Clinical trials: Genital Infection
Infertility, Female, Pelvic Inflammatory Disease
Effect of Prophylactic Antibiotics for Hysterosalpingography on Post Procedure Morbidity
The study will be a parallel randomised trial. There are two groups. The first group will be given prophylactic antibiotics before a procedure (hysterosalpingography) and the second group will be given a placebo(multivitamin).
- Trial name
- NCT04234945
- Testing
- Doxycycline Capsule, Multivitamins W/Iron Tab
- Where
- Nigeria
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Ahmadu Bello University Teaching Hospital
Infections, Papillomavirus
Evaluation of Immunogenicity and Safety of Two 2-dose Human Papillomavirus (HPV) Vaccine Schedules in 9-14 Year Old Girls
This study has been designed to evaluate the immunogenicity and safety of GSK Biologicals' HPV-16/18 vaccine when administered according to alternative 2-dose schedules (0,6 months and 0,12 months) in healthy 9-14 year old…
- Trial name
- NCT01381575
- Testing
- GSK Biologicals' HPV vaccine 580299
- Where
- 33 sites in Canada, Germany and 3 more
- Volunteers
- 1,447 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
HIV/AIDS
PrEPared and Strong: Clinic-Based PrEP for Black MSM
Black men who have sex with men (MSM) have among the highest rates of new HIV infections of any group in the United States. Developing effective HIV prevention interventions that work with this group is a critical element of the…
- Trial name
- P&S (NCT02167386)
- Testing
- Enhanced PrEP Adherence, Standard PrEP Adherence
- Where
- 2 sites in United States
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Columbia University
HIV Seropositivity
A Multilevel, Multiphase Optimization Strategy for PrEP (MOST:PrEP)
What is known: There are 1.2 million people in the US who meet the indications for PrEP; yet, disparities exist in uptake. For example, only 9% of Black and 16% of Latino individuals, compared to 65% of White individuals, have…
- Trial name
- MOST:PrEP (NCT06334341)
- Testing
- Computer-based simulation training for providers, Best Practice Alert, HIV Risk Assessment
- Where
- United States
- Volunteers
- 1,380 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
HIV Infections
A Randomized Phase II Study of Two Doses of Interferon Alfa-2a (IFN Alfa-2a) in Combination With Zidovudine (AZT) and Dideoxycytidine (ddC) Versus AZT and ddC Only in Patients With HIV Infection and Less Than 400 CD4 Cells/mm3
To determine the safety and efficacy of two doses of interferon alfa-2a ( IFN alfa-2a ) in combination with zidovudine ( AZT )/zalcitabine ( ddC ) versus AZT/ddC only in patients with HIV infection and CD4 count < 400 cells/mm3.
- Trial name
- NCT00000754
- Testing
- Interferon alfa-2a, Zidovudine, Zalcitabine
- Where
- 4 sites in United States
- Volunteers
- 60 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Impaired Cognition, HIV Infection
Mindfulness Based Stress Reduction for Older Adults With HIV Associated Neurocognitive Disorders
The purpose of this study is to determine the efficacy of Mindfulness Based Stress Reduction (MBSR) to alleviate stress, anxiety, and depressive symptoms, and improve attention among patients aged 60 or older who suffer from…
- Trial name
- NCT02936401
- Testing
- MBSR
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of California, San Francisco
HIV Infections
Phase I Trial of the Combination of Zidovudine and Recombinant Interleukin-2 in Patients With Persistent Generalized Lymphadenopathy
To evaluate the short-term effects of administering zidovudine ( AZT ) at the same time with increasing doses of aldesleukin ( interleukin-2; IL-2 ) in patients with persistent generalized lymphadenopathy syndrome ( PGL ).
- Trial name
- NCT00000728
- Testing
- Zidovudine, Aldesleukin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Chlamydia Trachomatis, Gonorrhea
Home Screening for Chlamydia Surveillance
This is a randomized controlled trial to determine whether a home screening test for chlamydia and gonorrhea will lead to increased use of screening tests and increased detection of sexually transmitted diseases.
- Trial name
- NCT00177437
- Testing
- home testing kit
- Where
- United States
- Volunteers
- 403 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
HPV Infection, HPV Vaccine
Intradermal, Fractional Dose of HPV Vaccines:
This randomized phase IV trial compares fractional dose of bivalent HPV vaccine to fractional dose of nonavalent HPV vaccine among men and women aged 27-45 years in Seattle, Washington.
- Trial name
- NCT04235257
- Testing
- HPV vaccine
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Washington
Human Papillomavirus (HPV) Infection
HPV Detection Using Self-Collected Menstrual Blood
This study is evaluating whether human papillomavirus (HPV) can be accurately detected from self-collected menstrual blood samples.
- Trial name
- NCT07733557
- Testing
- Endometrics Menstrual Blood Collection Kit
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Samantha Batman
HIV Positive
Safety and Effect on HIV Transcription of Vorinostat in Patients Receiving Suppressive Combination Anti-retroviral Therapy
The objective of the study is to assess the safety and ability of vorinostat, a drug currently licensed for the treatment of a type of lymphoma, to 'turn on' dormant HIV infected CD4 T-cells.
- Trial name
- NCT01365065
- Testing
- Vorinostat
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- Bayside Health
HPV Infection
Assessing Administration of pBI-11 Via Electroporation for the Treatment of Patients With HPV16/18+
This research is being done to test the safety and feasibility of an investigational DNA vaccine called pBI-11 and to find out what effects, if any, it has on women with persistent human papillomavirus 16 (HPV16+) and/or human…
- Trial name
- NCT06210854
- Testing
- pBI-11 (3 doses), pBI-11 (1 dose)
- Where
- 2 sites in United States
- Volunteers
- 48 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Acquired Immunodeficiency Syndrome
Clinical Trial of Recombinant Adenovirus Type 5 AIDS Vaccine
This is a randomized, double-blind placebo-controlled dose-escalation clinical trial to evaluate the safety and the immunogenicity of Adenoviral vector 5 HIV-1 vaccines in subjects receiving stable highly active antiretroviral…
- Trial name
- NCT02762045
- Testing
- Ad5-gag
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Centers for Disease Control and Prevention, China
Human Papillomavirus Infection, Cervical Intraepithelial Neoplasia (CIN)
Dual-Modality Immunotherapy for HPV Clearance (DUAL-HPV)
Persistent high-risk human papillomavirus infection is an important precursor of cervical cancer and related cervical lesions. This single-center, randomized, assessor-blinded, parallel-group controlled trial evaluates whether…
- Conditions
- Human Papillomavirus Infection, Cervical Intraepithelial Neoplasia (CIN), Low-Grade Squamous Intraepithelial Lesions
- Trial name
- DUAL-HPV (NCT07735039)
- Testing
- Oral Immunomodulator, Vaginal Ovule, Standard Supportive Care
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
HIV Infections
The Effectiveness of Ritonavir Plus Zidovudine Plus Lamivudine in HIV-Infected Patients
To determine whether administration of a highly active antiretroviral treatment regimen consisting of ritonavir (ABT-538), zidovudine (AZT), and lamivudine (3TC) is associated with the restoration of delayed type hypersensitivity…
- Trial name
- NCT00001075
- Testing
- Ritonavir, Lamivudine, Zidovudine
- Where
- 3 sites in United States
- Volunteers
- 55 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Papillomavirus Infections
Phase I of Human Papillomavirus (HPV) DNA Plasmid (VGX-3100) + Electroporation for CIN 2 or 3
DNA vaccines, which are small pieces of DNA also known as plasmids, have several advantages over traditional vaccines such as live attenuated virus and recombinant protein-based vaccines.
- Trial name
- NCT00685412
- Testing
- VGX-3100
- Where
- 4 sites in United States, Puerto Rico
- Volunteers
- 18 people
- Sponsor
- Inovio Pharmaceuticals
Infection, Human Immunodeficiency Virus, HIV Infections
An Efficacy, Safety, and Tolerability Study Comparing Dolutegravir Plus Lamivudine With Dolutegravir Plus Tenofovir/Emtricitabine in Treatment naïve HIV Infected Subjects (Gemini 1)
This study will compare safety, efficacy, and tolerability of a two drug regimen of dolutegravir (DTG) plus (+) lamivudine (3TC) administered once daily with DTG plus two nucleoside reverse transcriptase inhibitors (Tenofovir…
- Trial name
- NCT02831673
- Testing
- Dolutegravir (DTG), Lamivudine (3TC), Tenofovir disoproxil fumarate/Emtricitabine (TDF/FTC FDC)
- Where
- 90 sites in United States, Argentina and 16 more
- Volunteers
- 719 people
- Sponsor
- ViiV Healthcare
HIV Infections
Long-Term Supervised Treatment Interruption in HIV-Infected Patients
This trial is aimed at studying the safety of long term supervised treatment interruption in HIV infected patients with CD4 over 350/mm3 and plasma HIV RNA under 50 000/mL.
- Trial name
- NCT00118677
- Testing
- Treatment interruption
- Where
- France
- Volunteers
- 130 people
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
HIV Infections
Open-Label Program of Dideoxycytidine ( ddC ) to Be Used in Combination With Zidovudine ( AZT ) for Treatment of Advanced HIV Disease
To provide zalcitabine ( dideoxycytidine; ddC ) for use with zidovudine ( AZT ) in patients with advanced HIV infection. To observe serious toxicities in this population.
- Trial name
- NCT00002081
- Testing
- Zidovudine, Zalcitabine
- Where
- United States
- Sponsor
- Hoffmann-La Roche
HIV Infections
Non-virologic Methods to Diagnose Treatment Eligibility in HIV-exposed Infants
This study is designed to develop and evaluate a set of non-virologic diagnostic algorithms to monitor HIV-exposed children of unknown infection status for treatment eligibility during the first year of life.
- Trial name
- IDX (NCT01222130)
- Where
- 3 sites in Zambia
- Volunteers
- 1,126 people
- Sponsor
- University of North Carolina, Chapel Hill
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