Clinical trials: Genetic Polymorphism
Type 2 Diabetes Mellitus (T2DM), Cognitive Impairment
Exercise and PPARGC1A rs8192678 in Older Adults With Type 2 Diabetes and Cognitive Impairment
This completed single-arm interventional study evaluated changes in metabolic control, cognitive function, and health-related physical fitness following a 12-week combined aerobic and resistance exercise program in older adults…
- Trial name
- Association Be (NCT07711834)
- Testing
- Combined aerobic and resistance exercise
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Harbin Sport University
Long QT Syndrome, Brugada Syndrome
Healthy-related Quality of Life and Physical Activity of Children With Cardiac Malformations
The QUALIMYORYTHM trial is a multicentre controlled study, aiming to assess health-related quality of life (HRQoL) of 107 children aged 6 to 18 years old with inherited cardiac arrhythmia (long QT syndrome, Brugada syndrome…
- Conditions
- Long QT Syndrome, Brugada Syndrome, Catecholaminergic Polymorphic Ventricular Tachycardia, Arrhythmogenic Right Ventricular Dysplasia
- Trial name
- QUALIMYORYTHM (NCT04712136)
- Testing
- MRI
- Where
- France
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Type 1 and 2 Diabetes
Genetic Polymorphisms, Steatosis and Diabetes
Our research hypothesis is to show that a certain number of genetic polymorphisms of the proteins involved in glucose, lipid and adipocyte metabolism are factors that favour the development of steatosis in patients with Type 2…
- Trial name
- NCT02045563
- Testing
- prise de sang, magnetic resonance imaging and magnetic resonance spectroscopy
- Where
- France
- Volunteers
- 507 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
HIV
Preference of Genetic Polymorphism and Pharmacokinetics
Genetic polymorphism affects plasma concentration of antiretroviral therapy in HIV patients. The investigators investigate the prevalence of genetic polymorphism affecting efavirenz metabolism and the corresponding…
- Trial name
- NCT01658371
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Chinese University of Hong Kong
Pelvic Organ Prolapse
Do Patients With Early Post Operative Recurrence of Pelvic Organ Prolapse Have a Genetic Predisposition?
The objective is to explore the genetic predisposition to early pelvic organ prolapse after adequate surgical repair by exploring the association between pelvic organ prolapse recurrences and certain polymorphisms.
- Trial name
- NCT01614587
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Atlantic Health System
Myocardial Infarction, No-Reflow Phenomenon
Genetic Determinants of the Coronary Microvascular Obstruction in PCI
Myocardial infarction (MI) remains one of the most common causes of death. Percutaneous coronary intervention (PCI) is the main treatment option to restore blood flow through the infarction-related coronary artery (IRA) in MI…
- Trial name
- NCT05355532
- Testing
- different variants of SNPs that may be associated with the coronary microvascular obstruction development
- Where
- 2 sites in Russia
- Volunteers
- 80 people
- Sponsor
- Privolzhsky Research Medical University
HIV Infection
Analysis of Genetic Factors Which May Influence the Course of HIV Infection
Patients with HIV an have a variable course of their infection. We are trying to identify factors which worsen or ameliorate the course of the disease.
- Trial name
- NCT00159068
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Deborah Rund
Gene Polymorphism, Edoxaban
Prospective Observational Association Between SLCO1B1 Gene Polymorphism and the Anti-factor Xa Activity of Edoxaban in Patients With Moderate to Severe Renal Insufficiency
1. To provide reference for clinical rational use of edoxaban; 2. Optimize the individualized dosing regimen of edoxaban.
- Conditions
- Gene Polymorphism, Edoxaban, Renal Insufficiency
- Trial name
- NCT06431789
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Yi Han
Psychotic Disorders, Depressive Disorder
Genetics of Symptomatology and Treatment Response in Psychotic Major Depression
We hope to learn more about the biology of psychiatric illness with the hope of improving the diagnosis and treatment of such psychiatric conditions as major depression.
- Conditions
- Psychotic Disorders, Depressive Disorder, Depressive Disorder, Major
- Trial name
- NCT00691535
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Stanford University
Cytochrome P450 CYP3A5 Enzyme Polymorphism, Healthy Subjects
Polymorphic Effects of Cytochrome P450 3A5 on Pharmacokinetics of Maraviroc and Its Metabolites
The purpose of this study is to evaluate the influence of genetic polymorphism of cytochrome P450 3A5 on pharmacokinetics of maraviroc and its oxidative metabolites
- Conditions
- Cytochrome P450 CYP3A5 Enzyme Polymorphism, Healthy Subjects, Pharmacokinetics of Maraviroc
- Trial name
- NCT01980329
- Testing
- Maraviroc
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
STEMI, Microvascular Coronary Artery Disease
The 3q25 rs2305619 Polymorphism Associates With Microvascular Obstruction in STEMI
The investigators enrolled 217 patients with acute STEMI undergoing primary PCI. The rs2305619 polymorphism was evaluated by real time PCR and plasma PTX3 concentration was assessed by human PTX3 ELISA kit.
- Trial name
- NCT03907722
- Testing
- Long pentraxin 3
- Where
- Indonesia
- Volunteers
- 217 people
- Sponsor
- Indonesian Cardiovascular Research Center
Germ Cell Cancer
Toxicity Attributed to Genetic Polymorphisms in Testicular Germ Cell Tumor Survivors
The purpose of this study is to identify genetic variations in survivors of testicular cancer and connect these variations to differences in risks of late effects.
- Trial name
- NCT02303015
- Where
- Denmark
- Volunteers
- 430 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Pain
Genetic Basis For Variation In NSAID Analgesia In A Clinical Model Of Acute Pain
This study will evaluate how genetic makeup contributes to the variation in people regarding their sensitivity to and experience of pain.
- Trial name
- NCT00115752
- Testing
- Valdecoxib, COX Inhibitor
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- National Institute of Nursing Research (NINR)
Myocardial Infarction
Effect of Renin Angiotensin Aldosterone System Genetic Polymorphism on the Pharmacological Effect of Mineralocorticoid Receptor Antagonists in Patients With Myocardial Infarction
Early treatment of Myocardial Infarction patients with mineralocorticoid receptor antagonist with help reduces the incidence of cardiac remodeling and development into heart failure.
- Trial name
- NCT05873400
- Where
- Egypt
- Volunteers
- 102 people
- Sponsor
- Ain Shams University
Heart Failure - NYHA II - IV, Cardiac Fibrosis
Effect of Genetic Polymorphism on the Clinical Outcome to SGLT2 Inhibitors in Heart Failure Patients
Heart failure with reduced ejection fraction (HFrEF) is a significant cause of morbidity and mortality. Sodium-glucose co-transporter-2 (SGLT2) inhibitors have demonstrated efficacy in improving renal outcomes in patients with…
- Conditions
- Heart Failure - NYHA II - IV, Cardiac Fibrosis, Cardiac Remodeling
- Trial name
- NCT06901609
- Testing
- SGLT2 inhibitor (Dapagliflozin 10mg)
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Ain Shams University
COVID 19 Associated Coagulopathy
Prevalence of Thrombophilic Gene Polymorphism (MTHFR C677T) in COVID-19patients
Aim of the study is to find the prevalence of thrombophilic gene methylene tetrahydrofolate reductase (MTHFR) gene polymorphism in a sample of COVID-19 patients, aiming at early detection of MTHFR mutant patients and guiding…
- Trial name
- (MTHFR)C677T (NCT05679414)
- Testing
- RT- PCR of 2 ml EDTA blood sample to determine MTHFR C677T genotypes
- Where
- Egypt
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Thyrotoxicosis
Trial to Evaluate the Efficacy of a Zinc, Selenium, and L-Tyrosine Supplement in the Prevention of Thyrotoxicosis in Subjects With r25191G/A SEPP1 Polymorphism
This randomized, double-blind, placebo-controlled trial evaluates the efficacy of a zinc, selenium, and L-tyrosine supplement in preventing thyrotoxicosis among adults aged 18-85 with elevated TPOAb levels and the r25191G/A SEPP1…
- Trial name
- ZEST-PREP (NCT06264544)
- Testing
- zinc, selenium, and L-tyrosine in SEPP1
- Where
- Russia
- Volunteers
- 150 people
- Sponsor
- S.LAB (SOLOWAYS)
Polymorphosis, Cognitive Function
Effect of Gene Polymorphism on Cognitive Function
The goal of this observational study is to study the effect of gene polymorphism on cognitive improvement in response to exercise in healthy participants.
- Trial name
- NCT05879341
- Testing
- High intensitiy interval training
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Age-Related Macular Degeneration
Vascular Endothelial Growth Factor (VEGF) & LOC387715/HTRA1 Polymorphism in Polypoidal Choroidal Vasculopathy
This study is to investigate whether there is an association of the LOC387715/HTRA1 and vascular endothelial growth factor polymorphism with response to treatment with intravitreal ranibizumab injections for patients with…
- Trial name
- NCT01233128
- Where
- South Korea
- Volunteers
- 121 people
- Sponsor
- Kyungpook National University Hospital
Lymphoma
Biomarkers in Predicting Response to Rituximab Treatment in Samples From Patients With Indolent Follicular Lymphoma
RATIONALE: Studying samples of blood and tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT01381705
- Testing
- rituximab, DNA analysis, gene expression analysis
- Volunteers
- 259 people
- Sponsor
- ECOG-ACRIN Cancer Research Group