Clinical trials: Genetic Polymorphism
Irritable Bowel Syndrome (IBS), Genome-wide Association Study
GWAS to Identify Predictive Genetic Factors for the Success of Dietary Intervention in the Treatment of IBS Symptoms
This is a GWAS that aims to identify possible single nucleotide polymorphisms (SNPs) that are associated with the response in a combined dietary pattern low in fermentable oligosaccharides, disaccharides, monosaccharides, and…
- Conditions
- Irritable Bowel Syndrome (IBS), Genome-wide Association Study, Single Nucleotide Polymorphisms, Mediterranean Diet
- Trial name
- NCT06912828
- Testing
- Med-LFD intervention
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Attikon Hospital
Healthy
A Clinical Trial to Investigate the Influence of CES1 Polymorphism on Oseltamivir
Investigate genetic variability of CES1 gene on pharmacokinetics of oseltamivir in healthy Korean volunteers.
- Trial name
- CES1 (NCT01902342)
- Testing
- Oseltamivir 75 mg 1 cap
- Where
- South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Diabetes Mellitus
A Pilot Study of Berberine (Soloways ™) in Patients with Type 2 Diabetes Mellitus Carrying TCF7L2 Polymorphisms
This pilot, genotype-stratified clinical trial aims to investigate the safety and preliminary efficacy of berberine supplementation in adult patients with type 2 diabetes mellitus (T2DM) who carry a specific high-risk TCF7L2…
- Trial name
- NCT06863922
- Testing
- Berberine
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- S.LAB (SOLOWAYS)
Acute Lymphoblastic Leukemia
Pharmacogenetic Analysis of Korean Pediatric Patients With Acute Lymphoblastic Leukemia
This study is to find out distribution of genetic polymorphisms and genes related to the chemotherapeutic drugs of ALL.
- Trial name
- NCT01556386
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Seoul National University Hospital
UGT1A1*28 Polymorphism
Identification of Polymorphisms Involved in the Metabolism of Propofol
Identification of Polymorphisms Involved in the Metabolism of Propofol
- Trial name
- NCT02271542
- Testing
- propofol
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- TC Erciyes University
Fibromyalgia, Food Addiction
Effect of Transcranial Direct-current Stimulation in Eating Behavior of Women With Fibromyalgia
Introduction: Fibromyalgia (FM) is a syndrome characterized by generalized musculoskeletal pain, fatigue, non-repairing sleep, cognitive changes, depressive symptoms and other correlates of autonomic dysfunction.
- Trial name
- NCT04192058
- Testing
- Active transcranial direct current stimulation (tDCS)
- Where
- 2 sites in Brazil
- Volunteers
- 60 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Systemic Lupus Erythematosus
A Prospective Study of Cyclophosphamide in Systemic Lupus Erythematosus Treatment
The purpose of this study is to compare the genotype-based personal prescription of cyclophosphamide with the traditional prescription.
- Trial name
- SLE (NCT01689350)
- Testing
- Genotype Detection
- Where
- China
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Nicotine Dependence
Nicotine Reinforcement and Smoking-Cue Reactivity: Association With Genetic Polymorphisms
Background: Researchers have been studying behavioral components of nicotine addiction by looking at how drugs have a reinforcing effect, connecting the stimulation provided by the drug (nicotine) to the behavior that produces it…
- Trial name
- NCT01505725
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Diabetes, Hypoglycemia Unawareness
The Effect of Antecedent Hypoglycaemia on β2-adrenergic Sensitivity
Hypoglycaemia unawareness is a common complication in patients with type 1 diabetes and with insulin-treated type 2 diabetes of long duration.
- Trial name
- NCT00160056
- Testing
- Hypoglycemia
- Where
- Netherlands
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
ALL, Childhood, Pediatric Cancer
Pharmacogenomic Association Study in Indian Children With Acute Lymphoblastic Leukemia
A five-year prospective observational cohort study. The study is focused on observing the relation between static germline variants and therapeutic response in Indian children with acute lymphoblastic leukemia (ALL).
- Conditions
- ALL, Childhood, Pediatric Cancer, Toxicity, Drug, Adverse Drug Event
- Trial name
- MPGx-INDALL (NCT05512169)
- Where
- 2 sites in India
- Volunteers
- 556 people
- Sponsor
- University of Geneva, Switzerland
Nonsmall Cell Lung Cancer, EGFR Gene Mutation
EGFR-TKI With/Without Chemotherapy in NSCLC Patients With Both EGFR Mutation and BIM Deletion Polymorphism
BIM deletion polymorphism might be associated with a poor clinical response to EGFR-TKIs in patients who had NSCLC with EGFR mutations.
- Trial name
- NCT03002844
- Testing
- EGFR-TK Inhibitor, EGFR-TKI, EGFR-TKI and Chemotherapy
- Volunteers
- 50 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Respiratory Distress Syndrome (RDS), Respiratory Failure
SerpinB3 Expression, PAR2 and SCCA-PD Polymorphism in Acute Respiratory Distress Syndrome
The Acute Respiratory Distress Syndrome (ARDS) is a systemic syndrome characterized by severe respiratory failure, inflammation, loss of aerated tissue and high mortality.
- Trial name
- Serpin-ARDS (NCT06774534)
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Padova
Opioid-related Disorders, Opiate Dependence
Variation of COMT Val158Met Polymorphism Between COM-ON Patients and METHADOSE Patients
The main objective is to compare the genotypes of the COMT Val158Met polymorphism between opiate-users and opiate-dependent subjects.
- Conditions
- Opioid-related Disorders, Opiate Dependence, Opiate Addiction, Opiate Abuse
- Trial name
- COM-ON (NCT01570699)
- Testing
- COMT polymorphism
- Where
- France
- Volunteers
- 87 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Coronary Syndrome, Hypertension
Effect of Genetic Polymorphisms on Response to Beta Blocker Therapy in Egyptian Patients
Beta-blockers represent a cornerstone for the treatment of coronary artery disease (CAD). Their protective effect is based on the negative inotropic and chronotropic features, which have been tested in a large number of…
- Trial name
- NCT04900545
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Mohamed Saleh Fayed
Attention Deficit Disorder With Hyperactivity, Methylphenidate
Pharmacogenetic Study of Methylphenidate in Attention Deficit/Hyperactivity Disorder(ADHD)
The noradrenergic system plays a known role in attentional systems and suspected causal role in attention deficit/hyperactivity disorder(ADHD).Methylphenidate also has been suspected as a inhibitor of norepinephrine…
- Conditions
- Attention Deficit Disorder With Hyperactivity, Methylphenidate, Pharmacogenetics
- Trial name
- NETADHD (NCT00757029)
- Testing
- norepinephrine transporter polymorphism,
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Hallym University Medical Center
Periodontal Diseases, Periodontitis
Evaluation of Inflammasome Gene Polymorphisms in Periodontitis Patients
The present study aimed to evaluate the distribution of NLRP3, AIM2, and IFI16 inflammasome gene polymorphisms in individuals with Stage III Grade B and C periodontitis and periodontally healthy individuals.
- Trial name
- NCT06465095
- Testing
- Baseline
- Where
- Turkey (Türkiye)
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Marmara University
Dyslipidemia, Type 2 Diabetes Mellitus
Postprandial Fatty Acids and FABP2 in Type 2 Diabetes Mellitus (DM)
This study will be conducted in type 2 diabetic patient's to evaluate the if there is a different response of serum lipids after a standard meal (rich in saturated fatty acids) in patients who have the presence of a genetic…
- Trial name
- NCT00634673
- Testing
- sandwich
- Where
- Brazil
- Volunteers
- 26 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Healthy
Pharmacogenetics Study in Taiwan's Ethnic Groups
This main purpose of this study is to understand the difference and distribution of drug-metabolizing enzyme genetic polymorphisms among Taiwan ethnicities.
- Trial name
- NCT00459251
- Where
- Taiwan
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Mackay Memorial Hospital
Metastatic Breast Cancer
Polymorphism Interaction to Predict Bevacizumab Efficacy
Although many attempts have been done to identify vascular endothelial growth factor-A (VEGF-A) single nucleotide polymorphisms (SNPs) correlated with bevacizumab response, in advanced cancer patients, the results are still…
- Trial name
- BEVAGENE (NCT01935102)
- Where
- Italy
- Volunteers
- 169 people
- Sponsor
- University of Pisa
Pancreatic Cancer
Gemcitabine Hydrochloride in Treating Patients With Pancreatic Cancer That Has Been Removed by Surgery
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT01416662
- Testing
- gemcitabine hydrochloride
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Federation Francophone de Cancerologie Digestive