Clinical trials: Genetic Polymorphism
Healthy
Investigation of Drug-drug Interaction Between Clopidogrel and Fluoxetine
Clopidogrel is a platelet aggregation inhibitor witch prevents thrombotic events in patients with atherosclerotic vascular disease. To date, 4 to 30 % of patients are considered as poor, low or non-responder to this therapeutic.
- Trial name
- PLATINE (NCT00732290)
- Testing
- Clopidogrel then fluoxetine+clopidogrel, Fluoxetine+clopidogrel then clopidogrel
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Huntington Disease
Frequency of Selected Single Nucleotide Polymorphisms in Huntington Disease Gene Expansion Carriers
For participation in this epidemiological study, a single-day visit at the study site is required. Participants will be recruited from Huntington Disease clinics, and they will be asked to answer questions regarding their…
- Trial name
- NCT06667414
- Where
- 45 sites in United States, Argentina and 10 more
- Volunteers
- 574 people
- Sponsor
- Hoffmann-La Roche
Post-cesarean Pain, CYP2D6 Polymorphism
The Impact of CYP2D6 Polymorphism on Tramadol Pharmacodynamics
CYP2D6 is an enzyme involved in the hepatic metabolism of many clinically important drugs: antiarrhythmics, antidepressants, antipsychotics, β-blockers, and analgesics such as tramadol and codeine.
- Conditions
- Post-cesarean Pain, CYP2D6 Polymorphism, Tramadol Resistance
- Trial name
- NCT06814652
- Testing
- Trodon® Hemofarm
- Where
- Iraq
- Volunteers
- 40 people
- Sponsor
- Elweyia Maternity Teaching Hospital
Primary Open Angle Glaucoma (POAG)
Association Between Matrix Metalloproteinase-9 Gene Polymorphism and Susceptibility to Primary Open Angle Glaucoma Patients in Sohag University Hospital
The goal of this observational study is to investigate the potential association between MMP-9 gene polymorphism and susceptibility to Primary Open Angle Glaucoma development in Egyptian patients The main question it aims to
- Trial name
- NCT07119905
- Testing
- genotyping assay by polymerase chain reaction
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sohag University
Parkinson Disease
Trodat 1 SPECT and Dopamine Polymorphism
The study population will include 100 parkinsonian patients in early stage of disease, with total duration not exeeding 5 years.
- Trial name
- NCT01381302
- Where
- 2 sites in Israel
- Volunteers
- 90 people
- Sponsor
- Wolfson Medical Center
Heart Failure
The Impact of Genetic Polymorphism on the Echocardiographic Parameters and Cardiac Fibrosis Markers in Response to Empagliflozin Treatment Among Patients With Heart Failure
It is important to assess the implications of genetic variants of the TGF-β1 gene in patients with HFrEF and the association of this polymorphism with treatment response to SGLT2I.
- Trial name
- NCT06503601
- Where
- Egypt
- Volunteers
- 92 people
- Sponsor
- Ain Shams University
Breast Cancer
A Pilot Study of Varying Doses of Tamoxifen in the Setting of Genetic Polymorphisms of CYP2D6
The investigators plan to examine endoxifen and 4-OH-Tam as a function of the tamoxifen dose in patients with a genetic CYP2D6 polymorphism.
- Trial name
- NCT00900744
- Testing
- Tamoxifen
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Chronic Hepatitis C
A Randomized Trial of 24-Week Versus 48-Week Courses of Peginterferon Plus Ribavirin for Patients With Genotype 1 Hepatitis C and IL28B CC Polymorphism
Patients with HCV genotype 1 and IL28B CC Polymorphism who have a rapid virological response to treatment are randomised to either 24 or 48 weeks HCV treatment.
- Trial name
- NCT01441804
- Testing
- Peginterferon alfa2a, Ribavirin
- Where
- 4 sites in China
- Volunteers
- 200 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Gastric Adenocarcinoma
Using Genetic Polymorphisms to Predict the Efficacy and Toxicity - A Gastric Adenocarcinoma Study
This is an open-label, non-comparative phase II study of sequential capecitabine plus oxaliplatin followed by docetaxel plus capecitabine in patients with unresectable gastric adenocarcinoma.
- Trial name
- NCT01558011
- Testing
- Capecitabine, Oxaliplatin, Docetaxel
- Where
- Taiwan
- Volunteers
- 51 people
- Sponsor
- National Health Research Institutes, Taiwan
Rheumatoid Arthritis
The Genetic and the Functional Study of DNA Repair System and the Susceptibility to Rheumatoid Arthritis
This study is valuable for the understanding the role of DNA repair system plays in the progression of rheumatoid arthritis and for the development of new therapeutic modality in the future.
- Trial name
- NCT01285336
- Where
- Taiwan
- Volunteers
- healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Hyperkalemia, Chronic Renal Failure
Genetic Determinants of the Hypokalemic and Hyperglycemic Effect of Albuterol Inhalation
Several studies have indicated that albuterol administered either intravenously or by inhalation can significantly reduce plasma potassium concentration in patients suffering from chronic renal failure.In conjunction with the…
- Trial name
- NCT00162487
- Testing
- Albuterol (1,200 μg) through metered-dose inhaler
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Hadassah Medical Organization
Epilepsy, Seizures
Genetic Markers of Cardiovascular Disease in Epilepsy
Epilepsy is a common condition which affects over 3 million people in the US. Patients with uncontrolled epilepsy have a lifetime risk of sudden unexpected death (SUDEP) of 35%, which is greatest in those under 40 years of age.
- Conditions
- Epilepsy, Seizures, Syncope, Channelopathy
- Trial name
- NCT02824822
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Mayo Clinic
Parkinson's Disease
Genetic Polymorphism and Parkinson's Disease in Taiwanese
To observe and analyze the correlation between Single Nucleotide polymorphisms (SNPs) and the incidence of Parkinson's disease in Taiwanese.
- Trial name
- NCT01996878
- Where
- Taiwan
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- Changhua Christian Hospital
Thyroid Disease, Healthy
Pharmacogenomic Response to Thyrotropin-Releasing Hormone Stimulation in Healthy Volunteers: The Influence of a Common Type 2 Deiodinase Genetic Polymorphism on Serum T3
This study intends to examine how a common genetic pattern affects thyroid function. Recent studies have demonstrated that a substance (enzyme) produced by a gene has an important role in controlling circulating thyroid hormone…
- Trial name
- NCT00812149
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Hypertension
Effects of Sildenafil in Resistant Hypertensives and Genetic Polymorphism
Sildenafil citrate slightly reduces blood pressure in treated hypertensives patients. However, it is unknown if the simultaneous use of sildenafil plus, at least, 3 classes of antihypertensive agents in patients with resistant…
- Trial name
- NCT01392638
- Testing
- sugar pill, sildenafil
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- University of Campinas, Brazil
Colorectal Cancer, Capecitabine
Discovery and Validate of Multi-genetic Biomarkers for Capecitabine in Chinese Colorectal Patients
At present, chemotherapy is widely used in the adjuvant treatment of colorectal cancer patients after surgery. Capecitabine is one of the main chemotherapeutic drugs.
- Trial name
- NCT03030508
- Testing
- No intervention
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shanghai Changzheng Hospital
ICD, Arrythmia
Genome-Wide Association Study With the Aim of Implantable Cardioverter Defibrillator Implantation Genophenotypic Risk Stratification
This clinical study will be conducted with funding from European Innovation Council(EIC) after approval of the fund grant and is part of our organization's European Pathfinder Project(Ref…
- Conditions
- ICD, Arrythmia, Sudden Cardiac Death
- Trial name
- ICDGPSS (NCT05582252)
- Testing
- Non-Invasive saliva sampling
- Where
- Turkey (Türkiye)
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Renal Transplant
Influence of Genes on Sirolimus Metabolism in Patients With Kidney Transplantation
This study will evaluate the effects of certain genes (MDR-1, CYP3A4, and CYP3A5) on metabolism of the drug sirolimus, an immune-suppressing drug given to transplant recipients to prevent organ rejection.
- Trial name
- NCT00352547
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Allergic Conjunctivitis
The Role of Vitamin D in Corneal Epithelial Barrier Function, Ocular Microbiome, Ocular Inflammation, and Visual Acuity of Children With Allergic Conjunctivitis
A double-blind study to evaluate the role of vitamin D in corneal epithelial barrier function, ocular microbiome, ocular inflammation, and visual acuity of children with allergic conjunctivitis.
- Trial name
- NCT05839938
- Testing
- Vitamin D
- Where
- Taiwan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Severe Periodontitis, Risk Factors
Risk Factors for Severe Periodontitis in 30 to 40 Year Olds: a Retrospective Study
Periodontitis is one of the most common oral diseases, which is characterized by alveolar bone resorption and destruction. In China, as a major country in the incidence of periodontitis, there is a huge population of patients…
- Conditions
- Severe Periodontitis, Risk Factors, Gene Polymorphism
- Trial name
- NCT04960774
- Testing
- Observational study, no intervention
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine