Clinical trials: Genetic Polymorphism
Asthma, Inflammation
Pathogenesis and Genetics of Environmental Asthma Ozone Study
The goals of the research are designed to accomplish genetic association studies of candidate genes in healthy normal individuals exposed to 0.2 ppm for 2.25 hours with intermittent exercise in order to search for associations…
- Trial name
- NCT00574158
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Nephrolithiasis
Genetic Determinants of Opioids Analgesia
The response to opioids varies greatly among individuals. Some of these variability is accounted for by genetic factors. The present study was designed to evaluate the possibility that genetic polymorphism in the gene encoding…
- Trial name
- NCT00226564
- Testing
- Alfentanil
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Hadassah Medical Organization
Depression
Childhood Adversity, Genetic Polymorphisms and Stress in First Onset Major Depression
The Blue Sky Project, a 5-year study funded by the Canadian Institutes of Health Research, seeks to examine how genetics and early life experiences work together to cause a person's very first onset of depression by increasing…
- Trial name
- NCT00517764
- Testing
- escitalopram
- Where
- 2 sites in Canada
- Volunteers
- 299 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Healthy Volunteers
Platform for Clinical Trials in Nutrition and Health
Despite the known link between dietary patterns and disease, it has been observed that the specific response of each individual to dietary components highly varied, and this may limit the impact of the nutritional interventions…
- Trial name
- GENYALPlatform (NCT04067921)
- Where
- Spain
- Volunteers
- 1,963 people
- Sponsor
- IMDEA Food
Guillain-Barré Syndrome, Miller Fisher Syndrome
International Guillain-Barré Syndrome Outcome Study
International GBS Outcome Study (IGOS) is a study conducted by the members of the Inflammatory Neuropathy Consortium (INC) and Peripheral Nerve Society (PNS) on disease course and outcome in Guillain-Barré syndrome (GBS).
- Trial name
- IGOS (NCT01582763)
- Where
- 138 sites in United States, Argentina and 19 more
- Volunteers
- 2,000 people
- Sponsor
- Erasmus Medical Center
Metastatic Colorectal Cancer
Escalated Dose of Irinotecan in mCRC
Metastatic diseases were found in 20-25% of patients with initial diagnosis of colorectal cancer and developed in up to 50% of patients.
- Trial name
- NCT02256800
- Testing
- UGT1A1 genotyping (6,6), UGTIA1 genotyping (6,7), UGTIA1 genotyping (7,7)
- Where
- Taiwan
- Volunteers
- 213 people
- Sponsor
- Jaw-Yuan Wang, MD, PhD
Immune Thrombocytopenic Purpura
" Effect of Single-nucleotide Polymorphism of CD40 Gene rs1883832 C/T on the Risk of Immune Thrombocytopenic Purpura "
Immune thrombocytopenia is an acquired autoimmune disease, in which platelets are opsonized by auto-antibodies and destroyed by phagocytic cells .Genetic polymorphisms in the immune mediators have been suggested to play a pivotal…
- Trial name
- NCT05585944
- Testing
- Genotyping of rs1883832C/T related single-nucleotide polymorphism
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sohag University
Breast Cancer, Metastatic Breast Cancer
Impact of Genetic Variants on the Toxicity of Antibody-Drug Conjugates in Locally Advanced or Metastatic Breast Cancer: The Role of the UGT1A1 Gene as a Predictive Biomarker of Therapeutic Response
The metabolism of anticancer drugs is influenced by genetic variants that affect their bioavailability and toxicity. In the case of antibody-drug conjugates (ADCs), such as sacituzumab-govitecan (SG), trastuzumab-deruxtecan…
- Conditions
- Breast Cancer, Metastatic Breast Cancer, Drug-Related Side Effects and Adverse Reactions, Pharmacogenetic Variant
- Trial name
- NCT07582887
- Testing
- Sacituzumab Govitecan, Trastuzumab deruxtecan, Datopotamab Deruxtecan
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- Fundación Pública Andaluza para la Investigación Biomédica Andalucía Oriental
Hodgkin's Lymphoma, Non-Hodgkin's Lymphoma
SNP-Based Prediction of Oral Mucositis Risk in Patients Receiving Hematopoietic Stem Cell Transplants (HSCT)
The goal of this study is to gain new knowledge about genetic risk factors thta may affect the development of mucositis, the chemotherapy-induced sores in the mouth and esophagus following HSCT.
- Conditions
- Hodgkin's Lymphoma, Non-Hodgkin's Lymphoma, Multiple Myeloma
- Trial name
- NCT01402687
- Where
- United States
- Volunteers
- 181 people
- Sponsor
- Dana-Farber Cancer Institute
Heart Failure
Evaluation of Clinical and Genetic Modifiers of Long-term Survival in Heart Failure
The purpose of this study is to evaluate the beta-adrenergic receptor gene polymorphisms in the long-term effects of beta-blockade in patients with chronic heart failure.
- Trial name
- NCT03461107
- Testing
- No intervention
- Where
- China
- Volunteers
- 2,500 people
- Sponsor
- Tongji Hospital
Age-Related Macular Degeneration
Vascular Endothelial Growth Factor (VEGF) & LOC387715/HTRA1 Polymorphism in Polypoidal Choroidal Vasculopathy
This study is to investigate whether there is an association of the LOC387715/HTRA1 and vascular endothelial growth factor polymorphism with response to treatment with intravitreal ranibizumab injections for patients with…
- Trial name
- NCT01233128
- Where
- South Korea
- Volunteers
- 121 people
- Sponsor
- Kyungpook National University Hospital
Melanoma, Genetic Polymorphism
Multicentric Cohort of Melanoma Patients in Ile de France Area
This is a multicentric prospective cohort of all stage melanoma patients from AP-HP ,the largest consortium of University hospitals over Europe.
- Trial name
- Melan-Cohort (NCT00839410)
- Where
- France
- Volunteers
- 1,255 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Deep Venous Thromboembolism
The Association of Warfarin Dosage and Plasma Enantiomer Concentration With the Gene Polymorphisms of CYP and VKOR
Oral warfarin anticogulation for the prevention and treatment of patients with venous thromboembolism is one of the most used therapies in clinical practice.
- Trial name
- NCT00247702
- Testing
- warfarin
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Taiwan University Hospital
Coronary Heart Disease
Peking University & University of Michigan Study of MI and Atherosclerosis
Coronary heart disease and myocardial infarction have become a major threat to the health of our people. Their incidence rate and mortality rate are still rising. Dyslipidemia is one of the important risk factors.
- Trial name
- PUUMA (NCT04950699)
- Testing
- Single-nucleotide Polymorphism of genes related with Dyslipidemia
- Volunteers
- 4,700 people
- Sponsor
- Peking University Third Hospital
Obesity, Insulin Resistance
Apelin Levels and G212A Polymorphism of Apelin Receptor (APJ)
The aim of this study is to investigate serum apelin levels as well as their possible association with G212A polymorphism of the apelin receptor in obese children and adolescents.
- Conditions
- Obesity, Insulin Resistance, Diabetes Mellitus Type 2
- Trial name
- NCT01121172
- Where
- Greece
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Pharmacokinetic Study in Healthy Volunteers
Evaluation of Solanidine as an Exogenous Biomarker to Phenotype CYP2D6 Activity in Humans
This study investigates the evaluation of solanidine as an exogenous biomarker to phenotype CYP2D6-activity in humans. Participants will be classified by their CYP2D6 genotype into poor metabolizers (PM), low intermediate…
- Trial name
- SOLA-1 (NCT07817030)
- Testing
- Yohimbine, Consumption of a defined potato-rich meal
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Interaction
Contribution of UGT2B17 to the Pharmacokinetics of Diclofenac
The purpose of this pilot study is to gather preliminary data on the (1) contribution of the understudied drug metabolizing enzyme, UDP-glucuronosyltransferase (UGT) 2B17, to the metabolism of a widely used medication…
- Trial name
- NCT06053411
- Testing
- Diclofenac, curcumin
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Washington State University
Hepatocellular Carcinoma
The Assesment of MMP-1 Genotypes Polymorphism as a Risk Factor for HCC in Chronic HCV Patients With LC
Egypt is an endemic area of HCV.Cirrhosis and HCC are the most serious complications of chronic HCV infection.Some studies noted that the risk of HCC increased 17-fold among HCV-infected patients compared with anti-HCV negative…
- Trial name
- NCT03722628
- Testing
- MMP1 genotypes polymorphism
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Assiut University
Nonsmall Cell Lung Cancer, EGFR Gene Mutation
EGFR-TKI With/Without Chemotherapy in NSCLC Patients With Both EGFR Mutation and BIM Deletion Polymorphism
BIM deletion polymorphism might be associated with a poor clinical response to EGFR-TKIs in patients who had NSCLC with EGFR mutations.
- Trial name
- NCT03002844
- Testing
- EGFR-TK Inhibitor, EGFR-TKI, EGFR-TKI and Chemotherapy
- Volunteers
- 50 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Mammography
Single Nucleotide Polymorphism (SNP) Panels and Risk Assessment in Women Undergoing Mammography
The primary objective is to compare the predicted lifetime risk values produced by SNP panel assessment to the risk values produced by the prediction models that are most commonly used.
- Trial name
- NCT01124019
- Where
- United States
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Abramson Cancer Center at Penn Medicine