Clinical trials: Genetics Predisposition
Coronary Heart Disease
Rapid Engagement for Solutions to Population and Outcomes Through Networked Dialogue for Coronary Heart Disease
Cardiometabolic diseases are major causes of morbidity and mortality in the state of Wisconsin and are expected to pose an increasing burden over the next few decades.
- Trial name
- RESPOND (NCT07260552)
- Testing
- Polygenic risk score
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Lymphedema Arm
Integrating Clinical, Protein Expression, and Genetic Markers to Predict Lymphedema in Breast Cancer
The goal of this observational ambidirectional cohort study is to develop a prediction model to identify the risk of lymphedema after axillary lymph node dissection (ALND) in patients with breast cancer.
- Trial name
- NCT07252843
- Where
- Indonesia
- Volunteers
- 133 people
- Sponsor
- Dharmais National Cancer Center Hospital
Genetic Predisposition, Genetic Hypertension
Impact of a Family History of Hypertension and Physical Activity on Left Ventricular Mass
This is a retrospective analysis of data collected within two previous studies. The data has been combined and used to investigate the impact of having a family history of hypertension on left ventricular muscle mass with and…
- Trial name
- NCT05334355
- Testing
- Family history of hypertension
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Montclair State University
Lung Cancer, Single Primary Lung Cancer
DNA Repair and Genetic Susceptibility to Lung Cancer
The purpose of this study is to help us better understand the cellular changes that may lead to the development of lung cancer. We want to compare people with a second primary lung cancer with those who have only a first primary…
- Conditions
- Lung Cancer, Single Primary Lung Cancer, Second Primary Lung Cancer
- Trial name
- NCT00611598
- Testing
- Blood draw and Questionnaires
- Where
- United States
- Volunteers
- 218 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Pelvic Organ Prolapse
Do Patients With Early Post Operative Recurrence of Pelvic Organ Prolapse Have a Genetic Predisposition?
The objective is to explore the genetic predisposition to early pelvic organ prolapse after adequate surgical repair by exploring the association between pelvic organ prolapse recurrences and certain polymorphisms.
- Trial name
- NCT01614587
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Atlantic Health System
Huntington Disease
Clinicopathological MRI and CSF Correlates in Huntington's Disease.
In this study the investigators will link brain iron levels obtained from quantitative susceptibility maps of HD patients with specific and well-known clinical CSF markers for iron accumulation, neurodegeneration and…
- Trial name
- NCT05534139
- Testing
- 7T MRI-scan, CSF collection via lumbar puncture, Blood withdrawal
- Where
- Netherlands
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Cystic Fibrosis, Venous Thrombosis
Cystic Fibrosis and Totally Implantable Vascular Access Devices
The purpose of this study is to evaluate the incidence of venous thrombosis occurring on totally implantable vascular access devices in cystic fibrosis patients who need a new device (it can be the first one or a subsequent one)…
- Trial name
- RITHM (NCT00244270)
- Testing
- totally implantable vascular access device
- Volunteers
- 97 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Alcohol Use Disorder
Understanding Genetic Risk for Alcohol Use Disorder
The purpose of this study is to evaluate an online educational tool that will help individuals better understand alcohol use disorder, risk factors, and genetic risk information and to better understand participant's beliefs…
- Trial name
- NCT05143073
- Testing
- Alcohol use disorder and strategies to reduce risk educational material, Complex polygenic risk scores, alcohol use disorder, and strategies to reduce risk educational material
- Where
- United States
- Volunteers
- 338 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Whole Body Imaging, Cancer
Developing a Whole-body MRI and Diffusion-weighted Imaging State-of-the-art Protocol: a Pilot Study
Whole-body magnetic resonance imaging (WB-MRI) is a non-ionizing imaging method that can provide WB coverage using essential imaging contrasts with the possibility to include sequences focusing in specific body-regions as needed…
- Conditions
- Whole Body Imaging, Cancer, Genetic Predisposition
- Trial name
- WANDA (NCT06533189)
- Testing
- Enhanced Diffusion Software
- Where
- 2 sites in Italy
- Volunteers
- 120 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Glioblastoma
Key Longitudinal Associations With Risk and Glioblastoma Outcomes
The goal of this observational study is to find out what factors affect the health and risks in adults with glioblastoma (GBM), a grade 4 brain cancer.
- Trial name
- Key LARGO (NCT06625684)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Duke University
Genetic Predisposition to Disease, Celiac Disease
Gluten-free Diet in Gluten-genetically Predisposed Subjects
Undetected or untreated CD may cause severe complications later in life, such as autoimmune disorders. It is recommended for subjects with autoimmune diseases or at risk for CD to be screened for CD and to repeat serological…
- Trial name
- NCT00677495
- Testing
- Gluten-free diet
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS Burlo Garofolo
Gestational Diabetes, Pregnancy Complications
OneinSeven Gestational Diabetes Genetic and Socioeconomic Risk Study
The objective of the Gestational Diabetes Genetic Socioeconomic Risk Study is to generate genome wide association study data (GWAS) to calculate polygenic risk scores (PRS) for the development of gestational diabetes in pregnant…
- Conditions
- Gestational Diabetes, Pregnancy Complications, Pregnancy Related, Genetic Predisposition
- Trial name
- NCT04789473
- Testing
- Polygenic Risk Score Generation
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- Prenome
Hypercholesterolemia
Pharmacogenomic Informed Statin Prescribing
Statins are the most cost-effective medications to lower cholesterol and cardiovascular disease (CVD) risk. However, many patients at high-risk for CVD do not accept or adhere to statins.
- Trial name
- NCT06568601
- Testing
- Pharmacogenetic and polygenic risk testing, Active control
- Where
- 2 sites in United States
- Volunteers
- 214 people
- Sponsor
- VA Office of Research and Development
Influenza A Virus/H5N1 Subtype
Host Genetic Susceptibility to Avian Influenza A/H5N1
The identification and characterization of susceptibility loci for H5N1 infection in humans could have profound implications. The detection of host genetic factors may shed light on key pathogenic interactions between H5N1 and…
- Trial name
- NCT01074736
- Where
- Vietnam
- Volunteers
- 500 people
- Sponsor
- South East Asia Infectious Disease Clinical Research Network
Genetic Testing, BRCA1/2
Responses to Genetic Risk Modifier Testing Among Women With Pathogenic Variants in Breast Cancer Predisposition Genes
The purpose of this study is to describe how women with BRCA1/2 mutations react to genetic risk modifier testing, and to examine how they make decisions about their healthcare.
- Trial name
- NCT03396341
- Testing
- Salvia sample, Questionnaires, Buccal swab sample
- Where
- 7 sites in United States
- Volunteers
- 806 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Medulloblastoma, Central Nervous System Tumor, Pediatric
Genetic and Molecular Risk Profiles of Pediatric Malignant Brain Tumors in China
Primary malignant central nervous system (CNS) tumors are the second most common childhood malignancies. Amongst, medulloblastomas are the most common malignant brain tumor of childhood and occur primarily in the cerebellum.
- Conditions
- Medulloblastoma, Central Nervous System Tumor, Pediatric, Ependymoma, Germ Cell Tumor
- Trial name
- GRIPP (NCT05672043)
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Beijing Tiantan Hospital
Alzheimer Disease
Combined Aerobic Exercise and Cognitive Training in Seniors With Genetic Susceptibility for Alzheimer's Disease
The study aims to investigate the effect of a long-term combined aerobic exercise and cognitive training program on cognitive function, daily function, psychosocial status, and neural plasticity in seniors with genetic…
- Trial name
- NCT05163067
- Testing
- Combined aerobic exercise and cognitive training program
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xuanwu Hospital, Beijing
Thyroid Neoplasms, Genetic Susceptibility
Genetic Susceptibility to Radiation Induced Thyroid Cancer
Case control on thyroid cancer occuring in a cohort of 7300 subjects treated during their childhood, mostly by radiotherapy, for a skin Angioma at Gustave Roussy, Villejuif France between 1947 and 1973.
- Conditions
- Thyroid Neoplasms, Genetic Susceptibility, Radiation Exposure
- Trial name
- NCT04139096
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Genetic Predisposition to Disease, Genetic Predisposition
Enhancing Information Management for Young Adults After Genetic Cancer Risk Testing
This research is being done to develop the electronic platform Nest for young adults (ages 18-39) who have had prior cancer genetic testing.
- Trial name
- NCT05759143
- Testing
- Nest Platform
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute
Genetic Disease, Genetic Predisposition
Overcoming Barriers to Accessing Genetic Medicine
To learn about patient barriers to accessing genetic medicine, we will analyze anonymous posts from a membership-based online community [Inspire.com], and investigate how these barriers differ for various populations.
- Trial name
- NCT05064241
- Testing
- Access to Genetic Counselor for answering questions
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Boston Children's Hospital