Clinical trials: Genital Infection
Cytomegalovirus Retinitis, HIV Infections
Studies of Ocular Complications of AIDS (SOCA)--Ganciclovir-Cidofovir CMV Retinitis Trial (GCCRT)
To compare the newest CMV retinitis drug, cidofovir, with a regimen of the ganciclovir intraocular device plus oral ganciclovir with respect to efficacy in preventing vision loss.
- Trial name
- GCCRT (NCT00000143)
- Testing
- Ganciclovir implant and oral ganciclovir, Cidofovir intravenous
- Where
- 19 sites in United States
- Volunteers
- 61 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
HIV Infections, Osteopenia
Bisphosphonate Therapy for HIV-Infected Adults With Decreased Bone Mineral Density
Bisphosphonates are a type of drug used to prevent and treat bone loss. The purpose of this study is to determine if zoledronate, an investigational bisphosphonate, can improve bone mineral density (BMD) in HIV-infected adults.
- Conditions
- HIV Infections, Osteopenia, Osteoporosis
- Trial name
- NCT00102908
- Testing
- Zoledronate
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Breastfeeding, Exclusive, HIV Infections
Mobile Phone Text Messaging Plus Motivational Interviewing: Effects on Breastfeeding, Child Health Outcomes
Background Lack of breastfeeding, at a minimum, doubles the risk of infant death in the first six months of life. Many infants in low resourced settings at high risk of infectious disease morbidity and death are deprived of the…
- Trial name
- MTM-MI (NCT05063240)
- Testing
- Mobile phone text messaging plus prospective motivational interviewing, Standard infant feeding counselling
- Where
- South Africa
- Volunteers
- 275 people
- Sponsor
- University of Stellenbosch
Hepatitis C, HIV Infections
Peginterferon Alfa-2a, Ribavirin and Epoetin β in Coinfected Patients HCV/HIV Not Responding to Previous Treatment Regimens
This trial will assess the sustained virologic response to treatment with peginterferon alfa-2a combined with high-dose ribavirin in human immunodeficiency virus (HIV)-infected patients with hepatitis C virus (HCV) genotype 1 or…
- Trial name
- NCT00470210
- Testing
- Peginterferón alfa-2a (40 KD) (Pegasys®) 180 ug/week, Ribavirin (Copegus®) 1600 mg/day, Epoetin β (450 UI/kg/week)
- Where
- 2 sites in Spain
- Volunteers
- 10 people
- Sponsor
- Germans Trias i Pujol Hospital
Bacterial Vaginoses
Treatment of BV With Donaxyl and a Molecular Test of Cure
. Treatment with dequalinium chloride vaginal tablets for 6 days had a cure rate lower than expected; only 37% of patients were considered cured one month after treatment.
- Trial name
- NCT04057482
- Testing
- D
- Volunteers
- 58 people
- Sponsor
- Skaraborg Hospital
HIV Infections
Differences in Blood Levels of Lopinavir/Ritonavir in HIV Infected Men and Women
Men's and women's bodies may process anti-HIV drugs differently. The purpose of this study is to determine the differences in blood levels of soft gel capsules and tablets of lopinavir/ritonavir (LPV/r) in HIV infected men and…
- Trial name
- NCT00102986
- Testing
- Lopinavir/ritonavir
- Where
- 29 sites in United States, Puerto Rico
- Volunteers
- 116 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Cancer
Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation
RATIONALE: Giving itraconazole or fluconazole may be effective in preventing infections in patients undergoing peripheral stem cell or bone marrow transplantation.
- Trial name
- NCT00003883
- Testing
- fluconazole, itraconazole
- Where
- 2 sites in United States
- Volunteers
- 578 people
- Sponsor
- Fred Hutchinson Cancer Center
HIV Infection
Modulating the Impact of Critical Events in Early HIV Infection: Effect of ART Initiation and Alcohol Use
The overall objective is to determine the influence of timing of ART initiation and alcohol consumption on HIV disease course. ART initiation immediately after HIV infection largely results in smaller HIV reservoir and lower…
- Trial name
- MERLIN (NCT02744040)
- Testing
- ART initiation at time of HIV diagnosis, ART at 24 weeks
- Where
- Peru
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Covid19, Fertility Issues
Prospective Two-arm Study of Fertility in Men With COVID-19
COVID-19 infection is hypothesized to have a potentially negative effect on male fertility through direct damage to the testes. The current trial is aimed at investigating the effect of SARS-CoV-2 on fertility and determining if…
- Trial name
- NCT04716179
- Testing
- Sperm test, hormone levels (testosterone, FSH, LH, prolactin), SARS-CoV-2 Ig G levels
- Where
- Russia
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- I.M. Sechenov First Moscow State Medical University
HIV Infections
Safety and Acceptability of PRO 2000 Vaginal Gel in HIV Uninfected Women in India
PRO 2000 Gel is designed to be inserted into the vagina to protect women from getting HIV during sex. So far, PRO 2000 Gel has been tested for safety in 136 women from Europe and the United States.
- Trial name
- NCT00081640
- Testing
- PRO 2000/5 Gel (P)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Bacterial Vaginosis
Bacterial Vaginosis Home Screening to Prevent STDs
The purpose of this study is to determine whether regular screening (every 2 months) and treatment for bacterial vaginosis (BV [infection of the vagina]) will reduce the number of incidences of chlamydia and gonorrhea (sexually…
- Trial name
- NCT00667368
- Testing
- Metronidazole
- Where
- 7 sites in United States
- Volunteers
- 1,370 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV/AIDS, Tuberculosis
A Trial of Same-Day Testing and Treatment to Improve Outcomes Among Symptomatic Patients Newly Diagnosed With HIV
This is a randomized, unblinded study comparing standard vs. same-day treatment for patients with TB symptoms (cough, fever, night sweats, or weight loss) at HIV diagnosis.
- Trial name
- NCT03154320
- Testing
- Same-Day Treatment, Standard treatment
- Where
- Haiti
- Volunteers
- 500 people
- Sponsor
- Brigham and Women's Hospital
HIV Infections
Adherence Intervention for People With Low-literacy
Consistent adherence to antiretroviral therapy is necessary for treatment success. People with poor health literacy skills experience considerable difficulty adhering to their medications.
- Trial name
- NCT01061762
- Testing
- Stick To It, Standard medication adherence counseling, Health Counseling
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- University of Connecticut
AIDS Dementia Complex
Maraviroc and NeuroAIDS Pathogenesis
Maraviroc is an antiretroviral medication that may help in improving mental function in HIV infected patients with mental problems by decreasing inflammatory tendencies.
- Trial name
- NCT02159027
- Testing
- Maraviroc
- Where
- 2 sites in United States, Puerto Rico
- Volunteers
- 48 people
- Sponsor
- University of Hawaii
Hepatitis C, HIV Infection
Nucleic Acid Amplification Testing (NAT) of Blood Donors for HCV and HIV
This study will evaluate the accuracy of an experimental test method called nucleic acid amplification technology (NAT) in detecting human immunodeficiency virus (HIV) and hepatitis C virus (HCV).
- Trial name
- NCT00004846
- Testing
- ABC/Gen-Probe/Chiron HIV-1/HCV 001
- Where
- United States
- Volunteers
- 30,000 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
HIV Infections
A Test of Behavioral Intervention for Women at High Risk for HIV Infection
The purpose of this study is to find out if it is possible to conduct a group counseling program for women at risk for HIV infection. Women have been the fastest-growing group with new AIDS diagnoses.
- Trial name
- NCT00006440
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections, Influenza
Incidence of H1N1v Influenza-like Illness and Risk Factors for Serious Influenza Forms in HIV Infected Patients
To estimate the incidence of H1N1v influenza-like illness and to study the risk factors for serious influenza forms during pandemic period in French HIV infected patients.
- Trial name
- ANRS 2H (NCT01039220)
- Testing
- naso-pharyngeal swab
- Where
- France
- Volunteers
- 1,266 people
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
HIV-infection/AIDS
Vedolizumab Treatment in Antiretroviral Drug Treated Chronic HIV Infection
Background: In nearly all people with human immunodeficiency virus (HIV) infection, immunity cannot either control or eradicate the infection.
- Trial name
- HAVARTI (NCT03147859)
- Testing
- Vedolizumab (brand name Entyvio)
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Ottawa Hospital Research Institute
HIV Infections
Neurocognitive Assessment in Youth Initiating HAART
ATN 071 is a prospective cohort study comparing neurocognitive functioning in four groups of youth, age 18-24: Two groups with CD4+ T cells above 350 cells/mm3 and HIV RNA >1,000 copies/ml, one initiating HAART (Group 1) and the…
- Trial name
- NCT00683579
- Testing
- Early Treatment with HAART, No treatment, HAART Treatment - standard care
- Where
- 21 sites in United States, Puerto Rico
- Volunteers
- 220 people
- Sponsor
- University of North Carolina, Chapel Hill
Human Papilloma Virus Infection Type 11, Human Papilloma Virus Infection Type 16
HPV Vaccination: Evaluation of Reminder Prompts for Doses 2 & 3
Randomized, 2-arm observational study. The 2 arms (randomized at the level of health care provider) will be: 1. usual practice; 2.
- Conditions
- Human Papilloma Virus Infection Type 11, Human Papilloma Virus Infection Type 16, Human Papilloma Virus Infection Type 18, Human Papilloma Virus Infection Type 6
- Trial name
- NCT02558803
- Testing
- Simple Reminder
- Where
- 5 sites in United States
- Volunteers
- 1,305 people
- Sponsor
- Regenstrief Institute, Inc.
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