Clinical trials: Genetic Polymorphism
Obesity, Dietary Modification
Comparison of Two Calorie Restricted MediterrAsian Diet on Weight Loss in FTO rs9939609 Overweight Carriers
Background: Obesity treatment should be individualized since some calorie restricted diet doesn't work for some individuals. Objective: we assess the effect of two different calorie restriction with MediterrAsian diet on weight…
- Trial name
- NCT02940197
- Testing
- MediterrAsian diet
- Where
- Iran
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Shiraz University of Medical Sciences
Complete and Accurate Statistical Data of 60 Patients, CYP3A5*3 Genotypes of 60 Donors and Recipients Were Analyzed Accurately
Analysis of the Effect of Donor CYP3A5 Gene Polymorphism on Early Tacrolimus Concentration and Postoperative Acute Renal Injury After Liver Transplantation
Tacrolimus is the most commonly used immunosuppressant for preventing and treating rejection after liver transplantation. However, its treatment window is narrow, the pharmacokinetic individual differences are large, routine dose…
- Conditions
- Complete and Accurate Statistical Data of 60 Patients, CYP3A5*3 Genotypes of 60 Donors and Recipients Were Analyzed Accurately, Postoperative Tacrolimus Concentrations Were Accurately Recorded in 60 Patients, According to the Diagnosis and Grading Criteria of Acute Kidney Injury, the Cases and Grading of Postoperative Acute Kidney Injury in 60 Patients Were Counted
- Trial name
- NCT06319391
- Testing
- CYP3A5*1*、CYP3A5*1*3, CYP3A5*3*3
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ziqiang Li
Infections
The Role of Genetic Polymorphisms in Innate Immune Response Genes in Susceptibility to Infections
The purpose of this study is to better understand genetic susceptibility to infections and the interactions of specific genetic polymorphisms of innate immune receptors with microbial and fungal organisms.
- Trial name
- NCT00597090
- Where
- United States
- Volunteers
- 319 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Small Cell Carcinoma of Lung
Study of Relationship Between UGT1A1 Gene Polymorphism and Toxicity and Efficacy of Irinotecan in Small Cell Lung Cancer
The purpose of this study is to find out the correlation between uridine diphosphate glucuronosyl transferase 1A1(UGT1A1) gene polymorphisms and the side effect and efficacy of irinotecan in patients with small cell lung cancer.
- Trial name
- NCT01635400
- Testing
- Irinotecan
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Zhejiang Cancer Hospital
Infertility
Pharmacogenetic Algorithm for Individualized Controlled Ovarian Stimulation
In this study, the investigators will evaluate genetic variation or polymorphisms between individuals submitted to IVF/ICSI cycles, and how these variations influence response to COS and pregnancy outcomes.
- Trial name
- NCT03149536
- Testing
- Pharmacogenetic test
- Volunteers
- 1,350 people
- Sponsor
- Clínica Origen
Inflammatory Bowel Diseases
Differential EBI2 Expression Upon Allelic Status of the rs9557195 Polymorphism
EBI2 is a risk gene for inflammatory bowel diseases (rs9557195). Patients of the Swiss IBD cohort study have been genotyped for the allelic status of EBI2.
- Trial name
- NCT03633409
- Where
- Switzerland
- Volunteers
- 340 people
- Sponsor
- University of Zurich
High Caries Risk, Low Caries Risk
TAS1R1, TAS1R3, TLR2, TLR4, CA6 Gene Polymorphism on Dental Caries
The aim of this study is to examine the effects of TAS1R1, TAS1R3, TLR2, TLR4, CA6, gene polymorphism on caries risk in adults.
- Trial name
- NCT04066101
- Testing
- high caries risk, caries activity
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Coronary Artery Disease
Genetics Study of In-stent Restenosis
The investigators hypothesized that genetic variants of G protein influence the development of restenosis and clinical outcome of patients receiving drug-eluting stents (DES).
- Trial name
- ISR (NCT01670396)
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shanghai Zhongshan Hospital
Breast Cancer
Genetic Predictors of Response to Acupuncture for Cancer-related Fatigue Among Breast Cancer Patients After Chemotherapy
Genetic predictors of response to acupuncture for cancer-related fatigue among breast cancer patients after chemotherapy.
- Trial name
- NCT05094310
- Testing
- Acupuncture
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Affiliated Hospital of Qinghai University
Critical Illness
Innate Immunity Gene Polymorphisms and Yeast Colonization
It is proposed to carry out the study in three medical or surgical intensive care units (ICU) in the CHRU, Lille, and the CHU, Besançon.
- Trial name
- Candigene (NCT02888860)
- Where
- 6 sites in France
- Volunteers
- 2,200 people
- Sponsor
- University Hospital, Lille
Self Injurious Behavior Without Suicidal Intent, Self-Injurious Behavior
Genetics of Self-injurious Behaviour
Nonsuicidal Self-Injury (NSSI) is being increasingly regarded as a separate psychiatric disorder. Since the latest Diagnostic and Statistical Manual of Mental Disorders - DSM-5 from 2013 defined NSSI as a separate diagnosis under…
- Trial name
- NCT05563324
- Testing
- DNA extraction and genotyping of candidate genetic polymorphisms, self-assessment questionnaires
- Volunteers
- 234 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Maribor
Postsurgical Hypothyroidism, Hypothyroidism
Is Levothyroxine Alone Adequate Thyroid Hormone Replacement?
Patients taking thyroid hormone replacement after thyroid removal surgery often report feeling differently than they did prior to taking thyroid hormone.
- Trial name
- NCT02567877
- Testing
- thyroidectomy, levothyroxine in thyroidectomy patients
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Colorado, Denver
Colorectal Cancer, Non-Small Cell Lung Cancer
Single Nucleotide Polymorphism(SNP)Study. ICORG 08-40, V4
Primary Objective: Correlation of the skin and/or eye toxicity grade secondary to Cetuximab or Panitumumab and the SNP profile of the Epidermal Growth Factor Receptor (EGFR) domain III region.
- Trial name
- NCT01726309
- Where
- 10 sites in Ireland
- Volunteers
- 161 people
- Sponsor
- Cancer Trials Ireland
Infertility, Female, AMH
AMHR2 Polymorphism in Blood and Granulosa Cells in Unexplained Infertility
There are various known parameters for assessing ovarian reserve, including ovarian volume, antral follicle count, follicle stimulating hormone (FSH) and Inhibin B at the beginning of the menstrual cycle, as well as…
- Conditions
- Infertility, Female, AMH, IVF
- Trial name
- NCT05592730
- Testing
- AMHR2 polymorphism in blood, AMHR2 polymorphism in granulosa cell
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Obesity, Insulin Resistance
Apelin Levels and G212A Polymorphism of Apelin Receptor (APJ)
The aim of this study is to investigate serum apelin levels as well as their possible association with G212A polymorphism of the apelin receptor in obese children and adolescents.
- Conditions
- Obesity, Insulin Resistance, Diabetes Mellitus Type 2
- Trial name
- NCT01121172
- Where
- Greece
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Overweight and Obesity
Polymorphism C677T MTHFR and Effects of Folate Intake
The C677T polymorphism in the MTHFR gene is related to several significant biochemical changes, as dyslipidemia, changes in serum levels of homocysteine, folic acid, vitamin B12 and some oxidative stress markers such as the CAT…
- Trial name
- NCT02953522
- Testing
- 191 mcg/day of Folate, 90 mcg / day of Folate
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Federal University of Paraíba
Spinal Osteochondrosis
Genetic Polymorphisms Associated With Vertebral Osteochondrosis
The present study is proposed for the identification of phenotype, biochemical and genetic markers in adult symptomatic spinal osteochondrosis to promote the early diagnosis of this pathological condition and to establish…
- Trial name
- OSTEOGEN (NCT04195529)
- Testing
- presence of genetic variants
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Sepsis, Systemic Inflammatory Response Syndrome
IL8 Monitoring and Its Correlation With 251-gene Polymorphism
One hundred eighty critically ill African adult intensive care patients divided into two groups, eighty septic critically ill patients (sepsis group) while, eighty non-septic critically ill patients (SIRS) group.
- Trial name
- NCT01708759
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Tanta University
Esophageal Cancer, Gastric (Cardia, Body) Cancer
Esophageal Cancer Genetics Studies
The overall goal of this project is to understand the role of genetics in the etiology and prevention of upper gastrointestinal cancer, primarily esophageal cancer, but also cancers of the gastric cardia and body.
- Trial name
- NCT00341276
- Where
- 2 sites in China
- Volunteers
- 7,705 people
- Sponsor
- National Cancer Institute (NCI)
Liver Transplantation
Clinical Outcome of Liver Transplant Patients With Tacrolimus-based Immunosuppression
Genetic polymorphism and numerous clinical factors could influence tacrolimus pharmacokinetics, which led to large inter-and intra-individual variability.Since its narrow therapeutic range,predicting therapeutic outcome and…
- Trial name
- NCT03800576
- Where
- Taiwan
- Volunteers
- 113 people
- Sponsor
- National Taiwan University Hospital