Clinical trials: Genetics Predisposition
Rheumatoid Arthritis, Leukocytes, Mononuclear
Genetics and Mechanisms of Rheumatoid Arthritis
The study is aimed at revealing genetic background in rheumatoid arthritis (RA). For that purpose samples of DNA will be collected from 500 RA patients and similar number of controls from whole Slovakia.
- Conditions
- Rheumatoid Arthritis, Leukocytes, Mononuclear, Genetic Association Studies
- Trial name
- RASGENAS (NCT01788098)
- Where
- Slovakia
- Volunteers
- 790 people, healthy volunteers welcome
- Sponsor
- Slovak Academy of Sciences
Multiple Sclerosis
Genes and Environment in Multiple Sclerosis
The purpose of the research study is to identify the genetic, environmental and immune profiles that may increase a person's risk of developing multiple sclerosis (MS).
- Trial name
- GEMS (NCT01353547)
- Where
- 5 sites in United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Columbia University
Prostate Cancer, Genetic Predisposition
Prostate Tissue BioBank
Prostate cancer is also the most common cancer in men with inherited pathogenic variants in BRCA1 and BRCA2. Beyond BRCA1/2, other genes are known to increase the risk of prostate cancer, including ATM, TP53 and HOXB13.
- Trial name
- PTBB (NCT06659614)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Breast Carcinoma, Genetic Predisposition to Cancer
MEASUREMENT OF CIRCULATING MUTATION BURDEN
Cancer-free women with a hereditary predisposition to breast and/or ovarian cancer
- Conditions
- Breast Carcinoma, Genetic Predisposition to Cancer, BRCA Mutation, cfMB
- Trial name
- cRISK (NCT06792721)
- Testing
- Mutation Burden cfMB analysis
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Centre Francois Baclesse
Metabolic Disease, Nutrition Disorders
Observational Study on a Chinese Population
An observational study was conducted in a health examination center to distinguish risk factors for health in a randomly recruited volunteers of Chinese population.
- Conditions
- Metabolic Disease, Nutrition Disorders, Genetic Predisposition to Disease
- Trial name
- NCT03406234
- Testing
- No intervention.
- Where
- China
- Volunteers
- 2,650 people, healthy volunteers welcome
- Sponsor
- Shenzhen Center for Chronic Disease Control
Infectious Disease
Genetic Susceptibility to Severe Infections
Only a fraction of individuals infected with microbes develop clinical disease. This observation raises fundamental questions about the pathogenesis of infectious diseases.
- Trial name
- PREDISPOSITI (NCT06102070)
- Testing
- Blood samples drawing, Skin biopsy
- Where
- France
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Heart; Dysfunction Postoperative, Cardiac Surgery, Genetic Predisposition to Disease
Identification of Genomic Predictors of Adverse Events After Cardiac Surgery
This study aims to identify genetic causes of adverse events after cardiac surgery, such as atrial fibrillation, myocardial infarction, renal dysfunction and heart failure.
- Conditions
- Heart; Dysfunction Postoperative, Cardiac Surgery, Genetic Predisposition to Disease, Atrial Fibrillation, Myocardial Infarction
- Trial name
- CABGGenomics (NCT01258231)
- Where
- 3 sites in United States
- Volunteers
- 4,000 people
- Sponsor
- Brigham and Women's Hospital
ALL, Childhood, Pediatric Cancer
Pharmacogenomic Association Study in Indian Children With Acute Lymphoblastic Leukemia
A five-year prospective observational cohort study. The study is focused on observing the relation between static germline variants and therapeutic response in Indian children with acute lymphoblastic leukemia (ALL).
- Conditions
- ALL, Childhood, Pediatric Cancer, Toxicity, Drug, Adverse Drug Event
- Trial name
- MPGx-INDALL (NCT05512169)
- Where
- 2 sites in India
- Volunteers
- 556 people
- Sponsor
- University of Geneva, Switzerland
Genetic Predisposition, Carrier, Gestational
Prevalence of Carriers of Genetic Diseases in the Mexican Jewish Community
The Jewish Population is at an increased risk for genetic diseases, especially autosomal recessive, thus, screening should be done to determine carrier status of several genetic diseases.
- Trial name
- NCT04307719
- Where
- Mexico
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Anahuac University
Meningioma
Androcur® (Cyproterone Acetate) and Meningioma Development: a Genotype-environment Association Study
The primary objective of the study is to create a biobank of oral smears permitting to identify the genetic locus/loci associated with an increased risk to develop meningiomas after cyproterone acetate (CPA) (Androcur®)…
- Trial name
- ANDROMEDE-F (NCT04372095)
- Testing
- oral smears
- Where
- France
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hereditary Cancer Syndrome, Hereditary Breast and Ovarian Cancer
Evaluation of the Adhesion to the GENEPY Network
In order to best meet the needs of all those affected by the genetic risk of cancer in our region, it is important to identify the factors likely to influence the course leading to the GENEPY surveillance network.
- Conditions
- Hereditary Cancer Syndrome, Hereditary Breast and Ovarian Cancer, Hereditary Colorectal Endometrial Cancer Syndrome
- Trial name
- GENEPY (NCT03979612)
- Testing
- inclusion of subjects in the GENEPY network
- Where
- France
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Institut Claudius Regaud
Diabetes Mellitus, Type 2
Comparative Metabolomics in Diabetes Patients From Sri Lanka and Switzerland
This study is a case-control study, where the assumed different subtypes of type 2 diabetes in people of Tamil ethnicity and Swiss origin living in Bern, Switzerland will be examined by measuring the metabolite profiles and the…
- Trial name
- NCT05787457
- Testing
- Clinical examination, Blood testing, MRI
- Where
- Switzerland
- Volunteers
- 34 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Systemic Lupus Erythematosus
Hormonal and Environmental Risk Factors for Developing Systemic Lupus Erythematosus: The Carolina Lupus (CLU) Study
Systemic lupus erythematosus (SLE) is severe, chronic, disabling autoimmune disease that significantly affects health status and quality of life.
- Trial name
- NCT00342095
- Where
- 6 sites in United States
- Volunteers
- 640 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Prostate Cancer, Hereditary Prostate Cancer
Targeted Prostate Cancer Screening in Men With BRCA1/2 Mutations
This interventional study is a follow-up component of the IMPACT project, which aims to identify men at increased hereditary risk of prostate cancer.
- Trial name
- IMPACT (NCT07416812)
- Testing
- Targeted Prostate Cancer Screening, Telephone Follow-Up Interview
- Where
- Slovenia
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Institute of Oncology Ljubljana
Genetic Predisposition to Disease, Environment
Correlation Between Psychological Resilience and Genetic, Inflammatory Indicators
The goal of this observational study is to evaluate and analyze the influencing factors of the adaptive ability of young people, explore the impact of the interaction of environment and gene on the psychological adaptive ability…
- Conditions
- Genetic Predisposition to Disease, Environment, Adaptation, Psychological, Inflammation
- Trial name
- NCT06193005
- Testing
- no intervention
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Qianfoshan Hospital
Alcoholism, HIV Infection
Genetic Factors and Interrelationships for Sexual Orientation, Susceptibility to HIV and Kaposi's Sarcoma, Alcoholism and Psychological Traits, and Histocompatibility Antigens
We propose to test, by DNA linkage analysis of family pedigree members, the following interrelated hypotheses: 1) that sexual orientation is genetically influenced; 2) that the development of Kaposi's sarcoma and other outcomes…
- Conditions
- Alcoholism, HIV Infection, Homosexuality, Kaposi's Sarcoma
- Trial name
- NCT00001294
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Total Joint Arthroplasty, Periprosthetic Joint Infections
Genetic Susceptibility to Periprosthetic Joint Infections
The investigators primary objective is to identify genetic factors that may increase the risk of patients developing a periprosthetic joint infections (PJI) following total joint arthroplasty (TJA).
- Trial name
- NCT05159739
- Testing
- Blood Draw or Saliva/Cheek Cell Sample:
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Utah
Breast Cancer
Genetic and Non-Genetic Breast Cancer Risk Prediction Evaluation in Indonesian Samples
Breast cancer is the most common cancer and cause of cancer- related deaths among women, accounting for 1.67 million (25.2%) new cases and 521,907 (14.7%) deaths worldwide.
- Trial name
- NCT05570266
- Testing
- Breast Cancer Risk Prediction Software
- Where
- Indonesia
- Volunteers
- 322 people, healthy volunteers welcome
- Sponsor
- Nalagenetics Pte Ltd
Atrial Fibrillation
The Influence of Genetic Predisposition on Outcome After Catheter Ablation of Atrial Fibrillation.
Catheter ablation is an established standard therapy in interventional treatment of atrial fibrillation.The trial investigates the influence of genetic risk for the recurrence of atrial fibrillation after catheter ablation.
- Trial name
- AF GEN (NCT04753541)
- Testing
- no intervention
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Cancer, Genetic Predisposition
EXOME Analysis Position in the Strategy of Genetic Predisposition Factors Identification in Early-onset Cancer
5 to 10% of cancers are due to the presence of a constitutional genetic alteration. It can be inherited from parents (family form) or by accident, in the first moments of life after fertilization (sporadic form).
- Trial name
- EX²TRICAN (NCT04141462)
- Testing
- blood sample
- Where
- 6 sites in France
- Volunteers
- 613 people
- Sponsor
- Centre Georges Francois Leclerc