Clinical trials: Genetic Polymorphism
Prostate Cancer
Study of a Polymorphism in Patients With Prostate Cancer
RATIONALE: Studying samples of blood from patients with cancer and from healthy participants in the laboratory may help doctors learn more about changes that may occur in DNA.
- Trial name
- NCT00900185
- Testing
- mutation analysis, polymerase chain reaction, polymorphism analysis
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Genetic Differences of Lipid Metabolism/Healthy Subjects
Botanical Oils Study to Determine Genetic Differences in the Way Your Body Processes Fats in Edible Oils
A randomized, controlled, cross-over clinical trial of borage oil vs soybean oil to determine whether the metabolism and/or impact of medium chain-polyunsaturated fatty acids (MC-PUFAs) in botanical oil supplements are changed in…
- Trial name
- NCT02337231
- Testing
- soybean oil and borage oil
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Heart Failure
The Impact of Genetic Polymorphism on the Echocardiographic Parameters and Cardiac Fibrosis Markers in Response to Empagliflozin Treatment Among Patients With Heart Failure
It is important to assess the implications of genetic variants of the TGF-β1 gene in patients with HFrEF and the association of this polymorphism with treatment response to SGLT2I.
- Trial name
- NCT06503601
- Where
- Egypt
- Volunteers
- 92 people
- Sponsor
- Ain Shams University
Anticoagulants, Thromboembolism
Influence of ABCB1 Polymorphisms on Plasma Concentrations of New Oral Anticoagulants in Case of Serious Adverse Events
Vitamin K antagonists were hampered by several disadvantages, such as the need for frequent monitoring. In this context, new oral anticoagulants (NOACs) have been developed and are now available on the market.
- Conditions
- Anticoagulants, Thromboembolism, Hemorrhage
- Trial name
- Pgp NACO (NCT02103101)
- Testing
- Measurement of Plasma Concentrations of NOACs, Identification of ABCB1 polymorphisms coding for P-gp
- Where
- France
- Volunteers
- 68 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Delivery, Obstetric
The Occurrence of Single Nucleotide Polymorphism Among Women Who Experienced Obstetric Anal Sphincter Injury
Single-nucleotide polymorphisms (SNP's) in connective tissue components are associated with increased risk of pelvic organ prolapse (POP).
- Trial name
- NCT04047433
- Testing
- screening for single nucleotide polymorphism, whole exome sequencing
- Where
- Israel
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- HaEmek Medical Center, Israel
Hypothyroidism
Desiccated Thyroid Extract Versus Synthetic T3/T4 Combination (ThyrolarTM) Versus L-T4 Alone in the Therapy of Primary Hypothyroidism With Special Attention to the Gene Polymorphism
The proposed study design is a prospective, randomized, double-blind, crossover study. After informed consent is obtained, patients will be randomized to receive either desiccated thyroid in capsules, or L-T4/L-T3 (ThyrolarTM) in…
- Trial name
- NCT02317926
- Testing
- Levothyroxine, Levothyroxine Plus Liothyronine, Desiccated Thyroid Extract
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Bladder Cancer, Colorectal Cancer
The Molecular Predisposition to Hereditary Nonpolyposis Colon Cancer (HNPCC)
The goal of this study is to understand factors which may influence risk for colorectal and other cancers in families. These factors include genetic variability, in combination with diet and lifestyle.
- Conditions
- Bladder Cancer, Colorectal Cancer, Endometrial Cancer, Kidney Cancer
- Trial name
- NCT01447199
- Testing
- Health and Diet Questionnaire
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Crohn Disease
Mesenteric Bacterial Translocation in Evolved Crohn's Disease
Mesenteric fat can be invaded by gut bacteria through a process called bacterial translocation, which is the invasion of viable bacteria from the gastrointestinal tract to extraintestinal sites (mesenteric lymph nodes, liver…
- Trial name
- MESENCROHN (NCT05891756)
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Hospital Mutua de Terrassa
Periodontal Diseases, Periodontitis
Evaluation of Inflammasome Gene Polymorphisms in Periodontitis Patients
The present study aimed to evaluate the distribution of NLRP3, AIM2, and IFI16 inflammasome gene polymorphisms in individuals with Stage III Grade B and C periodontitis and periodontally healthy individuals.
- Trial name
- NCT06465095
- Testing
- Baseline
- Where
- Turkey (Türkiye)
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Marmara University
Vitamin D Deficiency, Pregnancy
Effects of Vitamin D on Health Promotion During Pregnancy and Its Impact on Prematurity-Related Outcome
The VitDTracking study focuses on the relevance of maternal vitamin D levels and their association with prematurity, aiming to improve maternal and child health outcomes, particularly by reducing avoidable preterm births.
- Trial name
- VitDTracking (NCT06292195)
- Testing
- Exposure
- Where
- 3 sites in Portugal
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Évora
Retinopathy of Prematurity, Genetic Polymorphism
Genetic Polymorphism and Retinopathy of Prematurity: Correlation of Clinical Presentations and Severity
Study Aim and Goals 1. Evaluate the correlation between genetic polymorphism and ROP development 2. To study the possibility if there are any specific genetic polymorphisms that lead to poor outcome or recurrence of ROP after…
- Trial name
- NCT05132257
- Testing
- Severe ROP
- Where
- Taiwan
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Lymphoma
Biomarkers in Predicting Response to Rituximab Treatment in Samples From Patients With Indolent Follicular Lymphoma
RATIONALE: Studying samples of blood and tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT01381705
- Testing
- rituximab, DNA analysis, gene expression analysis
- Volunteers
- 259 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
Healthy
Effects of Clopidogrel and Clarithromycin on the Oral Disposition of Sibutramine in Healthy Subjects
Effects of clopidogrel and clarithromycin on the oral disposition of sibutramine in healthy subjects
- Trial name
- sibu (NCT01421706)
- Testing
- Sibutramine-clopidogrel, sibutramine-Clarithromycin
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Inje University
POCD
Association Study Postoperative Cognitive Dysfunction Associated With Inflammation Polymorphism
This study use Loewenstein cognitive function rating scale to meet the standards of the elderly cognitive function assessment. POCD diagnostic criteria used is the recommended value Z current international law, in order to reduce…
- Trial name
- NCT02843152
- Where
- China
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- dengji wang
Enterovirus 71, Host Genetics, Social, Behavior, Environmental Factors
Children's Susceptibility to Enterovirus 71 in Different Areas of Taiwan
EV71 has caused large epidemics with lots of fatal cases and cases with sequelae. However, the clinical syndromes and severity of the same EV71 strain are very diverse, ranging from asymptomatic (71%) to fatal (0.05%) disease…
- Trial name
- DMR100-IRB-010 (NCT01311921)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Polymorphic Light Eruption, Psoriasis
Regulatory T Cells (Tregs) in Polymorphic Light Eruption
Polymorphic light eruption (PLE) is a photodermatosis with an extremely high prevalence, particularly among young women (up to 20%).
- Conditions
- Polymorphic Light Eruption, Psoriasis, Atopic Eczema
- Trial name
- NCT00555178
- Where
- 2 sites in Austria
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Non-alcoholic Fatty Liver Disease
Utilizing Non-Invasive Fibroscan® Technology to Identify Genetic Markers for Fatty Liver Progression
Non-alcoholic fatty liver disease (NAFLD) is a common disorder, affecting ~30% of people in the general population and up to 96% of obese individuals.
- Trial name
- NCT02267148
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- UNC Nutrition Research Institute
Liver Cirrhosis
To Study the Effects of Host Genetic Factors on Liver Cirrhosis and Hepatocellular Carcinoma (HCC)
The purpose of this study is to identify genetic determinants of susceptibility to liver cirrhosis and hepatocellular carcinoma.
- Trial name
- NCT00709085
- Where
- Taiwan
- Volunteers
- 320 people
- Sponsor
- National Taiwan University Hospital
Sudden Cardiac Death, Arrhythmias
Genetic Risk Assessment of Defibrillator Events
Arrhythmias remain a major health problem, causing at least 250,000 deaths annually in the United States. Pharmacological treatments often do more harm than good, and device therapies are limited by high cost and effects on…
- Conditions
- Sudden Cardiac Death, Arrhythmias, Congestive Heart Failure, Cardiomyopathy
- Trial name
- GRADE (NCT02045043)
- Where
- 6 sites in United States
- Volunteers
- 1,807 people
- Sponsor
- University of Iowa
Parkinson's Disease
Parkinson's Diseases Susceptibility Genes and Pesticides
Parkinson's disease (PD) occurrence is higher in rural than in urban populations of industrialized countries. Epidemiologic and human tissue studies suggest that pesticides may be responsible for causing dopaminergic cell death…
- Trial name
- NCT00044590
- Where
- United States
- Volunteers
- 1,870 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)