Clinical trials: Genetic Polymorphism
CYP1A2 Polymorphism, Caffeine and Resistance Training
Caffeine, CYPA12 and Resistance Training
Introduction: Several studies have evaluated and confirmed the ergogenic effect of acute caffeine intake on sports performance, specifically on strength and power performance.
- Trial name
- NCT06610123
- Testing
- Caffeine and Resistance training
- Where
- Spain
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Alcala
Cholestasis of Pregnancy
Genetic Polymorphisms of ABCB11 and ABCB4 in Women With Intrahepatic Cholestasis of Pregnancy (ICP) and in Their First Degree Relatives
To assess the occurrence of 11 SNP's in ABCB11 and ABCB4 genes in Greek women with ICP compared with healthy pregnant women. Moreover, these genetic polymorphisms will be examined in their first-degree relatives.
- Trial name
- NCT04281082
- Testing
- ursofalk
- Where
- Greece
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Alexandra Hospital, Athens, Greece
Thyroid Cancer
Salivary dysfuncTion After Radioiodine Treatment
Aim/Introduction: The treatment of differentiated thyroid cancer includes generally a total thyroidectomy, followed by a radioiodine (131I)-therapy.
- Trial name
- START (NCT04876287)
- Testing
- Radioiodine
- Where
- France
- Volunteers
- 138 people
- Sponsor
- French Nuclear Safety and Radiation Protection Authority (ASNR)
Inherited Cardiac Arrythmias, Long QT Syndrome (LQTS)
Derivation of Human Induced Pluripotent Stem (iPS) Cells to Heritable Cardiac Arrhythmias
Human induced pluripotent stem cells (hiPSCs) have driven a paradigm shift in the modeling of human disease; the ability to reprogram patient-specific cells holds the promise of an enhanced understanding of disease mechanisms and…
- Conditions
- Inherited Cardiac Arrythmias, Long QT Syndrome (LQTS), Brugada Syndrome (BrS), Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)
- Trial name
- NCT02413450
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Childhood Cancer, Genetic Predisposition
Genetic Risks for Childhood Cancer Complications in Switzerland
The objectives of the GECCOS project are to identify genetic variants associated with complications of childhood cancer using genotype-phenotype association studies.
- Conditions
- Childhood Cancer, Genetic Predisposition, Late Effect
- Trial name
- GECCOS (NCT04702321)
- Testing
- Procedure: Biospecimen Collection, Procedure: Medical Chart Review
- Where
- Switzerland
- Volunteers
- 6,000 people
- Sponsor
- University Hospital, Geneva
Exercise Training, Genetic Polymorphism
Effects of Exercise Training and Genetic Factors in Hypertensive Patients with Obstructive Sleep Apnea Sleep
The objective is to investigate the effects of exercise training in hypertensive individuals with obstructive sleep apnea (OSA) in neurovascular control taking into account genetic factors.
- Trial name
- NCT06687863
- Testing
- Exercise training
- Where
- Brazil
- Volunteers
- 72 people
- Sponsor
- University of Sao Paulo General Hospital
Polycystic Ovary Syndrome
71A/G HSD17B5 SNP and Effects of Oral Contraceptive Pill in PCOS Women
An association of the single nucleotide polymorphism (SNP) in the promoter gene that codify for 17b-HSD5 enzyme (71A>G) with polycystic ovary syndrome (PCOS) and hyperandrogenemia has been suggested in previous studies.
- Trial name
- 17b-ACO (NCT01372293)
- Testing
- oral contraceptive pill
- Volunteers
- 49 people
- Sponsor
- Federal University of Rio Grande do Sul
Diabetes Mellitus
SNP Study of DPP-4 and GLP-1R in Chinese People (Including Diabetes Patients)
Incretin-based therapy is currently one of the most popular diabetes treatment approaches. However, differences of response ware found in previous studies.
- Trial name
- NCT03108521
- Testing
- Sitagliptin
- Where
- China
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Sichuan Provincial People's Hospital
Coronary Artery Disease, Cardiovascular Risk Factor
Correlation of Genetic Polymorphisms and Clinical Parameters With the Complexity of Coronary Artery Disease
The purpose of the research project is to investigate the potential association of 6 genetic polymorphisms with the complexity and the severity of coronary artery disease (SYNTAX score).
- Conditions
- Coronary Artery Disease, Cardiovascular Risk Factor, Coronary Arteriosclerosis
- Trial name
- NCT03315234
- Testing
- SNPs associated with CAD
- Where
- Greece
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
antimüllerian Hormone and Gonadotrophin Receptor Polymorphism as Predictors of Ovarian Response
Impact of Gonadotrophin REceptor Polimorphisms on the Relationship Between Serum AMH and Ovarian Response
Aim of study: To compare the relationship between serum AMH and ovarian response for IVF with the GnRH antagonist protocol in patients who are carriers of FSH and/or LH receptor polymorphisms with those that are not.
- Trial name
- GREPAMOR (NCT03388099)
- Where
- Spain
- Volunteers
- 296 people
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Cardiovascular Disease, Type 2 Diabetes
Moderate Alcohol Consumption, Risk of Cardiovascular Disease and Type 2 Diabetes: Influence of Alcohol Oxidation
Moderate alcohol consumption is associated with a decreased risk of cardiovascular disease and type 2 diabetes. The association of alcohol consumption with cardiovascular disease is mediated by a functional polymorphism of…
- Trial name
- NCT00285909
- Testing
- Alcohol: 25 gday (white wine)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- TNO
Pulmonary Tuberculosis
Randomized Trial for Pharmacogenomics-based Tuberculosis Therapy (RT-PGTT)
The purpose of this study is to elucidate whether the individualized medicine based on NAT2 gene polymorphism could improve the safety, efficacy and economical benefits of multi-drug therapy for the pulmonary tuberculosis with…
- Trial name
- NCT00298870
- Testing
- Isoniazid, isoniazed
- Where
- 4 sites in Japan
- Volunteers
- 172 people
- Sponsor
- Osaka University
ITP - Immune Thrombocytopenia
"Cytotoxic T Lymphocyte-Associated Antigen-4 (CTLA-4) Gene Single-nucleotide Polymorphism in Primary Immune Thrombocytopenic Purpura in Children"
the investigators aim in this study to investigate the potential association of single gene polymorphisms of CTLA-4 (SNPs; rs: 3087243) using real-time PCR in children with primary ITP.
- Trial name
- ITP (NCT07014904)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sohag University
Diabetic Nephropathies
TCF7L2 Gene Polymorphism and AGEs in Diabetic Nephropathy
1. To study genotypic distribution of the TCF7L2 gene polymorphism in Diabetic nephropathy. 2. To assess level of AGEs and Insulin in patients with Diabetic nephropathy. 3.
- Trial name
- NCT04084886
- Volunteers
- 100 people
- Sponsor
- Assiut University
In Vitro Fertilization, Controlled Ovarian Stimulation
N680S Polymorphism of the FSHR Gene and Its Relationship With the Type of Gonadotropin Used in COS
This project wants to determinate whether there is a relationship between the N680S polymorphism genotype of the FSHR gene and the nature of the FSH used in controlled ovarian stimulation.
- Trial name
- NCT04122729
- Where
- 12 sites in Spain
- Volunteers
- 300 people
- Sponsor
- Angelini Farmacéutica
Polymorphism, mRNA Expression
Polymorphids an mRNA Expression in Obese Genes
Fat tissue from omenta, thigh and abdomen taken under anesthesia on subjects undergoing laparoscopic surgery, cholecystectomy, reflux surgery or gastric by-pass (GBP).
- Trial name
- NCT01708083
- Where
- 2 sites in Sweden
- Volunteers
- 50 people
- Sponsor
- Karolinska Institutet
Schizophrenia
Genes Polymorphisms and Metabolic Effects of the Second Generation Antipsychotic Drugs in Patients With Schizophrenia
The purpose of the study is to investigate these effects of Second-Generation Antipsychotic (SGAs) on glucose and lipid metabolic parameters in patients with schizophrenia, and explore the relationship between genes polymorphisms…
- Trial name
- NCT02964923
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Xijing Hospital
Fabry, Renal Disease
Relation Between Polymorphism in Genes Related to Kidney Disease and Renal Manifistations in Fabry Disease
The rational of the study is to try to predict which of the patients who suffer from Fabry disease will have End Stage Renal Disease.
- Trial name
- NCT00437944
- Volunteers
- healthy volunteers welcome
- Sponsor
- Shaare Zedek Medical Center
Healthy
Pharmacokinetic/Pharmacodynamic Study of Ilaprazole to Evaluate the Effect of CYP Genetic Polymorphism
Ilaprazole is a novel proton pump inhibitor and metabolized by CYP3A4 and 2C19. Thus genetic polymorphisms of CYP3A4 and 2C19 may have effect on the pharmacokinetics and pharmacodynamics of Ilaprazole.
- Trial name
- NCT01688544
- Testing
- Ilaprazole
- Where
- South Korea
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Inje University
Genetic Predisposition to Disease
Immunogenetics Predictors With COVID-19
Background: There is a current worldwide outbreak of the novel coronavirus Covid-19 which originated from Wuhan in China and has now spread to 6 continents including 210 countries.
- Trial name
- NCT04390269
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Mansoura University