
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Enterovirus 71, Host Genetics, Social, Behavior, Environmental Factors
Children's Susceptibility to Enterovirus 71 in Different Areas of Taiwan
EV71 has caused large epidemics with lots of fatal cases and cases with sequelae. However, the clinical syndromes and severity of the same EV71 strain are very diverse, ranging from asymptomatic (71%) to fatal (0.05%) disease…
- Trial name
- DMR100-IRB-010 (NCT01311921)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Death, Sudden, Cardiac, Ventricular Fibrillation
DISCOVERY: Diagnostic Data and Genetic Polymorphisms in ICD Patients.
To prospectively evaluate if the analysis of genetic polymorphisms can be used to identify patients at risk of ventricular tachycardia.
- Conditions
- Death, Sudden, Cardiac, Ventricular Fibrillation, Tachycardia, Atrial Fibrillation
- Trial name
- DISCOVERY (NCT00478933)
- Testing
- Defibrillator, Dual Chamber ; Implantable, Blood sampling
- Volunteers
- 1,223 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Disorder of Aging
Evaluation of the High Dose Vitamin D3 Supplementation Effect and Influence of Polymorphism VDR Gene on Oxidative Stress and Inflammatory Process in Elderly
A vitamin D3 high dose would act as an antioxidant and anti-inflammatory improving markers of oxidative stress and inflammation in the elderly.
- Trial name
- NCT02222649
- Testing
- Vitamin D3
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Federal University of Paraíba
Coronary Bypass Graft Surgery, Atrial Fibrillation
Effect of Genetic Polymorphism on the Occurrence of Post-Operative Atrial Fibrillation After CABG
Postoperative Atrial Fibrillation (POAF) is one of the most common complications following coronary artery bypass grafting (CABG) occurring to 20% - 40% of patients.
- Trial name
- NCT03871647
- Testing
- Beta blocker
- Where
- Egypt
- Volunteers
- 256 people
- Sponsor
- Ain Shams University
Alcohol Related Disorders, Alcoholism
Pharmacokinetic Study of Single Dose Dutasteride in Healthy Subjects
To monitor the inhibition of 5a-reductase (5AR) enzyme activity at 1, 3, 7, 14, 21, 28 and 42 days following administration of a single dose of dutasteride (2, 3, or 4 mg) by measuring the change in blood levels of…
- Conditions
- Alcohol Related Disorders, Alcoholism, Alcohol Abuse
- Trial name
- NCT00802321
- Testing
- Dutasteride
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- UConn Health
Breastfeeding, Exclusive
Profile of Human Milk Oligosaccharides and FUT2 Polymorphism of Mothers in Indonesia
Human milk oligosaccharides (HMOs), the third most abundant constituent of breastmilk, are known to have beneficial effects on infant immunity. Maternal genetic polymorphisms cause HMO variability.
- Trial name
- NCT05156255
- Where
- Indonesia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia