Clinical trials: Genetic Polymorphism
Acute Coronary Syndromes
PRAsugrel or clopIdogrel In Acute Coronary SyndromE With CYP2C19 GENEtic Variants
The investigators hypothesize that reduced loading dose of prasugrel followed by reduced maintenance dose of prasugrel in acute coronary syndrome patients with CYP2C19 polymorphism undergoing percutaneous coronary intervention…
- Trial name
- PRAISE-GENE (NCT01641510)
- Testing
- Prasugrel, Clopidogrel
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- Dong-A University
Cytochrome P450 CYP2D6 Enzyme Deficiency, Poor Metabolizer Due to Cytochrome P450 CYP2D6 Variant
Drug & Gene Interaction Risk Analysis With & Without Genetic Testing Among Patients Undergoing MTM
This randomized controlled trial will evaluate whether the use of pharmacogenetic testing through a Medication Therapy Management (MTM) program has a beneficial impact on drug therapy problems.
- Conditions
- Cytochrome P450 CYP2D6 Enzyme Deficiency, Poor Metabolizer Due to Cytochrome P450 CYP2D6 Variant, Ultrarapid Metabolizer Due to Cytochrome P450 CYP2D6 Variant, Extensive Metabolizer Due to Cytochrome P450 CYP2D6 Variant
- Trial name
- NCT02428660
- Testing
- Pharmacogenetic testing, Software-based drug & gene interaction risk analysis, MTM
- Where
- United States
- Volunteers
- 341 people
- Sponsor
- Genelex Corporation
Colorectal Cancer
Irinotecan in Treating Patients With Colorectal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of irinotecan in treating patients who have colorectal…
- Trial name
- NCT00003843
- Testing
- irinotecan hydrochloride, mutation analysis, polymorphism analysis
- Where
- 3 sites in United States
- Volunteers
- 28 people
- Sponsor
- California Cancer Consortium
Pseudoexfoliation Syndrome
LOXL1 Polymorphism in Pseudoexfoliation Syndrome
To evaluate the association profiles of the lysyl oxidase-like 1 gene polymorphisms with pseudoexfoliation syndrome in the Korean population, Genotypes of lysyl oxidase-like 1 gene were analyzed by direct sequencing.
- Trial name
- NCT01515735
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Samsung Medical Center
Gestational Diabetes Mellitus (GDM), Pregnancy
Effect of an Early and Intensified Nutritional Intervention on the Risk of Developing Gestational Diabetes Mellitus
The goal of this clinical trial is to learn if a nutritional intervention based on a Mediterranean diet (MedDiet), initiated early in pregnancy, reduces the incidence of gestational diabetes mellitus (GDM) and other adverse…
- Conditions
- Gestational Diabetes Mellitus (GDM), Pregnancy, Mediterranean Diet
- Trial name
- MedDiet in GDM (NCT07817017)
- Testing
- Nutritional intervention based on a Mediterranean diet
- Where
- Spain
- Volunteers
- 1,200 people
- Sponsor
- Hospital San Carlos, Madrid
Severe Periodontitis, Risk Factors
Risk Factors for Severe Periodontitis in 30 to 40 Year Olds: a Retrospective Study
Periodontitis is one of the most common oral diseases, which is characterized by alveolar bone resorption and destruction. In China, as a major country in the incidence of periodontitis, there is a huge population of patients…
- Conditions
- Severe Periodontitis, Risk Factors, Gene Polymorphism
- Trial name
- NCT04960774
- Testing
- Observational study, no intervention
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Hyperhomocysteinemia, Hyperlipoproteinemias
Evaluating the Impact of B Vitamin Supplementation (Soloways™) on Homocysteine and LDL-C Levels in Patients With MTHFR, MTR, and MTRR Polymorphisms.
This randomized, double-blind, placebo-controlled trial will evaluate the impact of methylfolate, pyridoxal-5'-phosphate (P5P), and methylcobalamin supplementation on homocysteine and LDL-C levels in individuals with low to…
- Trial name
- VITAGEN-H (NCT06163443)
- Testing
- Vitamin B
- Where
- Russia
- Volunteers
- 54 people
- Sponsor
- S.LAB (SOLOWAYS)
Type1diabetes
The Relationship of RAGE Gene Polymorphism With Type I Diabetes in Egyptian Patients
Type I Diabetes Mellitus (TIDM) is a chronic metabolic disorder caused by the immune-mediated T-cell and macrophages that typically affects insulin-producing β-cells of Langerhans leading to cell destruction and absolute insulin…
- Trial name
- NCT05874323
- Testing
- Detection of RAGE gene polymorphism (rs1800625)
- Where
- Egypt
- Volunteers
- 354 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Safety of Long Acting Beta Agnoists
Effect of Gly16Arg Polymorphism in ADRB2 Gene on Asthma Control in Children Receiving Long Acting Beta Agonists
Asthma is the most common chronic disease of childhood affecting 6.2 million children between 2 and 18 years of age, and is the most common cause of school absenteeism due to chronic disease.
- Trial name
- NCT01108627
- Testing
- open-labeled inhaled corticosteroids (ICS); FORADIL® AEROLIZER®, foradil
- Sponsor
- Nemours Children's Clinic
Polymorphism-Genetic, Amputation
Genetics and Phantom Limb Pain
Background: Many people who lose a limb feel pain in the missing limb. This feeling is called phantom limb pain. Researchers do not fully understand what causes this pain. Differences in people's genes may play a role.
- Conditions
- Polymorphism-Genetic, Amputation, Pain
- Trial name
- NCT01517061
- Sponsor
- National Institute of Nursing Research (NINR)
Gastric Cancer, Esophageal Cancer
Pharmacokinetic and Pharmacodynamic Study of S-1 in Patients With Digestive Organ Cancer
S-1 is a novel oral fluorouracil antitumor drug that consists of tegafur which is a prodrug of 5-fluorouracil (5-FU); 5-chloro-2,4-dihydropyridine (CDHP), which inhibits dihydropyrimidine dehydrogenase (DPD) activity; and…
- Conditions
- Gastric Cancer, Esophageal Cancer, Pancreatic Cancer, Colon Cancer
- Trial name
- NCT00197431
- Testing
- S-1
- Where
- Japan
- Sponsor
- Hamamatsu University
Hypertensive Disorder of Pregnancy, Vitamin D Deficiency
Vitamin D Deficiency With Selected Vitamin D Receptor Gene Polymorphism in Gestational Hypertension
This study aim to look into the prevalence of Vitamin D deficiency among Malaysian pregnant women and its associated risk factors.
- Trial name
- NCT05659173
- Testing
- Blood taking
- Where
- Malaysia
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Universiti Putra Malaysia
DAO Genetic Variants
Prevalence of DAO (diamino Oxidase) Deficiency in Newborns
Observational study to estimate the prevalence of genetic DAO deficiency in the population.
- Trial name
- DAO-NEO-2022 (NCT06710366)
- Where
- Spain
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- AB Biotek
Crohn's Disease
An Analysis of the Relationship Between the Genetic Polymorphisms of Interleukin 12 Receptor Subunit Beta 1 and Crohn's Disease in Chinese Patients
From January 2018 to May 2025, diagnosed CD patients and gender- and age-matched normal controls were collected from Department of Gastroenterology, the Second Affiliated Hospital of Wenzhou Medical University.
- Trial name
- NCT07057856
- Testing
- Ustekinumab (UST)
- Where
- China
- Volunteers
- 866 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Blastocystis Infections
Molecular Characterization of Blastocystis Isolates From Human by Restriction Fragment Length Polymorphism (RFLP) Analysis
Blastocystis is an anaerobic unicellular protozoal parasite infecting the gastrointestinal tract of humans and a wide range of animals.
- Trial name
- NCT05580393
- Testing
- RFLP analysis of SSU rRNA
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis), Polymorphism, Single Nucleotide
The Association Between TNFSF4 Polymorphism and CD
The goal of this observational study is to investigate the associations between tumor necrosis factor superfamily member 4 (TNFSF4) gene polymorphisms and the risk of Crohn's disease (CD), and to elucidate the impact of TNFSF4…
- Conditions
- Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis), Polymorphism, Single Nucleotide, Ustekinumab
- Trial name
- NCT07263464
- Testing
- Ustekinumab - Standard Dosage
- Where
- China
- Volunteers
- 818 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Glucose Homeostasis, Protein Metabolism
The Role of Glucocorticoid Receptor SNPs in Receptor Function and Metabolic Disease
Background: Glucocorticoids are primary stress response hormones released from the adrenal gland when an individual is under stress.
- Conditions
- Glucose Homeostasis, Protein Metabolism, Lipid Metabolism, Respiratory Function
- Trial name
- NCT01143493
- Where
- United States
- Volunteers
- 278 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Post-Infarction Heart Rupture, Gene Polymorphism
PCSK9 Polymorphism and Risk of Cardiac Rupture
Protein convertase subtilisin/kexin type 9 (PCSK9) plays a regulatory role in cholesterol homeostasis by promoting low-density lipoprotein receptor (LDLr) degradation.
- Trial name
- NCT05503095
- Testing
- Genetic analysis for PCSK9 polymorphisms
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Maastricht University Medical Center
In Vitro Fertilization, Controlled Ovarian Stimulation
N680S Polymorphism of the FSHR Gene and Its Relationship With the Type of Gonadotropin Used in COS
This project wants to determinate whether there is a relationship between the N680S polymorphism genotype of the FSHR gene and the nature of the FSH used in controlled ovarian stimulation.
- Trial name
- NCT04122729
- Where
- 12 sites in Spain
- Volunteers
- 300 people
- Sponsor
- Angelini Farmacéutica
Cancer, Breast Cancer
Role of Gene Variation in Effectiveness of Gleevec Treatment
This study will examine DNA from cancer patients previously treated with Gleevec to look for a variation (mutation) of the ABCG2 gene that may render the drug less effective in certain patients.
- Trial name
- NCT00342056
- Where
- 2 sites in United States, Belgium
- Volunteers
- 100 people
- Sponsor
- National Cancer Institute (NCI)